• 1160 Citations
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19942019
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Research Output 1994 2019

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Article
2019

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 1 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2017
11 Citations (Scopus)

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Endothelial Cells
Acid Sensing Ion Channels
Lung
Peptides
6 Citations (Scopus)
Adipose Tissue
Caveolin 1
Tumor Necrosis Factor-alpha
Obesity
Dilatation
2016
5 Citations (Scopus)
Growth Hormone-Releasing Hormone
Dyslipidemias
Glucagon-Like Peptide 1
Type 1 Diabetes Mellitus
Lipoproteins
2014
57 Citations (Scopus)
Caveolae
Peroxynitrous Acid
Arterioles
Dilatation
Diabetes Mellitus
2013
8 Citations (Scopus)

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in Immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

Arginase
Acute Lung Injury
Nitric Oxide Synthase Type III
Bacterial Toxins
Lung
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
12 Citations (Scopus)

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., Dec 1 2013, In : Frontiers in Immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

Citrulline
Arginase
Kidney
Streptozocin
Knockout Mice
2012
58 Citations (Scopus)

Diabetes-induced vascular dysfunction involves arginase

Romero Lucas, M. J., Iddings, J. A., Platt, D. H., Irfan Ali, M., Cederbaum, S. D., Stepp, D. W., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 1

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Fibrosis
Endothelial Cells
Vasodilation
94 Citations (Scopus)

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

Chandra, S., Romero, M. J., Shatanawi, A., Alkilany, A. M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : British Journal of Pharmacology. 165, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Endothelial Cells
Peroxynitrous Acid
Small Interfering RNA
33 Citations (Scopus)

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

Arginase
Protein Kinase C
Lung
Endothelial cells
Endothelial Cells
2011
83 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Blood Vessels
2010
41 Citations (Scopus)

Novel mechanisms of endothelial dysfunction in diabetes

Yang, G., Lucas, R., Caldwell, R. B., Yao, L., Romero Lucas, M. J. & Caldwell, R. W., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Peripheral Arterial Disease
Vascular Diseases
Morbidity
Mortality
37 Citations (Scopus)
Arginase
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide Synthase
Blood Pressure
39 Citations (Scopus)

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M. A., Zhang, W., Lee, D. L., Romero Lucas, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

Retinal Vessels
Angiotensin II
Interleukin-6
Inflammation
Vascular Endothelial Growth Factor A
2009
44 Citations (Scopus)

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M. A., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero Lucas, M. J., Caldwell, R. W. & Caldwell, R. B., Jan 1 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

Arginase
Uveitis
Endotoxins
Inflammation
Lipopolysaccharides
12 Citations (Scopus)

Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis

Chamberlain, S. M., Hall, J. D., Patel, J., Lee, J. R., Marcus, D. M., Sridhar, S., Romero Lucas, M. J., Labazi, M., Caldwell, R. W. & Bartoli, M., Jul 1 2009, In : Digestive Diseases and Sciences. 54, 7, p. 1460-1464 5 p.

Research output: Contribution to journalArticle

Carotenoids
Oxidative Stress
Liver Cirrhosis
Liver
Inflammation
2008
238 Citations (Scopus)

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

Romero Lucas, M. J., Platt, D. H., Tawfik, H. E. S., Labazi, M., El-Remessy, A. B., Bartoli, M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2008, In : Circulation research. 102, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Glucose
Citrulline
2005

Increased expression of apoptosis-associated proteins in puromycin aminonucleoside nephrosis

Viera, N. T., Pedreáñez, A., Romero Lucas, M. J., Rincón, J. C. & Mosquera, J. A., Sep 1 2005, In : Investigacion Clinica. 46, 3, p. 273-287 15 p.

Research output: Contribution to journalArticle

Puromycin Aminonucleoside
Nephrosis
Apoptosis
Proteins
Kidney
2004
31 Citations (Scopus)

Increased oxidative stress and apoptosis in acute puromycin aminonucleoside nephrosis

Rincon, J., Romero Lucas, M. J., Viera, N., Pedreañez, A. & Mosquera, J., Feb 1 2004, In : International Journal of Experimental Pathology. 85, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Puromycin Aminonucleoside
Nephrosis
Oxidative Stress
Apoptosis
Monocytes
22 Citations (Scopus)

Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis

Pedreañez, A., Rincón, J., Romero Lucas, M. J., Viera, N. & Mosquera, J. A., May 1 2004, In : Nephrology Dialysis Transplantation. 19, 5, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

Puromycin Aminonucleoside
Nephrosis
Melatonin
Apoptosis
Proteins
2003
4 Citations (Scopus)
Puromycin Aminonucleoside
Nephrosis
Proliferating Cell Nuclear Antigen
Intercellular Adhesion Molecule-1
CD45 Antigens
13 Citations (Scopus)
Mesangial Cells
Streptococcus
Chemokines
Chemokine CCL2
Chemokine CXCL2
2001
17 Citations (Scopus)

Increased apoptosis in acute puromycin aminonucleoside nephrosis

Fernandez, L., Romero Lucas, M. J., Soto, H. & Mosquera, J., Jan 17 2001, In : Experimental Nephrology. 9, 2, p. 99-108 10 p.

Research output: Contribution to journalArticle

Puromycin Aminonucleoside
Nephrosis
Proliferating Cell Nuclear Antigen
Apoptosis
CD45 Antigens
21 Citations (Scopus)

Streptococcal erythrogenic toxin B induces apoptosis and proliferation in human leukocytes

Viera, N. T., Romero Lucas, M. J., Montero, M. K., Rincon, J. & Mosquera, J. A., Jan 1 2001, In : Kidney International. 59, 3, p. 950-958 9 p.

Research output: Contribution to journalArticle

Leukocytes
Apoptosis
Mononuclear Leukocytes
Uridine Triphosphate
Annexin A5
1999
14 Citations (Scopus)

Erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci induce leukocyte infiltration in normal rat kidneys

Romero Lucas, M. J., Mosquera, J., Novo, E., Fernandez, L. & Parra, G., Aug 10 1999, In : Nephrology Dialysis Transplantation. 14, 8, p. 1867-1874 8 p.

Research output: Contribution to journalArticle

Streptococcus
Leukocytes
Kidney
Glomerulonephritis
Polyethyleneimine
1997
4 Citations (Scopus)

A simple method to identify NET-positive cells in isolated glomeruli

Romero Lucas, M. J., Mosquera, J. & Rodríguez-Iturbe, B., Jan 1 1997, In : Nephrology Dialysis Transplantation. 12, 1, p. 174-179 6 p.

Research output: Contribution to journalArticle

Nitroblue Tetrazolium
Reactive Oxygen Species
Ureteral Obstruction
Nephritis
Myristic Acid
1994
17 Citations (Scopus)

Expression of adhesion molecules in poststreptococcal glomerulonephrities

Parra, G., Romero Lucas, M. J., Henriquez-La Roche, C., Pineda, R. & Rodriguez-Iturbe, B., Jan 1 1994, In : Nephrology Dialysis Transplantation. 9, 10, p. 1412-1417 6 p.

Research output: Contribution to journalArticle

Biopsy
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1
Kidney