• 6006 Citations
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19952020

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2020

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Dalton, S., Smith, K., Singh, K., Kaiser, H., Kolhe, R., Mondal, A. K., Khayrullin, A., Isales, C. M., Hamrick, M. W., Hill, W. D. & Fulzele, S., Feb 2020, In : Experimental Gerontology. 130, 110800.

Research output: Contribution to journalArticle

1 Scopus citations

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Hagan, M. L., Yu, K., Zhu, J., Vinson, B. N., Roberts, R. L., Montesinos Cartagena, M., Johnson, M. H., Wang, L., Isales, C. M., Hamrick, M. W., McNeil, P. L. & McGee-Lawrence, M. E., Jan 1 2020, In : Aging Cell. 19, 1, e13056.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Deletion of PPARγin Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

Cao, J., Ding, K., Pan, G., Rosario, R., Su, Y., Bao, Y., Zhou, H., Xu, J., McGee Lawrence, M. E., Hamrick, M. W., Isales, C. M. & Shi, X., Apr 17 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 5, p. 826-834 9 p.

Research output: Contribution to journalArticle

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

Kondrikov, D., Elmansi, A., Bragg, R. T., Mobley, T., Barrett, T., Eisa, N., Kondrikova, G., Schoeinlein, P., Aguilar-Perez, A., Shi, X. M., Fulzele, S., Lawrence, M. M. G., Hamrick, M., Isales, C. & Hill, W., Feb 2020, In : Experimental Gerontology. 130, 110805.

Research output: Contribution to journalArticle

3 Scopus citations

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In : Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticle

1 Scopus citations

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Ding, K., McGee-Lawrence, M. E., Kaiser, H., Sharma, A. K., Pierce, J. L., Irsik, D. L., Bollag, W. B., Xu, J., Zhong, Q., Hill, W., Shi, X. M., Fulzele, S., Kennedy, E. J., Elsalanty, M., Hamrick, M. W. & Isales, C. M., May 2020, In : Experimental Gerontology. 133, 110885.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

Kim, B. J., Yoo, H. J., Park, S. J., Kwak, M. K., Lee, S. H., Kim, S. J., Hamrick, M. W., Isales, C. M., Ahn, S. H. & Koh, J. M., May 1 2019, In : Osteoporosis International. 30, 5, p. 1071-1078 8 p.

Research output: Contribution to journalArticle

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

Singleton, Q., Vaibhav, K., Braun, M., Patel, C., Khayrullin, A., Mendhe, B., Lee, B. R., Kolhe, R., Kaiser, H., Awad, M. E., Fariyike, T., Elsayed, R., Elsalanty, M., Isales, C. M., Liu, Y., Hamrick, M. W., Dhandapani, K. M. & Fulzele, S., Jan 17 2019, In : Fuel Cells. 8, 1

Research output: Contribution to journalArticle

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Kim, B. J., Lee, J. Y., Park, S. J., Lee, S. H., Kim, S. J., Yoo, H. J., De Pena, S. I. R., McGee-Lawrence, M., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jan 1 2019, In : Aging. 11, 21, p. 9388-9404 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: A nationwide population-based study

Kim, B. J., Ahn, S. H., Lee, S. H., Hong, S., Hamrick, M. W., Isales, C. M. & Koh, J. M., Jul 1 2019, In : Aging. 11, 13, p. 4547-4560 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Meta-analysis and evidence base for the efficacy of autologous bone marrow mesenchymal stem cells in knee cartilage repair: Methodological guidelines and quality assessment

Awad, M. E., Hussein, K. A., Helwa, I., Abdelsamid, M. F., Aguilar-Perez, A., Mohsen, I., Hunter, M., Hamrick, M. W., Isales, C. M., Elsalanty, M., Hill, W. D. & Fulzele, S., Jan 1 2019, In : Stem Cells International. 2019, 3826054.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

