• 5540 Citations
  • 28 h-Index
20002019

Research output per year

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Research Output

2019

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In : Oncogene. 38, 28, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Dietary myo-inositol chemoprevents lung carcinogenesis via boosting immune system in Kras mouse model

Piranlioglu, R., Korkaya, H. & Hassan, K. A., Jan 1 2019, In : Journal of Thoracic Disease. 11, 3, p. 632-635 4 p.

Research output: Contribution to journalReview article

Plasticity and potency of mammary stem cell subsets during mammary gland development

Lee, E., Piranlioglu, R., Wicha, M. S. & Korkaya, H., May 1 2019, In : International journal of molecular sciences. 20, 9, 2357.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

4 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Mimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer

La Manna, S., Lee, E., Ouzounova, M., Di Natale, C., Novellino, E., Merlino, A., Korkaya, H. & Marasco, D., Nov 1 2018, In : International Journal of Cancer. 143, 9, p. 2177-2186 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

SALL1 expression in acute myeloid leukemia

Salman, H., Shuai, X., Nguyen-Lefebvre, A. T., Giri, B., Ren, M., Rauchman, M., Robbins, L., Hou, W., Korkaya, H. & Ma, Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7442-7452 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

SRC increases MYC mRNA expression in estrogen receptor-positive breast cancer via mRNA stabilization and inhibition of p53 function

Abdullah, C., Korkaya, H., Iizuka, S. & Courtneidge, S. A., Mar 1 2018, In : Molecular and Cellular Biology. 38, 6, e00463-17.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer

Yu, X., Ghamande, S. A., Liu, H., Xue, L., Zhao, S., Tan, W., Zhao, L., Tang, S-C., Wu, D., Korkaya, H., Maihle, N. J. & Liu, H., Mar 2 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 317-330 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer

Kadi, N. E., Wang, L., Davis, A., Korkaya, H., Cooke, A., Vadnala, V., Brown, N. A., Betz, B. L., Cascalho, M., Kalemkerian, G. P. & Hassan, K. A., Dec 15 2018, In : Cancer Research. 78, 24, p. 6728-6735 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons

Üstün, R., Oğuz, E. K., Şeker, A. & Korkaya, H., Dec 2018, In : NeuroToxicology. 69, p. 68-76 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Thymoquinone protects DRG neurons from axotomy-induced cell death

Üstün, R., Oğuz, E. K., Şeker, A. & Korkaya, H., Nov 2 2018, In : Neurological Research. 40, 11, p. 930-937 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

Borin, T. F., Shankar, A., Angara, K., Rashid, M. H., Jain, M., Iskander, A., Ara, R., Lebedyeva, I., Korkaya, H., Achyut, B. R. & Arbab, A. S., Jun 2017, In : PloS one. 12, 6, 0178830.

Research output: Contribution to journalArticle

4 Scopus citations

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.

Research output: Contribution to journalArticle

66 Scopus citations

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

A novel IL6 antibody sensitizes multiple tumor types to chemotherapy including trastuzumab-resistant tumors

Zhong, H., Davis, A., Ouzounova, M., Carrasco, R. A., Chen, C., Breen, S., Chang, Y. S., Huang, J., Liu, Z., Yao, Y., Hurt, E., Moisan, J., Fung, M., Tice, D. A., Clouthier, S. G., Xiao, Z., Wicha, M. S., Korkaya, H. & Hollingsworth, R. E., Jan 15 2016, In : Cancer Research. 76, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated photothermal therapy

Paholak, H. J., Stevers, N. O., Chen, H., Burnett, J. P., He, M., Korkaya, H., McDermott, S. P., Deol, Y., Clouthier, S. G., Luther, T., Li, Q., Wicha, M. S. & Sun, D., Oct 1 2016, In : Biomaterials. 104, p. 145-157 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Interplay between cell cycle and autophagy induced by boswellic acid analog

Pathania, A. S., Guru, S. K., Kumar, S., Kumar, A., Ahmad, M., Bhushan, S., Sharma, P. R., Mahajan, P., Shah, B. A., Sharma, S., Nargotra, A., Vishwakarma, R., Korkaya, H. & Malik, F., Sep 29 2016, In : Scientific reports. 6, 33146.

