Haroldo Alfredo Flores Toque

Assistant Research Scientist

  • 1132 Citations
  • 21 h-Index
20062020

Research output per year

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Research Output

  • 1132 Citations
  • 21 h-Index
  • 45 Article
  • 3 Review article
  • 2 Comment/debate
2020

Impact of bacterial toxins in the lungs

Lucas, R., Hadizamani, Y., Gonzales, J., Gorshkov, B., Bodmer, T., Berthiaume, Y., Moehrlen, U., Lode, H., Huwer, H., Hudel, M., Mraheil, M. A., Toque, H. A. F., Chakraborty, T. & Hamacher, J., Apr 2020, In : Toxins. 12, 4, 223.

Research output: Contribution to journalArticle

Open Access
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
3 Scopus citations

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access
3 Scopus citations

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Arginase: A multifaceted enzyme important in health and disease

Caldwell, R. W., Rodriguez, P. C., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. B., Apr 1 2018, In : Physiological reviews. 98, 2, p. 641-665 25 p.

Research output: Contribution to journalReview article

39 Scopus citations

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In : Scientific reports. 7, 1, 2653.

Research output: Contribution to journalArticle

8 Scopus citations

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

7 Scopus citations

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

11 Scopus citations

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., Liu, Z., An, X., Flores Toque, H. A., Dong, Z., Jiang, X., Fulton, D. J., Weintraub, N. L., Li, Q., Bagi, Z., Hong, M., Boison, D., Wu, C. & Huo, Y., Dec 1 2017, In : Nature communications. 8, 1, 986.

Research output: Contribution to journalArticle

19 Scopus citations

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

Nunes, K. P., Bomfim, G. F., Toque, H. A., Szasz, T. & Clinton Webb, R., Dec 15 2017, In : Life sciences. 191, p. 219-226 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impaired corpus cavernosum relaxation is accompanied by increased oxidative stress and up-regulation of the rho-kinase pathway in diabetic (db/db) mice

Priviero, F. B. M., Toque, H. A. F., Nunes, K. P., Priolli, D. G., Teixeira, C. E. & Webb, R. C., May 1 2016, In : PloS one. 11, 5, e0156030.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

16 Scopus citations

Arginase: An old enzyme with new tricks

Caldwell, R. B., Toque, H. A., Narayanan, S. P. & Caldwell, R. W., Jan 1 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 395-405 11 p.

Research output: Contribution to journalReview article

120 Scopus citations

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
12 Scopus citations

Correction: Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Apr 21 2015, In : PLoS One. 10, 4, e0127110.

Research output: Contribution to journalComment/debate

2 Scopus citations
2014

New approaches to the design and discovery of therapies to prevent erectile dysfunction

Toque, H. A. & Caldwell, R. W., Dec 1 2014, In : Expert Opinion on Drug Discovery. 9, 12, p. 1447-1469 23 p.

Research output: Contribution to journalArticle

9 Scopus citations

Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum

Silva, F. H., Lanaro, C., Leiria, L. O., Rodrigues, R. L., Davel, A. P., Claudino, M. A., Toque, H. A. & Antunes, E., Nov 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 10, p. H1393-H1400

Research output: Contribution to journalArticle

22 Scopus citations

Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy

Liu, Z., Cai, H., Zhu, H., Toque, H., Zhao, N., Qiu, C., Guan, G., Dang, Y. & Wang, J., Dec 1 2014, In : Cellular Signalling. 26, 12, p. 2591-2600 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013
31 Scopus citations

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

20 Scopus citations

Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension

Toque, H. A., Nunes, K. P., Rojas, M., Bhatta, A., Yao, L., Xu, Z., Romero, M. J., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 219.

