Maria J Silva

Assistant Professor

  • 1148 Citations
  • 14 h-Index
20012019
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Research Output 2001 2019

  • 1148 Citations
  • 14 h-Index
  • 25 Article
  • 1 Conference article
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Article
2019
2 Citations (Scopus)

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Genes
Stem Cell Niche
Cell Movement
Malformations of Cortical Development
Null Lymphocytes
Premature Mortality
Actin Cytoskeleton
1 Citation (Scopus)

Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice

Silva, M. J., Qin, H. & Cowell, J. K., Feb 1 2019, In : Genesis. 57, 2, e23268.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Leucine
Glioma
Seizures
Epilepsy
2018
8 Citations (Scopus)

MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In : Cancer Research. 78, 13, p. 3522-3531 10 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Down-Regulation
Cell Survival
9 Citations (Scopus)

The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In : Oncogene. 37, 14, p. 1926-1938 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Phosphotransferases
Cell Proliferation
B-Cell Leukemia
Porifera
2016
4 Citations (Scopus)

YM155 inhibits topoisomerase function

Hong, M., Ren, M. Q., Silva, J., Paul, A., Wilson, W. D., Schroeder, C., Weinberger, P., Janik, J. & Hao, Z., Oct 13 2016, In : Anti-Cancer Drugs. 28, 2, p. 142-152 11 p.

Research output: Contribution to journalArticle

DNA
Intercalating Agents
DNA Cleavage
Double-Stranded DNA Breaks
Circular Dichroism
2015
11 Citations (Scopus)

Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In : Brain Pathology. 25, 5, p. 587-597 11 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Gene Deletion
Synapses
Neurons
Spine
2013
42 Citations (Scopus)

Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 1 2013, In : Oncology Reports. 29, 6, p. 2181-2190 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Non-Small Cell Lung Carcinoma
Growth
Lung Neoplasms
ponatinib
2011
13 Citations (Scopus)
Embryonic Development
Epilepsy
Brain
Hippocampus
Genes
2010
13 Citations (Scopus)

Homozygous inactivation of the Lgi1 gene results in hypomyelination in the peripheral and central nervous systems

Silva, J., Sharma, S., Hughes, B., Yu, Y. E. & Cowell, J. K., Nov 15 2010, In : Journal of Neuroscience Research. 88, 15, p. 3328-3336 9 p.

Research output: Contribution to journalArticle

Peripheral Nervous System
Gene Silencing
Central Nervous System
Seizures
Phenotype
77 Citations (Scopus)

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

Yu, Y. E., Wen, L., Silva, J., Li, Z., Head, K., Sossey-Alaoui, K., Pao, A., Mei, L. & Cowell, J. K., Feb 3 2010, In : Human Molecular Genetics. 19, 9, p. 1702-1711 10 p., ddq047.

Research output: Contribution to journalArticle

Seizures
Mutation
Synaptic Transmission
Running
Neurotransmitter Agents
2009
6 Citations (Scopus)
Cell Adhesion
Ligands
T-Lymphocytes
Small Interfering RNA
Transferases
2008
43 Citations (Scopus)

Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes

Wang, G., Silva, M. J., Dasgupta, S. & Bieberich, E., Mar 1 2008, In : Glia. 56, 4, p. 449-456 8 p.

Research output: Contribution to journalArticle

Presenilin-1
Ceramides
Astrocytes
Apoptosis
Brain
2007
37 Citations (Scopus)

Ceramide regulates atypical PKCζ/λ-mediated cell polarity in primitive ectoderm cells: A novel function of sphingolipids in morphogenesis

Krishnamurthy, K., Wang, G., Silva, J., Condie, B. G. & Bieberich, E., Jan 2 2007, In : Journal of Biological Chemistry. 282, 5, p. 3379-3390 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Ectoderm
Sphingolipids
Ceramides
Morphogenesis
2006
13 Citations (Scopus)

A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells

Wang, G., Silva, M. J., Krishnamurthy, K. & Bieberich, E., Mar 1 2006, In : Apoptosis. 11, 3, p. 315-325 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Actins
Prostate
Protein Isoforms
42 Citations (Scopus)

Lipids isolated from bone induce the migration of human breast cancer cells

Silva, J., Dasgupta, S., Wang, G., Krishnamurthy, K., Ritter, E. & Bieberich, E., Apr 1 2006, In : Journal of Lipid Research. 47, 4, p. 724-733 10 p.

