• 196 Citations
  • 8 h-Index
20102019
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Research Output 2010 2019

  • 196 Citations
  • 8 h-Index
  • 33 Article
  • 1 Comment/debate
13 Citations (Scopus)

The Thorpe-Ziegler-type reaction of 3-cyanopyridine-2(1H)-thiones with Biginelli 6-bromomethyl-3,4-dihydropyrimidin-2(1H)-ones: Cascade assembling of tetra- and pentacyclic heterocyclic scaffolds

Lebedyeva, I. O., Dotsenko, V. V., Turovtsev, V. V., Krivokolysko, S. G., Povstyanoy, VY. M. & Povstyanoy, M. V., Nov 25 2012, In : Tetrahedron. 68, 47, p. 9729-9737 9 p.

Research output: Contribution to journalArticle

Thiones
Scaffolds
Heating
Boiling liquids
Derivatives
5 Citations (Scopus)

Theophyllinylpyrimidine scaffolds undergo intramolecular cyclization reactions to form 1,3-diazepines and imidazopurines

Lebedyeva, I. O., Povstyanoy, VY. M., Ryabitskii, A. B., Panasyuk, O., Ivahnenko, E., Lozova, V. P., Markevich, I., Allakhverdova, S. & Povstyanoy, M. V., Jul 1 2013, In : European Journal of Organic Chemistry. 21, p. 4594-4606 13 p.

Research output: Contribution to journalArticle

Purines
Forms (concrete)
Cyclization
Theophylline
Scaffolds
8 Citations (Scopus)

The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

Research output: Contribution to journalArticle

Lectins
Peptides
Epithelial Sodium Channels
Membranes
Ubiquitination
13 Citations (Scopus)

Ternary condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo[3,2-a] pyrimidines and 5-arylidenethiazolidine-2,4-diones

Lebedyeva, I. O., Povstyanoy, M. V., Ryabitskii, A. B. & Povstyanoy, V. M., Mar 1 2010, In : Journal of Heterocyclic Chemistry. 47, 2, p. 368-372 5 p.

Research output: Contribution to journalArticle

Thiones
Pyrimidines
Aldehydes
Condensation
chloroacetic acid
5 Citations (Scopus)

Tandem deprotection-dimerization-macrocyclization route to C2 symmetric cyclo-tetrapeptides

Ha, K., Lebedyeva, I. O., Hamedzadeh, S., Li, Z., Quiñones, R., Pillai, G. G., Williams, B., Nasajpour, A., Martin, K., Asiri, A. M. & Katritzky, A. R., Apr 22 2014, In : Chemistry - A European Journal. 20, 17, p. 4874-4879 6 p.

Research output: Contribution to journalArticle

Dimerization
Cyclization
Palladium
Oligomers
Dimers
6 Citations (Scopus)

Synthesis of taurine-containing peptides, sulfonopeptides, and N - And O -conjugates

Vertesaljai, P., Biswas, S., Lebedyeva, I. O., Broggi, E., Asiri, A. M. & Katritzky, A. R., Mar 21 2014, In : Journal of Organic Chemistry. 79, 6, p. 2688-2693 6 p.

Research output: Contribution to journalArticle

Taurine
Peptides
Peptidomimetics
Acylation
Nucleophiles

Synthesis of l-lys-aminoxy-goralatide

Li, Z., Lebedyeva, I. O., Zhao, D., Myers, L., Pillai, G. G., Hall, C. D. & Katritzky, A. R., Oct 20 2014, In : Journal of Peptide Science. 20, 12, p. 923-927 5 p.

Research output: Contribution to journalArticle

Cell proliferation
Biological Availability
Half-Life
Cell Proliferation
goralatide

Synthesis and bioactivity of a Goralatide analog with antileukemic activity

Li, Z., Lebedyeva, I. O., Golubovskaya, V. M., Cance, W. G., Alamry, K. A., Faidallah, H. M., Dennis Hall, C. & Katritzky, A. R., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 5056-5060 5 p.

Research output: Contribution to journalArticle

Bioactivity
HEK293 Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
Cell proliferation
2 Citations (Scopus)

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

Tumor Escape
Cytotoxic T-Lymphocytes
Colon
Tumor Microenvironment
Microsatellite Repeats

Reaction of barbituric acid with organic azides and phosphonium ylides

Lebedyeva, I. O., Sileno, S. M., Patel, K., Ghiviriga, I., Steel, P. J. & Katritzky, A. R., Dec 1 2013, In : Central European Journal of Chemistry. 11, 6, p. 1019-1022 4 p.

Research output: Contribution to journalArticle

Azides
Amination
Triazoles
Acids
Nitrogen
4 Citations (Scopus)

Pharmacologically targeting the myristoylation of the scaffold protein FRS2 inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression

Li, Q., Alsaidan, O. A., Ma, Y., Kim, S., Liu, J., Albers, T., Liu, K., Beharry, Z., Zhao, S., Wang, F., Lebedyeva, I. O. & Cai, H., Jan 1 2018, In : Journal of Biological Chemistry. 293, 17, p. 6434-6448 15 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Fibroblast Growth Factor 2
Scaffolds
Tumors
3 Citations (Scopus)

Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sahu, S., Lebedyeva, I. O., Panda, S. S. & Katritzky, A. R., Apr 11 2013, In : Synthesis (Germany). 45, 9, p. 1256-1260 5 p., SS-2012-M0978-OP.

