Maria J Silva

Assistant Professor

  • 1157 Citations
  • 14 h-Index
20012020

Research output per year

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Research Output

  • 1157 Citations
  • 14 h-Index
  • 25 Article
  • 1 Conference article
2020

Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance pathways

Silva, J., Hawthorn, L. & Cowell, J. K., Mar 2020, In : Genomics. 112, 2, p. 1167-1172 6 p.

Research output: Contribution to journalArticle

2019

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice

Silva, J., Qin, H. & Cowell, J. K., Feb 1 2019, In : Genesis. 57, 2, e23268.

Research output: Contribution to journalArticle

1 Scopus citations
2018

MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In : Cancer Research. 78, 13, p. 3522-3531 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In : Oncogene. 37, 14, p. 1926-1938 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

YM155 inhibits topoisomerase function

Hong, M., Ren, M. Q., Silva, J., Paul, A., Wilson, W. D., Schroeder, C., Weinberger, P., Janik, J. & Hao, Z., Oct 13 2016, In : Anti-Cancer Drugs. 28, 2, p. 142-152 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In : Brain Pathology. 25, 5, p. 587-597 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 1 2013, In : Oncology Reports. 29, 6, p. 2181-2190 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011
13 Scopus citations
2010

Homozygous inactivation of the Lgi1 gene results in hypomyelination in the peripheral and central nervous systems

Silva, J., Sharma, S., Hughes, B., Yu, Y. E. & Cowell, J. K., Nov 15 2010, In : Journal of Neuroscience Research. 88, 15, p. 3328-3336 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

Yu, Y. E., Wen, L., Silva, J., Li, Z., Head, K., Sossey-Alaoui, K., Pao, A., Mei, L. & Cowell, J. K., Feb 3 2010, In : Human Molecular Genetics. 19, 9, p. 1702-1711 10 p., ddq047.

Research output: Contribution to journalArticle

78 Scopus citations
2009
6 Scopus citations
2008

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

Wang, G., Silva, M. J., Dasgupta, S. & Bieberich, E., Mar 1 2008, In : Glia. 56, 4, p. 449-456 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
2007

Ceramide regulates atypical PKCζ/λ-mediated cell polarity in primitive ectoderm cells: A novel function of sphingolipids in morphogenesis

Krishnamurthy, K., Wang, G., Silva, J., Condie, B. G. & Bieberich, E., Jan 2 2007, In : Journal of Biological Chemistry. 282, 5, p. 3379-3390 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
2006

A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells

Wang, G., Silva, J., Krishnamurthy, K. & Bieberich, E., Mar 1 2006, In : Apoptosis. 11, 3, p. 315-325 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lipids isolated from bone induce the migration of human breast cancer cells

Silva, J., Dasgupta, S., Wang, G., Krishnamurthy, K., Ritter, E. & Bieberich, E., Apr 1 2006, In : Journal of Lipid Research. 47, 4, p. 724-733 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

Wang, G., Silva, J., Krishnamurthy, K., Tran, E., Condie, B. G. & Bieberich, E., Jul 15 2005, In : Journal of Biological Chemistry. 280, 28, p. 26415-26424 10 p.

Research output: Contribution to journalArticle

121 Scopus citations
2004

Selective apoptosis of pluripotent mouse and human stem cell by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants

Bieberich, E., Silva, J., Wang, G., Krishnamurthy, K. & Condie, B. G., Nov 22 2004, In : Journal of Cell Biology. 167, 4, p. 723-734 12 p.

Research output: Contribution to journalArticle

130 Scopus citations
2003

Analgesic and anti-inflammatory effects of essential oils of Eucalyptus

Silva, J., Abebe, W., Sousa, S. M., Duarte, V. G., Machado, M. I. L. & Matos, F. J. A., Dec 2003, In : Journal of Ethnopharmacology. 89, 2-3, p. 277-283 7 p.

Research output: Contribution to journalArticle

280 Scopus citations

Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells

Silva, J., Beckedorf, A. & Bieberich, E., Jul 11 2003, In : Journal of Biological Chemistry. 278, 28, p. 25376-25385 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide

Bieberich, E., MacKinnon, S., Silva, J., Noggle, S. & Condie, B. G., Aug 4 2003, In : Journal of Cell Biology. 162, 3, p. 469-479 11 p.

Research output: Contribution to journalArticle

91 Scopus citations
2002

Nitric oxide enhances Ca2+-dependent K+ channel activity in rat carotid body cells

Silva, J. M. & Lewis, D. L., Mar 27 2002, In : Pflugers Archiv European Journal of Physiology. 443, 5-6, p. 671-675 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Novel ceramide analogs are new anti-cancer drugs

Bieberich, E., Hu, B., Silva, J., MacKinnon, S., Yu, R. K. & Ottenbrite, R. M., Jan 1 2002, In : American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 43, 2, p. 756-757 2 p.

Research output: Contribution to journalConference article

1 Scopus citations

Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases

Bieberich, E., MacKinnon, S., Silva, J., Li, D. D., Tencomnao, T., Irwin, L., Kapitonov, D. & Yu, R. K., Sep 24 2002, In : Biochemistry. 41, 38, p. 11479-11487 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

Bieberich, E., Hu, B., Silva, J., MacKinnon, S., Yu, R. K., Fillmore, H., Broaddus, W. C. & Ottenbrite, R. M., Jul 8 2002, In : Cancer Letters. 181, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

64 Scopus citations
2001

Regulation of Apoptosis during Neuronal Differentiation by Ceramide and b-Series Complex Gangliosides

Bieberich, E., MacKinnon, S., Silva, J. & Yu, R. K., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44396-44404 9 p.

Research output: Contribution to journalArticle

64 Scopus citations