Natasha Marie Savage

Associate Professor

  • 330 Citations
  • 9 h-Index
20082019
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Research Output 2008 2019

  • 330 Citations
  • 9 h-Index
  • 32 Article
  • 4 Review article
  • 2 Letter
  • 1 Comment/debate
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Article
2019
2 Citations (Scopus)

Loss of fas expression and function is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy

Xiao, W., Ibrahim, M. L., Redd, P. S., Klement, J. D., Lu, C., Yang, D., Savage, N. M. & Liu, K., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 420-430 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Colonic Neoplasms
Microsatellite Repeats
Neoplastic Stem Cells
Apoptosis
1 Citation (Scopus)

Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In : Cancer Research. 79, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

Guanidine
Nucleotides
Lymphoma
Leukemia
Stem Cells

SuV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

Lu, C., Yang, D., Klement, J. D., Oh, I. K., Savage, N. M., Waller, J. L., Colby, A. H., Grinstaff, M. W., Oberlies, N. H., Pearce, C. J., Xie, Z., Kulp, S. K., Coss, C. C., Phelps, M. A., Albers, T., Lebedyeva, I. O. & Liu, K., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 414-427 14 p.

Research output: Contribution to journalArticle

Tumor Escape
Cytotoxic T-Lymphocytes
Colon
Tumor Microenvironment
Microsatellite Repeats

Tumefactive fibroinflammatory lesion successfully treated with Rituximab

Bishop, J. L., Bryan, L. J., Savage, N. M. & Byrd, J. K., Jan 1 2019, In : Intractable and Rare Diseases Research. 8, 2, p. 138-141 4 p.

Research output: Contribution to journalArticle

Open Access
Steroids
Trismus
Trigeminal Ganglion
Otitis Media with Effusion
Hypesthesia
1 Citation (Scopus)

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Zhu, H., Bhatt, B., Sivaprakasam, S., Cai, Y., Liu, S., Kodeboyina, S. K., Patel, N., Savage, N. M., Sharma, A. K., Kaufman, R. J., Li, H. & Singh, N., Dec 1 2019, In : Nature Communications. 10, 1, 1084.

Research output: Contribution to journalArticle

Unfolded Protein Response
Plasma Cells
proteins
Plasmas
expansion
2018
1 Citation (Scopus)

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

Ibrahim, M. L., Klement, J. D., Lu, C., Redd, P. S., Xiao, W., Yang, D., Browning, D. D., Savage, N. M., Buckhaults, P. J., Morse, H. C. & Liu, K., Dec 11 2018, In : Cell Reports. 25, 11, p. 3036-3046.e6

Research output: Contribution to journalArticle

Colitis
Interleukin-10
Colon
Carcinogenesis
Inflammation
2017
5 Citations (Scopus)

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Mangaonkar, A., Mondal, A. K., Fulzule, S., Pundkar, C., Park, E. J., Jillella, A., Kota, V., Xu, H., Savage, N. M., Shi, H., Munn, D. H. & Kolhe, R. B., Dec 1 2017, In : Scientific Reports. 7, 1, 12892.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Acute Myeloid Leukemia
Mortality
Messenger RNA
Bone Marrow
21 Citations (Scopus)
Cytotoxic T-Lymphocytes
Lymphocyte Activation
Pancreatic Neoplasms
Immunotherapy
Inflammation
1 Citation (Scopus)

Persistent indolent pancolonic marginal zone lymphoma of MALT-type with plasmacytic differentiation – A rare post-transplant lymphoma?

Chaffin, J. M., Savage, N. M., Sharma, S., Bryan, L. J., Raffeld, M. & Jaffe, E. S., Nov 1 2017, In : Human Pathology: Case Reports. 10, p. 74-78 5 p.

Research output: Contribution to journalArticle

Marginal Zone B-Cell Lymphoma
Lymphoma
Transplants
Liver
Human Herpesvirus 4
34 Citations (Scopus)

The MLL1-H3K4me3 axis-mediated PD-L1 expression and pancreatic cancer immune evasion

Lu, C., Paschall, A. V., Shi, H., Savage, N. M., Waller, J. L., Sabbatini, M. E., Oberlies, N. H., Pearce, C. & Liu, K., Jan 1 2017, In : Journal of the National Cancer Institute. 109, 6, djw283.

Research output: Contribution to journalArticle

Immune Evasion
Pancreatic Neoplasms
Cytotoxic T-Lymphocytes
Immunotherapy
Neoplasms
2016
8 Citations (Scopus)

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In : International Journal of Cancer. 139, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Acute Myeloid Leukemia
Phosphotransferases
Chromosomes
Myeloproliferative Disorders
38 Citations (Scopus)

The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells

Lu, C., Redd, P. S., Lee, J. R., Savage, N. M. & Liu, K., Dec 1 2016, In : OncoImmunology. 5, 12, e1247135.

