Madhav D Sharma

Principal Research Scientist

  • 4292 Citations
  • 16 h-Index
1986 …2018
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Indoleamine-Pyrrole 2,3,-Dioxygenase Medicine & Life Sciences
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Regulatory T-Lymphocytes Medicine & Life Sciences
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Research Output 1986 2018

  • 4292 Citations
  • 16 h-Index
  • 22 Article
  • 1 Comment/debate
  • 1 Review article
5 Citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming

Treg Destabilization and reprogramming: Implications for cancer immunotherapy

Munn, D. H., Sharma, M. D. & Johnson, T. S., Sep 15 2018, In : Cancer Research. 78, 18, p. 5191-5199 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
PTEN Phosphohydrolase
Cross-Priming
Indoleamine-Pyrrole 2,3,-Dioxygenase
8 Citations

IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment

Munn, D. H., Sharma, M. D., Johnson, T. S. & Rodriguez, P., May 9 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-10 10 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Antigen Presentation
Immunosuppressive Agents
Cytotoxins

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M., Shinde, R., McGaha, T., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A., Blazar, B. & Munn, D., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
43 Citations
Open Access