• 3402 Citations
  • 34 h-Index
1985 …2020

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Article
2006

Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism

Bhagavath, B., Podolsky, R. H., Ozata, M., Bolu, E., Bick, D. P., Kulharya, A., Sherins, R. J. & Layman, L. C., Jan 1 2006, In : Fertility and Sterility. 85, 3, p. 706-713 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2005

Screening candidate genes for mutations in patients with hypogonadotropic hypogonadism using custom genome resequencing microarrays

Xu, N., Podolsky, R. H., Chudgar, P., Chorich, L. P., Liu, C., McDonough, P. G., Warrington, J. A. & Layman, L. C., Jan 1 2005, In : American Journal of Obstetrics and Gynecology. 192, 4, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism

Bhagavath, B., Ozata, M., Ozdemir, I. C., Bolu, E., Bick, D. P., Sherins, R. J. & Layman, L. C., Oct 1 2005, In : Fertility and Sterility. 84, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
2003

Analysis of the Cys82Arg mutation in follicle-stimulating hormone beta (FSHβ) using a novel FSH expression vector

Clark, A. D. & Layman, L. C., Feb 1 2003, In : Fertility and Sterility. 79, 2, p. 379-385 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2002
22 Scopus citations

FSHβ gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia

Layman, L. C., Porto, A. L. A., Xie, J., Da Motta, L. A. C. R., Da Motta, L. D. C., Weiser, W. & Sluss, P. M., Aug 24 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 8, p. 3702-3707 6 p.

Research output: Contribution to journalArticle

102 Scopus citations

The role of LH and FSH in ovarian androgen secretion and ovarian follicular development: Clinical studies in a patient with isolated FSH deficiency and multicystic ovaries

Barnes, R. B., Namnoum, A. B., Rosenfield, R. L. & Layman, L. C., Jan 1 2002, In : Human Reproduction. 17, 1, p. 88-91 4 p.

Research output: Contribution to journalArticle

47 Scopus citations
2001

Familial gonadotropin-releasing hormone resistance and hypogonadotropic hypogonadism in a family with multiple affected individuals

Layman, L. C., McDonough, P. G., Cohen, D. P., Maddox, M., Tho, S. P. T. & Reindollar, R. H., Jun 21 2001, In : Fertility and Sterility. 75, 6, p. 1148-1155 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2000

Essential genetics for the obstetrician/gynecologist

Layman, L. C., Jan 1 2000, In : Obstetrics and Gynecology Clinics of North America. 27, 3, p. 555-566 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mutations of follicle stimulating hormone-β and its receptor in human and mouse: Genotype/phenotype

Layman, L. C. & McDonough, P. G., Mar 30 2000, In : Molecular and Cellular Endocrinology. 161, 1-2, p. 9-17 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
1999

Administration of progesterone before oocyte retrieval negatively affects the implantation rate

Sohn, S. H., Penzias, A. S., Emmi, A. M., Dubey, A. K., Layman, L. C., Reindollar, R. H. & DeCherney, A. H., Jan 1 1999, In : Fertility and sterility. 71, 1, p. 11-14 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genetic aspects of amenorrhea

Layman, L. C., Apr 1 1999, In : Contemporary Ob-Gyn. 44, 4, p. 27-40 14 p.

Research output: Contribution to journalArticle

Molecular analysis of the gonadotropin-releasing hormone receptor in patients with polycystic ovary syndrome

Stein, E. M., Li, Z., Matulis, C. K. & Layman, L. C., Aug 1 1999, In : Fertility and sterility. 72, 2, p. 360-363 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay

Achermann, J. C., Gu, W. X., Kotlar, T. J., Meeks, J. J., Sabacan, L. P., Seminara, S. B., Habiby, R. L., Hindmarsh, P. C., Bick, D. P., Sherins, R. J., Crowley, W. F., Layman, L. C. & Jameson, J. L., Jan 1 1999, In : Journal of Clinical Endocrinology and Metabolism. 84, 12, p. 4497-4500 4 p.

