• 5682 Citations
  • 25 h-Index
1991 …2019
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Research Output 1991 2019

  • 5682 Citations
  • 25 h-Index
  • 42 Article
  • 1 Letter
  • 1 Review article
2019
3 Citations (Scopus)

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Paneth Cells
Ubiquitin
Homeostasis
Inflammation

Intracellular reduction in ATP levels contributes to CYT997-induced suppression of metastasis of head and neck squamous carcinoma

Zhao, X., Lang, L., He, L., Gao, L., Chyan, D., Xiong, Y., Li, H., Peng, H. & Teng, Y., Feb 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 2, p. 1174-1182 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Neck
Adenosine Triphosphate
Head
Neoplasm Metastasis

Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by ufmylation pathway

Chen, F., Xing, C., Zhang, W., Li, J., Hu, T., Li, L., Li, H. & Cai, Y., Oct 2019, In : Journal of Cellular Physiology. 234, 10, p. 18560-18570 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Anemia
Up-Regulation
Unfolded Protein Response
Erythrocyte Indices

Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma

Chen, J., Xing, C., Yan, L., Wang, Y., Wang, H., Zhang, Z., Yu, D., Li, J., Li, H., Li, J. & Cai, Y., Jan 1 2019, In : PeerJ. 2019, 1, e6352.

Research output: Contribution to journalArticle

Gene Expression Profiling
transcriptomics
Neuroblastoma
Genes
genes
4 Citations (Scopus)

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Zhu, H., Bhatt, B., Sivaprakasam, S., Cai, Y., Liu, S., Kodeboyina, S. K., Patel, N., Savage, N. M., Sharma, A. K., Kaufman, R. J., Li, H. & Singh, N., Dec 1 2019, In : Nature Communications. 10, 1, 1084.

Research output: Contribution to journalArticle

Unfolded Protein Response
Plasma Cells
proteins
Plasmas
expansion
7 Citations (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. & Lou, Z., Dec 1 2019, In : Nature Communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation
2018
5 Citations (Scopus)

Gpr109a limits microbiota-induced IL-23 production to constrain ILC3-mediated colonic inflammation

Bhatt, B., Zeng, P., Zhu, H., Sivaprakasam, S., Li, S., Xiao, H., Dong, L., Shiao, S-Y. P., Kolhe, R. B., Li, H., Levy Bercowski, D., Ganapathy, V., Singh, N. & Patel, N., Apr 15 2018, In : Journal of Immunology. 200, 8, p. 2905-2914 10 p.

Research output: Contribution to journalArticle

Interleukin-23
Microbiota
Inflammation
Mycoplasmataceae
Streptococcaceae
1 Citation (Scopus)

Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene

Zhang, Z., Chen, J., Chen, F., Yu, D., Li, R., Lv, C., Wang, H., Li, H., Li, J. & Cai, Y., Jul 1 2018, In : Cell Stress and Chaperones. 23, 4, p. 551-560 10 p.

Research output: Contribution to journalArticle

Spinal Cord Injuries
Up-Regulation
Genes
Endoplasmic Reticulum Stress
Apoptosis
8 Citations (Scopus)

Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure

Li, J., Yue, G., Ma, W., Zhang, A., Zou, J., Cai, Y., Tang, X., Wang, J., Liu, J., Li, H. & Su, H., Oct 1 2018, In : Circulation. Heart failure. 11, 10, p. e004917

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ligases
Ubiquitin
Endoplasmic Reticulum
Homeostasis
1 Citation (Scopus)

ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury

Chen, J., Yan, L., Wang, H., Zhang, Z., Yu, D., Xing, C., Li, J., Li, H., Li, J. & Cai, Y., Dec 15 2018, In : Gene. 678, p. 8-16 9 p.

