• 3734 Citations
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19962020

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Article
2020
2019

A Naturally Occurring Splice Variant of GGA1 Inhibits the Anterograde Post-Golgi Traffic of α2B-Adrenergic Receptor

Zhang, M., Xu, X., Li, C., Huang, W., Xu, N. & Wu, G., Dec 1 2019, In : Scientific reports. 9, 1, 10378.

Research output: Contribution to journalArticle

Open Access

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Li, Z. W., Sun, B., Gong, T., Guo, S., Zhang, J., Wang, J., Sugawara, A., Jiang, M., Yan, J., Gurary, A., Zheng, X., Gao, B., Xiao, S. Y., Chen, W., Ma, C., Farrar, C., Zhu, C., Chan, O. T. M., Xin, C., Winnicki, A. & 24 others, Winnicki, J., Tang, M., Park, R., Winnicki, M., Diener, K., Wang, Z., Liu, Q., Chu, C. H., Arter, Z. L., Yue, P., Alpert, L., Hui, G. S., Fei, P., Turkson, J., Yang, W., Wu, G., Tao, A., Ramos, J. W., Moisyadi, S., Holcombe, R. F., Jia, W., Birnbaumer, L., Zhou, X. & Chu, W. M., Jun 2019, In : Gastroenterology. 156, 8, p. 2297-2312 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury

Zhang, Y., Wang, L., Lv, Y., Jiang, C., Wu, G., Dull, R. O., Minshall, R. D., Malik, A. B. & Hu, G., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 194-206 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3

Du, R. H., Lu, M., Wang, C., Ding, J. H., Wu, G. & Hu, G., Aug 1 2019, In : Experimental and Molecular Medicine. 51, 8, 92.

Research output: Contribution to journalArticle

Open Access
2018

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

24 Scopus citations

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury

Dong, W., He, B., Qian, H., Liu, Q., Wang, D., Li, J., Wei, Z., Wang, Z., Xu, Z., Wu, G., Qian, G. & Wang, G., Oct 3 2018, In : Autophagy. 14, 10, p. 1677-1692 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regulation of SAP102 Synaptic Targeting by Phosphorylation

Wei, Z., Wu, G. & Chen, B. S., Aug 1 2018, In : Molecular Neurobiology. 55, 8, p. 6215-6226 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Wang, S., Liu, A., Wu, G., Ding, H. F., Huang, S., Nahman, S. & Dong, Z., Dec 1 2018, In : Nature communications. 9, 1, 1234.

Research output: Contribution to journalArticle

5 Scopus citations
2017
5 Scopus citations

Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons

Gao, J., Naughton, S. X., Beck, W. D., Hernandez, C. M., Wu, G., Wei, Z., Yang, X., Bartlett, M. G. & Terry, A. V., Sep 1 2017, In : NeuroToxicology. 62, p. 111-123 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

12 Scopus citations

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Davis, J. E., Xie, X., Guo, J., Huang, W., Chu, W. M., Huang, S., Teng, Y. & Wu, G., Jan 1 2016, In : Oncotarget. 7, 26, p. 39834-39845 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

Zhang, M., Huang, W., Gao, J., Terry, A. V. & Wu, G., Nov 30 2016, In : Scientific Reports. 6, 37921.

Research output: Contribution to journalArticle

9 Scopus citations

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

Xie, X., Tang, S. C., Cai, Y., Pi, W., Deng, L., Wu, G., Chavanieu, A. & Teng, Y., Jan 1 2016, In : Oncotarget. 7, 36, p. 58111-58120 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

Du, R. H., Wu, F. F., Lu, M., Shu, X. D., Ding, J. H., Wu, G. & Hu, G., Oct 1 2016, In : Redox Biology. 9, p. 178-187 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2015

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S., Zhang, M., Davis, J. E., Wu, W. H., Surrao, K., Wang, H. & Wu, G., Dec 1 2015, In : Cellular Signalling. 27, 12, p. 2371-2379 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific reports. 5, 10166.

