Haroldo Alfredo Flores Toque

Assistant Research Scientist

  • 952 Citations
  • 20 h-Index
20062019
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Research Output 2006 2019

  • 952 Citations
  • 20 h-Index
  • 44 Article
  • 3 Review article
  • 2 Comment/debate
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
Arginase
Oxidative stress
Muscle
Nitric Oxide
Skeletal Muscle
Arginase
Vasodilation
Hyperglycemia
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
1 Citation (Scopus)

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Flores Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Nitric Oxide
Adipocytes
Obesity
Open Access
adipose tissues
Arginase
Obese Mice
diets
sucrose

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 1 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2018
18 Citations (Scopus)

Arginase: A multifaceted enzyme important in health and disease

Caldwell, R. W., Rodriguez, P. C., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. B., Apr 1 2018, In : Physiological reviews. 98, 2, p. 641-665 25 p.

Research output: Contribution to journalReview article

Arginase
Health
Enzymes
Ornithine
Urea
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
2017
4 Citations (Scopus)

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In : Scientific Reports. 7, 1, 2653.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Resuscitation
AMP-Activated Protein Kinases
Wounds and Injuries
Orphan Drug Production
7 Citations (Scopus)

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

Medical problems
blood vessels
Blood Vessels
diabetes
aorta
17 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
6 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
10 Citations (Scopus)

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., Liu, Z., An, X., Flores Toque, H. A., Dong, Z., Jiang, X., Fulton, D. J., Weintraub, N. L., Li, Q., Bagi, Z., Hong, M., Boison, D., Wu, C. & Huo, Y., Dec 1 2017, In : Nature Communications. 8, 1, 986.

Research output: Contribution to journalArticle

Adenosine Kinase
adenosines
Adenosine
Blood Vessels
Inflammation
9 Citations (Scopus)

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

Nunes, K. P., Bomfim, G. F., Flores Toque, H. A., Szasz, T. & Webb, R. C., Dec 15 2017, In : Life sciences. 191, p. 219-226 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Angiotensin II
Nitric Oxide
Nitric Oxide Synthase
Smooth Muscle Myocytes
2016
8 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
6 Citations (Scopus)

Impaired corpus cavernosum relaxation is accompanied by increased oxidative stress and up-regulation of the rho-kinase pathway in diabetic (db/db) mice

Priviero, F. B. M., Toque, H. A. F., Nunes, K. P., Priolli, D. G., Teixeira, C. E. & Webb, R. C., May 1 2016, In : PloS one. 11, 5, e0156030.

Research output: Contribution to journalArticle

rho-Associated Kinases
Oxidative stress
phosphotransferases (kinases)
Oxidative Stress
oxidative stress
2015
13 Citations (Scopus)

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

Arginase
arginase
angiotensin II
fibrosis
Angiotensin II
89 Citations (Scopus)

Arginase: An old enzyme with new tricks

Caldwell, R. B., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. W., Jan 1 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 395-405 11 p.

Research output: Contribution to journalReview article

Arginase
Enzymes
Cardiovascular system
Ornithine
Neurology
9 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
11 Citations (Scopus)
Penile Erection
Obese Mice
Oxidative Stress
Antioxidants
NADPH Oxidase
2 Citations (Scopus)

Correction: Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Apr 21 2015, In : PLoS One. 10, 4, e0127110.

Research output: Contribution to journalComment/debate

Arginase
Angiotensin II
2014
9 Citations (Scopus)
Arginase
Erectile Dysfunction
Therapeutics
Nitric Oxide
Nitric Oxide Synthase
22 Citations (Scopus)

Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum

Silva, F. H., Lanaro, C., Leiria, L. O., Rodrigues, R. L., Davel, A. P., Claudino, M. A., Toque, H. A. & Antunes, E., Nov 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 10, p. H1393-H1400

Research output: Contribution to journalArticle

Oxidative Stress
Down-Regulation
Tyrosine 3-Monooxygenase
Reactive Oxygen Species
Messenger RNA
21 Citations (Scopus)
Diabetic Cardiomyopathies
Calcineurin
Endoplasmic Reticulum
Protein Kinases
Cardiac Arrhythmias
2013
28 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Blood Vessels
Nitrergic Neurons
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
36 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
20 Citations (Scopus)

Potential roles of adenosine deaminase-2 in diabetic retinopathy

Elsherbiny, N. M., Naime, M., Ahmad, S., Elsherbini, A. M., Mohammad, S., Fulzele, S., El-Remessy, A. B., Al-Gayyar, M. M., Eissa, L. A., El-Shishtawy, M. M., Han, G., White, R., Haroldo, T. F. & Liou, G. I., Jul 5 2013, In : Biochemical and Biophysical Research Communications. 436, 3, p. 355-361 7 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
Diabetic Retinopathy
Adenosine Kinase
Adenosine
Swine
54 Citations (Scopus)

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Blood Vessels
Aorta
Protein Isoforms
24 Citations (Scopus)

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular System Injuries
Medical problems
retina
blood vessels
29 Citations (Scopus)

Superoxide Anion Production by NADPH Oxidase Plays a Major Role in Erectile Dysfunction in Middle-Aged Rats: Prevention by Antioxidant Therapy

Silva, F. H., Mónica, F. Z., Báu, F. R., Brugnerotto, A. F., Priviero, F., Flores Toque, H. A. & Antunes, E., Jan 1 2013, In : Journal of Sexual Medicine. 10, 4, p. 960-971 12 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Erectile Dysfunction
Superoxides
Antioxidants
Nitric Oxide Synthase Type I
32 Citations (Scopus)

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

Arginase
Retinal Vessels
Myography
Vasodilation
Blood Vessels
2012
9 Citations (Scopus)

Erectile Function Is Improved in Aged Rats by PnTx2-6, a Toxin from Phoneutria nigriventer Spider Venom

Nunes, K. P., Flores Toque, H. A., Borges, M. H., Richardson, M., Webb, R. C. & de Lima, M. E., Jan 1 2012, In : Journal of Sexual Medicine. 9, 10, p. 2574-2581 8 p.