Research output: Contribution to journalArticle

29 Scopus citations

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

41 Scopus citations

Potential roles of adenosine deaminase-2 in diabetic retinopathy

Elsherbiny, N. M., Naime, M., Ahmad, S., Elsherbini, A. M., Mohammad, S., Fulzele, S., El-Remessy, A. B., Al-Gayyar, M. M., Eissa, L. A., El-Shishtawy, M. M., Han, G., White, R., Haroldo, T. F. & Liou, G. I., Jul 5 2013, In : Biochemical and Biophysical Research Communications. 436, 3, p. 355-361 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

27 Scopus citations

Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle-Aged Rats: Prevention by Antioxidant Therapy

Silva, F. H., Mónica, F. Z., Báu, F. R., Brugnerotto, A. F., Priviero, F. B. M., Toque, H. A. & Antunes, E., Apr 2013, In : Journal of Sexual Medicine. 10, 4, p. 960-971 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Erectile Function Is Improved in Aged Rats by PnTx2-6, a Toxin from Phoneutria nigriventer Spider Venom

Nunes, K. P., Toque, H. A., Borges, M. H., Richardson, M., Webb, R. C. & de Lima, M. E., Oct 2012, In : Journal of Sexual Medicine. 9, 10, p. 2574-2581 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice

Chen, Y. J., Liu, Y. L., Zhong, Q., Yu, Y. F., Su, H. L., Toque, H. A., Dang, Y. H., Chen, F., Xu, M. & Chen, T., Jun 1 2012, In : Neuroscience Bulletin. 28, 3, p. 222-232 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Mar 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

70 Scopus citations
16 Scopus citations

High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses

Toque, H. A., Da Silva, F. H., Calixto, M. C., Lintomen, L., Schenka, A. A., Saad, M. J., Zanesco, A. & Antunes, E., May 1 2011, In : BJU International. 107, 10, p. 1628-1634 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle

Toque, H. A., Mónica, F. Z. T., Morganti, R. P., De Nucci, G. & Antunes, E., Oct 1 2010, In : European Journal of Pharmacology. 645, 1-3, p. 158-164 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

p38 Mitogen-Activated Protein Kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice

Toque, H. A., Romero, M. J., Tostes, R. C., Shatanawi, A., Chandra, S., Carneiro, Z. N., Inscho, E. W., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Dec 2010, In : Journal of Sexual Medicine. 7, 12, p. 3857-3867 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

The role of RhoA/Rho kinase pathway in endothelial dysfunction

Yao, L., Romero, M. J., Toque, H. A., Yang, G., Caldwell, R. B. & Caldwell, R. W., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 4, p. 165-170 6 p.

Research output: Contribution to journalReview article

60 Scopus citations
2009

Comparative Relaxing Effects of Sildenafil, Vardenafil, and Tadalafil in Human Corpus Cavernosum: Contribution of Endogenous Nitric Oxide Release

Toque, H. A., Priviero, F. B. M., Teixeira, C. E., Claudino, M. A., Baracat, J. S., Fregonesi, A., De Nucci, G. & Antunes, E., Jul 1 2009, In : Urology. 74, 1, p. 216-221 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: Functional and biochemical aspects

Toque, H. A., Priviero, F. B. M., Zemse, S. M., Antunes, E., Teixeira, C. E. & Webb, R. C., Apr 1 2009, In : Clinical and Experimental Pharmacology and Physiology. 36, 4, p. 358-366 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2008
12 Scopus citations

Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

Toque, H. A., Teixeira, C. E., Lorenzetti, R., Okuyama, C. E., Antunes, E. & De Nucci, G., Sep 4 2008, In : European Journal of Pharmacology. 591, 1-3, p. 189-195 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction

Flores Toque, H. A., Priviero, F. B. M., Teixeira, C. E., Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Lorenzetti, R., Baracat, J. S., Santagada, V., Caliendo, G., Antunes, E. & De Nucci, G., May 8 2008, In : Journal of Medicinal Chemistry. 51, 9, p. 2807-2815 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

Toque, H. A., Teixeira, C. E., Priviero, F. B. M., Morganti, R. P., Antunes, E. & De Nucci, G., Jun 21 2008, In : British Journal of Pharmacology. 154, 4, p. 787-796 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2006

Vasorelaxing effects of propranolol in rat aorta and mesenteric artery: A role for nitric oxide and calcium entry blockade

Priviero, F., Teixeira, C. E., Flores Toque, H. A., Claudino, M. A., Webb, R. C., De Nucci, G., Zanesco, A. & Antunes, E., May 1 2006, In : Clinical and Experimental Pharmacology and Physiology. 33, 5-6, p. 448-455 8 p.

Research output: Contribution to journalArticle

23 Scopus citations