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Research Output

Article

Large-scale discovery and validation studies demonstrate significant reductions in circulating levels of IL8, IL-1Ra, MCP-1, and MIP-1β in patients with type 1 diabetes

Purohit, S. B., Sharma, A. K., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D., Yang, T. & She, J-X., Sep 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 9, p. E1179-E1187

Research output: Contribution to journalArticle

8 Scopus citations

Longitudinal metabolome-wide signals prior to the appearance of a first islet autoantibody in children participating in the TEDDY study

Li, Q., Parikh, H., Butterworth, M. D., Lernmark, Å., Hagopian, W., Rewers, M., She, J. X., Toppari, J., Ziegler, A. G., Akolkar, B., Fiehn, O., Fan, S., Krischer, J. P., Rewers, M., Barbour, A., Bautista, K., Baxter, J., Felipe-Morales, D., Driscoll, K., Frohnert, B. I. & 236 others, Stahl, M., Gesualdo, P., Hoffman, M., Karban, R., Liu, E., Norris, J., Peacock, S., Shorrosh, H., Steck, A., Stern, M., Villegas, E., Waugh, K., Toppari, J., Simell, O. G., Adamsson, A., Ahonen, S., Åkerlund, M., Hakola, L., Hekkala, A., Holappa, H., Hyöty, H., Ikonen, A., Ilonen, J., Jäminki, S., Jokipuu, S., Karlsson, L., Kero, J., Kähönen, M., Knip, M., Koivikko, M. L., Koskinen, M., Koreasalo, M., Kurppa, K., Kytölä, J., Latva-Aho, T., Lindfors, K., Lönnrot, M., Mäntymäki, E., Mattila, M., Miettinen, M., Multasuo, K., Mykkänen, T., Niininen, T., Niinistö, S., Nyblom, M., Oikarinen, S., Ollikainen, P., Othmani, Z., Pohjola, S., Rajala, P., Rautanen, J., Riikonen, A., Riski, E., Pekkola, M., Romo, M., Ruohonen, S., Simell, S., Sjöberg, M., Stenius, A., Tossavainen, P., Vähä-Mäkilä, M., Vainionpää, S., Varjonen, E., Veijola, R., Viinikangas, I., Virtanen, S. M., She, J. X., Schatz, D., Hopkins, D., Steed, L., Bryant, J., Silvis, K., Haller, M., Gardiner, M., McIndoe, R., Sharma, A., Anderson, S. W., Jacobsen, L., Marks, J., Towe, P. D., Ziegler, A. G., Bonifacio, E., Gavrisan, A., Gezginci, C., Heublein, A., Hoffmann, V., Hummel, S., Keimer, A., Knopff, A., Koch, C., Koletzko, S., Ramminger, C., Roth, R., Scholz, M., Stock, J., Warncke, K., Wendel, L., Winkler, C., Lernmark, Å., Agardh, D., Aronsson, C. A., Ask, M., Bennet, R., Cilio, C., Engqvist, H., Ericson-Hallström, E., Fors, A., Fransson, L., Gard, T., Hansen, M., Jisser, H., Johansen, F., Jonsdottir, B., Jovic, S., Larsson, H. E., Lindström, M., Lundgren, M., Maziarz, M., Månsson-Martinez, M., Markan, M., Melin, J., Mestan, Z., Nilsson, C., Ottosson, K., Rahmati, K., Ramelius, A., Salami, F., Sjöberg, A., Sjöberg, B., Svensson, M., Törn, C., Wallin, A., Wimar, Å., Åberg, S., Hagopian, W. A., Killian, M., Crouch, C. C., Skidmore, J., Chavoshi, M., Hervey, R., Lyons, R., Meyer, A., Mulenga, D., Radtke, J., Romancik, M., Schmitt, D., Zink, S., Becker, D., Franciscus, M., Smith, M. E. D. E., Daftary, A., Klein, M. B., Yates, C., Krischer, J. P., Austin-Gonzalez, S., Avendano, M., Baethke, S., Brown, R., Burkhardt, B., Butterworth, M., Clasen, J., Cuthbertson, D., Dankyi, S., Eberhard, C., Fiske, S., Garmeson, J., Gowda, V., Heyman, K., Hsiao, B., Karges, C., Laras, F. P., Lee, H. S., Li, Q., Liu, S., Liu, X., Lynch, K., Maguire, C., Malloy, J., McCarthy, C., Merrell, A., Parikh, H., Quigley, R., Remedios, C., Shaffer, C., Smith, L., Smith, S., Sulman, N., Tamura, R., Tewey, D., Toth, M., Uusitalo, U., Vehik, K., Vijayakandipan, P., Wood, K., Yang, J., Abbondondolo, M., Ballard, L., Hadley, D., McLeod, W., Meulemans, S., Akolkar, B., Bourcier, K., Briese, T., Johnson, S. B., Triplett, E., Yu, L., Miao, D., Bingley, P., Williams, A., Chandler, K., Ball, O., Kelland, I., Grace, S., Erlich, H., Mack, S. J., Fear, A. L., Fiehn, O., Wikoff, B., Defelice, B., Grapov, D., Kind, T., Palazoglu, M., Valdiviez, L., Wancewicz, B., Wohlgemuth, G., Wong, J., Rich, S. S., Chen, W. M., Onengut-Gumuscu, S., Farber, E., Pickin, R. R., Davis, J., Davis, J., Gallo, D., Bonnie, J. & Campolieto, P., Mar 1 2020, In : Diabetes. 69, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