Research output: Contribution to journalArticle

71 Scopus citations

Mutation analysis of the EMX2 gene in Kallmann's syndrome

Taylor, H. S., Block, K., Bick, D. P., Shering, R. J. & Layman, L. C., Nov 1 1999, In : Fertility and sterility. 72, 5, p. 910-914 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

The molecular basis of human hypogonadotropic hypogonadism

Layman, L. C., Jan 1 1999, In : Molecular Genetics and Metabolism. 68, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
1998

Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism

Layman, L. C., Cohen, D. P., Jin, M., Xie, J., Li, Z., Reindollar, R. H., Bolbolan, S., Bick, D. P., Sherins, R. R., Duck, L. W., Musgrove, L. C., Sellers, J. C. & Neill, J. D., Jan 1998, In : Nature Genetics. 18, 1, p. 14-15 2 p.

Research output: Contribution to journalArticle

224 Scopus citations

The Finnish follicle-stimulating hormone receptor gene mutation is rare in North American women with 46,XX ovarian failure

Layman, L. C., Amde, S., Cohen, D. P., Jin, M. & Xie, J., Mar 26 1998, In : Fertility and sterility. 69, 2, p. 300-302 3 p.

Research output: Contribution to journalArticle

94 Scopus citations

Use of denaturing gradient gel blots to screen for point mutations in the factor VIII gene

Laprise, S. L., Mak, E. K., Killoran, K. A., Layman, L. C. & Gray, M. R., Nov 19 1998, In : Human Mutation. 12, 6, p. 393-402 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1997

Delayed puberty and hypogonadism caused by mutations in the follicle- stimulating hormone β-subunit gene

Layman, L. C., Lee, E. J., Peak, D. B., Namnoum, A. B., Vu, K. V., Van Lingen, B. L., Gray, M. R., McDonough, P. G., Reindollar, R. H. & Jameson, J. L., Aug 28 1997, In : New England Journal of Medicine. 337, 9, p. 607-611 5 p.

Research output: Contribution to journalArticle

211 Scopus citations

Failed fertilization after intracytoplasmic sperm injection: The extent of paternal and maternal chromatin decondensation

Dubey, A. K., Layman, L. C., Penzias, A. S., Reindollar, R. H., Emmi, A. E. & Ducibella, T., Oct 1 1997, In : Fertility and Sterility. 68, 4, p. 714-717 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Human chorionic gonadotrophin-β gene sequences in women with disorders of HCG production

Layman, L. C., Edwards, J. L., Osborne, W. E., Peak, D. B., Gallup, D. G., Tho, S. P. T., Reindollar, R. H., Roach, D. J., McDonough, P. G. & Lanclos, K. D., Dec 1 1997, In : Molecular Human Reproduction. 3, 4, p. 315-320 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mutation analysis of the gonadotropin-releasing hormone receptor gene in idiopathic hypogonadotropic hypogonadism

Layman, L. C., Sohn, S. H., Peak, D. B., Reindollar, R. H., Xie, J. & Gray, M. R., Dec 1 1997, In : Fertility and sterility. 68, 6, p. 1079-1085 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
1996

Biochemical study of individual zonae from human oocytes that failed to undergo fertilization in intracytoplasmic sperm injection

Gross, V., Dubey, A., Penzias, A. S., Layman, L., Reindollar, R. & Ducibella, T., Jan 1 1996, In : Molecular Human Reproduction. 2, 12, p. 959-965 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
1995

A zona biochemical change and spontaneous cortical granule loss in eggs that fail to fertilize in in vitro fertilization

Ducibella, T., Dubey, A., Gross, V., Emmi, A., Penzias, A. S., Layman, L. & Reindollar, R., Jan 1 1995, In : Fertility and sterility. 64, 6, p. 1154-1161 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

The follicle-stimulating hormone receptor gene is polymorphic in premature ovarian failure and normal controls

Whitney, E. A., Layman, L. C., Chan, P. J., Lee, A., Peak, D. B. & McDonough, P. G., Jan 1 1995, In : Fertility and sterility. 64, 3, p. 518-524 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
1994

Ultrasound prediction of follicle volume: Is the mean diameter reflective?

Penzias, A. S., Emmi, A. M., Dubey, A. K., Layman, L. C., DeCherney, A. H. & Reindollar, R. H., Jan 1 1994, In : Fertility and sterility. 62, 6 I, p. 1274-1276 3 p.