Research output: Contribution to journalArticle

Autophagy
Spinal Cord Injuries
Transcriptome
Spinal Cord
Lentivirus
2017
9 Citations (Scopus)

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma

Poole, C. J., Zheng, W., Lodh, A., Yevtodiyenko, A., Liefwalker, D., Li, H., Felsher, D. W. & van Riggelen, J., Jan 1 2017, In : Oncotarget. 8, 44, p. 76898-76920 23 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
DNA Methylation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Maintenance
T-Lymphocytes
5 Citations (Scopus)
Exocrine Pancreas
Ubiquitin
Endoplasmic Reticulum
Amylases
Enzymes
12 Citations (Scopus)

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
G-Protein-Coupled Receptors
Sorting
Endoplasmic Reticulum
Membrane Proteins
2016
8 Citations (Scopus)

A selective inhibitor of the UFM1-activating enzyme, UBA5

da Silva, S. R., Paiva, S. L., Bancerz, M., Geletu, M., Lewis, A. M., Chen, J., Cai, Y., Lukkarila, J. L., Li, H. & Gunning, P. T., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 18, p. 4542-4547 6 p.

Research output: Contribution to journalArticle

Ubiquitin
Cells
Cell Proliferation
Organometallics
Enzymes
7 Citations (Scopus)

Essential role of Ufm1 conjugation in the hematopoietic system

Cai, Y., Singh, N. & Li, H., Jun 1 2016, In : Experimental Hematology. 44, 6, p. 442-446 5 p.

Research output: Contribution to journalReview article

Hematopoietic System
Ubiquitin
Ubiquitins
Ubiquitin-Protein Ligases
Hematologic Diseases
27 Citations (Scopus)

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

Teng, Y., Ren, X., Li, H., Shull, A., Kim, J. & Cowell, J. K., Jan 21 2016, In : Oncogene. 35, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein Family
Mitochondrial Membranes
Mitochondria
Neoplasm Metastasis
Breast Neoplasms
2015
5 Citations (Scopus)

Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein

Huang, P., Lu, C., Li, J., Xu, J., Liu, Z., Wang, Q., Wang, Z., Huo, J., Li, H., Teng, Y. & Cai, Y., Mar 15 2015, In : Gene. 559, 1, p. 62-72 11 p.

Research output: Contribution to journalArticle

Mastitis
Mutation
Single Nucleotide Polymorphism
Genes
Secondary Protein Structure
46 Citations (Scopus)

RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis

Zhang, M., Zhu, X., Zhang, Y., Cai, Y., Chen, J., Sivaprakasam, S., Gurav, A., Pi, W., Makala, L. H., Wu, J., Pace, B. S., Tuan Lo, D., Ganapathy, V., Singh, N. & Li, H., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 1922-1934 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Hematopoiesis
Hematopoietic Stem Cells
Unfolded Protein Response
Proteins
42 Citations (Scopus)

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development

Cai, Y., Pi, W., Sivaprakasam, S., Zhu, X., Zhang, M., Chen, J., Makala, L. H., Lu, C., Wu, J., Teng, Y., Pace, B. S., Tuan Lo, D., Singh, N. & Li, H., Nov 2015, In : PLoS Genetics. 11, 11, e1005643.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
endoplasmic reticulum
Embryonic Development
Hematopoiesis
Hematopoietic Stem Cells
2013
85 Citations (Scopus)

Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis

Bergmann, K. R., Liu, S. X. L., Tian, R., Kushnir, A., Turner, J. R., Li, H. L., Chou, P. M., Weber, C. R. & De Plaen, I. G., May 2013, In : American Journal of Pathology. 182, 5, p. 1595-1606 12 p.

