Lesleyann Hawthorn

Professor

  • 1892 Citations
  • 25 h-Index
1978 …2019
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Research Output 1984 2019

  • 1892 Citations
  • 25 h-Index
  • 58 Article
  • 1 Comment/debate
  • 1 Review article
2019
2 Citations (Scopus)

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Genes
Stem Cell Niche
2 Citations (Scopus)

Genomic analysis of racial differences in triple negative breast cancer

Chang, C. S., Kitamura, E., Johnson, J., Bollag, R. & Hawthorn, L., Dec 2019, In : Genomics. 111, 6, p. 1529-1542 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
African Americans
Gene Expression Profiling
Mutation Rate
Genes
Cell Movement
Malformations of Cortical Development
Null Lymphocytes
Premature Mortality
Actin Cytoskeleton
2018
8 Citations (Scopus)

MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In : Cancer Research. 78, 13, p. 3522-3531 10 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Down-Regulation
Cell Survival
2014
25 Citations (Scopus)

Evidence for field effect cancerization in colorectal cancer

Hawthorn, L., Lan, L. & Mojica, W., Feb 2014, In : Genomics. 103, 2-3, p. 211-221 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Chromosome Aberrations
Chromosomal Instability
Colonic Neoplasms
4 Citations (Scopus)

mRNA Transcript abundance during plant growth and the influence of Li+ exposure

Duff, M. C., Kuhne, W. W., Halverson, N. V., Chang, C. S., Kitamura, E., Hawthorn, L., Martinez, N. E., Stafford, C., Milliken, C. E., Caldwell, E. F. & Stieve-Caldwell, E., Dec 1 2014, In : Plant Science. 229, p. 262-279 18 p.

Research output: Contribution to journalArticle

lithium
Lithium
plant growth
Messenger RNA
Growth
46 Citations (Scopus)

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Lan, L., Singh, N., Martin, P. M., Hawthorn, L., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Feb 15 2014, In : Cancer Research. 74, 4, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

Butyrates
Niacin
Cell Survival
Carcinogenesis
Breast
48 Citations (Scopus)
Breast Neoplasms
Mesoderm
Neoplasm Metastasis
Chromosomes, Human, Pair 1
Cadherins
2013
86 Citations (Scopus)

A systematic evaluation of miRNA: MRNA interactions involved in the migration and invasion of breast cancer cells

Luo, D., Wilson, J. M., Harvel, N., Liu, J., Pei, L., Huang, S., Hawthorn, L. & Shi, H., Mar 5 2013, In : Journal of Translational Medicine. 11, 1, 57.

Research output: Contribution to journalArticle

MicroRNAs
Cells
Breast Neoplasms
Genes
Cell Line
16 Citations (Scopus)

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Human Mammary Glands
Breast
Mouse mammary tumor virus
2011
15 Citations (Scopus)

Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization

Hawthorn, L. & Cowell, J. K., May 4 2011, In : PloS one. 6, 4, e18941.

Research output: Contribution to journalArticle

comparative genomic hybridization
Comparative Genomic Hybridization
Wilms Tumor
Single Nucleotide Polymorphism
Tumors
2010
46 Citations (Scopus)

Copy number and gene expression alterations in radiation-induced papillary thyroid carcinoma from chernobyl pediatric patients

Stein, L., Rothschild, J., Luce, J., Cowell, J. K., Thomas, G., Bogdanova, T. I., Tronko, M. D. & Hawthorn, L., May 1 2010, In : Thyroid. 20, 5, p. 475-487 13 p.

Research output: Contribution to journalArticle

Factor IX
Radiation
Pediatrics
Gene Expression
Genes
36 Citations (Scopus)

Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast

Hawthorn, L., Luce, J., Stein, L. & Rothschild, J., Aug 27 2010, In : BMC Cancer. 10, 460.