Research output: Contribution to journalArticle

10 Scopus citations

Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer

Sun, L., Burnett, J., Gasparyan, M., Xu, F., Jiang, H., Lin, C. C., Myers, I., Korkaya, H., Liu, Y., Connarn, J., He, H., Zhang, N., Wicha, M. S. & Sun, D., Aug 1 2016, In : Oncotarget. 7, 32, p. 51408-51422 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers

Linklater, E. S., Tovar, E. A., Essenburg, C. J., Turner, L., Madaj, Z., Winn, M. E., Melnik, M. K., Korkaya, H., Maroun, C. R., Christensen, J. G., Steensma, M. R., Boerner, J. L. & Graveel, C. R., Jan 1 2016, In : Oncotarget. 7, 43, p. 69903-69915 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity

D'Angelo, R. C., Ouzounova, M., Davis, A., Choi, D., Tchuenkam, S. M., Kim, G., Luther, T., Quraishi, A. A., Senbabaoglu, Y., Conley, S. J., Clouthier, S. G., Hassan, K. A., Wicha, M. S. & Korkaya, H., Mar 1 2015, In : Molecular cancer therapeutics. 14, 3, p. 779-787 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic Niche

Malik, F., Korkaya, H., Clouthier, S. G. & Wicha, M. S., Mar 6 2015, Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics. Wiley-Blackwell, p. 123-143 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model

Kim, G., Ouzounova, M., Quraishi, A. A., Davis, A., Tawakkol, N., Clouthier, S. G., Malik, F., Paulson, A. K., D'Angelo, R. C., Korkaya, S., Baker, T. L., Esen, E. S., Prat, A., Liu, S., Kleer, C. G., Thomas, D. G., Wicha, M. S. & Korkaya, H., Feb 5 2015, In : Oncogene. 34, 6, p. 671-680 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors

Pathania, A. S., Wani, Z. A., Guru, S. K., Kumar, S., Bhushan, S., Korkaya, H., Seals, D. F., Kumar, A., Mondhe, D. M., Ahmed, Z., Chandan, B. K. & Malik, F., Jan 21 2015, In : Molecular cancer. 14, 1, 6.

Research output: Contribution to journalArticle

16 Scopus citations

Trastuzumab resistance induces EMT to transform HER2 + PTEN' to a triple negative breast cancer that requires unique treatment options

Burnett, J. P., Korkaya, H., Ouzounova, M. D., Jiang, H., Conley, S. J., Newman, B. W., Sun, L., Connarn, J. N., Chen, C. S., Zhang, N., Wicha, M. S. & Sun, D., Nov 2 2015, In : Scientific reports. 5, 15821.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Cancer Stem Cells and the Microenvironment

Korkaya, H., Davis, A. & Wicha, M. S., Mar 1 2014, The Molecular Basis of Cancer: Fourth Edition. Elsevier Inc.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Breast cancer stem cells: We've got them surrounded

Korkaya, H. & Wicha, M. S., Feb 1 2013, In : Clinical Cancer Research. 19, 3, p. 511-513 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Breast cancer stem cells: Responsible for therapeutic resistance and relapse?

Korkaya, H. & Malik, F., Aug 1 2013, Breast Cancer Metastasis and Drug Resistance: Progress and Prospects. Springer New York, Vol. 9781461456476. p. 385-398 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells

Lin, L., Hutzen, B., Lee, H. F., Peng, Z., Wang, W., Zhao, C., Lin, H. J., Sun, D., Li, P. K., Li, C., Korkaya, H., Wicha, M. S. & Lin, J., Feb 23 2013, In : PloS one. 8, 12, e82821.

Research output: Contribution to journalArticle

46 Scopus citations

HER2 and breast cancer stem cells: More than meets the eye

Korkaya, H. & Wicha, M. S., Jun 15 2013, In : Cancer Research. 73, 12, p. 3489-3493 5 p.

Research output: Contribution to journalReview article

75 Scopus citations

HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of

Trastuzumab, A., Ithimakin, S., Day, K. C., Malik, F., Zen, Q., Dawsey, S. J., Bersano-Begey, T. F., Quraishi, A. A., Ignatoski, K. W., Daignault, S., Davis, A., Hall, C. L., Palanisamy, N., Heath, A. N., Tawakkol, N., Luther, T. K., Clouthier, S. G., Chadwick, W. A., Day, M. L., Kleer, C. G. & 4 others, Thomas, D. G., Hayes, D. F., Korkaya, H. & Wicha, M. S., Mar 1 2013, In : Cancer Research. 73, 5, p. 1635-1646 12 p.

Research output: Contribution to journalArticle

151 Scopus citations

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma

Hassan, K. A., Wang, L., Korkaya, H., Chen, G., Maillard, I., Beer, D. G., Kalemkerian, G. P. & Wicha, M. S., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 1972-1980 9 p.