Periyasamy-Thandavan, S., Burke, J., Mendhe, B., Kondrikova, G., Kolhe, R., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W. D., Fulzele, S., Beerman, I. & Hare, J., Aug 16 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 9, p. 1368-1374 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

The detrimental effects of kynurenine, a tryptophan metabolite, on human bone metabolism

Kim, B. J., Hamrick, M. W., Yoo, H. J., Lee, S. H., Kim, S. J., Koh, J. M. & Isales, C. M., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 2334-2342 9 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

The effects of myokines on osteoclasts and osteoblasts

Lee, J. Y., Park, S. J., Han, S. A., Lee, S. H., Koh, J. M., Hamrick, M. W. & Kim, B. J., Oct 1 2019, In : Biochemical and Biophysical Research Communications. 517, 4, p. 749-754 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Association of serum TSH with handgrip strength in community-dwelling euthyroid elderly

Kim, B. J., Lee, S. H., Isales, C. M., Hamrick, M. W., Kwak, M. K. & Koh, J. M., Jan 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 11, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: A nationwide population-based study

Kim, B. J., Lee, S. H., Kwak, M. K., Isales, C. M., Koh, J. M. & Hamrick, M. W., Aug 1 2018, In : Aging. 10, 8, p. 2051-2061 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone

Yu, K., Sellman, D. P., Bahraini, A., Hagan, M. L., Elsherbini, A., Vanpelt, K. T., Marshall, P. L., Hamrick, M. W., McNeil, A., McNeil, P. L. & McGee Lawrence, M. E., Feb 1 2018, In : Journal of Orthopaedic Research. 36, 2, p. 653-662 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

4 Scopus citations

The positive association of total protein intake with femoral neck strength (KNHANES IV)

Kim, B. J., Lee, S. H., Isales, C. M., Koh, J. M. & Hamrick, M. W., Jun 1 2018, In : Osteoporosis International. 29, 6, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

Helwa, I., Cai, J., Drewry, M. D., Zimmerman, A., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., Hamrick, M. W. & Liu, Y., Jan 2017, In : PloS one. 12, 1, e0170628.

Research output: Contribution to journalArticle

161 Scopus citations

Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Carbone, L. D., Bůžková, P., Fink, H. A., Robbins, J. A., Bethel, M., Hamrick, M. W. & Hill, W. D., Jun 1 2017, In : Calcified Tissue International. 100, 6, p. 599-608 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Complex Anatomic Abnormalities of the Lower Leg Muscles and Tendons Associated With Phocomelia: A Case Report

Hodo, T., Hamrick, M. & Melenevsky, Y., Nov 2017, In : Journal of Foot and Ankle Surgery. 56, 6, p. 1335-1338 4 p.

Research output: Contribution to journalArticle

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific reports. 7, 1, 2029.

Research output: Contribution to journalArticle

54 Scopus citations

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

Kindler, J. M., Pollock, N. K., Laing, E. M., Oshri, A., Jenkins, N. T., Isales, C. M., Hamrick, M. W., Ding, K. H., Hausman, D. B., McCabe, G. P., Martin, B. R., Hill Gallant, K. M., Warden, S. J., Weaver, C. M., Peacock, M. & Lewis, R. D., Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1537-1545 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
44 Scopus citations

Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice

McGee-Lawrence, M. E., Wenger, K. H., Misra, S., Davis, C. L., Pollock, N. K., Elsalanty, M., Ding, K., Isales, C. M., Hamrick, M. W., Wosiski-Kuhn, M., Arounleut, P., Mattson, M. P., Cutler, R. G., Yu, J. C. & Stranahan, A. M., May 1 2017, In : Endocrinology. 158, 5, p. 1160-1171 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle

Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y. C. A. & Hamrick, M. W., Oct 21 2016, In : Biochemical and Biophysical Research Communications. 479, 3, p. 590-595 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Insulin resistance negatively influences the muscle- dependent igf-1-bone mass relationship in premenarcheal girls

Kindler, J. M., Pollock, N. K., Laing, E. M., Jenkins, N. T., Oshri, A., Isales, C., Hamrick, M. & Lewis, R. D., Jan 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 199-205 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy

