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Research Output

2018

Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies

on behalf of & TEDDY study group, Jan 2018, In : Journal of Autoimmunity. 86, p. 93-103 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort

TEDDY study group, May 2018, In : Journal of Autoimmunity. 89, p. 90-100 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs

Lin, H. P., Singla, B., Ghoshal, P., Faulkner, J. L., Cherian-Shaw, M., O'Connor, P. M., She, J. X., Belin de Chantemele, E. J. & Csányi, G., Sep 2018, In : British Journal of Pharmacology. 175, 18, p. 3640-3655 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

KLHL5 knockdown increases cellular sensitivity to anticancer drugs

Schleifer, R. J., Li, S., Nechtman, W., Miller, E., Bai, S., Sharma, A. & She, J. X., Dec 1 2018, In : Oncotarget. 9, 100, p. 37429-37438 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins

Purohit, S. B., Li, T., Guan, W., Song, X., Song, J., Tian, Y., Li, L., Sharma, A. K., Dun, B., Mysona, D., Ghamande, S. A., Rungruang, B. J., Cummings, R. D., Wang, P. G. & She, J-X., Dec 1 2018, In : Nature communications. 9, 1, 258.

Research output: Contribution to journalArticle

21 Scopus citations

Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children

for the TEDDY Study Group, Jan 1 2018, In : Diabetologia. 61, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity

Norris, J. M., Lee, H. S., Frederiksen, B., Erlund, I., Uusitalo, U., Yang, J., Lernmark, Å., Simell, O., Toppari, J., Rewers, M., Ziegler, A. G., She, J-X., Onengut-Gumuscu, S., Chen, W. M., Rich, S. S., Sundvall, J., Akolkar, B., Krischer, J., Virtanen, S. M. & Hagopian, W., Jan 1 2018, In : Diabetes. 67, 1, p. 146-154 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Proteins of TNF-α and IL6 pathways are elevated in serum of type-1 diabetes patients with microalbuminuria

Purohit, S. B., Sharma, A. K., Zhi, W., Bai, S., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D. & She, J-X., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 154.

Research output: Contribution to journalArticle

4 Scopus citations

Proteomic approach to identify biomarkers for invasive cervix cancer - a prospective pilot study

Mysona, D., Pyrzak, A., Allen, J., Powell, M., Kleven, D., Zhi, W., Sharma, A., Bai, S., She, J. X., Rungruang, B. & Ghamande, S., Jan 1 2018, In : European Journal of Gynaecological Oncology. 39, 5, p. 737-742 6 p.

Research output: Contribution to journalArticle

Temporal development of the gut microbiome in early childhood from the TEDDY study

Stewart, C. J., Ajami, N. J., O’Brien, J. L., Hutchinson, D. S., Smith, D. P., Wong, M. C., Ross, M. C., Lloyd, R. E., Doddapaneni, H. V., Metcalf, G. A., Muzny, D., Gibbs, R. A., Vatanen, T., Huttenhower, C., Xavier, R. J., Rewers, M., Hagopian, W., Toppari, J., Ziegler, A. G., She, J-X. & 6 others, Akolkar, B., Lernmark, A., Hyoty, H., Vehik, K., Krischer, J. P. & Petrosino, J. F., Oct 25 2018, In : Nature. 562, 7728, p. 583-588 6 p.

Research output: Contribution to journalArticle

190 Scopus citations

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

The TEDDY study group, Dec 1 2018, In : Current diabetes reports. 18, 12, 136.

Research output: Contribution to journalReview article

13 Scopus citations

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

Vatanen, T., Franzosa, E. A., Schwager, R., Tripathi, S., Arthur, T. D., Vehik, K., Lernmark, Å., Hagopian, W. A., Rewers, M. J., She, J-X., Toppari, J., Ziegler, A. G., Akolkar, B., Krischer, J. P., Stewart, C. J., Ajami, N. J., Petrosino, J. F., Gevers, D., Lähdesmäki, H., Vlamakis, H. & 2 others, Huttenhower, C. & Xavier, R. J., Oct 25 2018, In : Nature. 562, 7728, p. 589-594 6 p.

Research output: Contribution to journalArticle

123 Scopus citations
2019

A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer

Mysona, D., Pyrzak, A., Purohit, S., Zhi, W., Sharma, A., Tran, L., Tran, P., Bai, S., Rungruang, B., Ghamande, S. & She, J. X., Mar 2019, In : Gynecologic Oncology. 152, 3, p. 574-580 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential

Gobin, E., Bagwell, K., Wagner, J., Mysona, D., Sandirasegarane, S., Smith, N., Bai, S., Sharma, A., Schleifer, R. & She, J. X., Jun 14 2019, In : BMC Cancer. 19, 1, 581.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk

Andrén Aronsson, C., Lee, H. S., Hård Af Segerstad, E. M., Uusitalo, U., Yang, J., Koletzko, S., Liu, E., Kurppa, K., Bingley, P. J., Toppari, J., Ziegler, A. G., She, J. X., Hagopian, W. A., Rewers, M., Akolkar, B., Krischer, J. P., Virtanen, S. M., Norris, J. M. & Agardh, D., Aug 13 2019, In : JAMA - Journal of the American Medical Association. 322, 6, p. 514-523 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cell-based high throughput screening identified a novel compound that promotes regulatory T cells and prevents autoimmune colitis

Mao, R., Liu, H., Yi, B., Purohit, S., Kuczma, M., Kraj, P. & She, J. X., Nov 2019, In : Biochemical Pharmacology. 169, 113618.

