• 231 Citations
  • 8 h-Index
20102020

Research output per year

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Research Output

  • 231 Citations
  • 8 h-Index
  • 34 Article
  • 1 Comment/debate
2020

SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth

Lu, C., Klement, J. D., Yang, D., Albers, T., Lebedyeva, I. O., Waller, J. L. & Liu, K., Apr 28 2020, In : Cancer Letters. 476, p. 87-96 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Crystal structure of ethyl 2-methyl-5,10-dioxo-4-phenyl-5,10-dihydro-4H-11-thia-1,4a-diaza-benzo[b]fluorene-3-carboxylate

Yartsev, Y., Lyubashov, P., Povstyanoy, V., Povstyaniy, M. & Lebedyeva, I., Jan 1 2018, In : Acta Crystallographica Section E: Crystallographic Communications. 74, p. 124-126 3 p.

Research output: Contribution to journalArticle

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

Angara, K., Borin, T. F., Rashid, M. H., Lebedyeva, I., Ara, R., Lin, P. C., Iskander, A. S. M., Bollag, R. J., Achyut, B. R. & Arbab, A. S., Oct 2018, In : Neoplasia (United States). 20, 10, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Functionalized Diphenyl-Imidazolo-Pyrimidines

Lyubashov, P. P., Povstyanoy, V. M., Krysko, A. A., Plotkin, A., Lovett, I., Povstyaniy, M. V. & Lebedyeva, I. O., Jan 2018, In : Journal of Heterocyclic Chemistry. 55, 1, p. 276-281 6 p.

Research output: Contribution to journalArticle

Pharmacologically targeting the myristoylation of the scaffold protein FRS2 inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression

Li, Q., Alsaidan, O. A., Ma, Y., Kim, S., Liu, J., Albers, T., Liu, K., Beharry, Z., Zhao, S., Wang, F., Lebedyeva, I. & Cai, H., Apr 27 2018, In : Journal of Biological Chemistry. 293, 17, p. 6434-6448 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression

Kim, S., Alsaidan, O. A., Goodwin, O., Li, Q., Sulejmani, E., Han, Z., Bai, A., Albers, T., Beharry, Z., Zheng, Y. G., Norris, J. S., Szulc, Z. M., Bielawska, A., Lebedyeva, I., Pegan, S. D. & Cai, H., Dec 15 2017, In : Cancer Research. 77, 24, p. 6950-6952 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

Borin, T. F., Shankar, A., Angara, K., Rashid, M. H., Jain, M., Iskander, A., Ara, R., Lebedyeva, I., Korkaya, H., Achyut, B. R. & Arbab, A. S., Jun 2017, In : PloS one. 12, 6, 0178830.

Research output: Contribution to journalArticle

6 Scopus citations

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

Jain, M., Gamage, N. D. H., Alsulami, M., Shankar, A., Achyut, B. R., Angara, K., Rashid, M. H., Iskander, A., Borin, T. F., Zhi, W., Ara, R., Ali, M. M., Lebedyeva, I. O., Chwang, W. B., Guo, A., Bagher-Ebadian, H. & Arbab, A. S., Jan 31 2017, In : Scientific reports. 7, 41809.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Liu, F., Li, X., Lu, C., Bai, A., Bielawski, J., Bielawska, A., Marshall, B., Schoenlein, P. V., Lebedyeva, I. O. & Liu, K., 2016, In : Oncotarget. 7, 51, p. 83907-83925 19 p.

Research output: Contribution to journalArticle

31 Scopus citations

Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

Coe, G. L., Redd, P. S., Paschall, A. V., Lu, C., Gu, L., Cai, H., Albers, T., Lebedyeva, I. O. & Liu, K., Aug 4 2016, In : Scientific reports. 6, 30816.

Research output: Contribution to journalArticle

11 Scopus citations

Diazapentacene derivatives: Synthesis, properties, and structures

Hoff, J. J., Zhu, L., Dong, Y., Albers, T., Steel, P. J., Cui, X., Wen, Y., Lebedyeva, I. O. & Miao, S., Jan 1 2016, In : RSC Advances. 6, 90, p. 86824-86828 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells

Khater, M. K., Perucho, A. M., Mohamed, S. A., Laknaur, A., Lebedyeva, I., Liu, Y., Diamond, M. P. & Al-Hendy, A. A., Jun 2016, In : Fertility and Sterility. 105, 6, p. 1638-1648.e8

Research output: Contribution to journalArticle

8 Scopus citations

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

Booth, L., Shuch, B., Albers, T., Roberts, J. L., Tavallai, M., Proniuk, S., Zukiwski, A., Wang, D., Chen, C. S., Bottaro, D., Ecroyd, H., Lebedyeva, I. O. & Dent, P., Mar 15 2016, In : Oncotarget. 7, 11, p. 12975-12996 22 p.

Research output: Contribution to journalArticle

26 Scopus citations

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

Booth, L., Albers, T., Roberts, J. L., Tavallai, M., Poklepovic, A., Lebedyeva, I. O. & Dent, P., Jan 1 2016, In : Oncotarget. 7, 26, p. 40398-40417 20 p.