Herberg, S., Kondrikova, G., Hussein, K. A., Johnson, M. H., Elsalanty, M. E., Shi, X., Hamrick, M. W., Isales, C. M. & Hill, W. D., Feb 1 2015, In : Journal of Orthopaedic Research. 33, 2, p. 174-184 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells

Sangani, R., Periyasamy-Thandavan, S., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Isales, C., Hamrick, M., Hill, W. D. & Fulzele, S., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 19-26 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

Hamrick, M. W., Dukes, A., Arounleut, P., Davis, C., Periyasamy-Thandavan, S., Mork, S., Herberg, S., Johnson, M. H., Isales, C. M., Hill, W. D., Otvos, L. & Belin de Chantemèle, E. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 92-96 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro

Dukes, A., Davis, C. M., El Refaey, M., Upadhyay, S., Mork, S., Arounleut, P., Johnson, M. H., Hill, W. D., Isales, C. M. & Hamrick, M. W., Jan 1 2015, In : Nutrition. 31, 7-8, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis

Sangani, R., Periyasamy-Thandavan, S., Pathania, R., Ahmad, S., Kutiyanawalla, A., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Sep 1 2015, In : Stem Cell Research. 15, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension

Refaey, M. E., Zhong, Q., Hill, W. D., Shi, X. M., Hamrick, M. W., Bailey, L., Johnson, M., Xu, J., Bollag, W. B., Chutkan, N. & Isales, C. M., Apr 11 2014, In : PloS one. 9, 4, e91108.

Research output: Contribution to journalArticle

9 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of dietary aromatic amino acids on osteoclastic activity

Refaey, M. E., Zhong, Q., Ding, K. H., Shi, X. M., Xu, J., Bollag, W. B., Hill, W. D., Chutkan, N., Robbins, R., Nadeau, H., Johnson, M., Hamrick, M. W. & Isales, C. M., Aug 2014, In : Calcified Tissue International. 95, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Knockdown of SVCT2 impairs in-vitro cell attachment, migration and wound healing in bone marrow stromal cells

Sangani, R., Pandya, C. D., Bhattacharyya, M. H., Periyasamy-Thandavan, S., Chutkan, N., Markand, S., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Mar 2014, In : Stem Cell Research. 12, 2, p. 354-363 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects

Herberg, S., Susin, C., Pelaez, M., Howie, R. N., Moreno De Freitas, R., Lee, J., Cray, J. J., Johnson, M. H., Elsalanty, M. E., Hamrick, M. W., Isales, C. M., Wikesjö, U. M. E. & Hill, W. D., May 1 2014, In : Tissue Engineering - Part A. 20, 9-10, p. 1444-1453 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition

Pan, G., Cao, J., Yang, N., Ding, K., Fan, C., Xiong, W. C., Hamrick, M., Isales, C. M. & Shi, X. M., Jul 11 2014, In : Journal of Biological Chemistry. 289, 28, p. 19373-19382 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation

Herberg, S., Kondrikova, G., Hussein, K. A., Periyasamy-Thandavan, S., Johnson, M. H., Elsalanty, M. E., Shi, X., Hamrick, M. W., Isales, C. M. & Hill, W. D., Dec 1 2014, In : Tissue Engineering - Part A. 20, 23-24, p. 3212-3227 16 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013
27 Scopus citations

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

Arounleut, P., Bialek, P., Liang, L. F., Upadhyay, S., Fulzele, S., Johnson, M., Elsalanty, M., Isales, C. M. & Hamrick, M. W., Sep 1 2013, In : Experimental Gerontology. 48, 9, p. 898-904 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

Bowser, M., Herberg, S., Arounleut, P., Shi, X., Fulzele, S., Hill, W. D., Isales, C. M. & Hamrick, M. W., Feb 1 2013, In : Experimental Gerontology. 48, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., Dec 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

9 Scopus citations