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19962019
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Research Output 1996 2019

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Article
2019

A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor

Zhang, M., Xu, X., Li, C., Huang, W., Xu, N. & Wu, G., Dec 1 2019, In : Scientific Reports. 9, 1, 10378.

Research output: Contribution to journalArticle

Open Access
Adrenergic Receptors
Clathrin
G-Protein-Coupled Receptors
ADP-Ribosylation Factors
trans-Golgi Network
1 Citation (Scopus)

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
1 Citation (Scopus)

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
Cell membranes
G-Protein-Coupled Receptors
Cell Membrane
Proteins
GTPase-Activating Proteins
2 Citations (Scopus)

The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury

Zhang, Y., Wang, L., Lv, Y., Jiang, C., Wu, G., Dull, R. O., Minshall, R. D., Malik, A. B. & Hu, G., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 194-206 13 p.

Research output: Contribution to journalArticle

Inflammasomes
Interleukin-18
GTP Phosphohydrolases
Lung Injury
Interleukin-1
2018
18 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
12 Citations (Scopus)

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

Dong, W., He, B., Qian, H., Liu, Q., Wang, D., Li, J., Wei, Z., Wang, Z., Xu, Z., Wu, G., Qian, G. & Wang, G., Oct 3 2018, In : Autophagy. 14, 10, p. 1677-1692 16 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Adherens Junctions
Autophagy
Endothelial Cells
Lung
2 Citations (Scopus)

Regulation of SAP102 Synaptic Targeting by Phosphorylation

Wei, Z., Wu, G. & Chen, B-S., Aug 1 2018, In : Molecular Neurobiology. 55, 8, p. 6215-6226 12 p.

Research output: Contribution to journalArticle

Synapses
Phosphorylation
Proteins
Glutamate Receptors
Casein Kinase II
3 Citations (Scopus)
STAT1 Transcription Factor
effectors
ischemia
kidneys
Reperfusion Injury
2017
5 Citations (Scopus)
Bone Morphogenetic Protein 4
Calpain
Pulmonary Artery
Smooth Muscle Myocytes
Collagen
7 Citations (Scopus)

Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons

Gao, J., Naughton, S. X., Beck, W. D., Hernandez, C. M., Wu, G., Wei, Z., Yang, X., Bartlett, M. G. & Terry, A. V., Sep 1 2017, In : NeuroToxicology. 62, p. 111-123 13 p.

Research output: Contribution to journalArticle

Chlorpyrifos
Organelles
Axons
Rats
Membranes
11 Citations (Scopus)

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Endothelial Cells
Acid Sensing Ion Channels
Lung
Peptides
13 Citations (Scopus)

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
MicroRNAs
Cisplatin
Homeobox Genes
Kidney
12 Citations (Scopus)

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
G-Protein-Coupled Receptors
Sorting
Endoplasmic Reticulum
Membrane Proteins
2016
14 Citations (Scopus)

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Davis, J. E., Xie, X., Guo, J., Huang, W., Chu, W. M., Huang, S., Teng, Y. & Wu, G., Jan 1 2016, In : Oncotarget. 7, 26, p. 39834-39845 12 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinases
Prostate
Carcinogenesis
Prostatic Neoplasms
12 Citations (Scopus)

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
trans-Golgi Network
Vesicular Transport Adaptor Proteins
ADP-Ribosylation Factors
Mitogen-Activated Protein Kinase 3
9 Citations (Scopus)

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

Zhang, M., Huang, W., Gao, J., Terry, A. V. & Wu, G., Nov 30 2016, In : Scientific Reports. 6, 37921.

Research output: Contribution to journalArticle

Adrenergic Receptors
G-Protein-Coupled Receptors
Small Interfering RNA
ADP-Ribosylation Factors
Ear
15 Citations (Scopus)

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

Xie, X., Tang, S. C., Cai, Y., Pi, W., Deng, L., Wu, G., Chavanieu, A. & Teng, Y., Jan 1 2016, In : Oncotarget. 7, 36, p. 58111-58120 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Breast Neoplasms
Neoplasm Metastasis
Zebrafish
Genes
11 Citations (Scopus)

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

Du, R. H., Wu, F. F., Lu, M., Shu, X. D., Ding, J. H., Wu, G. & Hu, G., Oct 1 2016, In : Redox Biology. 9, p. 178-187 10 p.

Research output: Contribution to journalArticle

Inflammasomes
Astrocytes
Modulation
Depression
Proteins
2015
7 Citations (Scopus)

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S., Zhang, M., Davis, J. E., Wu, W. H., Surrao, K., Wang, H. & Wu, G., Dec 1 2015, In : Cellular Signalling. 27, 12, p. 2371-2379 9 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Mutation
Coat Protein Complex I
Transport Vesicles
Inositol Phosphates
27 Citations (Scopus)

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific Reports. 5, 10166.

