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Research Output 1973 2019

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Article
2019

PD-L1-specific helper T-cells exhibit effective antitumor responses: New strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma

Hirata-Nozaki, Y., Ohkuri, T., Ohara, K., Kumai, T., Nagata, M., Harabuchi, S., Kosaka, A., Nagato, T., Ishibashi, K., Oikawa, K., Aoki, N., Ohara, M., Harabuchi, Y., Uno, Y., Takei, H., Celis, E. & Kobayashi, H., Jun 20 2019, In : Journal of Translational Medicine. 17, 1, 207.

Research output: Contribution to journalArticle

Open Access
Th1 Cells
T-cells
Immunotherapy
Ligands
Helper-Inducer T-Lymphocytes
2 Citations (Scopus)

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature Communications. 10, 1, 1430.

Research output: Contribution to journalArticle

immunity
mice
Tumors
Immunity
tumors
2 Citations (Scopus)

The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

Sultan, H., Kumai, T., Nagato, T., Wu, J., Salazar, A. M. & Celis, E., Mar 13 2019, In : Cancer Immunology, Immunotherapy. 68, 3, p. 455-466 12 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Subunit Vaccines
Cytotoxic T-Lymphocytes
Peptides
Vaccines
2018
5 Citations (Scopus)

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K. & Liu, K., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5549-5560 12 p.

Research output: Contribution to journalArticle

Tumor Escape
Osteopontin
T-Lymphocytes
Immunotherapy
Colon
3 Citations (Scopus)

H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

Redd, P. S., Lu, C., Klement, J. D., Ibrahim, M. L., Zhou, G., Kumai, T., Celis, E. & Liu, K., Sep 2 2018, In : OncoImmunology. 7, 9, e1483302.

Research output: Contribution to journalArticle

T-Lymphocytes
CD8 Antigens
Immunologic Monitoring
CD4 Antigens
T-Cell Antigen Receptor
6 Citations (Scopus)

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T. D., Kruse, E. J. & He, Y., Aug 2018, In : Hepatology. 68, 2, p. 574-589 16 p.

Research output: Contribution to journalArticle

Fetal Proteins
T-Cell Antigen Receptor
Immunotherapy
Hepatocellular Carcinoma
T-Lymphocytes
1 Citation (Scopus)

Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

Sultan, H., Wu, J., Kumai, T., Salazar, A. M. & Celis, E., Jul 1 2018, In : Cancer Immunology, Immunotherapy. 67, 7, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

Melanoma-Specific Antigens
Cancer Vaccines
Subunit Vaccines
Differentiation Antigens
Cytotoxic T-Lymphocytes
3 Citations (Scopus)

Sustained persistence of il2 signaling enhances the antitumor effect of peptide vaccines through t-cell expansion and preventing pd-1 inhibition

Sultan, H., Kumai, T., Fesenkova, V. I., Fan, A. E., Wu, J., Cho, H. II., Kobayashi, H., Harabuchi, Y. & Celis, E., May 2018, In : Cancer Immunology Research. 6, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Interleukin-2
T-Lymphocytes
Neoplasms
Neoplasm Antigens

Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma

Ohara, K., Ohkuri, T., Kumai, T., Nagato, T., Nozaki, Y., Ishibashi, K., Kosaka, A., Nagata, M., Harabuchi, S., Ohara, M., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1466771.

Research output: Contribution to journalArticle

Epitopes
Peptides
Squamous Cell Neoplasms
Neoplasms
Head and Neck Neoplasms
2017
Immunotherapy
Canada
Neoplasms
4 Citations (Scopus)

Effective antitumor peptide vaccines can induce severe autoimmune pathology

Sultan, H., Trillo-Tinoco, J., Rodriguez, P. & Celis, E., Jan 1 2017, In : Oncotarget. 8, 41, p. 70317-70331 15 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Interleukin-2
Pathology
Antibodies
T-Lymphocytes
16 Citations (Scopus)

Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-δ inhibition

Abu Eid, R., Ahmad, S., Lin, Y., Webb, M., Berrong, Z., Shrimali, R. K., Kumai, T., Ananth, S., Rodriguez, P. C., Celis, E., Janik, J. E., Mkrtichyan, M. & Khleif, S. N., Aug 1 2017, In : Cancer Research. 77, 15, p. 4135-4145 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
T-Lymphocytes
Aptitude
Neoplasms
Protein Isoforms
19 Citations (Scopus)

Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site

Ohkuri, T., Kosaka, A., Ishibashi, K., Kumai, T., Hirata, Y., Ohara, K., Nagato, T., Oikawa, K., Aoki, N., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 1 2017, In : Cancer Immunology, Immunotherapy. 66, 6, p. 705-716 12 p.