Research output: Contribution to journalArticle

Claudins
Necrotizing Enterocolitis
Bifidobacterium
Tight Junctions
Claudin-4
10 Citations (Scopus)

Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

Wu, J., Jiang, H., Luo, S., Zhang, M., Zhang, Y., Sun, F., Huang, S. & Li, H., May 1 2013, In : Cell Research. 23, 5, p. 691-704 14 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Caspases
Microtubules
Rupture
Proteins
18 Citations (Scopus)

Trefoil factor 3 peptide regulates migration via a Twist-dependent pathway in gastric cell

Zheng, Q., Gao, J., Li, H., Guo, W., Mao, Q., Gao, E. & Zhu, Y. Q., Aug 16 2013, In : Biochemical and Biophysical Research Communications. 438, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Twist-Related Protein 1
Stomach
Peptides
Matrix Metalloproteinases
Interleukin-8
2012
49 Citations (Scopus)

Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking

Zhang, Y., Zhang, M., Wu, J., Lei, G. & Li, H., Nov 13 2012, In : PloS one. 7, 11, e48587.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum
endoplasmic reticulum
homeostasis
unfolded protein response
2011
61 Citations (Scopus)

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

Zhu, S., Zhang, Y., Bai, G. & Li, H., Jan 1 2011, In : Cell Death and Disease. 2, 1, e115.

Research output: Contribution to journalLetter

Imidazoles
GTPase-Activating Proteins
Indoles
Animal Disease Models
Huntington Disease
2010
44 Citations (Scopus)

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing protein 1 (DDRGK1) and modulates NF-κB signaling

Wu, J., Lei, G., Mei, M., Tang, Y. & Li, H., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15126-15136 11 p.

Research output: Contribution to journalArticle

Protein Stability
Tumors
Assays
Proteins
Ubiquitination
2009
28 Citations (Scopus)

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

Jiang, H., Wu, J., He, C., Yang, W. & Li, H., Apr 1 2009, In : Cell Research. 19, 4, p. 458-468 11 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Tumor Suppressor Proteins
Phosphotransferases
DNA Damage
Centrosome
2007
22 Citations (Scopus)

Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: Impact of duration of untreated disease

Zhao, Y., Fedczyna, T. O., McVicker, V., Caliendo, J., Li, H. & Pachman, L. M., Nov 1 2007, In : Clinical Immunology. 125, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Muscle Weakness
In Situ Nick-End Labeling
Apoptosis
Caspase 3
2006
40 Citations (Scopus)

Proteasome inhibition induces both pro- and anti-cell death pathways in prostate cancer cells

Yang, W., Monroe, J., Zhang, Y., George, D., Bremer, E. & Li, H., Nov 18 2006, In : Cancer Letters. 243, 2, p. 217-227 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Prostatic Neoplasms
Cell Death
Proteasome Inhibitors
Autophagy
2005
48 Citations (Scopus)

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint

Jiang, H., Luo, S. & Li, H., May 27 2005, In : Journal of Biological Chemistry. 280, 21, p. 20651-20659 9 p.

Research output: Contribution to journalArticle

Cyclin B1
DNA Damage
Carrier Proteins
Apoptosis
DNA
31 Citations (Scopus)

Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein

Wu, J., Luo, S., Jiang, H. & Li, H., Jan 17 2005, In : FEBS Letters. 579, 2, p. 421-426 6 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Proteins
Disease Resistance
Adenosine Triphosphatases
vpr Genes
2004
37 Citations (Scopus)

eNOS protects prostate cancer cells from TRAIL-induced apoptosis

Tong, X. & Li, H., Jul 8 2004, In : Cancer Letters. 210, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Prostatic Neoplasms
Apoptosis
Cell Line
TNF-Related Apoptosis-Inducing Ligand Receptors
37 Citations (Scopus)

Hypothermia inhibits Fas-mediated apoptosis of primary mouse hepatocytes in culture

Fu, T., Blei, A. T., Takamura, N., Lin, T., Guo, D., Li, H., O'Gorman, M. R. & Soriano, H. E., Jan 1 2004, In : Cell Transplantation. 13, 6, p. 667-676 10 p.

