• 5817 Citations
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20002020

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Article
2020

Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice

Gunebakan, E., Yalcin, E., Dulger, E. C., Yigitbasi, A., Ates, N., Caglayan, A., Beker, M. C., Sahin, K., Korkaya, H. & Kilic, E., Feb 1 2020, In : Biomedicines. 8, 2, 23.

Research output: Contribution to journalArticle

Open Access
2019

Plasticity and potency of mammary stem cell subsets during mammary gland development

Lee, E., Piranlioglu, R., Wicha, M. S. & Korkaya, H., May 1 2019, In : International journal of molecular sciences. 20, 9, 2357.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature communications. 10, 1, 1430.

Research output: Contribution to journalArticle

6 Scopus citations

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R., Maihle, N., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Apr 5 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Mimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer

La Manna, S., Lee, E., Ouzounova, M., Di Natale, C., Novellino, E., Merlino, A., Korkaya, H. & Marasco, D., Nov 1 2018, In : International Journal of Cancer. 143, 9, p. 2177-2186 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

SALL1 expression in acute myeloid leukemia

Salman, H., Shuai, X., Nguyen-Lefebvre, A. T., Giri, B., Ren, M., Rauchman, M., Robbins, L., Hou, W., Korkaya, H. & Ma, Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7442-7452 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

SRC increases MYC mRNA expression in estrogen receptor-positive breast cancer via mRNA stabilization and inhibition of p53 function

Abdullah, C., Korkaya, H., Iizuka, S. & Courtneidge, S. A., Mar 1 2018, In : Molecular and Cellular Biology. 38, 6, e00463-17.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer

Yu, X., Ghamande, S. A., Liu, H., Xue, L., Zhao, S., Tan, W., Zhao, L., Tang, S-C., Wu, D., Korkaya, H., Maihle, N. J. & Liu, H., Mar 2 2018, In : Molecular Therapy - Nucleic Acids. 10, p. 317-330 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer

Kadi, N. E., Wang, L., Davis, A., Korkaya, H., Cooke, A., Vadnala, V., Brown, N. A., Betz, B. L., Cascalho, M., Kalemkerian, G. P. & Hassan, K. A., Dec 15 2018, In : Cancer Research. 78, 24, p. 6728-6735 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons

Üstün, R., Oğuz, E. K., Şeker, A. & Korkaya, H., Dec 2018, In : NeuroToxicology. 69, p. 68-76 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Thymoquinone protects DRG neurons from axotomy-induced cell death

Üstün, R., Oğuz, E. K., Şeker, A. & Korkaya, H., Nov 2 2018, In : Neurological Research. 40, 11, p. 930-937 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

Borin, T. F., Shankar, A., Angara, K., Rashid, M. H., Jain, M., Iskander, A., Ara, R., Lebedyeva, I., Korkaya, H., Achyut, B. R. & Arbab, A. S., Jun 2017, In : PloS one. 12, 6, 0178830.

Research output: Contribution to journalArticle

7 Scopus citations

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature communications. 8, 14979.

Research output: Contribution to journalArticle

92 Scopus citations

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

A novel IL6 antibody sensitizes multiple tumor types to chemotherapy including trastuzumab-resistant tumors

Zhong, H., Davis, A., Ouzounova, M., Carrasco, R. A., Chen, C., Breen, S., Chang, Y. S., Huang, J., Liu, Z., Yao, Y., Hurt, E., Moisan, J., Fung, M., Tice, D. A., Clouthier, S. G., Xiao, Z., Wicha, M. S., Korkaya, H. & Hollingsworth, R. E., Jan 15 2016, In : Cancer Research. 76, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated photothermal therapy

Paholak, H. J., Stevers, N. O., Chen, H., Burnett, J. P., He, M., Korkaya, H., McDermott, S. P., Deol, Y., Clouthier, S. G., Luther, T., Li, Q., Wicha, M. S. & Sun, D., Oct 1 2016, In : Biomaterials. 104, p. 145-157 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Interplay between cell cycle and autophagy induced by boswellic acid analog

Pathania, A. S., Guru, S. K., Kumar, S., Kumar, A., Ahmad, M., Bhushan, S., Sharma, P. R., Mahajan, P., Shah, B. A., Sharma, S., Nargotra, A., Vishwakarma, R., Korkaya, H. & Malik, F., Sep 29 2016, In : Scientific reports. 6, 33146.

