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Research Output

  • 2561 Citations
  • 27 h-Index
  • 48 Article
  • 7 Review article
  • 3 Comment/debate
  • 2 Editorial
2020
Open Access
1 Scopus citations

Eicosanoids and oxidative stress in diabetic retinopathy

Wang, M. H., Hsiao, G. & Al-Shabrawey, M., Jun 2020, In : Antioxidants. 9, 6, p. 1-20 20 p., 520.

Research output: Contribution to journalReview article

Open Access

Homocysteine induces inflammation in retina and brain

Elsherbiny, N. M., Sharma, I., Kira, D., Alhusban, S., Samra, Y. A., Jadeja, R., Martin, P., Al-Shabrawey, M. & Tawfik, A., Mar 2020, In : Biomolecules. 10, 3, 393.

Research output: Contribution to journalArticle

Open Access
Open Access
2019

A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury

Elmarakby, A. A., Ibrahim, A. S., Katary, M. A., Elsherbiny, N. M., El-Shafey, M., Abd-Elrazik, A. M., Abdelsayed, R. A., Maddipati, K. R. & Al-Shabrawey, M., Nov 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 11, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Bioactive lipids and pathological retinal angiogenesis

Elmasry, K., Ibrahim, A. S., Abdulmoneim, S. & Al-Shabrawey, M., Jan 2019, In : British Journal of Pharmacology. 176, 1, p. 93-109 17 p.

Research output: Contribution to journalReview article

6 Scopus citations

Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells

Valle, M. L., Dworshak, J., Sharma, A., Ibrahim, A. S., Al-Shabrawey, M. & Sharma, S., Jan 2019, In : Experimental eye research. 178, p. 27-36 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

A controlled impact of optic nerve as a new model of traumatic optic neuropathy in Mouse

Ibrahim, A. S., Elmasry, K., Wan, M., Abdulmoneim, S., Still, A., Khan, F., Khalil, A., Saul, A., Hoda, M. N. & Al-Shabrawey, M., Nov 2018, In : Investigative Ophthalmology and Visual Science. 59, 13, p. 5548-5557 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Epigenetic modifications in hyperhomocysteinemia; potential role in diabetic retinopathy and age-related macular degeneration

Elmasry, K., Mohamed, R., Sharma, I., Elsherbiny, N. M., Liu, Y., Al-Shabrawey, M. & Tawfik, A., 2018, In : Oncotarget. 9, 16, p. 12562-12590 29 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

Elmasry, K., Ibrahim, A. S., Saleh, H., Elsherbiny, N., Elshafey, S., Hussein, K. A. & Al-Shabrawey, M., May 1 2018, In : Diabetologia. 61, 5, p. 1220-1232 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

Adenosine deaminase-2–induced hyperpermeability in human retinal vascular endothelial cells is suppressed by microRNA-146b-3p

Samra, Y. A., Saleh, H. M., Hussein, K. A., Elsherbiny, N. M., Ibrahim, A. S., Elmasry, K., Fulzele, S., El-Shishtawy, M. M., Eissa, L. A., Al-Shabrawey, M. & Liou, G. I., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 933-943 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., Xu, X., Yang, Q., Zeng, X., Zhou, Y., Gu, X., Lu, S., Fu, Z., Fulton, D. J., Weintraub, N. L., Caldwell, R. B., Zhang, W., Wu, C., Liu, X. L., Chen, J. F. & 10 others, Ahmad, A., Kaddour-Djebbar, I., Al-Shabrawey, M., Li, Q., Jiang, X., Sun, Y., Sodhi, A., Smith, L., Hong, M. & Huo, Y., Dec 1 2017, In : Nature communications. 8, 1, 584.

Research output: Contribution to journalArticle

21 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journalArticle

11 Scopus citations

Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis

Ibrahim, A. S., Saleh, H., El-Shafey, M., Hussein, K. A., El-Masry, K., Baban, B., Sheibani, N., Wang, M. H., Tawfik, A. & Al-Shabrawey, M., Jun 1 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 6, p. 636-645 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke

Huang, H., Al-Shabrawey, M. & Wang, M-H., Jan 2016, In : Prostaglandins and Other Lipid Mediators. 122, p. 45-53 9 p.