Research output: Contribution to journalArticle

Hypothermia
Cell death
Cell culture
Hepatocytes
Effector Caspases
2000
106 Citations (Scopus)

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

Ruffolo, S. C., Breckenridge, D. G., Nguyen, M., Goping, I. S., Gross, A., Korsmeyer, S. J., Li, H., Yuan, J. & Shore, G. C., Jan 1 2000, In : Cell Death and Differentiation. 7, 11, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

Mitochondria
Caspase 8
Mitochondrial Membranes
Cytochromes c
Protein Conformation
1999
157 Citations (Scopus)

Deciphering the pathways of life and death

Li, H. & Yuan, J., Apr 1 1999, In : Current Opinion in Cell Biology. 11, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

Caspases
Knockout Mice
Signal Transduction
Apoptosis
Phenotype
385 Citations (Scopus)

Solution structure of BID, an intracellular amplifier of apoptotic signaling

Chou, J. J., Li, H., Salvesen, G. S., Yuan, J. & Wagner, G., Mar 5 1999, In : Cell. 96, 5, p. 615-624 10 p.

Research output: Contribution to journalArticle

Caspase 8
Bacterial Toxins
Mitochondria
Sequence Homology
1998
148 Citations (Scopus)

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

Zhou, B. B., Li, H., Yuan, J. & Kirschner, M. W., Jun 9 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 12, p. 6785-6790 6 p.

Research output: Contribution to journalArticle

Jurkat Cells
Cyclin-Dependent Kinases
Caspases
Apoptosis
Caspase 3
3539 Citations (Scopus)

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Li, H., Zhu, H., Xu, C. J. & Yuan, J., Aug 21 1998, In : Cell. 94, 4, p. 491-501 11 p.

Research output: Contribution to journalArticle

Mitochondria
Caspase 8
Apoptosis
Caspases
Membranes
1997
164 Citations (Scopus)

Activation of caspase-2 in apoptosis

Li, H., Bergeron, L., Cryns, V., Pasternack, M. S., Zhu, H., Shi, L., Greenberg, A. & Yuan, J., Aug 22 1997, In : Journal of Biological Chemistry. 272, 34, p. 21010-21017 8 p.

Research output: Contribution to journalArticle

Caspase 2
Caspase 3
Caspase 1
Chemical activation
Apoptosis
1996
73 Citations (Scopus)

Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B

Shi, L., Chen, G., Macdonald, G., Bergeron, L., Li, H., Miura, M., Rotello, R. J., Miller, D. K., Li, P., Seshadri, T., Yuan, J. & Greenberg, A. H., Oct 1 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 20, p. 11002-11007 6 p.

Research output: Contribution to journalArticle

Granzymes
Caspase 1
Apoptosis
Peptide Hydrolases
Cytotoxic T-Lymphocytes
62 Citations (Scopus)
Ribonuclease III
Hydroxyl Radical
Signal processing
Substrates
Enzymes
194 Citations (Scopus)
Caspase 1
Poly(ADP-ribose) Polymerases
Proteolysis
Peptide Hydrolases
Tumor Necrosis Factor-alpha
1993
48 Citations (Scopus)

Mutational Analysis of a Ribonuclease III Processing Signal

Chelladurai, B., Li, H., Zhang, K. & Nicholson, A. W., Jan 1 1993, In : Biochemistry. 32, 29, p. 7549-7558 10 p.

Research output: Contribution to journalArticle

Ribonuclease III
Signal processing
RNA
Buffers
Nucleotides
62 Citations (Scopus)

Ribonuclease III cleavage of a bacteriophage T7 processing signal. Divalent cation specificity, and specific anion effects

Li, H., Chelladurai, B. S., Zhang, K. & Nicholson, A. W., Apr 25 1993, In : Nucleic Acids Research. 21, 8, p. 1919-1925 7 p.

Research output: Contribution to journalArticle

Ribonuclease III
Bacteriophage T7
Divalent Cations
Anions
Salts
1991
44 Citations (Scopus)

A conserved sequence element in ribonuclease III processing signals is not required for accurate in vitro enzymatic cleavage

Chelladurai, B. S., Li, H. & Nicholson, A. W., Apr 25 1991, In : Nucleic Acids Research. 19, 8, p. 1759-1766 8 p.

Research output: Contribution to journalArticle

Ribonuclease III
Conserved Sequence
RNA
Base Pairing
RNA Phages