Open Access

Loss-of-Function Mutations in HPSE2 Cause the Autosomal Recessive Urofacial Syndrome

Pang, J., Zhang, S., Yang, P., Lee, B. H., Zhong, J., Zhang, Y., Ochoa, B., Agundez, J. A. G., Voelckel, M. A., Gu, W., Xiong, W., Mei, L., She, J-X. & Wang, C. Y., Jul 11 2010, In : American journal of human genetics. 86, 6, p. 957-962 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Mapping DNA-binding domains of the autoimmune regulator protein

Purohit, S. B., Kumar, P. G., Laloraya, M. & She, J-X., Feb 18 2005, In : Biochemical and Biophysical Research Communications. 327, 3, p. 939-944 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Maternal anxiety about a child's diabetes risk in the TEDDY study: The potential role of life stress, postpartum depression, and risk perception

TEDDY study group, Jun 1 2015, In : Pediatric Diabetes. 16, 4, p. 287-298 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Maternal Anxiety Associated with Newborn Genetic Screening for Type 1 Diabetes

Johnson, S. B., Baughcum, A. E., Carmichael, S. K., She, J-X. & Schatz, D. A., Feb 1 2004, In : Diabetes Care. 27, 2, p. 392-397 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study

The TEDDY study group, Feb 1 2019, In : Pediatric Diabetes. 20, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Maternal understanding of infant diabetes risk: Differential effects of maternal anxiety and depression

Hood, K. K., Johnson, S. B., Baughcum, A. E., She, J-X. & Schatz, D. A., Oct 1 2006, In : Genetics in Medicine. 8, 10, p. 665-670 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study

Yang, J., Tamura, R. N., Aronsson, C. A., Uusitalo, U. M., Lernmark, Å., Rewers, M., Hagopian, W. A., She, J. X., Toppari, J., Ziegler, A. G., Akolkar, B., Krischer, J. P., Norris, J. M., Virtanen, S. M. & Agardh, D., Feb 14 2017, In : British Journal of Nutrition. 117, 3, p. 466-472 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Metabolite-related dietary patterns and the development of islet autoimmunity

The TEDDY study group, Dec 1 2019, In : Scientific reports. 9, 1, 14819.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY

Vehik, K., Fiske, S. W., Logan, C. A., Agardh, D., Cilio, C. M., Hagopian, W., Simell, O., Roivainen, M., She, J. X., Briese, T., Oikarinen, S., Hyoty, H., Ziegler, A. G., Rewers, M., Lernmark, A., Akolkar, B., Krischer, J. P. & Burkhardt, B. R., Oct 1 2013, In : Diabetes/Metabolism Research and Reviews. 29, 7, p. 557-567 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Microarray analysis of gene expression in the kidneys of new- and post-onset diabetic NOD mice

Wilson, K. H. S., Eckenrode, S. E., Li, Q. Z., Ruan, Q. G., Yang, P., Shi, J. D., Davoodi-Semiromi, A., McIndoe, R. A., Croker, B. P. & She, J-X., Aug 1 2003, In : Diabetes. 52, 8, p. 2151-2159 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Microarray experimental design: Power and sample size considerations

Yang, M. C. K., Yang, J. J., McIndoe, R. A. & She, J. X., Apr 1 2004, In : Physiological Genomics. 16, p. 24-28 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival

Bhatt, K., Zhou, L., Mi, Q. S., Huang, S., She, J-X. & Dong, Z., Sep 1 2010, In : Molecular Medicine. 16, 9-10, p. 409-416 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)

Wang, C. Y., Shi, J. D., Yang, P., Kumar, P. G., Li, Q. Z., Run, Q. G., Su, Y., Scott, H. S., Kao, K. J. & She, J-X., Mar 13 2003, In : Gene. 306, 1-2, p. 37-44 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

Molecular Cloning and Characterization of a Novel Mammalian Endo-apyrase (LALP1)

Shi, J. D., Kukar, T., Wang, C. Y., Li, Q. Z., Cruz, P. E., Davoodi-Semiromi, A., Yang, P., Gu, Y., Lian, W., Wu, D. H. & She, J-X., May 18 2001, In : Journal of Biological Chemistry. 276, 20, p. 17474-17478 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