Research output: Contribution to journalArticle

130 Scopus citations
2012

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

Korkaya, H., Kim, G. I., Davis, A., Malik, F., Henry, N. L., Ithimakin, S., Quraishi, A. A., Tawakkol, N., D'Angelo, R., Paulson, A. K., Chung, S., Luther, T., Paholak, H. J., Liu, S., Hassan, K. A., Zen, Q., Clouthier, S. G. & Wicha, M. S., Aug 24 2012, In : Molecular Cell. 47, 4, p. 570-584 15 p.

Research output: Contribution to journalArticle

300 Scopus citations

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Conley, S. J., Gheordunescu, E., Kakarala, P., Newman, B., Korkaya, H., Heath, A. N., Clouthier, S. G. & Wicha, M. S., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2784-2789 6 p.

Research output: Contribution to journalArticle

409 Scopus citations

Are cancer stem cells ready for prime time?

Liu, S., Korkaya, H. & Wicha, M. S., Apr 1 2012, In : Scientist. 26, 4

Research output: Contribution to journalArticle

2 Scopus citations

Breast cancer heterogeneity: Need to review current treatment strategies

Malik, F., Korkaya, H., Clouthier, S. G. & Wicha, M. S., Dec 1 2012, In : Current Breast Cancer Reports. 4, 4, p. 225-231 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer

Malik, F., Korkaya, H., Clouthier, S. G. & Wicha, M. S., Aug 1 2012, In : Cell Cycle. 11, 15, p. 2780-2781 2 p.

Research output: Contribution to journalComment/debate

16 Scopus citations

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells

Liu, S., Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J. & Wicha, M. S., Jun 1 2012, In : PLoS Genetics. 8, 6, e1002751.

Research output: Contribution to journalArticle

112 Scopus citations

Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors

Petrillo, L. A., Wolf, D. M., Kapoun, A. M., Wang, N. J., Barczak, A., Xiao, Y., Korkaya, H., Baehner, F., Lewicki, J., Wicha, M., Park, J. W., Spellman, P. T., Gray, J. W., Van'T Veer, L. & Esserman, L. J., Oct 1 2012, In : Breast Cancer Research and Treatment. 135, 3, p. 913-922 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Korkaya, H., Liu, S. & Wicha, M. S., Oct 3 2011, In : Journal of Clinical Investigation. 121, 10, p. 3804-3809 6 p.

Research output: Contribution to journalReview article

358 Scopus citations

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R. & Wicha, M. S., Jan 15 2011, In : Cancer Research. 71, 2, p. 614-624 11 p.

Research output: Contribution to journalArticle

404 Scopus citations

Inflammation and autophagy conspire to promote tumor growth

Korkaya, H. & Wicha, M. S., Aug 15 2011, In : Cell Cycle. 10, 16, 1 p.

Research output: Contribution to journalShort survey

11 Scopus citations

Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots

Korkaya, H., Liu, S. & Wicha, M. S., Oct 1 2011, In : Clinical Cancer Research. 17, 19, p. 6125-6128 4 p.

Research output: Contribution to journalReview article

178 Scopus citations
2010

Cancer stem cells: Nature versus nurture

Korkaya, H. & Wicha, M. S., May 1 2010, In : Nature Cell Biology. 12, 5, p. 419-421 3 p.

Research output: Contribution to journalShort survey

37 Scopus citations

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J. L., Dontu, G. & Wicha, M. S., Feb 1 2010, In : Journal of Clinical Investigation. 120, 2, p. 485-497 13 p.

Research output: Contribution to journalArticle

516 Scopus citations

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., Yu, Y., Clouthier, S. G., Schwartz, S. J., Wicha, M. S. & Sun, D., May 1 2010, In : Clinical Cancer Research. 16, 9, p. 2580-2590 11 p.

Research output: Contribution to journalArticle

336 Scopus citations

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G. & Wicha, M. S., Aug 1 2010, In : Breast Cancer Research and Treatment. 122, 3, p. 777-785 9 p.

Research output: Contribution to journalArticle

298 Scopus citations
2009

HER-2, notch, and breast cancer stem cells: Targeting an axis of evil

Korkaya, H. & Wicha, M. S., Mar 15 2009, In : Clinical Cancer Research. 15, 6, p. 1845-1847 3 p.

Research output: Contribution to journalArticle

101 Scopus citations

Regulation of mammary stem/progenitor cells by PTEN/Akt/β-catenin signaling

Korkaya, H., Paulson, A., Charafe-Jauffret, E., Ginestier, C., Brown, M., Dutcher, J., Clouthier, S. G. & Wicha, M. S., Jun 1 2009, In : PLoS Biology. 7, 6, e1000121.

Research output: Contribution to journalArticle

386 Scopus citations