• 11671 Citations
  • 55 h-Index
1973 …2020

Research output per year

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Research Output

2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw

Elsayed, R., Kurago, Z., Cutler, C. W., Arce, R. M., Gerber, J., Celis, E., Sultan, H., Elashiry, M., Meghil, M., Sun, C., Auersvald, C. M., Awad, M. E., Zeitoun, R., Elsayed, R., Eldin M. Elshikh, M., Isales, C. & Elsalanty, M. E., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2595-2608 14 p.

Research output: Contribution to journalArticle

Open Access
2019

PD-L1-specific helper T-cells exhibit effective antitumor responses: New strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma

Hirata-Nozaki, Y., Ohkuri, T., Ohara, K., Kumai, T., Nagata, M., Harabuchi, S., Kosaka, A., Nagato, T., Ishibashi, K., Oikawa, K., Aoki, N., Ohara, M., Harabuchi, Y., Uno, Y., Takei, H., Celis, E. & Kobayashi, H., Jun 20 2019, In : Journal of Translational Medicine. 17, 1, 207.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

4 Scopus citations

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T. D., Kruse, E. J. & He, Y., Aug 2018, In : Hepatology. 68, 2, p. 574-589 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

Sultan, H., Wu, J., Kumai, T., Salazar, A. M. & Celis, E., Jul 1 2018, In : Cancer Immunology, Immunotherapy. 67, 7, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sustained persistence of il2 signaling enhances the antitumor effect of peptide vaccines through t-cell expansion and preventing pd-1 inhibition

Sultan, H., Kumai, T., Fesenkova, V. I., Fan, A. E., Wu, J., Cho, H. II., Kobayashi, H., Harabuchi, Y. & Celis, E., May 2018, In : Cancer Immunology Research. 6, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma

Ohara, K., Ohkuri, T., Kumai, T., Nagato, T., Nozaki, Y., Ishibashi, K., Kosaka, A., Nagata, M., Harabuchi, S., Ohara, M., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1466771.

Research output: Contribution to journalArticle

2017

Cancer immunotherapy: moving forward with peptide T cell vaccines

Kumai, T., Fan, A., Harabuchi, Y. & Celis, E., Aug 2017, In : Current Opinion in Immunology. 47, p. 57-63 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

Designing therapeutic cancer vaccines by mimicking viral infections

Sultan, H., Fesenkova, V. I., Addis, D., Fan, A. E., Kumai, T., Wu, J., Salazar, A. M. & Celis, E., Feb 1 2017, In : Cancer Immunology, Immunotherapy. 66, 2, p. 203-213 11 p.

Research output: Contribution to journalReview article

15 Scopus citations

Effective antitumor peptide vaccines can induce severe autoimmune pathology

Sultan, H., Trillo-Tinoco, J., Rodriguez, P. & Celis, E., Jan 1 2017, In : Oncotarget. 8, 41, p. 70317-70331 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-δ inhibition

Abu Eid, R., Ahmad, S., Lin, Y., Webb, M., Berrong, Z., Shrimali, R. K., Kumai, T., Ananth, S., Rodriguez, P. C., Celis, E., Janik, J. E., Mkrtichyan, M. & Khleif, S. N., Aug 1 2017, In : Cancer Research. 77, 15, p. 4135-4145 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site

Ohkuri, T., Kosaka, A., Ishibashi, K., Kumai, T., Hirata, Y., Ohara, K., Nagato, T., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 1 2017, In : Cancer Immunology, Immunotherapy. 66, 6, p. 705-716 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Veglia, F., Tyurin, V. A., Mohammadyani, D., Blasi, M., Duperret, E. K., Donthireddy, L., Hashimoto, A., Kapralov, A., Amoscato, A., Angelini, R., Patel, S., Alicea-Torres, K., Weiner, D., Murphy, M. E., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Dec 1 2017, In : Nature communications. 8, 1, 2122.

Research output: Contribution to journalArticle

21 Scopus citations

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses

Kumai, T., Lee, S., Cho, H. I., Sultan, H., Kobayashi, H., Harabuchi, Y. & Celis, E., Jan 2017, In : Cancer Immunology Research. 5, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Peptide vaccines in cancer — old concept revisited

Kumai, T., Kobayashi, H., Harabuchi, Y. & Celis, E., Apr 1 2017, In : Current Opinion in Immunology. 45, p. 1-7 7 p.