37 Scopus citations

Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily

Li, Q. Z., Wang, C. Y., Shi, J. D., Ruan, Q. G., Eckenrode, S., Davoodi-Semiromi, A., Kukar, T., Gu, Y., Lian, W., Wu, D. & She, J-X., Aug 8 2001, In : Gene. 273, 2, p. 275-284 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular pathways altered by insulin B9-23 immunization

Eckenrode, S. E., Ruan, Q. G., Collins, C. D., Yang, P., McIndoe, R. A., Muir, A. & She, J-X., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1037, p. 175-185 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular phylogenies in the genus Mus: Comparative analysis of electrophoretic, scnDNA hybridization, and mtDNA RFLP data

SHE, J. X., BONHOMME, F., BOURSOT, P., THALER, L. & CATZEFLIS, F., Sep 1990, In : Biological Journal of the Linnean Society. 41, 1-3, p. 83-103 21 p.

Research output: Contribution to journalArticle

158 Scopus citations

Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins

Purohit, S. B., Li, T., Guan, W., Song, X., Song, J., Tian, Y., Li, L., Sharma, A. K., Dun, B., Mysona, D., Ghamande, S. A., Rungruang, B. J., Cummings, R. D., Wang, P. G. & She, J-X., Dec 1 2018, In : Nature communications. 9, 1, 258.

Research output: Contribution to journalArticle

20 Scopus citations

Multivariate analysis of genetic exchanges between Solea aegyptiaca and Solea senegalensis (Teleosts, Soleidae)

SHE, J. X., AUTEM, M., KOTULAS, G., PASTEUR, N. & BONHOMME, F., Jan 1 1987, In : Biological Journal of the Linnean Society. 32, 4, p. 357-371 15 p.

Research output: Contribution to journalArticle

107 Scopus citations

Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways

Dun, B., Sharma, A., Teng, Y., Liu, H., Purohit, S., Xu, H., Zeng, L. & She, J. X., Nov 15 2013, In : PloS one. 8, 11, e81702.

Research output: Contribution to journalArticle

21 Scopus citations

NeuroD/Beta2 polymorphism is not associated with type 1 diabetes in Chinese, Korean, or Caucasian populations

Marron, M. P., Hopkins, D. I., She, J. X., Park, Y. S. & She, J. X., Apr 1999, In : Journal of Endocrine Genetics. 1, 2, p. 73-77 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

Lee, H. S., Briese, T., Winkler, C., Rewers, M., Bonifacio, E., Hyoty, H., Pflueger, M., Simell, O., She, J. X., Hagopian, W., Lernmark, A., Akolkar, B., Krischer, J. P. & Ziegler, A. G., Aug 1 2013, In : Diabetologia. 56, 8, p. 1705-1711 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

No primary association between the 308 polymorphism in the tumor necrosis factor α promoter region and insulin-dependent diabetes mellitus

Deng, G. Y., Maclaren, N. K., Huang, H. S., Zhang, L. P. & She, J. X., Feb 1996, In : Human Immunology. 45, 2, p. 137-142 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Novel TSHβ subunit gene mutation causing congenital central hypothyroidism in a newborn male

Morales, A. E., Shi, J. D., Wang, C. Y., She, J. X. & Muir, A., Jan 1 2004, In : Journal of Pediatric Endocrinology and Metabolism. 17, 3, p. 355-359 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Nucleotide sequence of a novel HLA-DRB1 allele, DRB1*0806

She, J-X., Zhang, L. P., Scornik, J. & Wakeland, E. K., Jan 1 1994, In : Immunogenetics. 39, 1, 1 p.

Research output: Contribution to journalArticle

7 Scopus citations

Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2β predict immune-mediated (type 1) diabetes in relatives

Maclaren, N., Lan, M., Coutant, R., Schatz, D., Silverstein, J., Muir, A., Clare-Salzer, M., She, J-X., Malone, J., Crockett, S., Schwartz, S., Quattrin, T., Desilva, M., Vander Vegt, P., Notkins, A. & Krischer, J., Jun 1999, In : Journal of Autoimmunity. 12, 4, p. 279-287 9 p.