Research output: Contribution to journalArticle

Carcinoma, Ductal, Breast
Loss of Heterozygosity
Genes
Gene Expression Profiling
Chromosomes
5 Citations (Scopus)
Loss of Heterozygosity
Glioma
Ploidies
Karyotype
Tumors
18 Citations (Scopus)
Alternative Splicing
Colon
Epithelium
Epithelial Cells
Gene Expression
18 Citations (Scopus)

Reexpression of LGI1 in glioma cells results in dysregulation of genes implicated in the canonical axon guidance pathway

Kunapuli, P., Lo, K., Hawthorn, L. & Cowell, J. K., Feb 1 2010, In : Genomics. 95, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Glioma
Genes
Stress Fibers
Clone Cells
Cell Movement
2008
20 Citations (Scopus)

Identification of genes involved in squamous cell carcinoma of the lung using synchronized data from DNA copy number and transcript expression profiling analysis

Lo, K. C., Stein, L. C., Panzarella, J. A., Cowell, J. K. & Hawthorn, L., Mar 1 2008, In : Lung Cancer. 59, 3, p. 315-331 17 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Squamous Cell Carcinoma
Lung
DNA
Genes
18 Citations (Scopus)

Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

Zientek-Targosz, H., Kunnev, D., Hawthorn, L., Venkov, M., Matsui, S. I., Cheney, R. T. & Ionov, Y., Jun 5 2008, In : Molecular cancer. 7, 51.

Research output: Contribution to journalArticle

Mutagenesis
Mutagens
Tumors
Genes
Breast Neoplasms
4 Citations (Scopus)

Universal reference RNA is not a representative normal sample for oligonucleotide microarray studies

Mojica, W. D., Stein, L. & Hawthorn, L., Sep 1 2008, In : Pathology and Oncology Research. 14, 3, p. 243-251 9 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
RNA
Translational Medical Research
Colonic Neoplasms
Colon
2007
8 Citations (Scopus)
Formaldehyde
Laser Capture Microdissection
RNA
Frozen Sections
Tissue and Organ Procurement
25 Citations (Scopus)

Candidate glioblastoma development gene identification using concordance between copy number abnormalities and gene expression level changes

Lo, K. C., Rossi, M. R., LaDuca, J., Hicks, D. G., Turpaz, Y., Hawthorn, L. & Cowell, J. K., Oct 1 2007, In : Genes Chromosomes and Cancer. 46, 10, p. 875-894 20 p.

Research output: Contribution to journalArticle

Glioblastoma
Gene Expression
Genes
Neoplasms
Chromosomes
25 Citations (Scopus)

Development of a murine model for blastoid variant mantle-cell lymphoma

Ford, R. J., Shen, L., Lin-Lee, Y. C., Pham, L. V., Multani, A., Zhou, H. J., Tamayo, A. T., Zhang, C. J., Hawthorn, L., Cowell, J. K. & Ambrus, J. L., Jun 1 2007, In : Blood. 109, 11, p. 4899-4906 8 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Transgenic Mice
Tumors
Cells
Interleukins
1 Citation (Scopus)
MAP Kinase Signaling System
Tumor Suppressor Genes
Matrix Metalloproteinases
Glioma
Tumors
65 Citations (Scopus)

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

Ivanov, I., Lo, K. C., Hawthorn, L., Cowell, J. K. & Ionov, Y., May 3 2007, In : Oncogene. 26, 20, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Tumor Suppressor Genes
Colonic Neoplasms
Genes
Nonsense Codon
17 Citations (Scopus)

Platinum drug effects on the expression of genes in the polyamine pathway: Time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells

Varma, R., Hector, S., Greco, W. R., Clark, K., Hawthorn, L., Porter, C. & Pendyala, L., Jun 1 2007, In : Cancer Chemotherapy and Pharmacology. 59, 6, p. 711-723 13 p.

Research output: Contribution to journalArticle

oxaliplatin
Polyamines
Gene Expression Profiling
Platinum
Gene expression
43 Citations (Scopus)

The application of microarray technology to the analysis of the cancer genome

Cowell, J. K. & Hawthorn, L., Feb 1 2007, In : Current Molecular Medicine. 7, 1, p. 103-120 18 p.