Research output: Contribution to journalReview article

29 Scopus citations

Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy

Nagato, T., Ohkuri, T., Ohara, K., Hirata, Y., Kishibe, K., Komabayashi, Y., Ueda, S., Takahara, M., Kumai, T., Ishibashi, K., Kosaka, A., Aoki, N., Oikawa, K., Uno, Y., Akiyama, N., Sado, M., Takei, H., Celis, E., Harabuchi, Y. & Kobayashi, H., Jul 1 2017, In : Cancer Immunology, Immunotherapy. 66, 7, p. 877-890 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2016

CD4 T Cells in Antitumor Immunity

Fesenkova, V., Sultan, H. & Celis, E., Apr 27 2016, Immunity to Pathogens and Tumors. Elsevier Inc., Vol. 4. p. 441-450 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Editorial: A matter of survival: HMGB1 regulates autophagy in tumor MDSC

Kumai, T., Celis, E. & Rodriguez, P. C., Sep 2016, In : Journal of Leukocyte Biology. 100, 3, p. 447-449 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy

Ishibashi, K., Kumai, T., Ohkuri, T., Kosaka, A., Nagato, T., Hirata, Y., Ohara, K., Oikawa, K., Aoki, N., Akiyama, N., Sado, M., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 2 2016, In : OncoImmunology. 5, 6, e1169356.

Research output: Contribution to journalArticle

8 Scopus citations

T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Raber, P. L., Sierra, R. A., Thevenot, P. T., Shuzhong, Z., Wyczechowska, D. D., Kumai, T., Celis, E. & Rodriguez, P. C., Jan 1 2016, In : Oncotarget. 7, 14, p. 17565-17578 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

An optimized peptide vaccine strategy capable of inducing multivalent CD8+ T cell responses with potent antitumor effects

Cho, H. I., Jung, S. H., Sohn, H. J., Celis, E. & Kim, T. G., Nov 2 2015, In : OncoImmunology. 4, 11

Research output: Contribution to journalArticle

15 Scopus citations

CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma

Kumai, T., Nagato, T., Kobayashi, H., Komabayashi, Y., Ueda, S., Kishibe, K., Ohkuri, T., Takahara, M., Celis, E. & Harabuchi, Y., Jun 6 2015, In : Cancer Immunology, Immunotherapy. 64, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma

Kumai, T., Matsuda, Y., Ohkuri, T., Oikawa, K., Ishibashi, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Jan 1 2015, In : OncoImmunology. 4, 2, p. 1-10 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Consensus nomenclature for CD8+ T cell phenotypes in cancer

Apetoh, L., Smyth, M. J., Drake, C. G., Abastado, J. P., Apte, R. N., Ayyoub, M., Blay, J. Y., Bonneville, M., Butterfield, L. H., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Chen, L., Colombo, M. P., Comin-Anduix, B., Coukos, G., Dhodapkar, M. V., Dranoff, G., Frazer, I. H. & 39 others, Fridman, W. H., Gabrilovich, D. I., Gilboa, E., Gnjatic, S., Jäger, D., Kalinski, P., Kaufman, H. L., Kiessling, R., Kirkwood, J., Knuth, A., Liblau, R., Lotze, M. T., Lugli, E., Marincola, F., Melero, I., Melief, C. J., Mempel, T. R., Mittendorf, E. A., Odun, K., Overwijk, W. W., Palucka, A. K., Parmiani, G., Ribas, A., Romero, P., Schreiber, R. D., Schuler, G., Srivastava, P. K., Tartour, E., Valmori, D., van der Burg, S. H., van der Bruggen, P., van den Eynde, B. J., Wang, E., Zou, W., Whiteside, T. L., Speiser, D. E., Pardoll, D. M., Restifo, N. P. & Anderson, A. C., Jan 1 2015, In : OncoImmunology. 4, 4

Research output: Contribution to journalArticle

61 Scopus citations

Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells

Ortiz, M. L., Kumar, V., Martner, A., Mony, S., Donthireddy, L., Condamine, T., Seykora, J., Knight, S. C., Malietzis, G., Lee, G. H., Moorghen, M., Lenox, B., Luetteke, N., Celis, E. & Gabrilovich, D., Jan 1 2015, In : Journal of Experimental Medicine. 212, 3, p. 351-367 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mutated BRAF emerges as a major effector of recurrence in a murine melanoma model after treatment with immunomodulatory agents

Zaidi, S., Blanchard, M., Shim, K., Ilett, E., Rajani, K., Parrish, C., Boisgerault, N., Kottke, T., Thompson, J., Celis, E., Pulido, J., Selby, P., Pandha, H., Melcher, A., Harrington, K. & Vile, R., May 9 2015, In : Molecular Therapy. 23, 5, p. 845-856 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

Wang, Z. & Celis, E., Aug 28 2015, In : Cancer Immunology, Immunotherapy. 64, 8, p. 1057-1066 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma

Kumai, T., Ohkuri, T., Nagato, T., Matsuda, Y., Oikawa, K., Aoki, N., Kimura, S., Celis, E., Harabuchi, Y. & Kobayashi, H., Nov 5 2015, In : Scientific reports. 5, 16280.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