Research output: Contribution to journalArticle

12 Scopus citations

Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer

Sun, L., Burnett, J., Gasparyan, M., Xu, F., Jiang, H., Lin, C. C., Myers, I., Korkaya, H., Liu, Y., Connarn, J., He, H., Zhang, N., Wicha, M. S. & Sun, D., Aug 1 2016, In : Oncotarget. 7, 32, p. 51408-51422 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers

Linklater, E. S., Tovar, E. A., Essenburg, C. J., Turner, L., Madaj, Z., Winn, M. E., Melnik, M. K., Korkaya, H., Maroun, C. R., Christensen, J. G., Steensma, M. R., Boerner, J. L. & Graveel, C. R., 2016, In : Oncotarget. 7, 43, p. 69903-69915 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Notch reporter activity in breast cancer cell lines identifies a subset of cells with stem cell activity

D'Angelo, R. C., Ouzounova, M., Davis, A., Choi, D., Tchuenkam, S. M., Kim, G., Luther, T., Quraishi, A. A., Senbabaoglu, Y., Conley, S. J., Clouthier, S. G., Hassan, K. A., Wicha, M. S. & Korkaya, H., Mar 1 2015, In : Molecular cancer therapeutics. 14, 3, p. 779-787 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model

Kim, G., Ouzounova, M., Quraishi, A. A., Davis, A., Tawakkol, N., Clouthier, S. G., Malik, F., Paulson, A. K., D'Angelo, R. C., Korkaya, S., Baker, T. L., Esen, E. S., Prat, A., Liu, S., Kleer, C. G., Thomas, D. G., Wicha, M. S. & Korkaya, H., Feb 5 2015, In : Oncogene. 34, 6, p. 671-680 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors

Pathania, A. S., Wani, Z. A., Guru, S. K., Kumar, S., Bhushan, S., Korkaya, H., Seals, D. F., Kumar, A., Mondhe, D. M., Ahmed, Z., Chandan, B. K. & Malik, F., Jan 21 2015, In : Molecular cancer. 14, 1, 6.

Research output: Contribution to journalArticle

17 Scopus citations

Trastuzumab resistance induces EMT to transform HER2 + PTEN' to a triple negative breast cancer that requires unique treatment options

Burnett, J. P., Korkaya, H., Ouzounova, M. D., Jiang, H., Conley, S. J., Newman, B. W., Sun, L., Connarn, J. N., Chen, C. S., Zhang, N., Wicha, M. S. & Sun, D., Nov 2 2015, In : Scientific reports. 5, 15821.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Breast cancer stem cells: We've got them surrounded

Korkaya, H. & Wicha, M. S., Feb 1 2013, In : Clinical Cancer Research. 19, 3, p. 511-513 3 p.

Research output: Contribution to journalArticle

23 Scopus citations

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells

Lin, L., Hutzen, B., Lee, H. F., Peng, Z., Wang, W., Zhao, C., Lin, H. J., Sun, D., Li, P. K., Li, C., Korkaya, H., Wicha, M. S. & Lin, J., Feb 23 2013, In : PloS one. 8, 12, e82821.

Research output: Contribution to journalArticle

48 Scopus citations

HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of

Trastuzumab, A., Ithimakin, S., Day, K. C., Malik, F., Zen, Q., Dawsey, S. J., Bersano-Begey, T. F., Quraishi, A. A., Ignatoski, K. W., Daignault, S., Davis, A., Hall, C. L., Palanisamy, N., Heath, A. N., Tawakkol, N., Luther, T. K., Clouthier, S. G., Chadwick, W. A., Day, M. L., Kleer, C. G. & 4 others, Thomas, D. G., Hayes, D. F., Korkaya, H. & Wicha, M. S., Mar 1 2013, In : Cancer Research. 73, 5, p. 1635-1646 12 p.

Research output: Contribution to journalArticle

156 Scopus citations

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma

Hassan, K. A., Wang, L., Korkaya, H., Chen, G., Maillard, I., Beer, D. G., Kalemkerian, G. P. & Wicha, M. S., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 1972-1980 9 p.

Research output: Contribution to journalArticle

137 Scopus citations
2012

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

Korkaya, H., Kim, G. I., Davis, A., Malik, F., Henry, N. L., Ithimakin, S., Quraishi, A. A., Tawakkol, N., D'Angelo, R., Paulson, A. K., Chung, S., Luther, T., Paholak, H. J., Liu, S., Hassan, K. A., Zen, Q., Clouthier, S. G. & Wicha, M. S., Aug 24 2012, In : Molecular Cell. 47, 4, p. 570-584 15 p.