Research output: Contribution to journalArticle

Acylation
Nitriles
Chirality
Amino acids
Dipeptides
4 Citations (Scopus)

One-pot synthesis of diethyl 4,4′-(1,4-phenylene)bis-[6-(halomethyl)- 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates] and their bispyrrolocyclization

Lebedyeva, I. O., Povstyanoy, M. V., Povstyanoy, V. M., Panasyuk, O. G., Guban', E. S. & Ryabitskii, A. B., Sep 1 2010, In : Monatshefte fur Chemie. 141, 9, p. 997-1000 4 p.

Research output: Contribution to journalArticle

Aldehydes
Amines
Urea
Condensation
Esters
4 Citations (Scopus)

One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids

Lebedyeva, I. O., Biswas, S., Goncalves, K., Sileno, S. M., Jackson, A. R., Patel, K., Steel, P. J. & Katritzky, A. R., Jan 1 2014, In : Chemistry - A European Journal. 20, 37, p. 11695-11698 4 p.

Research output: Contribution to journalArticle

Acylation
Nucleophiles
Peptides
Chemical activation
Peptidomimetics
12 Citations (Scopus)

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

Booth, L., Albers, T., Roberts, J. L., Tavallai, M., Poklepovic, A., Lebedyeva, I. O. & Dent, P., Jan 1 2016, In : Oncotarget. 7, 26, p. 40398-40417 20 p.

Research output: Contribution to journalArticle

Phosphotransferases
Neoplasms
Clone Cells
Phosphorylation
Phosphodiesterase 5 Inhibitors
25 Citations (Scopus)

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

Booth, L., Shuch, B., Albers, T., Roberts, J. L., Tavallai, M., Proniuk, S., Zukiwski, A., Wang, D., Chen, C. S., Bottaro, D., Ecroyd, H., Lebedyeva, I. O. & Dent, P., Mar 15 2016, In : Oncotarget. 7, 11, p. 12975-12996 22 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Phosphotransferases
Thioredoxins
Proteins
Adenosine Triphosphatases
1 Citation (Scopus)

Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker

Vertesaljai, P., Lebedyeva, I. O., Oliferenko, A. A., Qi, X., Fu, J., Ostrov, D. A., Asiri, A. M., Dennis Hall, C. & Katritzky, A., Jul 13 2015, In : Tetrahedron Letters. 56, 48, p. 6653-6655 3 p.

Research output: Contribution to journalArticle

Cyclopentanes
Proline
Peptidomimetics
Acids
prolyl-proline
8 Citations (Scopus)

Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells

Khater, M. K., Perucho, A. M., Mohamed, S. A., Laknaur, A., Lebedyeva, I., Liu, Y., Diamond, M. P. & Al-Hendy, A. A., Jun 2016, In : Fertility and Sterility. 105, 6, p. 1638-1648.e8

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Leiomyoma
Adenoviridae
Genetic Therapy
Nanoparticles
1 Citation (Scopus)

Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry

Lebedyeva, I. O., Oliferenko, A. A., Oliferenko, P. V., Hromas, R. A., Neubert, J. K., Caudle, R. M., Wickersham, J., Castleman, W. L., Altschuler, G. I., Ostrov, D. A., Hall, C. D. & Katritzky, A. R., Sep 23 2015, In : Journal of Materials Chemistry B. 3, 43, p. 8492-8498 7 p.

Research output: Contribution to journalArticle

Dentistry
Sweetening Agents
Anesthetics
Lidocaine
Local Anesthetics
6 Citations (Scopus)

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

Jain, M., Gamage, N. D. H., Alsulami, M., Shankar, A., Achyut, B. R., Angara, K., Rashid, M. H., Iskander, A., Borin, T. F., Zhi, W., Ara, R., Ali, M. M., Lebedyeva, I. O., Chwang, W. B., Guo, A., Bagher-Ebadian, H. & Arbab, A. S., Jan 31 2017, In : Scientific Reports. 7, 41809.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Survival
Growth
Neoplasms
4 Citations (Scopus)

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

Borin, T. F., Shankar, A., Angara, K., Rashid, M. H., Jain, M., Iskander, A., Ara, R., Lebedyeva, I., Korkaya, H., Achyut, B. R. & Arbab, A. S., Jun 2017, In : PloS one. 12, 6, 0178830.

Research output: Contribution to journalArticle

metastasis
breast neoplasms
Tumors
animal models
lungs
8 Citations (Scopus)

Gabapentin hybrid peptides and bioconjugates

Lebedyeva, I. O., Ostrov, D. A., Neubert, J., Steel, P. J., Patel, K., Sileno, S. M., Goncalves, K., Ibrahim, M. A., Alamry, K. A. & Katritzky, A. R., Feb 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 4, p. 1479-1486 8 p.

