Jessica Andrea Filosa

Professor

  • 2411 Citations
  • 24 h-Index
20012019
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Research Output 2001 2019

  • 2411 Citations
  • 24 h-Index
  • 35 Article
  • 4 Review article
  • 1 Short survey
2019
2 Citations (Scopus)

Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice

Diaz, J. R., Kim, K. J., Brands, M. W. & Filosa, J. A., Mar 1 2019, In : Glia. 67, 3, p. 551-565 15 p.

Research output: Contribution to journalArticle

Arterioles
Angiotensin II
Astrocytes
Hypertension
TRPV Cation Channels
5 Citations (Scopus)

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Ward, R., Li, W., Abdul, Y., Jackson, L. D., Dong, G., Jamil, S., Filosa, J., Fagan, S. C. & Ergul, A., Apr 2019, In : Pharmacological Research. 142, p. 237-250 14 p.

Research output: Contribution to journalArticle

Inflammasomes
Ischemia
Stroke
Brain-Derived Neurotrophic Factor
Aquaporin 4
5 Citations (Scopus)

Stroke and the neurovascular unit: Glial cells, sex differences, and hypertension

Morrison, H. W. & Filosa, J. A., Mar 2019, In : American Journal of Physiology - Cell Physiology. 316, 3, p. C325-C339

Research output: Contribution to journalArticle

Neuroglia
Sex Characteristics
Stroke
Hypertension
Translational Medical Research
2018
4 Citations (Scopus)

Oral NaHCO 3 activates a splenic anti-inflammatory pathway: Evidence that cholinergic signals are transmitted via mesothelial cells

Ray, S. C., Baban, B., Tucker, M. A., Seaton, A. J., Chang, K. C., Mannon, E. C., Sun, J., Patel, B., Wilson, K., Musall, J. B., Ocasio, H., Irsik, D., Filosa, J. A., Sullivan, J. C., Marshall, B., Harris, R. A. & O'Connor, P. M., May 15 2018, In : Journal of Immunology. 200, 10, p. 3568-3586 19 p.

Research output: Contribution to journalArticle

Cholinergic Agents
Anti-Inflammatory Agents
Spleen
Esterases
Acetylcholine
2017
4 Citations (Scopus)

Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation

Marins, F. R., Iddings, J. A., Fontes, M. A. P. & Filosa, J. A., Mar 1 2017, In : Physiological reports. 5, 5, e13156.

Research output: Contribution to journalArticle

Inbred SHR Rats
Cerebral Cortex
Hypertension
Blood Vessels
Microglia

Upstream current for a downstream flow

Filosa, J. A., May 1 2017, In : Nature Neuroscience. 20, 5, p. 631-633 3 p.

Research output: Contribution to journalShort survey

2016
64 Citations (Scopus)

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W. & Kim, K. J., May 26 2016, In : Neuroscience. 323, p. 96-109 14 p.

Research output: Contribution to journalReview article

Astrocytes
Blood Vessels
Cerebrovascular Circulation
Neurons
Pericytes
24 Citations (Scopus)

Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice

Morrison, H. W. & Filosa, J. A., Dec 17 2016, In : Neuroscience. 339, p. 85-99 15 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Microglia
Sex Characteristics
Astrocytes
Stroke
28 Citations (Scopus)

Vasculo-neuronal coupling: Retrograde vascular communication to brain neurons

Kim, K. J., Diaz, J. R., Iddings, J. A. & Filosa, J. A., Dec 14 2016, In : Journal of Neuroscience. 36, 50, p. 12624-12639 16 p.

Research output: Contribution to journalArticle

Arterioles
Blood Vessels
Pyramidal Cells
Communication
Neurons
2015
97 Citations (Scopus)

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis

Huby, A. C., Antonova, G., Groenendyk, J., Gomez-Sanchez, C. E., Bollag, W. B., Filosa, J. A. & De Chantemèle, E. J. B., Dec 1 2015, In : Circulation. 132, 22, p. 2134-2145 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Leptin
Aldosterone
Adipocytes
Fibrosis
36 Citations (Scopus)

Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction

Kim, K. J., Iddings, J. A., Stern, J. E., Blanco, V. M., Croom, D., Kirov, S. A. & Filosa, J. A., May 27 2015, In : Journal of Neuroscience. 35, 21, p. 8245-8257 13 p.

Research output: Contribution to journalArticle

Arterioles
Vasoconstriction
Astrocytes
Pressure
Giant Cells
16 Citations (Scopus)
Arterioles
Inbred SHR Rats
Vasodilation
Astrocytes
Dilatation
11 Citations (Scopus)
Supraoptic Nucleus
Vasopressins
Nitric Oxide
Vasodilation
Arterioles
2014
102 Citations (Scopus)

Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier

Biancardi, V. C., Son, S. J., Ahmadi, S., Filosa, J. A. & Stern, J. E., Mar 1 2014, In : Hypertension. 63, 3, p. 572-579 8 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Angiotensin II
Hypothalamus
Brain Stem
Hypertension
118 Citations (Scopus)

Hormones and diet, but not body weight, control hypothalamic microglial activity

Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., García-Cáceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J. A., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschöp, M. H. & Yi, C. X., Jan 1 2014, In : Glia. 62, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Body Weight
Hormones
Diet
High Fat Diet
Microglia
2013
180 Citations (Scopus)

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

Morrison, H. W. & Filosa, J. A., Jan 11 2013, In : Journal of Neuroinflammation. 10, 4.