Research output: Contribution to journalArticle

27 Scopus citations

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium

Yang, J., Yao, W., Qian, G., Wei, Z., Wu, G. & Wang, G., Dec 1 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4849-4866 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of β-adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase

Yang, J., Sun, H., Zhang, J., Hu, M., Wang, J., Wu, G. & Wang, G., Jun 1 2015, In : International Journal of Biological Sciences. 11, 8, p. 868-878 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

Jang, J. H., Chun, J. N., Godo, S., Wu, G., Shimokawa, H., Jin, C. Z., Jeon, J. H., Kim, S. J., Jin, Z. H. & Zhang, Y. H., May 1 2015, In : Basic Research in Cardiology. 110, 3

Research output: Contribution to journalArticle

14 Scopus citations

The mechanism and function of mitogen-activated protein kinase activation by ARF1

Zhou, F., Dong, C., Davis, J. E., Wu, W. H., Surrao, K. & Wu, G., Oct 1 2015, In : Cellular Signalling. 27, 10, p. 2035-2044 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- And Rab8-Dependent and recycling endosome-independent

Bertuccio, C. A., Lee, S. L., Wu, G., Butterworth, M. B., Hamilton, K. L. & Devor, D. C., Mar 14 2014, In : PloS one. 9, 3, e92013.

Research output: Contribution to journalArticle

16 Scopus citations

Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis

Teoh, J. P., Park, K. M., Wang, Y., Hu, Q., Kim, S., Wu, G., Huang, S., Maihle, N. J. & Kim, I., Sep 3 2014, In : Cellular Signalling. 26, 12, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

The Angiotensin II Type 1 Receptor C-Terminal Lys Residues Interact with Tubulin and Modulate Receptor Export Trafficking

Zhang, X., Wang, H., Duvernay, M. T., Zhu, S. & Wu, G., Feb 25 2013, In : PloS one. 8, 2, e57805.

Research output: Contribution to journalArticle

7 Scopus citations
2012

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Fan, Y., Li, C., Guo, J., Hu, G. & Wu, G., Dec 5 2012, In : PloS one. 7, 12, e50416.

Research output: Contribution to journalArticle

5 Scopus citations

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 1 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of post-golgi traf fic of G protein-coupled receptors

Wu, G., May 29 2012, In : Subcellular Biochemistry. 63, p. 83-95 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 1 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Anterograde Trafficking of Nascent α2B-Adrenergic Receptor: Structural Basis, Roles of Small GTPases

Dong, C. & Wu, G., Jul 4 2011, In : Current Topics in Membranes. 67, p. 79-100 22 p.

Research output: Contribution to journalArticle

2 Scopus citations

Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface

Zhang, X., Dong, C., Wu, Q. J., Balch, W. E. & Wu, G., Jun 10 2011, In : Journal of Biological Chemistry. 286, 23, p. 20525-20535 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia

Yin, H., Li, Q., Qian, G., Wang, Y., Li, Y., Wu, G. & Wang, G., Mar 1 2011, In : International Journal of Biochemistry and Cell Biology. 43, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regulation of α 2B-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1

Dong, C., Li, C. & Wu, G., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43361-43369 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

α2B-Adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface

Duvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L. & Wu, G., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14080-14089 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2010

Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia

Wang, G., Zhang, Z., Xu, Z., Yin, H., Bai, L., Ma, Z., DeCoster, M. A., Qian, G. & Wu, G., Dec 1 2010, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 12, p. 1359-1367 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors

Dong, C., Zhang, X., Zhou, F., Dou, H., Duvernay, M. T., Zhang, P. & Wu, G., Apr 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 174-183 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Rab1 GTPase promotes expression of β-adrenergic receptors in rat pulmonary microvascular endothelial cells

Li, Y., Wang, G., Lin, K., Yin, H., Zhou, C., Liu, T., Wu, G. & Qian, G., Jul 2010, In : International Journal of Biochemistry and Cell Biology. 42, 7, p. 1201-1209 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rab8 interacts with distinct motifs in α2B- and β2-adrenergic receptors and differentially modulates their transport

Dong, C., Yang, L., Zhang, X., Gu, H., Lam, M. L., Claycomb, W. C., Xia, H. & Wu, G., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20369-20380 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Anterograde trafficking of G protein-coupled receptors: Function of the C-terminal F(X) 6LL motif in export from the endoplasmic reticulum

Duvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D. & Wu, G., Apr 1 2009, In : Molecular Pharmacology. 75, 4, p. 751-761 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors

Duvernay, M. T., Dong, C., Zhang, X., Robitaille, M., Hébert, T. E. & Wu, G., Apr 23 2009, In : Traffic. 10, 5, p. 552-566 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas

Huang, W., Wu, G. & Wang, G. Y., Nov 1 2009, In : Visual Neuroscience. 26, 5-6, p. 443-452 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor

Zhang, X., Wang, G., Dupré, D. J., Feng, Y., Robitaille, M., Lazartigues, E., Feng, Y. H., Hébert, T. E. & Wu, G., Jul 2009, In : Journal of Pharmacology and Experimental Therapeutics. 330, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

28 Scopus citations