• 2755 Citations
  • 31 h-Index
1990 …2020

Research output per year

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Research Output

  • 2755 Citations
  • 31 h-Index
  • 66 Article
  • 3 Review article
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Article
2020

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc

Wang, L., Liu, Y., Du, T., Yang, H., Lei, L., Guo, M., Ding, H., Zhang, J., Wang, H., Chen, X. & Yan, C., Feb 1 2020, In : Cell Death and Differentiation. 27, 2, p. 662-675 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2019

Competitive ubiquitination activates the tumor suppressor p53

Li, X., Guo, M., Cai, L., Du, T., Liu, Y., Ding, H. F., Wang, H., Zhang, J., Chen, X. & Yan, C., Jan 1 2019, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

Alptekin, A., Ye, B., Yu, Y., Poole, C. J., van Riggelen, J., Zha, Y. & Ding, H. F., Dec 12 2019, In : Oncogene. 38, 50, p. 7504-7520 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2018

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
4 Scopus citations
2017

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1194-1205 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

Fang, D., Chen, H., Zhu, J. Y., Wang, W., Teng, Y., Ding, H., Jing, Q., Su, S. B. & Huang, S., Mar 1 2017, In : Oncogene. 36, 11, p. 1546-1558 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

Antibiotic drug tigecycline reduces neuroblastoma cells proliferation by inhibiting Akt activation in vitro and in vivo

Zhong, X., Zhao, E., Tang, C., Zhang, W., Tan, J., Dong, Z., Ding, H. & Cui, H., Jun 1 2016, In : Tumor Biology. 37, 6, p. 7615-7623 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1

Xuan, F., Huang, M., Liu, W., Ding, H., Yang, L. & Cui, H., Jun 10 2016, In : Neuro-Oncology. 18, 6, p. 819-829 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J. H., Yan, C., Dong, Z., Huang, S., Zha, Y., Yang, L., Cui, H. & Ding, H. F., Jan 26 2016, In : Cell Reports. 14, 3, p. 506-519 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

Livingston, M. J., Ding, H., Huang, S., Hill, J. A., Yin, X. M. & Dong, Z., Jun 2 2016, In : Autophagy. 12, 6, p. 976-998 23 p.

Research output: Contribution to journalArticle

63 Scopus citations

The stress-responsive gene ATF3 mediates dichotomous UV responses by regulating the Tip60 and p53 proteins

Cui, H., Li, X., Han, C., Wang, Q. E., Wang, H., Ding, H. F., Zhang, J. & Yan, C., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10847-10857 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Liu, M., Xia, Y., Ding, J., Ye, B., Zhao, E., Choi, J. H., Alptekin, A., Yan, C., Dong, Z., Huang, S., Yang, L., Cui, H., Zha, Y. & Ding, H. F., Oct 4 2016, In : Cell Reports. 17, 2, p. 609-623 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Triple negative breast cancer development can be selectively suppressed by sustaining an elevated level of cellular cyclic AMP through simultaneously blocking its efflux and decomposition

Wang, W., Li, Y., Zhu, J. Y., Fang, D., Ding, H., Dong, Z., Jing, Q., Su, S. B. & Huang, S., Jan 1 2016, In : Oncotarget. 7, 52, p. 87232-87245 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

A novel Lozenge gene in silkworm, Bombyx mori regulates the melanization response of hemolymph

Xu, M., Wang, X., Tan, J., Zhang, K., Guan, X., Patterson, L. H., Ding, H. & Cui, H., Jan 1 2015, In : Developmental and Comparative Immunology. 53, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

Yang, L., Fang, D., Chen, H., Lu, Y., Dong, Z., Ding, H. F., Jing, Q., Su, S. B. & Huang, S., Jan 1 2015, In : Oncotarget. 6, 25, p. 20801-20812 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds

Lang, L., Ding, H., Chen, X., Sun, S. Y., Liu, G. & Yan, C., Jul 24 2015, In : Chemistry and Biology. 22, 7, p. 957-964 8 p., 3080.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