Research output: Contribution to journalArticle

glycyl-alanyl-phenylalanine
Peptides
Lactams
Acylation
Peptide Hormones

Functionalized Diphenyl-Imidazolo-Pyrimidines

Lyubashov, P. P., Povstyanoy, V. M., Krysko, A. A., Plotkin, A., Lovett, I., Povstyaniy, M. V. & Lebedyeva, I. O., Jan 1 2018, In : Journal of Heterocyclic Chemistry. 55, 1, p. 276-281 6 p.

Research output: Contribution to journalArticle

Bromine
Pyrimidines
Nucleophiles
Amides
diphenyl
1 Citation (Scopus)

Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetrahydropyrimidine-5- carboxylate

Zubatyuk, R. I., Shishkin, O. V., Ihmels, H., Lebedyeva, I. A. & Povstyanoy, M. V., Jul 14 2010, In : Acta Crystallographica Section E: Structure Reports Online. 66, 7, p. o1762-o1763

Research output: Contribution to journalArticle

quinoline
carboxylates
Hydrogen bonds
Pyrimidinones
hydrogen bonds
3 Citations (Scopus)

Diazapentacene derivatives: Synthesis, properties, and structures

Hoff, J. J., Zhu, L., Dong, Y., Albers, T., Steel, P. J., Cui, X., Wen, Y., Lebedyeva, I. O. & Miao, S., Jan 1 2016, In : RSC Advances. 6, 90, p. 86824-86828 5 p.

Research output: Contribution to journalArticle

Single crystals
Semiconductor materials
Derivatives
X rays
4 Citations (Scopus)

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

Angara, K., Borin, T. F., Rashid, M. H., Lebedyeva, I. O., Ara, R., Lin, P-C., Iskander, A. S. M., Bollag, R. J., Achyut, B. R. & Arbab, A. S., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1070-1082 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood Vessels
Neoplasms
Interleukin-8
Therapeutics

Crystal structure of ethyl 2-methyl-5,10-dioxo-4-phenyl-5,10-dihydro-4H-11-thia-1,4a-diaza-benzo[b]fluorene-3-carboxylate

Yartsev, Y., Lyubashov, P., Povstyanoy, V., Povstyaniy, M. & Lebedyeva, I., Jan 1 2018, In : Acta Crystallographica Section E: Crystallographic Communications. 74, p. 124-126 3 p.

Research output: Contribution to journalArticle

carboxylates
Crystal structure
Thiazoles
Crystals
crystal structure
Glioblastoma
Blood Vessels
Phenotype
Manuscripts
Neoplasms
5 Citations (Scopus)

Conformationally assisted lactamizations for the synthesis of symmetrical and unsymmetrical bis-2,5-diketopiperazines

Ha, K., Lebedyeva, I. O., Li, Z., Martin, K., Williams, B., Faby, E., Nasajpour, A., Pillai, G. G., Al-Youbi, A. O. & Katritzky, A. R., Sep 6 2013, In : Journal of Organic Chemistry. 78, 17, p. 8510-8523 14 p.

Research output: Contribution to journalArticle

Diketopiperazines
Proline
8 Citations (Scopus)

Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

Coe, G. L., Redd, P. S., Paschall, A. V., Lu, C., Gu, L., Cai, H., Albers, T., Lebedyeva, I. O. & Liu, K., Aug 4 2016, In : Scientific Reports. 6, 30816.

Research output: Contribution to journalArticle

Caspase 8
Ceramides
Cytotoxic T-Lymphocytes
Colon
Carcinoma
26 Citations (Scopus)

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Liu, F., Li, X., Lu, C., Bai, A., Bielawski, J., Bielawska, A., Marshall, B., Schoenlein, P. V., Lebedyeva, I. O. & Liu, K., Jan 1 2016, In : Oncotarget. 7, 51, p. 83907-83925 19 p.

Research output: Contribution to journalArticle

Cathepsin B
Cathepsin D
Ceramides
Autophagy
Apoptosis
9 Citations (Scopus)

Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression

Kim, S., Alsaidan, O. A., Goodwin, O., Li, Q., Sulejmani, E., Han, Z., Bai, A., Albers, T., Beharry, Z., Zheng, Y. G., Norris, J. S., Szulc, Z. M., Bielawska, A., Lebedyeva, I. O., Pegan, S. D. & Cai, H., Dec 15 2017, In : Cancer Research. 77, 24, p. 6950-6952 3 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Phosphotransferases
Protein Conformation
Proteins
src-Family Kinases
3 Citations (Scopus)
Diketopiperazines
disulfides
Proline
routes
activation
5 Citations (Scopus)

17α-ethynylestradiol peptide labeling by 'click' chemistry

Bol'Shakov, O. I., Lebedyeva, I. O. & Katritzky, A. R., Aug 21 2012, In : Synthesis (Germany). 44, 18, p. 2926-2932 7 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Steroid hormones
Molecules
Triazoles