Research output: Contribution to journalReview article

30 Scopus citations

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Jan 1 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Diabetic retinopathy: Mechanism, diagnosis, prevention, and treatment

Al-Shabrawey, M., Zhang, W. & McDonald, D., Jan 1 2015, In : BioMed Research International. 2015, 854593.

Research output: Contribution to journalEditorial

12 Scopus citations

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The chemokine platelet factor-4 variant (PF-4var)/CXCL4L1 inhibits diabetes-induced blood–retinal barrier breakdown

Abu El-Asrar, A. M., Mohammad, G., Nawaz, M. I., Abdelsaid, M., Siddiquei, M. M., Alam, K., Van Den Eynde, K., De Hertogh, G., Opdenakker, G., Al-Shabrawey, M., Van Damme, J. & Struyf, S., Feb 24 2015, In : Investigative Ophthalmology and Visual Science. 56, 3, p. 1956-1974 19 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

Pye, C., Elsherbiny, N. M., Ibrahim, A. S., Liou, G. I., Chadli, A., Al-Shabrawey, M. & Elmarakby, A. A., Jul 2014, In : Pharmacological Research. 85, p. 45-54 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Bone morphogenetic protein 2: A potential new player in the pathogenesis of diabetic retinopathy

Hussein, K. A., Choksi, K., Akeel, S., Ahmad, S., Megyerdi, S., El-Sherbiny, M., Nawaz, M., Abu El-Asrar, A. & Al-Shabrawey, M., Aug 2014, In : Experimental eye research. 125, p. 79e88

Research output: Contribution to journalArticle

24 Scopus citations

Caspase-14 expression impairs retinal pigment epithelium barrier function: Potential role in diabetic macular edema

Beasley, S., El-Sherbiny, M., Megyerdi, S., El-Shafey, S., Choksi, K., Kaddour-Djebbar, I., Sheibani, N., Hsu, S. & Al-Shabrawey, M., 2014, In : BioMed Research International. 2014, 417986.

Research output: Contribution to journalArticle

13 Scopus citations

Effects of tricalcium silicate cements on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells in vitro

Eid, A. A., Hussein, K. A., Niu, L. N., Li, G. H., Watanabe, I., Al-Shabrawey, M., Pashley, D. H. & Tay, F. R., Jul 2014, In : Acta biomaterialia. 10, 7, p. 3327-3334 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase

Othman, A., Ahmad, S., Megyerdi, S., Mussell, R., Choksi, K., Maddipati, K. R., Elmarakby, A., Rizk, N. & Al-Shabrawey, M., Feb 20 2013, In : PloS one. 8, 2, e57254.

Research output: Contribution to journalArticle

52 Scopus citations

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Erratum: Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: Implications in retinal neovascularization (Diabetes (2011) 60 (614-624))

Al-Shabrawey, M., Mussell, R., Kahook, K., Tawfik, A., Eladl, M., Sarthy, V., Nussbaum, J., El-Marakby, A., Park, S. Y., Gurel, Z., Sheibani, N. & Maddipati, K. R., Mar 1 2013, In : Diabetes. 62, 3, 1 p.

Research output: Contribution to journalComment/debate

High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina

Mohammad, G., Siddiquei, M. M., Othman, A., Al-Shabrawey, M. & Abu El-Asrar, A. M., Feb 1 2013, In : Experimental eye research. 107, p. 101-109 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

New developments in the pathophysiology and management of diabetic retinopathy

Abu El-Asrar, A. M., Midena, E., Al-Shabrawey, M. & Mohammad, G., Dec 1 2013, In : Journal of Diabetes Research. 2013, 424258.

Research output: Contribution to journalEditorial

11 Scopus citations

Targeting neovascularization in ischemic retinopathy: Recent advances

Al-Shabrawey, M., Elsherbiny, M., Nussbaum, J., Othman, A., Megyerdi, S. & Tawfik, A., Jun 1 2013, In : Expert Review of Ophthalmology. 8, 3, p. 267-286 20 p.