Wang, Z., Xu, D., Ding, H., Kim, J., Zhang, J., Hai, T. & Yan, C., Sep 17 2015, In : Oncogene. 34, 38, p. 4975-4984 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

mTOR contributes to ER stress and associated apoptosis in renal tubular cells

Dong, G., Liu, Y., Zhang, L., Huang, S., Ding, H. F. & Dong, Z., Jan 1 2015, In : American Journal of Physiology - Renal Physiology. 308, 3, p. F267-F274

Research output: Contribution to journalArticle

21 Scopus citations

Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development

Ke, X. X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R., Zhu, S., Xia, Q., Ding, H. F. & Cui, H., Jan 1 2015, In : Oncology Letters. 9, 6, p. 2507-2514 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

Cui, H., Guo, M., Xu, D., Ding, Z-C., Zhou, G., Ding, H., Zhang, J., Tang, Y. & Yan, C., Apr 13 2015, In : Nature communications. 6, 6752.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

Wang, X., Yang, L., Choi, J. H., Kitamura, E., Chang, C. S., Ding, J., Lee, E. J., Cui, H. & Ding, H. F., Jan 1 2014, In : Genomics Data. 2, p. 50-52 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression

Zha, Y., Xia, Y., Ding, J., Choi, J. H., Yang, L., Dong, Z., Yan, C., Huang, S. & Ding, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 9, e1417.

Research output: Contribution to journalArticle

20 Scopus citations

SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cells

Hong, S., Noh, H., Teng, Y., Shao, J., Rehmani, H., Ding, H., Dong, Z., Su, S. B., Shi, H., Kim, J. & Huang, S., Jan 1 2014, In : Neoplasia (United States). 16, 4, p. 279-290.e5

Research output: Contribution to journalArticle

47 Scopus citations
2013

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation

Calao, M., Sekyere, E. O., Cui, H. J., Cheung, B. B., Thomas, W. D., Keating, J., Chen, J. B., Raif, A., Jankowski, K., Davies, N. P., Bekkum, M. V., Chen, B., Tan, O., Ellis, T., Norris, M. D., Haber, M., Kim, E. S., Shohet, J. M., Trahair, T. N., Liu, T. & 3 others, Wainwright, B. J., Ding, H. F. & Marshall, G. M., Aug 1 2013, In : Oncogene. 32, 31, p. 3616-3626 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation

Wang, X., Choi, J-H., Ding, J., Yang, L., Ngoka, L. C., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., Cowell, J. K., Huang, S., Shi, H., Cui, H. & Ding, H., Nov 25 2013, In : BMC Genomics. 14, 1, 830.

Research output: Contribution to journalArticle

15 Scopus citations

Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression

Hu, Q., Lu, Y. Y., Noh, H., Hong, S., Dong, Z., Ding, H., Su, S. B. & Huang, S., Aug 22 2013, In : Oncogene. 32, 34, p. 3933-3943 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Leflunomide Reduces Proliferation and Induces Apoptosis in Neuroblastoma Cells In Vitro and In Vivo

Zhu, S., Yan, X., Xiang, Z., Ding, H. F. & Cui, H., Aug 9 2013, In : PloS one. 8, 8, e71555.

Research output: Contribution to journalArticle

27 Scopus citations

Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression

Patil, M., Pabla, N., Ding, H. F. & Dong, Z., Aug 15 2013, In : Cell Cycle. 12, 16, p. 2608-2616 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary MicroRNAs

Hong, S., Noh, H., Chen, H., Padia, R., Pan, Z. K., Su, S. B., Jing, Q., Ding, H. F. & Huang, S., Mar 12 2013, In : Science Signaling. 6, 266

Research output: Contribution to journalArticle

41 Scopus citations

The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation

Ding, J., Li, T., Wang, X., Zhao, E., Choi, J. H., Yang, L., Zha, Y., Dong, Z., Huang, S., Asara, J. M., Cui, H. & Ding, H. F., Dec 3 2013, In : Cell Metabolism. 18, 6, p. 896-907 12 p.