Research output: Contribution to journalArticle

Energy Transfer
Adrenergic Receptors
Membrane Proteins
G-Protein-Coupled Receptors
Protein Subunits
5 Citations (Scopus)

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

Lanthanoid Series Elements
Energy Transfer
Energy transfer
Membrane Proteins
Excited states
20 Citations (Scopus)

Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium

Yang, J., Yao, W., Qian, G., Wei, Z., Wu, G. & Wang, G., Dec 1 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4849-4866 18 p.

Research output: Contribution to journalArticle

Endothelium
Lipopolysaccharides
Lung
Cell Polarity
Endothelial Cells
8 Citations (Scopus)

Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase

Yang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G. & Wang, G., Jun 1 2015, In : International Journal of Biological Sciences. 11, 8, p. 868-878 11 p.

Research output: Contribution to journalArticle

trafficking
GTP Phosphohydrolases
guanosinetriphosphatase
adrenergic receptors
Adrenergic Receptors
14 Citations (Scopus)

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

Jang, J. H., Chun, J. N., Godo, S., Wu, G., Shimokawa, H., Jin, C. Z., Jeon, J. H., Kim, S. J., Jin, Z. H. & Zhang, Y. H., May 1 2015, In : Basic Research in Cardiology. 110, 3

Research output: Contribution to journalArticle

Angiotensin Type 2 Receptor
Nitric Oxide Synthase Type III
Cardiac Myocytes
Angiotensin II
Up-Regulation
6 Citations (Scopus)

The mechanism and function of mitogen-activated protein kinase activation by ARF1

Zhou, F., Dong, C., Davis, J. E., Wu, W. H., Surrao, K. & Wu, G., Oct 1 2015, In : Cellular Signalling. 27, 10, p. 2035-2044 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinases
Ribosomal Protein S6 Kinases
Cell Proliferation
Monomeric GTP-Binding Proteins
2014
15 Citations (Scopus)

Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- And Rab8-Dependent and recycling endosome-independent

Bertuccio, C. A., Lee, S. L., Wu, G., Butterworth, M. B., Hamilton, K. L. & Devor, D. C., Mar 14 2014, In : PloS one. 9, 3, e92013.

Research output: Contribution to journalArticle

endosomes
Endosomes
recycling
Recycling
epithelium
18 Citations (Scopus)

Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis

Teoh, J. P., Park, K. M., Wang, Y., Hu, Q., Kim, S., Wu, G., Huang, S., Maihle, N. J. & Kim, I., Sep 3 2014, In : Cellular Signalling. 26, 12, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Endothelin-1
Ovarian Neoplasms
Carcinogenesis
Arrestin
2013
6 Citations (Scopus)

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

Zhang, X., Wang, H., Duvernay, M. T., Zhu, S. & Wu, G., Feb 25 2013, In : PloS one. 8, 2, e57805.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
angiotensin II
Tubulin
tubulin
receptors
2012
5 Citations (Scopus)

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Fan, Y., Li, C., Guo, J., Hu, G. & Wu, G., Dec 5 2012, In : PloS one. 7, 12, e50416.

Research output: Contribution to journalArticle

adrenergic receptors
Endoplasmic Reticulum
endoplasmic reticulum
Adrenergic Receptors
G-Protein-Coupled Receptors
39 Citations (Scopus)

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 1 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Adrenergic Receptors
Capsid Proteins
G-Protein-Coupled Receptors
Machinery
23 Citations (Scopus)

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Adrenergic Receptors
Small Interfering RNA
Membrane Proteins
Protein Transport
39 Citations (Scopus)

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 1 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Energy transfer
Membrane Proteins
Design of experiments
2011
2 Citations (Scopus)

Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases

Dong, C. & Wu, G., Jul 4 2011, In : Current Topics in Membranes. 67, p. 79-100 22 p.

Research output: Contribution to journalArticle

Adrenergic alpha-2 Receptors
Biological Models
Monomeric GTP-Binding Proteins
Dimerization
Golgi Apparatus
31 Citations (Scopus)

Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface

Zhang, X., Dong, C., Wu, Q. J., Balch, W. E. & Wu, G., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20525-20535 11 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Endoplasmic Reticulum
G-Protein-Coupled Receptors
Membranes
Cell membranes
83 Citations (Scopus)

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
GTP-Binding Proteins
Gq-G11 GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins
Muscarinic Receptors
18 Citations (Scopus)

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia

Yin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G. & Wang, G., Mar 1 2011, In : International Journal of Biochemistry and Cell Biology. 43, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
GTP Phosphohydrolases
Pulmonary Artery
Smooth Muscle Myocytes
Muscle
18 Citations (Scopus)

Regulation of α 2B-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1

Dong, C., Li, C. & Wu, G., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43361-43369 9 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factor 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Adrenergic Receptors
Chemical activation
30 Citations (Scopus)

α2B-Adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface

Duvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L. & Wu, G., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14080-14089 10 p.

