Jessica Andrea Filosa

Professor

  • 2608 Citations
  • 26 h-Index
20012020

Research output per year

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Research Output

  • 2608 Citations
  • 26 h-Index
  • 36 Article
  • 4 Review article
  • 1 Short survey
2020

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization

Jackson, L., Dong, G., Althomali, W., Sayed, M. A., Eldahshan, W., Baban, B., Johnson, M. H., Filosa, J., Fagan, S. C. & Ergul, A., Aug 1 2020, In : Translational Stroke Research. 11, 4, p. 762-775 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice

Diaz, J. R., Kim, K. J., Brands, M. W. & Filosa, J. A., Mar 2019, In : Glia. 67, 3, p. 551-565 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Ward, R., Li, W., Abdul, Y., Jackson, L. D., Dong, G., Jamil, S., Filosa, J., Fagan, S. C. & Ergul, A., Apr 2019, In : Pharmacological Research. 142, p. 237-250 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stroke and the neurovascular unit: Glial cells, sex differences, and hypertension

Morrison, H. W. & Filosa, J. A., Mar 2019, In : American Journal of Physiology - Cell Physiology. 316, 3, p. C325-C339

Research output: Contribution to journalArticle

9 Scopus citations
2018

Oral NaHCO 3 activates a splenic anti-inflammatory pathway: Evidence that cholinergic signals are transmitted via mesothelial cells

Ray, S. C., Baban, B., Tucker, M. A., Seaton, A. J., Chang, K. C., Mannon, E. C., Sun, J., Patel, B., Wilson, K., Musall, J. B., Ocasio, H., Irsik, D., Filosa, J. A., Sullivan, J. C., Marshall, B., Harris, R. A. & O’Connor, P. M., May 15 2018, In : Journal of Immunology. 200, 10, p. 3568-3586 19 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation

Marins, F. R., Iddings, J. A., Fontes, M. A. P. & Filosa, J. A., Mar 1 2017, In : Physiological reports. 5, 5, e13156.

Research output: Contribution to journalArticle

4 Scopus citations

Upstream current for a downstream flow

Filosa, J. A., May 1 2017, In : Nature Neuroscience. 20, 5, p. 631-633 3 p.

Research output: Contribution to journalShort survey

2016

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W. & Kim, K. J., May 26 2016, In : Neuroscience. 323, p. 96-109 14 p.

Research output: Contribution to journalReview article

75 Scopus citations

Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice

Morrison, H. W. & Filosa, J. A., Dec 17 2016, In : Neuroscience. 339, p. 85-99 15 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vasculo-neuronal coupling: Retrograde vascular communication to brain neurons

Kim, K. J., Diaz, J. R., Iddings, J. A. & Filosa, J. A., Dec 14 2016, In : Journal of Neuroscience. 36, 50, p. 12624-12639 16 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis

Huby, A. C., Antonova, G., Groenendyk, J., Gomez-Sanchez, C. E., Bollag, W. B., Filosa, J. A. & De Chantemèle, E. J. B., Dec 1 2015, In : Circulation. 132, 22, p. 2134-2145 12 p.

Research output: Contribution to journalArticle

118 Scopus citations

Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction

Kim, K. J., Iddings, J. A., Stern, J. E., Blanco, V. M., Croom, D., Kirov, S. A. & Filosa, J. A., May 27 2015, In : Journal of Neuroscience. 35, 21, p. 8245-8257 13 p.

Research output: Contribution to journalArticle

37 Scopus citations
16 Scopus citations
12 Scopus citations
2014

Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier

Biancardi, V. C., Son, S. J., Ahmadi, S., Filosa, J. A. & Stern, J. E., Mar 2014, In : Hypertension. 63, 3, p. 572-579 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

Hormones and diet, but not body weight, control hypothalamic microglial activity

Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., García-Cáceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J. A., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschöp, M. H. & Yi, C. X., Jan 2014, In : Glia. 62, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

129 Scopus citations
2013

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

Morrison, H. W. & Filosa, J. A., Jan 11 2013, In : Journal of Neuroinflammation. 10, 782.

Research output: Contribution to journalArticle

207 Scopus citations

Astrocyte regulation of cerebral vascular tone

Filosa, J. A. & Iddings, J. A., Sep 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 5, p. H609-H619

Research output: Contribution to journalReview article

64 Scopus citations

Bidirectional neuro-glial signaling modalities in the hypothalamus: Role in neurohumoral regulation

Stern, J. E. & Filosa, J. A., Apr 2013, In : Autonomic Neuroscience: Basic and Clinical. 175, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks

Son, S. J., Filosa, J. A., Potapenko, E. S., Biancardi, V. C., Zheng, H., Patel, K. P., Tobin, V. A., Ludwig, M. & Stern, J. E., Jun 19 2013, In : Neuron. 78, 6, p. 1036-1049 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

Li, W., Prakash, R., Chawla, D., Du, W., Didion, S. P., Filosa, J. A., Zhang, Q., Brann, D. W., Lima, V. V., Tostes, R. C. & Ergul, A., 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. R1001-R1008

Research output: Contribution to journalArticle

60 Scopus citations

Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced Obesity

Lynch, C. M., Kinzenbaw, D. A., Chen, X., Zhan, S., Mezzetti, E., Filosa, J., Ergul, A., Faulkner, J. L., Faraci, F. M. & Didion, S. P., Nov 2013, In : Stroke. 44, 11, p. 3195-3201 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Potassium buffering in the neurovascular unit: Models and sensitivity analysis

Witthoft, A., Filosa, J. A. & Karniadakis, G. E., Nov 5 2013, In : Biophysical Journal. 105, 9, p. 2046-2054 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Tissue oxygen demand in regulation of the behavior of the cells in the vasculature

Barvitenko, N. N., Aslam, M., Filosa, J., Matteucci, E., Nikinmaa, M., Pantaleo, A., Saldanha, C. & Baskurt, O. K., Aug 2013, In : Microcirculation. 20, 6, p. 484-501 18 p.