Research output: Contribution to journalArticle

Spider Venoms
Cyclic GMP
Nitric Oxide
Erectile Dysfunction
Nitric Oxide Synthase
18 Citations (Scopus)

Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice

Chen, Y. J., Liu, Y. L., Zhong, Q., Yu, Y. F., Su, H. L., Toque, H. A., Dang, Y. H., Chen, F., Xu, M. & Chen, T., Jun 1 2012, In : Neuroscience Bulletin. 28, 3, p. 222-232 11 p.

Research output: Contribution to journalArticle

Methamphetamine
Prefrontal Cortex
Hippocampus
tetrahydropalmatine
Spatial Memory
2011
45 Citations (Scopus)

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Flores Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

Arginase
Knockout Mice
Endothelium
Erectile Dysfunction
Experimental Diabetes Mellitus
67 Citations (Scopus)

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Hypertension
Rodentia
Lung
Epidermal Growth Factor
15 Citations (Scopus)
Arginase
Extracellular Signal-Regulated MAP Kinases
Streptozocin
Erectile Dysfunction
Endothelium
21 Citations (Scopus)

High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses

Toque, H. A., Da Silva, F. H., Calixto, M. C., Lintomen, L., Schenka, A. A., Saad, M. J., Zanesco, A. & Antunes, E., May 1 2011, In : BJU International. 107, 10, p. 1628-1634 7 p.

Research output: Contribution to journalArticle

High Fat Diet
Obesity
Erectile Dysfunction
Diet
Adrenergic Agents
2010
12 Citations (Scopus)

Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle

Toque, H. A., Mónica, F. Z. T., Morganti, R. P., De Nucci, G. & Antunes, E., Oct 1 2010, In : European Journal of Pharmacology. 645, 1-3, p. 158-164 7 p.

Research output: Contribution to journalArticle

Smooth Muscle
Nitric Oxide
Muscle Relaxation
Carbachol
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
37 Citations (Scopus)
Arginase
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide Synthase
Blood Pressure
37 Citations (Scopus)

The role of RhoA/Rho kinase pathway in endothelial dysfunction

Yao, L., Romero, M. J., Toque, H. A., Yang, G., Caldwell, R. B. & Caldwell, R. W., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 4, p. 165-170 6 p.

Research output: Contribution to journalReview article

rho-Associated Kinases
Blood Vessels
Vascular Diseases
Pathology
2009
9 Citations (Scopus)

Comparative Relaxing Effects of Sildenafil, Vardenafil, and Tadalafil in Human Corpus Cavernosum: Contribution of Endogenous Nitric Oxide Release

Flores Toque, H. A., Priviero, F., Teixeira, C. E., Claudino, M. A., Baracat, J. S., Fregonesi, A., De Nucci, G. & Antunes, E., Jul 1 2009, In : Urology. 74, 1, p. 216-221 6 p.

Research output: Contribution to journalArticle

Phosphodiesterase 5 Inhibitors
Nitric Oxide
Phenylephrine
Smooth Muscle
Penile Erection
4 Citations (Scopus)
Phosphodiesterase 5 Inhibitors
Muscles
Nitroglycerin
Baths
Penile Erection
2008
12 Citations (Scopus)
Cyclic GMP
Urethra
Nitric Oxide
Rabbits
Calcium
36 Citations (Scopus)

Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

Toque, H. A., Teixeira, C. E., Lorenzetti, R., Okuyama, C. E., Antunes, E. & De Nucci, G., Sep 4 2008, In : European Journal of Pharmacology. 591, 1-3, p. 189-195 7 p.

Research output: Contribution to journalArticle

Phosphodiesterase 5 Inhibitors
Pharmacology
Rabbits
Oral Administration
Nitric Oxide
38 Citations (Scopus)

Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction

Flores Toque, H. A., Priviero, F. B. M., Teixeira, C. E., Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Lorenzetti, R., Baracat, J. S., Santagada, V., Caliendo, G., Antunes, E. & De Nucci, G., May 8 2008, In : Journal of Medicinal Chemistry. 51, 9, p. 2807-2815 9 p.

Research output: Contribution to journalArticle

Erectile Dysfunction
Pharmacology
Aorta
Phosphodiesterase 5 Inhibitors
ethylenediamine
39 Citations (Scopus)

Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

Flores Toque, H. A., Teixeira, C. E., Priviero, F., Morganti, R. P., Antunes, E. & De Nucci, G., Jun 21 2008, In : British Journal of Pharmacology. 154, 4, p. 787-796 10 p.

Research output: Contribution to journalArticle

Calcium Channels
Pulmonary Artery
Blood Platelets
Rabbits
Endothelium
2006
22 Citations (Scopus)

Vasorelaxing effects of propranolol in rat aorta and mesenteric artery: A role for nitric oxide and calcium entry blockade

Priviero, F., Teixeira, C. E., Flores Toque, H. A., Claudino, M. A., Webb, R. C., De Nucci, G., Zanesco, A. & Antunes, E., May 1 2006, In : Clinical and Experimental Pharmacology and Physiology. 33, 5-6, p. 448-455 8 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Propranolol
Aorta
Nitric Oxide
Calcium