Research output: Contribution to journalArticle

Ligands
Neoplasms
Tumor Microenvironment
Myeloid-Derived Suppressor Cells
Microsatellite Repeats
1 Citation (Scopus)
Refractory Anemia
Thrombocytosis
Mutation
Hematologic Neoplasms
Rare Diseases
2015
2 Citations (Scopus)

FDG PET/CT in evaluation of unusual cutaneous manifestations of breast cancer

Dave, S. R., Samuel, T. A., Pucar, D., Savage, N. M. & Williams, H. T., Jan 1 2015, In : Clinical Nuclear Medicine. 40, 1, p. e63-e67

Research output: Contribution to journalArticle

Skin Manifestations
Breast Neoplasms
Neoplasm Metastasis
Skin
Incidence
2014
1 Citation (Scopus)

Acute facial paralysis and otomastoiditis as presenting symptoms of myeloid sarcoma

Howell, J., Segel, J., Jajosky, R., Savage, N. M., Fields, B., Kota, V. & Mowry, S., Aug 19 2014, (Accepted/In press) In : Otology and Neurotology.

Research output: Contribution to journalArticle

Mastoiditis
Myeloid Sarcoma
Second Primary Neoplasms
Facial Paralysis
Acute Myeloid Leukemia
4 Citations (Scopus)

Azacitidine as salvage therapy for acute myeloid leukemia in a severely ill patient

Powers, H. R., Bachar, M., Savage, N. M., Toscano, M. P. & Dainer, P. M., Jan 1 2014, In : Hematology Reports. 6, 3, p. 58-60 3 p., 5516.

Research output: Contribution to journalArticle

Azacitidine
Salvage Therapy
Acute Myeloid Leukemia
Myeloid Progenitor Cells
Remission Induction
27 Citations (Scopus)

Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): A Bone Marrow Pathology Group study

Rogers, H. J., Vardiman, J. W., Anastasi, J., Raca, G., Savage, N. M., Cherry, A. M., Arber, D., Moore, E., Morrissette, J. J. D., Bagg, A., Liu, Y. C., Mathew, S., Orazi, A., Lin, P., Wang, S. A., Bueso-Ramos, C. E., Foucar, K., Hasserjian, R. P., Tiu, R. V., Karafa, M. & 1 others, Hsi, E. D., May 1 2014, In : Haematologica. 99, 5, p. 821-829 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Karyotype
Acute Myeloid Leukemia
Bone Marrow
Pathology
2013
15 Citations (Scopus)

Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)

Johnson, R. C., Savage, N. M., Chiang, T., Gotlib, J. R., Cherry, A. M., Arber, D. A. & George, T. I., Oct 1 2013, In : American Journal of Clinical Pathology. 140, 4, p. 525-535 11 p.

Research output: Contribution to journalArticle

Systemic Mastocytosis
Mastocytosis
Acute Myeloid Leukemia
Mast Cells
Immunophenotyping
8 Citations (Scopus)

Myeloid and lymphoid Neoplasms with FGFR1 abnormalities: Diagnostic and therapeutic challenges

Savage, N. M., Johnson, R. C., Gotlib, J. & George, T. I., May 1 2013, In : American Journal of Hematology. 88, 5, p. 427-430 4 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Chromosome Disorders
Lymphoid Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Genetic Translocation
9 Citations (Scopus)

The spectrum of lymphoblastic, nodal and extranodal T-cell lymphomas: Characteristic features and diagnostic dilemmas

Savage, N. M., Johnson, R. C. & Natkunam, Y., Apr 1 2013, In : Human Pathology. 44, 4, p. 451-471 21 p.

Research output: Contribution to journalArticle

T-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
Natural Killer T-Cells
Hodgkin Disease
2012
14 Citations (Scopus)

Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: Implications of accurate diagnosis

Savage, N. M., Linn, D., McDonough, C. H., Donohoe, J. M., Franco, A., Reuter, V., Biddinger, P. W., Eaton, K. W., Biegel, J. A. & Sharma, S., Dec 1 2012, In : Annals of Diagnostic Pathology. 16, 6, p. 504-507 4 p.

Research output: Contribution to journalArticle

Rhabdoid Tumor
Urinary Bladder Neoplasms
Urinary Bladder
Rhabdomyosarcoma
Sequence Deletion
6 Citations (Scopus)

The cytologic findings in choroid plexus carcinoma: Report of a case with differential diagnosis

Savage, N. M., Crosby, J. H. & Reid-Nicholson, M. D., Jan 1 2012, In : Diagnostic Cytopathology. 40, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Differential Diagnosis
Cerebrospinal Fluid
Choroid Plexus Neoplasms
Literature
Cucurbita
2011
5 Citations (Scopus)
Carcinoma
Frozen Sections
Meningioma
Neoplasms
Neoplasm Metastasis
8 Citations (Scopus)

Isolated russell body duodenitis

Savage, N. M., Fortson, T., Schubert, M., Chamberlain, S., Lee, J. & Ramalingam, P., Jul 1 2011, In : Digestive Diseases and Sciences. 56, 7, p. 2202-2204 3 p.

Research output: Contribution to journalArticle

Duodenitis
Viral RNA
Metaplasia
Gastritis
CD4 Lymphocyte Count
1 Citation (Scopus)

Transfusion considerations concerning patients with anti-hrB and confounding co-morbid conditions: Pregnancy and coagulopathy

Savage, N. M., Nugent, W. F., Devoe, L. D., Bollag, R. J. & Cook, L. O., Apr 11 2011, In : Blood Transfusion. 9, 2, p. 225-229 5 p.

Research output: Contribution to journalArticle

Hematologic Pregnancy Complications
Rh-Hr Blood-Group System
Isoantibodies
Erythrocyte Transfusion
Sickle Cell Anemia
2010
9 Citations (Scopus)

Acute leukemia with PICALM-MLLT10 fusion gene: Diagnostic and treatment struggle

Savage, N. M., Kota, V., Manaloor, E. J., Kulharya, A. S., Pierini, V., Mecucci, C. & Ustun, C., Jan 1 2010, In : Cancer Genetics and Cytogenetics. 202, 2, p. 129-132 4 p.

Research output: Contribution to journalArticle

Gene Fusion
Leukemia
Acute Myeloid Leukemia
Histiocytic Sarcoma
Myeloid Sarcoma

Benign osteonecrosis of the temporal bone: A rare etiology

Bhatt, N., Savage, N. M. & McKinnon, B. J., Dec 1 2010, In : Laryngoscope. 120, SUPPL. 4

Research output: Contribution to journalArticle

Osteonecrosis
Temporal Bone
Debridement
Retrospective Studies
2009
1 Citation (Scopus)

Amyloidosis, Evans syndrome and management options of lymphoplasmacytic lymphoma

Ustun, C., Savage, N., Manaloor, E., Kunavarapu, C. & Jillella, A., Mar 1 2009, In : Amyloid. 16, 1, p. 42-46 5 p.

Research output: Contribution to journalArticle

Amyloidosis
Lymphoma
Hard Palate
Gastrointestinal Hemorrhage
Myocardial Infarction
59 Citations (Scopus)

Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KITD816V

Ustun, C., Corless, C. L., Savage, N., Fiskus, W., Manaloor, E., Heinrich, M. C., Lewis, G., Ramalingam, P., Kepten, I., Jillella, A. & Bhalla, K., May 1 2009, In : Leukemia Research. 33, 5, p. 735-741 7 p.

Research output: Contribution to journalArticle

Systemic Mastocytosis
Acute Myeloid Leukemia
Drug Therapy
Bone Marrow
Mast-Cell Leukemia
2 Citations (Scopus)

Neurosarcoidosis with necrotising sarcoid granulomatosis mimicking meningiomatosis cerebri: Case report and literature search

Savage, N. M., Shah, H., Alleyne, C. H., Switzer, J. A., Lee, J. R., Steele, J. & Sharma, S., May 25 2009, In : BMJ Case Reports. 1187.

Research output: Contribution to journalArticle

Meningioma
Granuloma
Lactulose
Biopsy
Hepatic Encephalopathy
2008
1 Citation (Scopus)

Coombs'-negative autoimmune hemolytic anemia in a patient with small lymphocytic lymphoma involving the bone marrow

Savage, N. M., Georgi, D., Kutlar, A. & Cook, L., Dec 1 2008, In : Laboratory Medicine. 39, 8, p. 465-466 2 p.

Research output: Contribution to journalArticle

Autoimmune Hemolytic Anemia
B-Cell Chronic Lymphocytic Leukemia
Bone
Bone Marrow
1 Citation (Scopus)

Enterobacter sakazakii: A case of coincidental infantile sepsis

Savage, N. M., Walker, R. & Steele, J., Dec 1 2008, In : Laboratory Medicine. 39, 11, p. 658-660 3 p.

Research output: Contribution to journalArticle

Cronobacter sakazakii
Necrotizing Enterocolitis
Brain
Sepsis
Blood