Research output: Contribution to journalArticle

Spatio-Temporal Analysis
Microglia
Reperfusion
Stroke
Wounds and Injuries
61 Citations (Scopus)

Astrocyte regulation of cerebral vascular tone

Filosa, J. A. & Iddings, J. A., Sep 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 5, p. H609-H619

Research output: Contribution to journalReview article

Astrocytes
Blood Vessels
Cerebrovascular Circulation
Homeostasis
Arterioles
15 Citations (Scopus)

Bidirectional neuro-glial signaling modalities in the hypothalamus: Role in neurohumoral regulation

Stern, J. E. & Filosa, J. A., Apr 1 2013, In : Autonomic Neuroscience: Basic and Clinical. 175, 1-2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Neuroglia
Astrocytes
Hypothalamus
Automatic Data Processing
Supraoptic Nucleus
82 Citations (Scopus)

Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks

Son, S. J., Filosa, J. A., Potapenko, E. S., Biancardi, V. C., Zheng, H., Patel, K. P., Tobin, V. A., Ludwig, M. & Stern, J. E., Jun 19 2013, In : Neuron. 78, 6, p. 1036-1049 14 p.

Research output: Contribution to journalArticle

Neurons
Peptides
Carisoprodol
Vasopressins
Paraventricular Hypothalamic Nucleus
57 Citations (Scopus)

Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

Li, W., Prakash, R., Chawla, D., Du, W., Didion, S. P., Filosa, J. A., Zhang, Q., Brann, D. W., Lima, V. V., Tostes, R. C. & Ergul, A., Jun 10 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. R1001-R1008

Research output: Contribution to journalArticle

High Fat Diet
Brain Injuries
Basilar Artery
Middle Cerebral Artery Infarction
Stroke
43 Citations (Scopus)

Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced Obesity

Lynch, C. M., Kinzenbaw, D. A., Chen, X., Zhan, S., Mezzetti, E., Filosa, J., Ergul, A., Faulkner, J. L., Faraci, F. M. & Didion, S. P., Nov 1 2013, In : Stroke. 44, 11, p. 3195-3201 7 p.

Research output: Contribution to journalArticle

High Fat Diet
Superoxides
Blood Vessels
Obesity
Diet
24 Citations (Scopus)

Potassium buffering in the neurovascular unit: Models and sensitivity analysis

Witthoft, A., Filosa, J. A. & Karniadakis, G. E., Nov 5 2013, In : Biophysical Journal. 105, 9, p. 2046-2054 9 p.

Research output: Contribution to journalArticle

Astrocytes
Potassium
Potassium Channels
Hyperemia
Arterioles
8 Citations (Scopus)

Tissue oxygen demand in regulation of the behavior of the cells in the vasculature

Barvitenko, N. N., Aslam, M., Filosa, J., Matteucci, E., Nikinmaa, M., Pantaleo, A., Saldanha, C. & Baskurt, O. K., Aug 1 2013, In : Microcirculation. 20, 6, p. 484-501 18 p.

Research output: Contribution to journalReview article

Oxygen
Rheology
Microvessels
Blood Vessels
Permeability
67 Citations (Scopus)

TRPV4 and the regulation of vascular tone

Filosa, J. A., Yao, X. & Rath, G., Feb 1 2013, In : Journal of Cardiovascular Pharmacology. 61, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Blood Vessels
Vasodilation
Smooth Muscle Myocytes
Caveolins
2012
21 Citations (Scopus)

Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation

Kim, K. J. & Filosa, J. A., Apr 1 2012, In : Journal of Physiology. 590, 7, p. 1757-1770 14 p.

Research output: Contribution to journalArticle

Arterioles
Microcirculation
Brain
Fluorescence Recovery After Photobleaching
Cerebrovascular Disorders
7 Citations (Scopus)

Endothelin-Mediated Calcium Responses in Supraoptic Nucleus Astrocytes Influence Magnocellular Neurosecretory Firing Activity

Filosa, J. A., Naskar, K., Perfume, G., Iddings, J. A., Biancardi, V. C., Vatta, M. S. & Stern, J. E., Feb 1 2012, In : Journal of Neuroendocrinology. 24, 2, p. 378-392 15 p.

Research output: Contribution to journalArticle

Supraoptic Nucleus
Endothelins
Astrocytes
Endothelin B Receptors
Calcium
32 Citations (Scopus)

High calorie diet triggers hypothalamic angiopathy

Yi, C. X., Gericke, M., Krüger, M., Alkemade, A., Kabra, D. G., Hanske, S., Filosa, J. A., Pfluger, P., Bingham, N., Woods, S. C., Herman, J., Kalsbeek, A., Baumann, M., Lang, R., Stern, J. E., Bechmann, I. & Tschöp, M. H., Dec 1 2012, In : Molecular Metabolism. 1, 1-2, p. 95-100 6 p.