Research output: Contribution to journalArticle

29 Scopus citations
1993

Dicavitary uteri with twin gestation: A case following clomiphene citrate therapy and review of obstetric outcomes

Vandermolen, D. T., Layman, L. C. & Devoe, L. D., Jan 1 1993, In : American Journal of Perinatology. 10, 6, p. 444-447 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Follicle-stimulating hormone beta gene structure in premature ovarian failure

Layman, L. C., Shelley, M. E., Huey, L. O., Wall, S. W., Tho, S. P. T. & McDonough, P. G., Jan 1 1993, In : Fertility and sterility. 60, 5, p. 852-857 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Patients with idiopathic hypogonadotropic hypogonadism have normal gonadotropin-releasing hormone gene structure

Layman, L. C., Lanclos, K. D., Tho, S. P. T., Sweet, C. R. & McDonough, P. G., Jan 1 1993, In : Adolescent and Pediatric Gynecology. 6, 4, p. 214-219 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
1992

Absence of the testicular determining factor gene SRY in XX true hermaphrodites and presence of this locus in most subjects with gonadal dysgenesis caused by Y aneuploidy

Tho, S. P. T., Layman, L. C., Lanclos, K. D., Plouffe, L., Rogers Byrd, J. & McDonough, P. G., Dec 1992, In : American journal of obstetrics and gynecology. 167, 6, p. 1794-1802 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Etiologic factors of recurrent abortion and subsequent reproductive performance of couples: Have we made any progress in the past 10 years?

Plouffe, L., White, E. W., Tho, S. P., Sweet, C. S., Layman, L. C., Whitman, G. F. & McDonough, P. G., Jan 1 1992, In : American Journal of Obstetrics and Gynecology. 167, 2, p. 313-321 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Gonadotropin-releasing hormone, follicle-stimulating hormone beta, luteinizing hormone beta gene structure in idiopathic hypogonadotropic hypogonadism

Layman, L. C., Wilson, J. T., Huey, L. O., Lanclos, K. D., Plouffe, L. & McDonough, P. G., Jan 1 1992, In : Fertility and sterility. 57, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Gonadotropin-releasing hormone-associated peptide gene sequences in women with hyperprolactinemia

Moretuzzo, R. W., Layman, L. C., Tho, S. P. T., Reindollar, R. H., Gray, M. R. & McDonough, P. G., Jan 1 1992, In : Fertility and sterility. 58, 5, p. 908-913 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of restriction-fragment length polymorphisms for the human chorionic gonadotropin-β/luteinizing hormone-β gene cluster

Roach, D. J., Layman, L. C., McDonough, P. G., Lanclos, K. D., Wall, S. W. & Wilson, J. T., Jan 1 1992, In : Fertility and sterility. 58, 5, p. 914-918 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
1991

The genetics of gonadotropin genes and the GnRH/GAP gene

Layman, L. C., Jan 1 1991, In : Seminars in Reproductive Endocrinology. 9, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
1990

Febrile and Infectious Morbidity After Laparotomy for Ectopic Pregnancy: Potential for Antibiotic Prophylaxis

Layman, L. C. & Sanfilippo, J. S., Jan 1 1990, In : Journal of Gynecologic Surgery. 6, 3, p. 161-167 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The detection of Hind III restriction-fragment length polymorphisms using a deoxyribonucleic acid probe for the beta subunit of follicle-stimulating hormone

Layman, L. C., Roach, D. J., Plouffe, L., McDonough, P. G. & Wilson, J. T., Jan 1 1990, In : Fertility and sterility. 53, 2, p. 261-265 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
1986

Sonographic evaluation of the adnexa during early pregnancy

Lavery, J. P., Koontz, W. L., Layman, L. C., Shaw, L. & Gumpel, U., Dec 1 1986, In : Surgery Gynecology and Obstetrics. 163, 4, p. 319-323 5 p.

Research output: Contribution to journalArticle

31 Scopus citations
1985

Antenatal sonographic diagnosis of conjoined twins in a triplet pregnancy

Koontz, W. L., Layman, L. C., Adams, A. & Patrick Lavery, J., Sep 15 1985, In : American Journal of Obstetrics and Gynecology. 153, 2, p. 230-231 2 p.

Research output: Contribution to journalArticle

13 Scopus citations