Research output: Contribution to journalReview article

11 Scopus citations

TRPV4 and the regulation of vascular tone

Filosa, J. A., Yao, X. & Rath, G., Feb 2013, In : Journal of Cardiovascular Pharmacology. 61, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

75 Scopus citations
2012

Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation

Kim, K. J. & Filosa, J. A., Apr 2012, In : Journal of Physiology. 590, 7, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Endothelin-Mediated Calcium Responses in Supraoptic Nucleus Astrocytes Influence Magnocellular Neurosecretory Firing Activity

Filosa, J. A., Naskar, K., Perfume, G., Iddings, J. A., Biancardi, V. C., Vatta, M. S. & Stern, J. E., Feb 1 2012, In : Journal of Neuroendocrinology. 24, 2, p. 378-392 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

High calorie diet triggers hypothalamic angiopathy

Yi, C. X., Gericke, M., Krüger, M., Alkemade, A., Kabra, D. G., Hanske, S., Filosa, J., Pfluger, P., Bingham, N., Woods, S. C., Herman, J., Kalsbeek, A., Baumann, M., Lang, R., Stern, J. E., Bechmann, I. & Tschöp, M. H., Dec 2012, In : Molecular Metabolism. 1, 1-2, p. 95-100 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K + signaling in perivascular astrocytes

Higashimori, H., Blanco, V. M., Tuniki, V. R., Falck, J. R. & Filosa, J. A., Nov 2010, In : American Journal of Physiology - Cell Physiology. 299, 5, p. C1068-C1078

Research output: Contribution to journalArticle

34 Scopus citations
2008

Diminished A-type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats

Sonner, P. M., Filosa, J. A. & Stern, J. E., Mar 15 2008, In : Journal of Physiology. 586, 6, p. 1605-1622 18 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tone-dependent vascular responses to astrocyte-derived signals

Blanco, V. M., Stern, J. E. & Filosa, J. A., Jun 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 6, p. H2855-H2863

Research output: Contribution to journalArticle

82 Scopus citations
2007

Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels

Filosa, J. A., Nelson, M. T. & Gonzalez Bosc, L. V., Dec 1 2007, In : American Journal of Physiology - Cell Physiology. 293, 6, p. C1797-C1805

Research output: Contribution to journalArticle

20 Scopus citations

Neural-glial-vascular communication in the brain

Filosa, J. A., Jan 1 2007, In : Experimental Physiology. 92, 4, 1 p.

Research output: Contribution to journalArticle

Neurovascular coupling in the mammalian brain

Filosa, J. A. & Blanco, V. M., Jul 2007, In : Experimental Physiology. 92, 4, p. 641-646 6 p.

Research output: Contribution to journalArticle

66 Scopus citations
2006

Local potassium signaling couples neuronal activity to vasodilation in the brain

Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Wilkerson, M. K., Aldrich, R. W. & Nelson, M. T., Nov 1 2006, In : Nature Neuroscience. 9, 11, p. 1397-1403 7 p.

Research output: Contribution to journalArticle

356 Scopus citations

N-Acetylaspartate as a reservoir for glutamate

Clark, J. F., Doepke, A., Filosa, J. A., Wardle, R. L., Lu, A., Meeker, T. J. & Pyne-Geithman, G. J., Jun 28 2006, In : Medical Hypotheses. 67, 3, p. 506-512 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
2004

Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.

Filosa, J. A., Bonev, A. D. & Nelson, M. T., Nov 12 2004, In : Circulation research. 95, 10, p. e73-81

Research output: Contribution to journalArticle

Open Access
185 Scopus citations

Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons

Putnam, R. W., Filosa, J. A. & Ritucci, N. A., Dec 2004, In : American Journal of Physiology - Cell Physiology. 287, 6 56-6, p. C1493-C1526

Research output: Contribution to journalReview article

231 Scopus citations
2003

Multiple targets of chemosensitive signaling in locus coeruleus neurons: Role of K+ and Ca2+ channels

Filosa, J. A. & Putnam, R. W., Jan 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 1 53-1, p. C145-C155

Research output: Contribution to journalArticle

60 Scopus citations
2002

Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones

Filosa, J. A., Dean, J. B. & Putnam, R. W., Jun 1 2002, In : Journal of Physiology. 541, 2, p. 493-509 17 p.

Research output: Contribution to journalArticle

114 Scopus citations
2001

Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats

Stunden, C. E., Filosa, J. A., Garcia, A. J., Dean, J. B. & Putnam, R. W., Aug 18 2001, In : Respiration Physiology. 127, 2-3, p. 135-155 21 p.

Research output: Contribution to journalArticle

99 Scopus citations