Research output: Contribution to journalArticle

Immunity
Macrophages
Neoplasms
Tumor Microenvironment
Genes
17 Citations (Scopus)

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

Veglia, F., Tyurin, V. A., Mohammadyani, D., Blasi, M., Duperret, E. K., Donthireddy, L., Hashimoto, A., Kapralov, A., Amoscato, A., Angelini, R., Patel, S., Alicea-Torres, K., Weiner, D., Murphy, M. E., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Dec 1 2017, In : Nature Communications. 8, 1, 2122.

Research output: Contribution to journalArticle

Cross-Priming
Antigen Presentation
antigens
Dendritic Cells
lipids
18 Citations (Scopus)

Local activation of p53 in the tumor microenvironment overcomes immune suppression and enhances antitumor immunity

Guo, G., Yu, M., Xiao, W., Celis, E. & Cui, Y., May 1 2017, In : Cancer Research. 77, 9, p. 2292-2305 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunity
Neoplasms
Immunosuppression
Tumor Escape
19 Citations (Scopus)

Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses

Kumai, T., Lee, S., Cho, H. I., Sultan, H., Kobayashi, H., Harabuchi, Y. & Celis, E., Jan 2017, In : Cancer Immunology Research. 5, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

Subunit Vaccines
T-Lymphocytes
Vaccination
Immunotherapy
Peptides
42 Citations (Scopus)

Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy

Nagato, T., Ohkuri, T., Ohara, K., Hirata, Y., Kishibe, K., Komabayashi, Y., Ueda, S., Takahara, M., Kumai, T., Ishibashi, K., Kosaka, A., Aoki, N., Oikawa, K., Uno, Y., Akiyama, N., Sado, M., Takei, H., Celis, E., Harabuchi, Y. & Kobayashi, H., Jul 1 2017, In : Cancer Immunology, Immunotherapy. 66, 7, p. 877-890 14 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-Cell Lymphoma
Nose
Immunotherapy
Ligands
2016
8 Citations (Scopus)

Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy

Ishibashi, K., Kumai, T., Ohkuri, T., Kosaka, A., Nagato, T., Hirata, Y., Ohara, K., Oikawa, K., Aoki, N., Akiyama, N., Sado, M., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., Jun 2 2016, In : OncoImmunology. 5, 6, e1169356.

Research output: Contribution to journalArticle

Neoplasm Antigens
HLA Antigens
Epigenomics
Immunotherapy
T-Lymphocytes
10 Citations (Scopus)

T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy

Raber, P. L., Sierra, R. A., Thevenot, P. T., Shuzhong, Z., Wyczechowska, D. D., Kumai, T., Celis, E. & Rodriguez, P. C., Jan 1 2016, In : Oncotarget. 7, 14, p. 17565-17578 14 p.

Research output: Contribution to journalArticle

Immunotherapy
T-Lymphocytes
Neoplasms
Sirolimus
Myeloid-Derived Suppressor Cells
2015
14 Citations (Scopus)

An optimized peptide vaccine strategy capable of inducing multivalent CD8+ T cell responses with potent antitumor effects

Cho, H. I., Jung, S. H., Sohn, H. J., Celis, E. & Kim, T. G., Nov 2 2015, In : OncoImmunology. 4, 11

Research output: Contribution to journalArticle

Subunit Vaccines
T-Lymphocytes
Neoplasms
Cancer Vaccines
Vaccination
17 Citations (Scopus)

CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma

Kumai, T., Nagato, T., Kobayashi, H., Komabayashi, Y., Ueda, S., Kishibe, K., Ohkuri, T., Takahara, M., Celis, E. & Harabuchi, Y., Jun 6 2015, In : Cancer Immunology, Immunotherapy. 64, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

C Chemokines
Natural Killer T-Cells
T-Cell Lymphoma
Chemokine Receptors
Nose
17 Citations (Scopus)

c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma

Kumai, T., Matsuda, Y., Ohkuri, T., Oikawa, K., Ishibashi, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Jan 1 2015, In : OncoImmunology. 4, 2, p. 1-10 10 p.