Research output: Contribution to journalArticle

Early probiotic supplementation and the risk of celiac disease in children at genetic risk

TEDDY study group, Aug 2019, In : Nutrients. 11, 8, 1790.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families

The TEDDY study group, Apr 1 2019, In : Diabetes. 68, 4, p. 847-857 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Identification of novel T1D risk loci and their association with age and islet function at diagnosis in autoantibody-positive T1D individuals: Based on a two-stage genome-wide association study

Zhu, M., Xu, K., Chen, Y., Gu, Y., Zhang, M., Luo, F., Liu, Y., Gu, W., Hu, J., Xu, H., Xie, Z., Sun, C., Li, Y., Sun, M., Xu, X., Hsu, H. T., Chen, H., Fu, Q., Shi, Y., Xu, J. & 33 others, Ji, L., Liu, J., Bian, L., Zhu, J., Chen, S., Xiao, L., Li, X., Jiang, H., Shen, M., Huang, Q., Fang, C., Li, X., Huang, G., Fan, J., Jiang, Z., Jiang, Y., Dai, J., Ma, H., Zheng, S., Cai, Y., Dai, H., Zheng, X., Zhou, H., Ni, S., Jin, G., She, J. X., Yu, L., Polychronakos, C., Hu, Z., Zhou, Z., Weng, J., Shen, H. & Yang, T., Aug 1 2019, In : Diabetes Care. 42, 8, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study

The TEDDY study group, Feb 1 2019, In : Pediatric Diabetes. 20, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Metabolite-related dietary patterns and the development of islet autoimmunity

The TEDDY study group, Dec 1 2019, In : Scientific reports. 9, 1, 14819.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Predicting islet cell autoimmunity and type 1 diabetes: An 8-year teddy study progress report

TEDDY study group, Jun 1 2019, In : Diabetes Care. 42, 6, p. 1051-1060 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children

The TEDDY study group, May 2019, In : Pediatric Diabetes. 20, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: Results from the prospective TEDDY study

Beyerlein, A., Bonifacio, E., Vehik, K., Hippich, M., Winkler, C., Frohnert, B. I., Steck, A. K., Hagopian, W. A., Krischer, J. P., Lernmark, Å., Rewers, M. J., She, J. X., Toppari, J., Akolkar, B., Rich, S. S. & Ziegler, A. G., Sep 1 2019, In : Journal of medical genetics. 56, 9, p. 602-605 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

The TEDDY study group, Dec 1 2019, In : Nature Medicine. 25, 12, p. 1865-1872 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children

TEDDY study group, Sep 18 2019, In : BMC pediatrics. 19, 1, 339.

Research output: Contribution to journalArticle

Open Access

Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children

for the TEDDY Study Group*, Jan 1 2019, In : Diabetes. 68, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2020

A 73-gene proliferative transcriptomic signature predicts uterine serous carcinoma patient survival and response to primary therapy

Tran, L. K. H., Tran, P. M. H., Mysona, D. P., Purohit, S. B., Myers, E., Lee, W. S., Dun, B., Xu, D., Liu, H., Hopkins, D., Nechtman, J., Scelsi, C. L., Mittal, P. K., Kleven, D., Wallbillich, J. J., Rungruang, B., Ghamande, S. & She, J. X., May 2020, In : Gynecologic Oncology. 157, 2, p. 340-347 8 p.

Research output: Contribution to journalArticle

Better survival is observed in cervical cancer patients positive for specific anti-glycan antibodies and receiving brachytherapy

Purohit, S., Ferris, D. G., Alvarez, M., Tran, P. M. H., Tran, L. K. H., Mysona, D. P., Hopkins, D., Zhi, W., Dun, B., Wallbillich, J. J., Cummings, R. D., Wang, P. G. & She, J. X., Apr 2020, In : Gynecologic Oncology. 157, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Clinical calculator predictive of chemotherapy benefit in stage 1A uterine papillary serous cancers

Mysona, D. P., Tran, L. K. H., Tran, P. M. H., Gehrig, P. A., Van Le, L., Ghamande, S., Rungruang, B. J., Java, J., Mann, A. K., Liao, J., Kapp, D. S., Santos, B. D., She, J. X. & Chan, J. K., Jan 2020, In : Gynecologic Oncology. 156, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distinct growth phases in early life associated with the risk of type 1 diabetes: The teddy study

TEDDY study group, Mar 1 2020, In : Diabetes Care. 43, 3, p. 556-562 7 p.