Woan, K. V., Lienlaf, M., Perez-Villaroel, P., Lee, C., Cheng, F., Knox, T., Woods, D. M., Barrios, K., Powers, J., Sahakian, E., Wang, H. W., Canales, J., Marante, D., Smalley, K. S. M., Bergman, J., Seto, E., Kozikowski, A., Pinilla-Ibarz, J., Sarnaik, A., Celis, E. & 3 others, Weber, J., Sotomayor, E. M. & Villagra, A., Aug 1 2015, In : Molecular Oncology. 9, 7, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A. L., Blazar, B. & Munn, D. H., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

2014

A novel combinatorial cancer immunotherapy: Poly-IC and blockade of the PD-1/PD-L1 pathway

Nagato, T. & Celis, E., Jan 1 2014, In : OncoImmunology. 3, 5, e28440.

Research output: Contribution to journalArticle

12 Scopus citations

Classification of current anticancer immunotherapies

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J. M., Buqué, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J. P., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J. Y., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E. & 68 others, Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucíková, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jäger, D., Kalinski, P., Kärre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J. P., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautès-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W. & Kroemer, G., Jan 1 2014, In : Oncotarget. 5, 24, p. 12472-12508 37 p.

Research output: Contribution to journalArticle

211 Scopus citations

Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 t-cell responses against established tumors

Nagato, T., Lee, Y. R., Harabuchi, Y. & Celis, E., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Erratum: Oxidized lipids block antigen cross-presentation by dendritic cells in cancer (Journal of Immunology (2014) 192 (2920-2931))

Ramakrishnan, R., Tyurin, V. A., Veglia, F., Condamine, T., Amoscato, A., Mohammadyani, D., Johnson, J. J., Zhang, L. M., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., May 15 2014, In : Journal of Immunology. 192, 10, 1 p.

Research output: Contribution to journalComment/debate

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

Condamine, T., Kumar, V., Ramachandran, I. R., Youn, J. I., Celis, E., Finnberg, N., El-Deiry, W. S., Winograd, R., Vonderheide, R. H., English, N. R., Knight, S. C., Yagita, H., McCaffrey, J. C., Antonia, S., Hockstein, N., Witt, R., Masters, G., Bauer, T. & Gabrilovich, D. I., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2626-2639 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Induction of tumor-reactive T helper responses by a posttranslational modified epitope from tumor protein p53

Kumai, T., Ishibashi, K., Oikawa, K., Matsuda, Y., Aoki, N., Kimura, S., Hayashi, S., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., May 2014, In : Cancer Immunology, Immunotherapy. 63, 5, p. 469-478 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation

Bronk, C. C., Yoder, S., Hopewell, E. L., Yang, S., Celis, E., Yu, X. Z. & Beg, A. A., Jan 1 2014, In : European Journal of Immunology. 44, 12, p. 3741-3746 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Oxidized lipids block antigen cross-presentation by dendritic cells in cancer

Cao, W., Ramakrishnan, R., Tuyrin, V. A., Veglia, F., Condamine, T., Amoscato, A., Mohammadyani, D., Johnson, J. J., Zhang, L. M., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2920-2931 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor

Kumai, T., Oikawa, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 21 2014, In : Journal of Translational Medicine. 12, 1, 265.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms

Yu, Y., Hyun-II Cho, C., Wang, D., Kaosaard, K., Anasetti, C., Celis, E. & Yu, X. Z., Feb 15 2013, In : Journal of Immunology. 190, 4, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

BiVax: A peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses

Cho, H. I., Barrios, K., Lee, Y. R., Linowski, A. K. & Celis, E., Apr 1 2013, In : Cancer Immunology, Immunotherapy. 62, 4, p. 787-799 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy

Kumai, T., Matsuda, Y., Oikawa, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Oct 15 2013, In : British Journal of Cancer. 109, 8, p. 2155-2166 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance

Hopewell, E. L., Zhao, W., Fulp, W. J., Bronk, C. C., Lopez, A. S., Massengill, M., Antonia, S., Celis, E., Haura, E. B., Enkemann, S. A., Chen, D. T. & Beg, A. A., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2509-2522 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

Dougan, S. K., Dougan, M., Kim, J., Turner, J. A., Ogata, S., Cho, H. I., Jaenisch, R., Celis, E. & Ploegh, H. L., Aug 1 2013, In : Cancer Immunology Research. 1, 2, p. 99-111 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope

Kobayashi, H., Kumai, T., Hayashi, S., Matsuda, Y., Aoki, N., Sato, K., Kimura, S. & Celis, E., Dec 1 2012, In : Cancer Immunology, Immunotherapy. 61, 12, p. 2215-2225 11 p.

Research output: Contribution to journalArticle

7 Scopus citations