Research output: Contribution to journalArticle

97 Scopus citations
6 Scopus citations

Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children

for the TEDDY Study Group, Jan 1 2018, In : Diabetologia. 61, 1, p. 193-202 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas

Bui, M. M., Luo, D. F., She, J. Y., Maclaren, N. K., Muir, A., Thomson, G. & Jin-Xiong, S., Feb 1996, In : Journal of Autoimmunity. 9, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission

Lamers, S. L., Sleasman, J. W., She, J. X., Barrie, K. A., Pomeroy, S. M., Barrett, D. J. & Goodenow, M. M., Jan 1994, In : Journal of Clinical Investigation. 93, 1, p. 380-390 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Pharmacophore-based discovery of new human dihydroorotate dehydrogenase inhibitor

Lu, P., Wang, Y., Ma, B., She, J., Zhang, Q., He, M. & Liu, Y., Jun 2014, In : Medicinal Chemistry. 10, 4, p. 402-408 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
22 Scopus citations

Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+CD25+ regulatory T cells

Setiady, Y. Y., Ohno, K., Samy, E. T., Bagavant, H., Qiao, H., Sharp, C., Jin, X. S. & Tung, K. S. K., Feb 1 2006, In : Blood. 107, 3, p. 1056-1062 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity

Norris, J. M., Lee, H. S., Frederiksen, B., Erlund, I., Uusitalo, U., Yang, J., Lernmark, Å., Simell, O., Toppari, J., Rewers, M., Ziegler, A. G., She, J-X., Onengut-Gumuscu, S., Chen, W. M., Rich, S. S., Sundvall, J., Akolkar, B., Krischer, J., Virtanen, S. M. & Hagopian, W., Jan 1 2018, In : Diabetes. 67, 1, p. 146-154 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications

Li, S., Nguyen, L., Xiong, H., Wang, M., Hu, T. C. C., She, J-X., Serkiz, S. M., Wicks, G. G. & Dynan, W. S., Jan 1 2010, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 6, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Poststreptococcal reactive arthritis: Clinical characteristics and association with HLA-DR alleles

Ahmed, S., Ayoub, E. M., Scornik, J. C., Wang, C. Y. & She, J-X., Jun 1 1998, In : Arthritis and Rheumatism. 41, 6, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

84 Scopus citations

Prediabetic markers in children with stress hyperglycemia

Bhisitkul, D. M., Vinik, A. I., Morrow, A. L., She, J. X., Shults, J., Powers, A. C. & Maclaren, N. K., Sep 1996, In : Archives of Pediatrics and Adolescent Medicine. 150, 9, p. 936-941 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Predicting islet cell autoimmunity and type 1 diabetes: An 8-year teddy study progress report

TEDDY study group, Jun 1 2019, In : Diabetes Care. 42, 6, p. 1051-1060 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children

The TEDDY study group, May 2019, In : Pediatric Diabetes. 20, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
70 Scopus citations

Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - A new surrogate measure of non-progression?

Schatz, D., Cuthbertson, D., Atkinson, M., Salzer, M. C., Winter, W., Muir, A., Silverstein, J., Cook, R., Maclaren, N., She, J-X., Greenbaum, C. & Krischer, J., Jun 1 2004, In : Pediatric Diabetes. 5, 2, p. 72-79 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes

Yang, J., Lernmark, Uusitalo, U. M., Lynch, K. F., Veijola, R., Winkler, C., Larsson, H. E., Rewers, M., She, J. X., Ziegler, A. G., Simell, O. G., Hagopian, W. A., Akolkar, B., Krischer, J. P. & Vehik, K., Dec 11 2014, In : International Journal of Obesity. 38, 12, p. 1491-1496 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Proficiency testing of human leukocyte antigen-DR and human leukocyte antigen-DQ genetic risk assessment for type 1 diabetes using dried blood spots

Dantonio, P., Meredith-Molloy, N., Hagopian, W. A., She, J. X., Akolkar, B., Cordovado, S. K., Hendrix, M., Henderson, L. O., Hannon, W. H. & Vogt, R. F., Jul 2010, In : Journal of Diabetes Science and Technology. 4, 4, p. 929-941 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: Results from the prospective TEDDY study

Beyerlein, A., Bonifacio, E., Vehik, K., Hippich, M., Winkler, C., Frohnert, B. I., Steck, A. K., Hagopian, W. A., Krischer, J. P., Lernmark, Å., Rewers, M. J., She, J. X., Toppari, J., Akolkar, B., Rich, S. S. & Ziegler, A. G., Sep 1 2019, In : Journal of medical genetics. 56, 9, p. 602-605 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prospective assessment in newborns of diabetes autoimmunity (PANDA): Maternal understanding of infant diabetes risk

Carmichael, S. K., Johnson, S. B., Baughcum, A., North, K., Hopkins, D., Dukes, M. G., She, J-X. & Schatz, D. A., Mar 1 2003, In : Genetics in Medicine. 5, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

The TEDDY study group, Dec 1 2019, In : Nature Medicine. 25, 12, p. 1865-1872 8 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Protein microarrays to detect protein-protein interactions using red and green fluorescent proteins

Kukar, T., Eckenrode, S., Gu, Y., Lian, W., Megginson, M., She, J. X. & Wu, D., Jul 1 2002, In : Analytical Biochemistry. 306, 1, p. 50-54 5 p.

Research output: Contribution to journalArticle

83 Scopus citations