Research output: Contribution to journalArticle

T-Cell Lymphoma
Neoplasm Antigens
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Immunotherapy
59 Citations (Scopus)

Consensus nomenclature for CD8+ T cell phenotypes in cancer

Apetoh, L., Smyth, M. J., Drake, C. G., Abastado, J. P., Apte, R. N., Ayyoub, M., Blay, J. Y., Bonneville, M., Butterfield, L. H., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Chen, L., Colombo, M. P., Comin-Anduix, B., Coukos, G., Dhodapkar, M. V., Dranoff, G., Frazer, I. H. & 39 others, Fridman, W. H., Gabrilovich, D. I., Gilboa, E., Gnjatic, S., Jäger, D., Kalinski, P., Kaufman, H. L., Kiessling, R., Kirkwood, J., Knuth, A., Liblau, R., Lotze, M. T., Lugli, E., Marincola, F., Melero, I., Melief, C. J., Mempel, T. R., Mittendorf, E. A., Odun, K., Overwijk, W. W., Palucka, A. K., Parmiani, G., Ribas, A., Romero, P., Schreiber, R. D., Schuler, G., Srivastava, P. K., Tartour, E., Valmori, D., van der Burg, S. H., van der Bruggen, P., van den Eynde, B. J., Wang, E., Zou, W., Whiteside, T. L., Speiser, D. E., Pardoll, D. M., Restifo, N. P. & Anderson, A. C., Jan 1 2015, In : OncoImmunology. 4, 4

Research output: Contribution to journalArticle

Terminology
T-Lymphocytes
Phenotype
Neoplasms
Tumor Microenvironment
33 Citations (Scopus)

Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells

Ortiz, M. L., Kumar, V., Martner, A., Mony, S., Donthireddy, L., Condamine, T., Seykora, J., Knight, S. C., Malietzis, G., Lee, G. H., Moorghen, M., Lenox, B., Luetteke, N., Celis, E. & Gabrilovich, D., Jan 1 2015, In : Journal of Experimental Medicine. 212, 3, p. 351-367 17 p.

Research output: Contribution to journalArticle

Interleukin-17
Myeloid Cells
T-Lymphocytes
Skin
Neoplasms
7 Citations (Scopus)

Mutated BRAF emerges as a major effector of recurrence in a murine melanoma model after treatment with immunomodulatory agents

Zaidi, S., Blanchard, M., Shim, K., Ilett, E., Rajani, K., Parrish, C., Boisgerault, N., Kottke, T., Thompson, J., Celis, E., Pulido, J., Selby, P., Pandha, H., Melcher, A., Harrington, K. & Vile, R., May 9 2015, In : Molecular Therapy. 23, 5, p. 845-856 12 p.

Research output: Contribution to journalArticle

Melanoma
Recurrence
Gene Library
Neoplasms
Immunotherapy
32 Citations (Scopus)

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

Wang, Z. & Celis, E., Aug 28 2015, In : Cancer Immunology, Immunotherapy. 64, 8, p. 1057-1066 10 p.

Research output: Contribution to journalArticle

Subunit Vaccines
Melanoma
T-Lymphocytes
Virus Diseases
Neoplasms
4 Citations (Scopus)

Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma

Kumai, T., Ohkuri, T., Nagato, T., Matsuda, Y., Oikawa, K., Aoki, N., Kimura, S., Celis, E., Harabuchi, Y. & Kobayashi, H., Nov 5 2015, In : Scientific Reports. 5, 16280.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Epitopes
Neoplasms
T-Lymphocytes
Oncogene Proteins
40 Citations (Scopus)

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

Woan, K. V., Lienlaf, M., Perez-Villaroel, P., Lee, C., Cheng, F., Knox, T., Woods, D. M., Barrios, K., Powers, J., Sahakian, E., Wang, H. W., Canales, J., Marante, D., Smalley, K. S. M., Bergman, J., Seto, E., Kozikowski, A., Pinilla-Ibarz, J., Sarnaik, A., Celis, E. & 3 others, Weber, J., Sotomayor, E. M. & Villagra, A., Aug 1 2015, In : Molecular Oncology. 9, 7, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Immunity
Melanoma
Cell Proliferation
Neoplasms

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A. L., Blazar, B. & Munn, D. H., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
2014
10 Citations (Scopus)

A novel combinatorial cancer immunotherapy: Poly-IC and blockade of the PD-1/PD-L1 pathway

Nagato, T. & Celis, E., Jan 1 2014, In : OncoImmunology. 3, 5, e28440.