Research output: Contribution to journalReview article

Microarrays
Genes
Genome
Technology
Oligonucleotide Array Sequence Analysis
2006
34 Citations (Scopus)

Characterization of cell-type specific profiles in tissues and isolated cells from squamous cell carcinomas of the lung

Hawthorn, L., Stein, L., Panzarella, J., Loewen, G. M. & Baumann, H., Aug 1 2006, In : Lung Cancer. 53, 2, p. 129-142 14 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Lung
Lung Neoplasms
Carcinogenesis
Neoplasms
20 Citations (Scopus)

Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in atypical myeloproliferative disease

Kasyapa, C. S., Kunapuli, P., Hawthorn, L. & Cowell, J. K., May 1 2006, In : Blood. 107, 9, p. 3693-3699 7 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 2
Phosphotransferases
Fusion reactions
Cells
Genes
2005
56 Citations (Scopus)

Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors

Huang, H., Groth, J., Sossey-Alaoui, K., Hawthorn, L., Beall, S. & Geradts, J., Jun 15 2005, In : Clinical Cancer Research. 11, 12, p. 4357-4364 8 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Cell Membrane
Breast Neoplasms
Estrogen Receptors
Cell Line
48 Citations (Scopus)

Gene expression profiling of a clonal isolate of oxaliplatin resistant ovarian carcinoma cell line A2780/C10

Varma, R. R., Hector, S. M., Clark, K., Greco, W. R., Hawthorn, L. & Pendyala, L., Oct 1 2005, In : Oncology Reports. 14, 4, p. 925-932 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Gene Expression Profiling
Carcinoma
Cell Line
Genes
24 Citations (Scopus)
Janus Kinase 1
Microarray Analysis
Prostatic Neoplasms
Mutation
Cell Line
32 Citations (Scopus)

Microarray data mining for potential selenium targets in chemoprevention of prostate cancer

Zhang, H., Dong, Y., Zhao, H., Brooks, J. D., Hawthorn, L., Nowak, N., Marshall, J. R., Gao, A. C. & Ip, C., Jan 1 2005, In : Cancer Genomics and Proteomics. 2, 2, p. 97-113 17 p.

Research output: Contribution to journalArticle

Data Mining
Chemoprevention
Microarrays
Selenium
Data mining
37 Citations (Scopus)

Novel amplicons on the short arm of chromosome 7 identified using high resolution array CGH contain over expressed genes in addition to EGFR in glioblastoma multiforme

Rossi, M. R., Duca, J. L., Matsui, S. I., Nowak, N. J., Hawthorn, L. & Cowell, J. K., Dec 1 2005, In : Genes Chromosomes and Cancer. 44, 4, p. 392-404 13 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 7
Glioblastoma
Epidermal Growth Factor Receptor
erbB-1 Genes
Comparative Genomic Hybridization
63 Citations (Scopus)
Succinic Acid
Prostatic Neoplasms
Mitochondria
Phosphotransferases
Up-Regulation
2004
82 Citations (Scopus)
Phosphorylation
MAP Kinase Signaling System
Tumor Suppressor Genes
Matrix Metalloproteinases
Glioma
42 Citations (Scopus)

TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma

Hawthorn, L., Stein, L., Varma, R., Wiseman, S., Loree, T. & Tan, D. F., Dec 1 2004, In : Head and Neck. 26, 12, p. 1069-1083 15 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Goiter
Biomarkers
Nodular Goiter
Thyroid Gland
2003
173 Citations (Scopus)

Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array

Dong, Y., Zhang, H., Hawthorn, L., Ganther, H. E. & Ip, C., Jan 1 2003, In : Cancer Research. 63, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

Selenium
Oligonucleotide Array Sequence Analysis
Prostatic Neoplasms
Growth
Cell Cycle
2000
13 Citations (Scopus)

A transcription map of the minimally deleted region from 13q14 in B-cell chronic lymphocytic leukemia as defined by large scale sequencing of the 650 kb critical region

Kitamura, E., Su, G., Sossey-Alaoui, K., Malaj, E., Lewis, J., Pan, H. Q., Hawthorn, L., Roe, B. & Cowell, J. K., Nov 23 2000, In : Oncogene. 19, 50, p. 5772-5780 9 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Genes
Tumor Suppressor Genes
Chromosome Deletion
Expressed Sequence Tags
188 Citations (Scopus)

Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays

Yang, J., Moravec, C. S., Sussman, M. A., DiPaola, N. R., Fu, D., Hawthorn, L., Mitchell, C. A., Young, J. B., Francis, G. S., McCarthy, P. M. & Bond, M., Dec 19 2000, In : Circulation. 102, 25, p. 3046-3052 7 p.