Research output: Contribution to journalArticle

Arcuate Nucleus of Hypothalamus
Diet
High Fat Diet
Type 2 Diabetes Mellitus
Blood Vessels
2010
34 Citations (Scopus)

Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K + signaling in perivascular astrocytes

Higashimori, H., Blanco, V. M., Tuniki, V. R., Falck, J. R. & Filosa, J. A., Nov 1 2010, In : American Journal of Physiology - Cell Physiology. 299, 5

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Astrocytes
Glutamic Acid
Acids
Apamin
2008
29 Citations (Scopus)

Diminished A-type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats

Sonner, P. M., Filosa, J. A. & Stern, J. E., Mar 15 2008, In : Journal of Physiology. 586, 6, p. 1605-1622 18 p.

Research output: Contribution to journalArticle

Paraventricular Hypothalamic Nucleus
Potassium
Neurons
Action Potentials
Renovascular Hypertension
78 Citations (Scopus)

Tone-dependent vascular responses to astrocyte-derived signals

Blanco, V. M., Stern, J. E. & Filosa, J. A., Jun 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 6, p. H2855-H2863

Research output: Contribution to journalArticle

Astrocytes
Blood Vessels
Metabotropic Glutamate Receptors
Arterioles
Constriction
2007
20 Citations (Scopus)

Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels

Filosa, J. A., Nelson, M. T. & Gonzalez Bosc, L. V., Dec 1 2007, In : American Journal of Physiology - Cell Physiology. 293, 6, p. C1797-C1805

Research output: Contribution to journalArticle

Pericytes
Microvessels
Astrocytes
Metabotropic Glutamate Receptors
Electric Stimulation

Neural-glial-vascular communication in the brain

Filosa, J. A., Jan 1 2007, In : Experimental Physiology. 92, 4, 1 p.

Research output: Contribution to journalArticle

Neuroglia
Blood Vessels
Brain
60 Citations (Scopus)

Neurovascular coupling in the mammalian brain

Filosa, J. A. & Blanco, V. M., Jul 2007, In : Experimental Physiology. 92, 4, p. 641-646 6 p.

Research output: Contribution to journalArticle

Astrocytes
Brain
Smooth Muscle Myocytes
Vascular Smooth Muscle
Cerebrovascular Circulation
2006
337 Citations (Scopus)

Local potassium signaling couples neuronal activity to vasodilation in the brain

Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Wilkerson, M. K., Aldrich, R. W. & Nelson, M. T., Nov 1 2006, In : Nature Neuroscience. 9, 11, p. 1397-1403 7 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Vasodilation
Smooth Muscle Myocytes
Potassium
Brain
64 Citations (Scopus)

N-Acetylaspartate as a reservoir for glutamate

Clark, J. F., Doepke, A., Filosa, J. A., Wardle, R. L., Lu, A., Meeker, T. J. & Pyne-Geithman, G. J., Jun 28 2006, In : Medical Hypotheses. 67, 3, p. 506-512 7 p.

Research output: Contribution to journalArticle

Glutamic Acid
Brain
Oxaloacetic Acid
Acetyl Coenzyme A
Carbon
2004
183 Citations (Scopus)

Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.

Filosa, J. A., Bonev, A. D. & Nelson, M. T., Jan 1 2004, In : Circulation Research. 95, 10

Research output: Contribution to journalArticle

Arterioles
Astrocytes
Calcium
Electric Stimulation
Hyperemia
227 Citations (Scopus)

Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons

Putnam, R. W., Filosa, J. A. & Ritucci, N. A., Dec 2004, In : American Journal of Physiology - Cell Physiology. 287, 6 56-6, p. C1493-C1526

Research output: Contribution to journalReview article

Neurons
Acids
Carbon Monoxide
Brain Stem
Carotid Body
2003
59 Citations (Scopus)

Multiple targets of chemosensitive signaling in locus coeruleus neurons: Role of K+ and Ca2+ channels

Filosa, J. A. & Putnam, R. W., Jan 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 1 53-1, p. C145-C155

Research output: Contribution to journalArticle

Locus Coeruleus
Tetraethylammonium
Nifedipine
Neurons
Hypercapnia
2002
111 Citations (Scopus)

Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones

Filosa, J. A., Dean, J. B. & Putnam, R. W., Jun 1 2002, In : Journal of Physiology. 541, 2, p. 493-509 17 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Neurons
Acidosis
Acids
Hypercapnia
2001
96 Citations (Scopus)

Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats

Stunden, C. E., Filosa, J. A., Garcia, A. J., Dean, J. B. & Putnam, R. W., Aug 18 2001, In : Respiration Physiology. 127, 2-3, p. 135-155 21 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Hypercapnia
Ventilation
Neurons
Acidosis