Research output: Contribution to journalArticle

311 Scopus citations

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Conley, S. J., Gheordunescu, E., Kakarala, P., Newman, B., Korkaya, H., Heath, A. N., Clouthier, S. G. & Wicha, M. S., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2784-2789 6 p.

Research output: Contribution to journalArticle

429 Scopus citations

Are cancer stem cells ready for prime time?

Liu, S., Korkaya, H. & Wicha, M. S., Apr 1 2012, In : Scientist. 26, 4

Research output: Contribution to journalArticle

2 Scopus citations

Breast cancer heterogeneity: Need to review current treatment strategies

Malik, F., Korkaya, H., Clouthier, S. G. & Wicha, M. S., Dec 1 2012, In : Current Breast Cancer Reports. 4, 4, p. 225-231 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells

Liu, S., Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J. & Wicha, M. S., Jun 2012, In : PLoS Genetics. 8, 6, e1002751.

Research output: Contribution to journalArticle

119 Scopus citations

Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors

Petrillo, L. A., Wolf, D. M., Kapoun, A. M., Wang, N. J., Barczak, A., Xiao, Y., Korkaya, H., Baehner, F., Lewicki, J., Wicha, M., Park, J. W., Spellman, P. T., Gray, J. W., Van'T Veer, L. & Esserman, L. J., Oct 2012, In : Breast Cancer Research and Treatment. 135, 3, p. 913-922 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R. & Wicha, M. S., Jan 15 2011, In : Cancer Research. 71, 2, p. 614-624 11 p.

Research output: Contribution to journalArticle

417 Scopus citations
2010

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J. L., Dontu, G. & Wicha, M. S., Feb 1 2010, In : Journal of Clinical Investigation. 120, 2, p. 485-497 13 p.

Research output: Contribution to journalArticle

540 Scopus citations

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., Yu, Y., Clouthier, S. G., Schwartz, S. J., Wicha, M. S. & Sun, D., May 1 2010, In : Clinical Cancer Research. 16, 9, p. 2580-2590 11 p.

Research output: Contribution to journalArticle

355 Scopus citations

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G. & Wicha, M. S., Aug 2010, In : Breast Cancer Research and Treatment. 122, 3, p. 777-785 9 p.

Research output: Contribution to journalArticle

316 Scopus citations
2009

HER-2, notch, and breast cancer stem cells: Targeting an axis of evil

Korkaya, H. & Wicha, M. S., Mar 15 2009, In : Clinical Cancer Research. 15, 6, p. 1845-1847 3 p.

Research output: Contribution to journalArticle

102 Scopus citations

Regulation of mammary stem/progenitor cells by PTEN/Akt/β-catenin signaling

Korkaya, H., Paulson, A., Charafe-Jauffret, E., Ginestier, C., Brown, M., Dutcher, J., Clouthier, S. G. & Wicha, M. S., Jun 2009, In : PLoS Biology. 7, 6, e1000121.

Research output: Contribution to journalArticle

399 Scopus citations
2008

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

Korkaya, H., Paulson, A., Iovino, F. & Wicha, M. S., Oct 16 2008, In : Oncogene. 27, 47, p. 6120-6130 11 p.

Research output: Contribution to journalArticle

435 Scopus citations
2005

Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts

Bromann, P. A., Korkaya, H., Webb, C. P., Miller, J., Calvin, T. L. & Courtneidge, S. A., Mar 18 2005, In : Journal of Biological Chemistry. 280, 11, p. 10253-10263 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2004

The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphatase

Kar-Roy, A., Korkaya, H., Oberoi, R., Lal, S. K. & Jameel, S., Jul 2 2004, In : Journal of Biological Chemistry. 279, 27, p. 28345-28357 13 p.

Research output: Contribution to journalArticle

63 Scopus citations
2002

The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2

Tyagi, S., Korkaya, H., Zafrullah, M., Jameel, S. & Lal, S. K., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22759-22767 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2001

The ORF3 Protein of Hepatitis E Virus Binds to Src Homology 3 Domains and Activates MAPK

Korkaya, H., Jameel, S., Gupta, D., Tyagi, S., Kumar, R., Zafrullah, M., Mazumdar, M., Lal, S. K., Xiaofang, L., Sehgal, D., Das, S. R. & Sahal, D., Nov 9 2001, In : Journal of Biological Chemistry. 276, 45, p. 42389-42400 12 p.

Research output: Contribution to journalArticle

113 Scopus citations