Research output: Contribution to journalArticle

98 Scopus citations
2012

Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells

Chen, X. Y., Gu, X. T., Saiyin, H., Wan, B., Zhang, Y. J., Li, J., Wang, Y. L., Gao, R., Wang, Y. F., Dong, W. P., Najjar, S. M., Zhang, C. Y., Ding, H. F., Liu, J. O. & Yu, L., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30368-30375 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression

Mao, L., Ding, J., Perdue, A., Yang, L., Zha, Y., Ren, M., Huang, S., Cui, H. & Ding, H. F., Aug 16 2012, In : Oncogene. 31, 33, p. 3785-3795 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation

Zha, Y., Ding, E., Yang, L., Mao, L., Wang, X., McCarthy, B. A., Huang, S. & Ding, H., Aug 7 2012, In : PloS one. 7, 8, e40728.

Research output: Contribution to journalArticle

23 Scopus citations

Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia

Pei, L., Choi, J-H., Liu, J., Lee, E. J., McCarthy, B., Wilson, J. M., Speir, E., Awan, F., Tae, H., Arthur, G., Schnabel, J. L., Taylor, K. H., Wang, X., Xu, D., Ding, H., Munn, D. H., Caldwell, C. W. & Shi, H., Jun 2012, In : Epigenetics. 7, 6, p. 567-578 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

McCarthy, B. A., Yang, L., Ding, J., Ren, M., King, W., Elsalanty, M. E., Zakhary, I., Sharawy, M. M. H., Cui, H. & Ding, H., May 29 2012, In : BMC Cancer. 12, 203.

Research output: Contribution to journalArticle

2 Scopus citations
2011

HOXC8-Dependent Cadherin 11 Expression Facilitates Breast Cancer Cell Migration through Trio and Rac

Li, Y., Guo, Z., Chen, H., Dong, Z., Pan, Z. K., Ding, H., Su, S. B. & Huang, S., Sep 1 2011, In : Genes and Cancer. 2, 9, p. 880-888 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma

Mao, L., Ding, J., Zha, Y., Yang, L., McCarthy, B. A., King, W., Cui, H. & Ding, H., Jun 15 2011, In : Cancer Research. 71, 12, p. 4314-4324 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells

Li, Z., Zhang, Z., Xie, J. X., Li, X., Tian, J., Cai, T., Cui, H., Ding, H., Shapiro, J. I. & Xie, Z., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 32394-32403 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2010

Analysis of specialized DNA polymerases expression in human gliomas: Association with prognostic significance

Wang, H., Wu, W., Wang, H. W., Wang, S., Chen, Y., Zhang, X., Yang, J., Zhao, S., Ding, H. F. & Lu, D., Jul 1 2010, In : Neuro-Oncology. 12, 7, p. 679-686 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Loss of negative feedback control of nuclear factor-κB2 activity in lymphocytes leads to fatal lung inflammation

Yang, L., Cui, H., Wang, Z., Zhang, B., Ding, J., Liu, L. & Ding, H., Jun 2010, In : American Journal of Pathology. 176, 6, p. 2646-2657 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009

MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development

Alam, G., Cui, H., Shi, H., Yang, L., Ding, J., Mao, L., Maltese, W. A. & Ding, H. F., Aug 2009, In : American Journal of Pathology. 175, 2, p. 856-866 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008

Constitutive production of NF-κB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression

Wang, Z., Zhang, B., Yang, L., Ding, J. & Ding, H., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10698-10706 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia

Shi, H., Cui, H., Alam, G., Gunning, W. T., Nestor, A., Giovannucci, D., Zhang, M. & Ding, H., Jun 20 2008, In : Journal of Comparative Neurology. 508, 6, p. 867-878 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2007

Adeno-associated virus induces apoptosis during coinfection with adenovirus

Timpe, J. M., Verrill, K. C., Black, B. N., Ding, H. F. & Trempe, J. P., Feb 20 2007, In : Virology. 358, 2, p. 391-401 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Bmi-1 is essential for the tumorigenicity of neuroblastoma cells

Cui, H., Hu, B., Li, T., Ma, J., Alam, G., Gunning, W. T. & Ding, H. F., Apr 2007, In : American Journal of Pathology. 170, 4, p. 1370-1378 9 p.

Research output: Contribution to journalArticle

110 Scopus citations