Research output: Contribution to journalArticle

Immunotherapy
Cell Death
Neoplasms
Blocking Antibodies
T-Lymphocytes
202 Citations (Scopus)

Classification of current anticancer immunotherapies

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J. M., Buqué, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J. P., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J. Y., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E. & 68 others, Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucíková, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jäger, D., Kalinski, P., Kärre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J. P., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautès-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W. & Kroemer, G., Jan 1 2014, In : Oncotarget. 5, 24, p. 12472-12508 37 p.

Research output: Contribution to journalArticle

Immunotherapy
Immune System
Neoplasms
Neoplasm Antigens
United States Food and Drug Administration
35 Citations (Scopus)

Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 t-cell responses against established tumors

Nagato, T., Lee, Y. R., Harabuchi, Y. & Celis, E., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

Poly I-C
Immunotherapy
Ligands
Neoplasms
Poly C
110 Citations (Scopus)

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

Condamine, T., Kumar, V., Ramachandran, I. R., Youn, J. I., Celis, E., Finnberg, N., El-Deiry, W. S., Winograd, R., Vonderheide, R. H., English, N. R., Knight, S. C., Yagita, H., McCaffrey, J. C., Antonia, S., Hockstein, N., Witt, R., Masters, G., Bauer, T. & Gabrilovich, D. I., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2626-2639 14 p.

Research output: Contribution to journalArticle

Apoptosis
Myeloid Cells
Neoplasms
Ligands
Monocytes
12 Citations (Scopus)

Induction of tumor-reactive T helper responses by a posttranslational modified epitope from tumor protein p53

Kumai, T., Ishibashi, K., Oikawa, K., Matsuda, Y., Aoki, N., Kimura, S., Hayashi, S., Kitada, M., Harabuchi, Y., Celis, E. & Kobayashi, H., Jan 1 2014, In : Cancer Immunology, Immunotherapy. 63, 5, p. 469-478 10 p.

Research output: Contribution to journalArticle

Epitopes
Neoplasms
Proteins
Post Translational Protein Processing
Peptides
7 Citations (Scopus)

NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation

Bronk, C. C., Yoder, S., Hopewell, E. L., Yang, S., Celis, E., Yu, X. Z. & Beg, A. A., Jan 1 2014, In : European Journal of Immunology. 44, 12, p. 3741-3746 6 p.

Research output: Contribution to journalArticle

Calcium Signaling
T-Lymphocytes
Transcription Factor AP-1
Inbred C57BL Mouse
Signal Transduction
51 Citations (Scopus)

Oxidized lipids block antigen cross-presentation by dendritic cells in cancer

Cao, W., Ramakrishnan, R., Tuyrin, V. A., Veglia, F., Condamine, T., Amoscato, A., Mohammadyani, D., Johnson, J. J., Zhang, L. M., Klein-Seetharaman, J., Celis, E., Kagan, V. E. & Gabrilovich, D. I., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2920-2931 12 p.

Research output: Contribution to journalArticle

Cross-Priming
Antigen Presentation
Dendritic Cells
Lipids
Neoplasms
15 Citations (Scopus)

Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor

Kumai, T., Oikawa, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Sep 21 2014, In : Journal of Translational Medicine. 12, 1, 265.

Research output: Contribution to journalArticle

Dinoprostone
Transforming Growth Factor beta
Tumors
Neoplasms
Cells
2013
38 Citations (Scopus)

Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms

Yu, Y., Hyun-II Cho, C., Wang, D., Kaosaard, K., Anasetti, C., Celis, E. & Yu, X. Z., Feb 15 2013, In : Journal of Immunology. 190, 4, p. 1873-1881 9 p.

Research output: Contribution to journalArticle

Adoptive Transfer
Immunity
Melanoma
Interleukin-17
Neoplasms
36 Citations (Scopus)

BiVax: A peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses

Cho, H. I., Barrios, K., Lee, Y. R., Linowski, A. K. & Celis, E., Apr 1 2013, In : Cancer Immunology, Immunotherapy. 62, 4, p. 787-799 13 p.