Research output: Contribution to journalArticle

Tubulin
Endoplasmic Reticulum
Adrenergic Receptors
G-Protein-Coupled Receptors
Glutathione Transferase
2010
38 Citations (Scopus)

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia

Wang, G., Zhang, Z., Xu, Z., Yin, H., Bai, L., Ma, Z., DeCoster, M. A., Qian, G. & Wu, G., Dec 1 2010, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 12, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Cell Proliferation
Lung
Hypoxia-Inducible Factor 1
Cell Hypoxia
29 Citations (Scopus)

ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors

Dong, C., Zhang, X., Zhou, F., Dou, H., Duvernay, M. T., Zhang, P. & Wu, G., Apr 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 174-183 10 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factors
G-Protein-Coupled Receptors
Adrenergic Receptors
Carrier Proteins
Membrane Proteins
14 Citations (Scopus)

Rab1 GTPase promotes expression of β-adrenergic receptors in rat pulmonary microvascular endothelial cells

Li, Y., Wang, G., Lin, K., Yin, H., Zhou, C., Liu, T., Wu, G. & Qian, G., Jul 1 2010, In : International Journal of Biochemistry and Cell Biology. 42, 7, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Endothelial cells
Adrenergic Receptors
Rats
Endothelial Cells
42 Citations (Scopus)

Rab8 interacts with distinct motifs in α2B- and β2-adrenergic receptors and differentially modulates their transport

Dong, C., Yang, L., Zhang, X., Gu, H., Lam, M. L., Claycomb, W. C., Xia, H. & Wu, G., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20369-20380 12 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
trans-Golgi Network
GTP Phosphohydrolases
Mutation
Protein Transport
2009
52 Citations (Scopus)

Anterograde trafficking of G protein-coupled receptors: Function of the C-terminal F(X) 6LL motif in export from the endoplasmic reticulum

Duvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D. & Wu, G., Apr 1 2009, In : Molecular Pharmacology. 75, 4, p. 751-761 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Endoplasmic Reticulum
Adrenergic Agents
Angiotensin Type 1 Receptor
Mutation
42 Citations (Scopus)

A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors

Duvernay, M. T., Dong, C., Zhang, X., Robitaille, M., Hébert, T. E. & Wu, G., Apr 23 2009, In : Traffic. 10, 5, p. 552-566 15 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Leucine
Endoplasmic Reticulum
Adrenergic Receptors
Mutagenesis
2 Citations (Scopus)

Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas

Huang, W., Wu, G. & Wang, G. Y., Nov 1 2009, In : Visual Neuroscience. 26, 5-6, p. 443-452 10 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Retina
Light
rab GTP-Binding Proteins
Rhodopsin
28 Citations (Scopus)

Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor

Zhang, X., Wang, G., Dupré, D. J., Feng, Y., Robitaille, M., Lazartigues, E., Feng, Y. H., Hébert, T. E. & Wu, G., Jul 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Angiotensin Type 2 Receptor
GTP Phosphohydrolases
Dimerization
Endoplasmic Reticulum
Angiotensin II
2008
89 Citations (Scopus)

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

Feng, Y., Yue, X., Xia, H., Bindom, S. M., Hickman, P. J., Filipeanu, C. M., Wu, G. & Lazartigues, E., Mar 1 2008, In : Circulation research. 102, 6, p. 729-736 8 p.

Research output: Contribution to journalArticle

Subfornical Organ
Angiotensin Type 1 Receptor
Angiotensin II
Drinking
Down-Regulation
30 Citations (Scopus)

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase

Dong, C., Zhou, F., Fugetta, E. K., Filipeanu, C. M. & Wu, G., Jun 1 2008, In : Cellular Signalling. 20, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
GTP Phosphohydrolases
Endoplasmic Reticulum
Adrenergic Agents
Angiotensin Type 1 Receptor
44 Citations (Scopus)

Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells

Wang, G., Qian, P., Jackson, F. R., Qian, G. & Wu, G., Feb 18 2008, In : International Journal of Biochemistry and Cell Biology. 40, 3, p. 461-470 10 p.

Research output: Contribution to journalArticle

Xanthine Dehydrogenase
Janus Kinases
Xanthine Oxidase
Endothelial cells
Transcription
2007
47 Citations (Scopus)

Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases

Dong, C. & Wu, G., Nov 1 2007, In : Cellular Signalling. 19, 11, p. 2388-2399 12 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
GTP Phosphohydrolases
Adrenergic Agents
Angiotensin Type 1 Receptor
G-Protein-Coupled Receptors