Research output: Contribution to journalArticle

Deoxycholic Acid
Bone
Cells
Breast Neoplasms
Lipids
2005
121 Citations (Scopus)

Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

Wang, G., Silva, J., Krishnamurthy, K., Tran, E., Condie, B. G. & Bieberich, E., Jul 15 2005, In : Journal of Biological Chemistry. 280, 28, p. 26415-26424 10 p.

Research output: Contribution to journalArticle

Ceramides
Stem cells
Protein Kinase C
Prostate
Stem Cells
2004
130 Citations (Scopus)

Selective apoptosis of pluripotent mouse and human stem cell by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants

Bieberich, E., Silva, J., Wang, G., Krishnamurthy, K. & Condie, B. G., Nov 22 2004, In : Journal of Cell Biology. 167, 4, p. 723-734 12 p.

Research output: Contribution to journalArticle

Ceramides
Teratoma
Embryonic Stem Cells
Embryoid Bodies
Stem Cells
2003
275 Citations (Scopus)

Analgesic and anti-inflammatory effects of essential oils of Eucalyptus

Silva, J., Abebe, W., Sousa, S. M., Duarte, V. G., Machado, M. I. L. & Matos, F. J. A., Dec 2003, In : Journal of Ethnopharmacology. 89, 2-3, p. 277-283 7 p.

Research output: Contribution to journalArticle

Eucalyptus
Non-Steroidal Anti-Inflammatory Agents
Volatile Oils
Carrageenan
Traditional Medicine
25 Citations (Scopus)

Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells

Silva, J., Beckedorf, A. & Bieberich, E., Jul 11 2003, In : Journal of Biological Chemistry. 278, 28, p. 25376-25385 10 p.

Research output: Contribution to journalArticle

Osteoblasts
MCF-7 Cells
Conditioned Culture Medium
Cells
Breast Neoplasms
91 Citations (Scopus)

Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide

Bieberich, E., MacKinnon, S., Silva, J., Noggle, S. & Condie, B. G., Aug 4 2003, In : Journal of Cell Biology. 162, 3, p. 469-479 11 p.

Research output: Contribution to journalArticle

Ceramides
Prostate
Cell Death
Stem Cells
Apoptosis
2002
16 Citations (Scopus)

Nitric oxide enhances Ca2+-dependent K+ channel activity in rat carotid body cells

Silva, J. M. & Lewis, D. L., Mar 27 2002, In : Pflugers Archiv European Journal of Physiology. 443, 5-6, p. 671-675 5 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Carotid Body
Penicillamine
Rats
Nitric Oxide
40 Citations (Scopus)

Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases

Bieberich, E., MacKinnon, S., Silva, J., Li, D. D., Tencomnao, T., Irwin, L., Kapitonov, D. & Yu, R. K., Sep 24 2002, In : Biochemistry. 41, 38, p. 11479-11487 9 p.

Research output: Contribution to journalArticle

Glycosyltransferases
Gangliosides
Biosynthesis
Enzymes
Transfection
64 Citations (Scopus)

Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

Bieberich, E., Hu, B., Silva, M. J., MacKinnon, S., Yu, R. K., Fillmore, H., Broaddus, W. C. & Ottenbrite, R. M., Jul 8 2002, In : Cancer Letters. 181, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

Ceramides
Apoptosis
Neoplasms
diethanolamine
Neuroblastoma
2001
64 Citations (Scopus)

Regulation of Apoptosis during Neuronal Differentiation by Ceramide and b-Series Complex Gangliosides

Bieberich, E., MacKinnon, S., Silva, J. & Yu, R. K., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44396-44404 9 p.

Research output: Contribution to journalArticle

Gangliosides
Ceramides
Apoptosis
Prostate
Brain