Modesto Antonio Rojas

Assistant Research Scientist

  • 617 Citations
  • 14 h-Index
20062018
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Research Output 2006 2018

  • 617 Citations
  • 14 h-Index
  • 19 Article
  • 1 Review article
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Article
2018

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

Rojas, M. A., Shen, Z. T., Caldwell, R. B. & Sigalov, A. B., Sep 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
Oxygen
Retinal Neovascularization
Pathologic Neovascularization
Macrophage Colony-Stimulating Factor
3 Citations (Scopus)

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

Arginase
Cell Aging
Endothelial cells
Medical problems
Endothelial Cells

Neurofibromin deficiency induces endothelial cell proliferation and retinal neovascularization

Zhang, H., Hudson, F. Z., Xu, Z., Tritz, R., Rojas, M., Patel, C., Haigh, S. B., Bordán, Z., Ingram, D. A., Fulton, D. J., Weintraub, N. L., Caldwell, R. B. & Stansfield, B. K., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2520-2528 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Retinal Neovascularization
Retina
Neurofibromatosis 1
Endothelial Cells
2016
13 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
2015
9 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
2014
17 Citations (Scopus)

Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

Jittiporn, K., Suwanpradid, J., Patel, C., Rojas, M. A., Thirawarapan, S., Moongkarndi, P., Suvitayavat, W. & Caldwell, R. B., Jan 1 2014, In : Microvascular Research. 93, p. 72-79 8 p.

Research output: Contribution to journalArticle

Garcinia mangostana
Xanthones
Vascular Endothelial Growth Factor A
Endothelial cells
Endothelial Cells
17 Citations (Scopus)

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PloS one. 9, 11, 110604.

Research output: Contribution to journalArticle

Hyperargininemia
hyperoxia
Arginase
arginase
Retinal Vessels
2013
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
25 Citations (Scopus)

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

Arginase
Diabetic Retinopathy
Retinal Vessels
Retina
Glucose
38 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
55 Citations (Scopus)

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Blood Vessels
Aorta
Protein Isoforms
24 Citations (Scopus)

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular System Injuries
Medical problems
retina
blood vessels
32 Citations (Scopus)

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

Arginase
Retinal Vessels
Myography
Vasodilation
Blood Vessels
2011
50 Citations (Scopus)

Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion

Yokota, H., Narayanan, S. P., Zhang, W., Liu, H., Rojas, M. A., Xu, Z., Lemtalsi, T., Nagaoka, T., Yoshida, A., Brooks, S. E., Caldwell, R. W. & Caldwell, R. B., Oct 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8123-8131 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Reperfusion Injury
Reperfusion
Ischemia
Retina
2010
39 Citations (Scopus)

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

Retinal Vessels
Angiotensin II
Interleukin-6
Inflammation
Vascular Endothelial Growth Factor A
2009
44 Citations (Scopus)

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M. A., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero Lucas, M. J., Caldwell, R. W. & Caldwell, R. B., Jan 1 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

Arginase
Uveitis
Endotoxins
Inflammation
Lipopolysaccharides
25 Citations (Scopus)

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation

Zhang, W., Rojas, M., Lilly, B., Tsai, N. T., Lemtalsi, T., Liou, G. I., Caldwell, R. W. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 3033-3040 8 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Inflammation
Retinal Vessels
Uveitis
Phosphorylation
2008
134 Citations (Scopus)

Role of NADPH oxidase in retinal vascular inflammation

Al-Shabrawey, M., Rojas, M. A., Sanders, T., Behzadian, A., El-Remessy, A., Bartoli, M., Parpia, A. K., Liou, G. I. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

Retinal Vessels
NADPH Oxidase
Leukostasis
Inflammation
Reactive Oxygen Species
2006
10 Citations (Scopus)

Blood Pressure Early in Diabetes Depends on a Balance Between Glomerular Filtration Rate and the Renin-Angiotensin System

Rojas, M. A., Bell, T. D., Sturgis, L., Springfield, V., Janardhanan, R., Fleming, C. & Brands, M. W., Dec 1 2006, In : American Journal of Hypertension. 19, 12, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Glomerular Filtration Rate
Blood Pressure
Angiotensin II
Arterial Pressure