Research output: Contribution to journalReview article

23 Scopus citations
2012

Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy

Al-Shabrawey, M., Ahmad, S., Megyerdi, S., Othman, A., Baban, B., Palenski, T. L., Shin, E. S., Gurel, Z., Hsu, S. & Sheibani, N., Sep 11 2012, In : Molecular Vision. 18, p. 1895-1906 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Difference in soft tissue response between immediate and delayed delivery suggests a new mechanism for recombinant human bone morphogenetic protein 2 action in large segmental bone defects

Hussein, K. A., Zakhary, I. E., Elawady, A. R., Emam, H. A., Sharawy, M., Baban, B., Akeel, S., Al-Shabrawey, M. & Elsalanty, M. E., Mar 1 2012, In : Tissue Engineering - Part A. 18, 5-6, p. 665-675 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death

Kaddour-Djebbar, I., Choudhary, V., Lakshmikanthan, V., Shirley, R., El Gaish, M., Al-Shabrawey, M., Al-Husein, B., Zhong, R., Davis, M., Dong, Z., Bollag, W. B. & Kumar, M. V., Jun 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 3, p. 646-655 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Recombinant bone morphogenetic protein-2 induces up-regulation of vascular endothelial growth factor and interleukin 6 in human pre-osteoblasts: Role of reactive oxygen species

Akeel, S., El-Awady, A., Hussein, K., El-Refaey, M., Elsalanty, M. E., Sharawy, M. M. H. & Al-Shabrawey, M., May 1 2012, In : Archives of Oral Biology. 57, 5, p. 445-452 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2011
60 Scopus citations

High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy

El-Asrar, A. M. A., Nawaz, M. I., Kangave, D., Geboes, K., Ola, M. S., Ahmad, S. & Al-Shabrawey, M., Jul 29 2011, In : Molecular Vision. 17, p. 1829-1838 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: Implications in retinal neovascularization

Al-Shabrawey, M., Mussell, R., Kahook, K., Tawfik, A., Eladl, M., Sarthy, V., Nussbaum, J., El-Marakby, A., Park, S. Y., Gurel, Z., Sheibani, N. & Maddipati, K. R., Feb 1 2011, In : Diabetes. 60, 2, p. 614-624 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Inflammation and diabetic retinal microvascular complications

Zhang, W., Liu, H., Al-Shabrawey, M., Caldwell, R. & Caldwell, R., Jan 1 2011, In : Journal of Cardiovascular Disease Research. 2, 2, p. 96-103 8 p.

Research output: Contribution to journalReview article

123 Scopus citations
2010

Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy

Abdelsaid, M. A., Pillai, B. A., Matragoon, S., Prakash, R., Al-Shabrawey, M. & El-Remessy, A. B., Jan 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Prediction of diabetic retinopathy: Role of oxidative stress and relevance of apoptotic biomarkers

Al-Shabrawey, M. & Smith, S., Mar 1 2010, In : EPMA Journal. 1, 1, p. 56-72 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2009

Exogenous expression of caspase-14 induces tumor suppression in human salivary cancer cells by inhibiting tumor vascularization

Wu, M., Kodani, I., Dickinson, D., Huff, F., Ogbureke, K. U. E., Qin, H., Arun, S., Dulebohn, R., Al-Shabrawey, M., Tawhk, A., Prater, S., Lewis, J., Wataha, J., Messer, R. L. W. & Hsu, S., Oct 1 2009, In : Anticancer research. 29, 10, p. 3811-3818 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy

Bartoli, M., Al-Shabrawey, M., Labazi, M., Ali Behzadian, M., Istanboli, M., El-Remessy, A. B., Caldwell, R. W., Marcus, D. M. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4934-4940 7 p.

Research output: Contribution to journalArticle

46 Scopus citations
63 Scopus citations
2008

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

Role of NADPH oxidase in retinal vascular inflammation

Al-Shabrawey, M., Rojas, M., Sanders, T., Behzadian, A., El-Remessy, A., Bartoli, M., Parpia, A. K., Liou, G. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3239-3244 6 p.

Research output: Contribution to journalArticle

140 Scopus citations
2007

Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells

El-Remessy, A. B., Al-Shabrawey, M., Platt, D. H., Bartoli, M., Behzadian, M. A., Ghaly, N., Tsai, N., Motamed, K. & Caldwell, R. B., Aug 2007, In : FASEB Journal. 21, 10, p. 2528-2539 12 p.

Research output: Contribution to journalArticle

75 Scopus citations
2006

Erratum: Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-β (GLIA 24, (216-225))

Behzadian, M. A., Wang, X. L., Shabrawey, M. & Caldwell, R. B., May 1 2006, In : Glia. 53, 7, 1 p.

Research output: Contribution to journalComment/debate