Research output: Contribution to journalArticle

Subunit Vaccines
T-Lymphocytes
Peptides
Infection
Neoplasms
28 Citations (Scopus)

EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy

Kumai, T., Matsuda, Y., Oikawa, K., Aoki, N., Kimura, S., Harabuchi, Y., Celis, E. & Kobayashi, H., Oct 15 2013, In : British Journal of Cancer. 109, 8, p. 2155-2166 12 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Epidermal Growth Factor Receptor
Immunotherapy
T-Lymphocytes
Epitopes
47 Citations (Scopus)

Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance

Hopewell, E. L., Zhao, W., Fulp, W. J., Bronk, C. C., Lopez, A. S., Massengill, M., Antonia, S., Celis, E., Haura, E. B., Enkemann, S. A., Chen, D. T. & Beg, A. A., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2509-2522 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Lung
Neoplasms
Lung Neoplasms
Growth
22 Citations (Scopus)

Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

Dougan, S. K., Dougan, M., Kim, J., Turner, J. A., Ogata, S., Cho, H. I., Jaenisch, R., Celis, E. & Ploegh, H. L., Aug 1 2013, In : Cancer Immunology Research. 1, 2, p. 99-111 13 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Melanoma-Specific Antigens
Experimental Melanomas
Immunomodulation
2012
7 Citations (Scopus)

A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope

Kobayashi, H., Kumai, T., Hayashi, S., Matsuda, Y., Aoki, N., Sato, K., Kimura, S. & Celis, E., Dec 1 2012, In : Cancer Immunology, Immunotherapy. 61, 12, p. 2215-2225 11 p.

Research output: Contribution to journalArticle

Interleukin-9 Receptors
Deltaretrovirus
HLA-DR Antigens
Epitopes
Adult T Cell Leukemia Lymphoma
26 Citations (Scopus)

A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy

Cho, H. I., Reyes-Vargas, E., Delgado, J. C. & Celis, E., Apr 15 2012, In : Cancer Research. 72, 8, p. 1986-1995 10 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Interleukin-2
Vaccination
T-Lymphocytes
Whole-Body Irradiation
36 Citations (Scopus)

Autophagy induced by conventional chemotherapy mediates tumor cell sensitivity to immunotherapy

Ramakrishnan, R., Huang, C., Cho, H. I., Lloyd, M., Johnson, J., Ren, X., Altiok, S., Sullivan, D., Weber, J., Celis, E. & Gabrilovich, D. I., Nov 1 2012, In : Cancer Research. 72, 21, p. 5483-5493 11 p.

Research output: Contribution to journalArticle

Autophagy
Immunotherapy
Drug Therapy
IGF Type 2 Receptor
Neoplasms
23 Citations (Scopus)

Design of immunogenic and effective multi-epitope DNA vaccines for melanoma

Cho, H. I. & Celis, E., Mar 1 2012, In : Cancer Immunology, Immunotherapy. 61, 3, p. 343-351 9 p.

Research output: Contribution to journalArticle

DNA Vaccines
T-Lymphocyte Epitopes
Epitopes
Melanoma
Furin
33 Citations (Scopus)

InducTION of mage-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma

Voskens, C. J., Sewell, D., Hertzano, R., Desanto, J., Rollins, S., Lee, M., Taylor, R., Wolf, J., Suntharalingam, M., Gastman, B., Papadimitriou, J. C., Lu, C., Tan, M., Morales, R., Cullen, K., Celis, E., Mann, D. & Strome, S. E., Dec 1 2012, In : Head and Neck. 34, 12, p. 1734-1746 13 p.

Research output: Contribution to journalArticle

Human papillomavirus 16
Immunity
Neck
Vaccines
Head
25 Citations (Scopus)

Intratumoral electroporation of IL-12 cDNA eradicates established melanomas by Trp2180-188-specific CD8+ CTLs in a perforin/granzyme-mediated and IFN-c-dependent manner: Application of Trp2180-188 peptides

Sin, J. I., Park, J. B., Lee, I. H., Park, D., Choi, Y. S., Choe, J. & Celis, E., Oct 1 2012, In : Cancer Immunology, Immunotherapy. 61, 10, p. 1671-1682 12 p.

Research output: Contribution to journalArticle

Granzymes
Perforin
Electroporation
Interleukin-12
Melanoma
19 Citations (Scopus)

Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy

Huynh, A. S., Chung, W. J., Cho, H. I., Moberg, V. E., Celis, E., Morse, D. L. & Vagner, J., Nov 26 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9751-9762 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Pancreatic Neoplasms
Immunotherapy
Ligands
Neoplasms
34 Citations (Scopus)

Vaccine-elicited CD8+T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB/c mice

Lee, S., Stokes, K. L., Currier, M. G., Sakamoto, K., Lukacs, N. W., Celis, E. & Moore, M. L., Dec 1 2012, In : Journal of Virology. 86, 23, p. 13016-13024 9 p.

Research output: Contribution to journalArticle

Respiratory Syncytial Viruses
varespladib methyl
Vaccines
pathogenesis
T-lymphocytes