Research output: Contribution to journalArticle

Gelsolin
Oligonucleotide Array Sequence Analysis
Crystallins
Genes
Proteins
1998
2 Citations (Scopus)
Bacterial Artificial Chromosomes
B-Cell Chronic Lymphocytic Leukemia
Loss of Heterozygosity
Retinoblastoma Genes
Expressed Sequence Tags
1996
6 Citations (Scopus)

Incorporation of 35 novel gene transcripts into the physical and genetic map of human chromosome 13

Still, I. H., Roberts, T., Bia, B., Hawthorn, L., Auffray, C. & Cowell, J. K., Apr 15 1996, In : Genomics. 33, 2, p. 159-166 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 13
Human Chromosomes
Genes
Genetic Linkage
Hybrid Cells
10 Citations (Scopus)

Regional assignment of EST sequences on human chromosome 13

Hawthorn, L. & Cowell, J. K., Jan 1 1996, In : Cytogenetic and Genome Research. 72, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 13
Expressed Sequence Tags
Human Chromosomes
Hybrid Cells
propylene glycol methyl ether
1995
20 Citations (Scopus)
Yeast Artificial Chromosomes
Chromosomes, Human, Pair 13
Human Chromosomes
B-Cell Chronic Lymphocytic Leukemia
Hybrid Cells
16 Citations (Scopus)

Integration of the physical and genetic linkage map for human chromosome 13

Hawthorn, L. & Cowell, J. K., Jun 10 1995, In : Genomics. 27, 3, p. 399-404 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 13
Genetic Linkage
Hybrid Cells
Human Chromosomes
Chromosomes
3 Citations (Scopus)

Regional localisation of tri- and tetranucleotide repeat sequence-containing cosmids on chromosome 13

Hawthorn, L., Kapanadse, B., Yankovsky, N. & Cowell, J. K., Jan 1 1995, In : Cytogenetic and Genome Research. 70, 1-2, p. 102-103 2 p.

Research output: Contribution to journalArticle

Trinucleotide Repeats
Chromosomes, Human, Pair 13
Cosmids
Microsatellite Repeats
Human Chromosomes
1994
12 Citations (Scopus)

A deletion hybrid breakpoint map of the chromosomal region 13q14-q21 orders 19 genetic markers in 10 intervals

Kooy, R. F., Verlind, E., Houwen, R. H. J., Shapiro, D. N., Hawthorn, L., Cowell, J. K., Scheffer, H. & Buys, C. H. C. M., Jan 1 1994, In : European Journal of Human Genetics. 2, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Genetic Markers
Cell Line
Restriction Fragment Length Polymorphisms
Microsatellite Repeats
7 Citations (Scopus)

Assignment of 55 novel cosmids to seven subregions of chromosome 13 using fluorescence in situ hybridization

Hawthorn, L., Nizetic, D., Lehrach, H. & Cowell, J. K., May 1 1994, In : Genomics. 21, 1, p. 248-250 3 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 13
Cosmids
Fluorescence In Situ Hybridization
Libraries
Chromosomes
61 Citations (Scopus)

Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia

Chapman, R. M., Corcoran, M. M., Gardiner, A., Hawthorn, L., Cowell, J. K. & Oscier, D. G., Apr 1 1994, In : Oncogene. 9, 4, p. 1289-1293 5 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Chromosomes
Alleles
Genes
Neoplasms
1993
80 Citations (Scopus)
Retinoblastoma Genes
B-Cell Chronic Lymphocytic Leukemia
B-Cell Leukemia
Chromosomes, Human, Pair 13
Chromosomes
1991
21 Citations (Scopus)

Ability of uropathogens to bind to tamm horsfall protein-coated renal tubular cells

Hawthorn, L., Bruce, A. W. & Reid, G., Sep 1 1991, In : Urological Research. 19, 5, p. 301-304 4 p.

Research output: Contribution to journalArticle

Uromodulin
Kidney
Proteus mirabilis
Uropathogenic Escherichia coli
Escherichia coli