Research output: Contribution to journalArticle

13 Scopus citations

The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015
4 Scopus citations

Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry

Lebedyeva, I. O., Oliferenko, A. A., Oliferenko, P. V., Hromas, R. A., Neubert, J. K., Caudle, R. M., Wickersham, J., Castleman, W. L., Altschuler, G. I., Ostrov, D. A., Hall, C. D. & Katritzky, A. R., Sep 23 2015, In : Journal of Materials Chemistry B. 3, 43, p. 8492-8498 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker

Vertesaljai, P., Lebedyeva, I. O., Oliferenko, A. A., Qi, X., Fu, J., Ostrov, D. A., Asiri, A. M., Dennis Hall, C. & Katritzky, A., Jul 13 2015, In : Tetrahedron Letters. 56, 48, p. 6653-6655 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and bioactivity of a Goralatide analog with antileukemic activity

Li, Z., Lebedyeva, I. O., Golubovskaya, V. M., Cance, W. G., Alamry, K. A., Faidallah, H. M., Dennis Hall, C. & Katritzky, A. R., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 5056-5060 5 p.

Research output: Contribution to journalArticle

2014

Gabapentin hybrid peptides and bioconjugates

Lebedyeva, I. O., Ostrov, D. A., Neubert, J., Steel, P. J., Patel, K., Sileno, S. M., Goncalves, K., Ibrahim, M. A., Alamry, K. A. & Katritzky, A. R., Feb 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 4, p. 1479-1486 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids

Lebedyeva, I. O., Biswas, S., Goncalves, K., Sileno, S. M., Jackson, A. R., Patel, K., Steel, P. J. & Katritzky, A. R., Jan 1 2014, In : Chemistry - A European Journal. 20, 37, p. 11695-11698 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of l-lys-aminoxy-goralatide

Li, Z., Lebedyeva, I. O., Zhao, D., Myers, L., Pillai, G. G., Hall, C. D. & Katritzky, A. R., Oct 20 2014, In : Journal of Peptide Science. 20, 12, p. 923-927 5 p.

Research output: Contribution to journalArticle

Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

Vertesaljai, P., Biswas, S., Lebedyeva, I., Broggi, E., Asiri, A. M. & Katritzky, A. R., Mar 21 2014, In : Journal of Organic Chemistry. 79, 6, p. 2688-2693 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Tandem deprotection-dimerization-macrocyclization route to C2 symmetric cyclo-tetrapeptides

Ha, K., Lebedyeva, I. O., Hamedzadeh, S., Li, Z., Quiñones, R., Pillai, G. G., Williams, B., Nasajpour, A., Martin, K., Asiri, A. M. & Katritzky, A. R., Apr 22 2014, In : Chemistry - A European Journal. 20, 17, p. 4874-4879 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Conformationally assisted lactamizations for the synthesis of symmetrical and unsymmetrical bis-2,5-diketopiperazines

Ha, K., Lebedyeva, I. O., Li, Z., Martin, K., Williams, B., Faby, E., Nasajpour, A., Pillai, G. G., Al-Youbi, A. O. & Katritzky, A. R., Sep 6 2013, In : Journal of Organic Chemistry. 78, 17, p. 8510-8523 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sahu, S., Lebedyeva, I. O., Panda, S. S. & Katritzky, A. R., Apr 11 2013, In : Synthesis (Germany). 45, 9, p. 1256-1260 5 p., SS-2012-M0978-OP.

Research output: Contribution to journalArticle

3 Scopus citations

Reaction of barbituric acid with organic azides and phosphonium ylides

Lebedyeva, I. O., Sileno, S. M., Patel, K., Ghiviriga, I., Steel, P. J. & Katritzky, A. R., Dec 1 2013, In : Central European Journal of Chemistry. 11, 6, p. 1019-1022 4 p.

Research output: Contribution to journalArticle

Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines

Lebedyeva, I. O., Povstyanoy, VY. M., Ryabitskii, A. B., Panasyuk, O., Ivahnenko, E., Lozova, V. P., Markevich, I., Allakhverdova, S. & Povstyanoy, M. V., Jul 1 2013, In : European Journal of Organic Chemistry. 21, p. 4594-4606 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

17α-ethynylestradiol peptide labeling by 'click' chemistry

Bol'Shakov, O. I., Lebedyeva, I. O. & Katritzky, A. R., Aug 21 2012, In : Synthesis (Germany). 44, 18, p. 2926-2932 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Thorpe-Ziegler-type reaction of 3-cyanopyridine-2(1H)-thiones with Biginelli 6-bromomethyl-3,4-dihydropyrimidin-2(1H)-ones: Cascade assembling of tetra- and pentacyclic heterocyclic scaffolds

Lebedyeva, I. O., Dotsenko, V. V., Turovtsev, V. V., Krivokolysko, S. G., Povstyanoy, VY. M. & Povstyanoy, M. V., Nov 25 2012, In : Tetrahedron. 68, 47, p. 9729-9737 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetrahydropyrimidine-5- carboxylate

Zubatyuk, R. I., Shishkin, O. V., Ihmels, H., Lebedyeva, I. A. & Povstyanoy, M. V., Jul 14 2010, In : Acta Crystallographica Section E: Structure Reports Online. 66, 7, p. o1762-o1763

Research output: Contribution to journalArticle

1 Scopus citations

One-pot synthesis of diethyl 4,4′-(1,4-phenylene)bis-[6-(halomethyl)- 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates] and their bispyrrolocyclization

Lebedyeva, I. O., Povstyanoy, M. V., Povstyanoy, V. M., Panasyuk, O. G., Guban', E. S. & Ryabitskii, A. B., Sep 1 2010, In : Monatshefte fur Chemie. 141, 9, p. 997-1000 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ternary condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo[3,2-a] pyrimidines and 5-arylidenethiazolidine-2,4-diones

Lebedyeva, I. O., Povstyanoy, M. V., Ryabitskii, A. B. & Povstyanoy, V. M., Mar 1 2010, In : Journal of Heterocyclic Chemistry. 47, 2, p. 368-372 5 p.

Research output: Contribution to journalArticle

13 Scopus citations