Research output: Contribution to journalArticle

Longitudinal metabolome-wide signals prior to the appearance of a first islet autoantibody in children participating in the TEDDY study

Li, Q., Parikh, H., Butterworth, M. D., Lernmark, Å., Hagopian, W., Rewers, M., She, J. X., Toppari, J., Ziegler, A. G., Akolkar, B., Fiehn, O., Fan, S., Krischer, J. P., Rewers, M., Barbour, A., Bautista, K., Baxter, J., Felipe-Morales, D., Driscoll, K., Frohnert, B. I. & 236 others, Stahl, M., Gesualdo, P., Hoffman, M., Karban, R., Liu, E., Norris, J., Peacock, S., Shorrosh, H., Steck, A., Stern, M., Villegas, E., Waugh, K., Toppari, J., Simell, O. G., Adamsson, A., Ahonen, S., Åkerlund, M., Hakola, L., Hekkala, A., Holappa, H., Hyöty, H., Ikonen, A., Ilonen, J., Jäminki, S., Jokipuu, S., Karlsson, L., Kero, J., Kähönen, M., Knip, M., Koivikko, M. L., Koskinen, M., Koreasalo, M., Kurppa, K., Kytölä, J., Latva-Aho, T., Lindfors, K., Lönnrot, M., Mäntymäki, E., Mattila, M., Miettinen, M., Multasuo, K., Mykkänen, T., Niininen, T., Niinistö, S., Nyblom, M., Oikarinen, S., Ollikainen, P., Othmani, Z., Pohjola, S., Rajala, P., Rautanen, J., Riikonen, A., Riski, E., Pekkola, M., Romo, M., Ruohonen, S., Simell, S., Sjöberg, M., Stenius, A., Tossavainen, P., Vähä-Mäkilä, M., Vainionpää, S., Varjonen, E., Veijola, R., Viinikangas, I., Virtanen, S. M., She, J. X., Schatz, D., Hopkins, D., Steed, L., Bryant, J., Silvis, K., Haller, M., Gardiner, M., McIndoe, R., Sharma, A., Anderson, S. W., Jacobsen, L., Marks, J., Towe, P. D., Ziegler, A. G., Bonifacio, E., Gavrisan, A., Gezginci, C., Heublein, A., Hoffmann, V., Hummel, S., Keimer, A., Knopff, A., Koch, C., Koletzko, S., Ramminger, C., Roth, R., Scholz, M., Stock, J., Warncke, K., Wendel, L., Winkler, C., Lernmark, Å., Agardh, D., Aronsson, C. A., Ask, M., Bennet, R., Cilio, C., Engqvist, H., Ericson-Hallström, E., Fors, A., Fransson, L., Gard, T., Hansen, M., Jisser, H., Johansen, F., Jonsdottir, B., Jovic, S., Larsson, H. E., Lindström, M., Lundgren, M., Maziarz, M., Månsson-Martinez, M., Markan, M., Melin, J., Mestan, Z., Nilsson, C., Ottosson, K., Rahmati, K., Ramelius, A., Salami, F., Sjöberg, A., Sjöberg, B., Svensson, M., Törn, C., Wallin, A., Wimar, Å., Åberg, S., Hagopian, W. A., Killian, M., Crouch, C. C., Skidmore, J., Chavoshi, M., Hervey, R., Lyons, R., Meyer, A., Mulenga, D., Radtke, J., Romancik, M., Schmitt, D., Zink, S., Becker, D., Franciscus, M., Smith, M. E. D. E., Daftary, A., Klein, M. B., Yates, C., Krischer, J. P., Austin-Gonzalez, S., Avendano, M., Baethke, S., Brown, R., Burkhardt, B., Butterworth, M., Clasen, J., Cuthbertson, D., Dankyi, S., Eberhard, C., Fiske, S., Garmeson, J., Gowda, V., Heyman, K., Hsiao, B., Karges, C., Laras, F. P., Lee, H. S., Li, Q., Liu, S., Liu, X., Lynch, K., Maguire, C., Malloy, J., McCarthy, C., Merrell, A., Parikh, H., Quigley, R., Remedios, C., Shaffer, C., Smith, L., Smith, S., Sulman, N., Tamura, R., Tewey, D., Toth, M., Uusitalo, U., Vehik, K., Vijayakandipan, P., Wood, K., Yang, J., Abbondondolo, M., Ballard, L., Hadley, D., McLeod, W., Meulemans, S., Akolkar, B., Bourcier, K., Briese, T., Johnson, S. B., Triplett, E., Yu, L., Miao, D., Bingley, P., Williams, A., Chandler, K., Ball, O., Kelland, I., Grace, S., Erlich, H., Mack, S. J., Fear, A. L., Fiehn, O., Wikoff, B., Defelice, B., Grapov, D., Kind, T., Palazoglu, M., Valdiviez, L., Wancewicz, B., Wohlgemuth, G., Wong, J., Rich, S. S., Chen, W. M., Onengut-Gumuscu, S., Farber, E., Pickin, R. R., Davis, J., Davis, J., Gallo, D., Bonnie, J. & Campolieto, P., Mar 1 2020, In : Diabetes. 69, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations