• 3601 Citations
  • 37 h-Index
1989 …2020

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Article
2020

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

Stoeber, M., Jullié, D., Li, J., Chakraborty, S., Majumdar, S., Lambert, N. A., Manglik, A. & von Zastrow, M., Feb 2020, In : eLife. 9, e54208.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β2-adrenergic receptor activation

Bondar, A., Jang, W., Sviridova, E. & Lambert, N. A., Apr 1 2020, In : Traffic. 21, 4, p. 324-332 9 p.

Research output: Contribution to journalArticle

Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome

Pritchard, A. B., Kanai, S. M., Krock, B., Schindewolf, E., Oliver-Krasinski, J., Khalek, N., Okashah, N., Lambert, N. A., Tavares, A. L. P., Zackai, E. & Clouthier, D. E., May 1 2020, In : American Journal of Medical Genetics, Part A. 182, 5, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

Zhuang, Y., Liu, H., Edward Zhou, X., Kumar Verma, R., de Waal, P. W., Jang, W., Xu, T. H., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Fan, H., Lambert, N. A., Eric Xu, H. & Zhang, C., Dec 1 2020, In : Nature communications. 11, 1, 885.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Wright, S. C., Kozielewicz, P., Kowalski-Jahn, M., Petersen, J., Bowin, C. F., Slodkowicz, G., Marti-Solano, M., Rodríguez, D., Hot, B., Okashah, N., Strakova, K., Valnohova, J., Babu, M. M., Lambert, N. A., Carlsson, J. & Schulte, G., Dec 1 2019, In : Nature communications. 10, 1, 667.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Common activation mechanism of class a GPCRs

Zhou, Q., Yang, D., Wu, M., Guo, Y., Guo, W., Zhong, L., Cai, X., Dai, A., Jang, W., Shakhnovich, E., Liu, Z. J., Stevens, R. C., Lambert, N. A., Babu, M. M., Wang, M. W. & Zhao, S., Dec 2019, In : eLife. 8, e50279.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Variable G protein determinants of GPCR coupling selectivity

Okashah, N., Wan, Q., Ghosh, S., Sandhu, M., Inoue, A., Vaidehi, N. & Lambert, N. A., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 12054-12059 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

Mini G protein probes for active G protein– coupled receptors (GPCRs) in live cells

Wan, Q., Okashah, N., Inoue, A., Nehme, R., Carpenter, B., Tate, C. G. & Lambert, N. A., May 11 2018, In : Journal of Biological Chemistry. 293, 19, p. 7466-7473 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

Activated G protein Gαs samples multiple endomembrane compartments

Martin, B. R. & Lambert, N. A., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20295-20302 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M. L., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., Feb 9 2016, In : Science Signaling. 9, 414, ra16.

Research output: Contribution to journalArticle

40 Scopus citations
4 Scopus citations
2015

A high-throughput drug screening strategy for detecting rhodopsin P23H mutant rescue and degradation

Chen, Y., Tang, H., Seibel, W., Papoian, R., Li, X., Lambert, N. A. & Palczewski, K., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 4, p. 2553-2567 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific reports. 5, 10166.

Research output: Contribution to journalArticle

27 Scopus citations

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Monitoring G protein activation in cells with BRET

Masuho, I., Martemyanov, K. A. & Lambert, N. A., Jan 1 2015, In : Methods in Molecular Biology. 1335, p. 107-113 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors

Donthamsetti, P., Quejada, J. R., Javitch, J. A., Gurevich, V. V. & Lambert, N. A., Sep 1 2015, In : Current protocols in pharmacology. 70, 1, p. 2.14.1-2.14.14

Research output: Contribution to journalArticle

12 Scopus citations
2014

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R., Choy, K. H. C., Lambert, N. A., Sexton, P. M., Christopoulos, A. & Canals, M., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15856-15866 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A. & O'Connor, P. M., Sep 2014, In : Hypertension. 64, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium

Promsote, W., Veeranan-Karmegam, R., Ananth, S., Shen, D., Chan, C. C., Lambert, N. A., Ganapathy, V. & Martin, P. M., Jan 7 2014, In : Molecular Vision. 20, p. 73-88 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor

Clayton, C. C., Donthamsetti, P., Lambert, N. A., Javitch, J. A. & Neve, K. A., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33663-33675 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Segregation of family A G protein-coupled receptor protomers in the plasma membrane

Gavalas, A., Lan, T. H., Liu, Q., Corrêa, I. R., Javitch, J. A. & Lambert, N. A., Sep 1 2013, In : Molecular Pharmacology. 84, 3, p. 346-352 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Jensen, D. D., Godfrey, C. B., Niklas, C., Canals, M., Kocan, M., Poole, D. P., Murphy, J. E., Alemi, F., Cottrell, G. S., Korbmacher, C., Lambert, N. A., Bunnett, N. W. & Corvera, C. U., Aug 9 2013, In : Journal of Biological Chemistry. 288, 32, p. 22942-22960 19 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 1 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi

Li, C., Fan, Y., Lan, T. H., Lambert, N. A. & Wu, G., Dec 14 2012, In : Journal of Biological Chemistry. 287, 51, p. 42784-42794 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

Lan, T. H., Liu, Q., Li, C., Wu, G. & Lambert, N. A., Nov 1 2012, In : Traffic. 13, 11, p. 1450-1456 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Urizar, E., Yano, H., Kolster, R., Galés, C., Lambert, N. & Javitch, J. A., Sep 2011, In : Nature Chemical Biology. 7, 9, p. 624-630 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons

Middlemore-Risher, M. L., Adam, B. L., Lambert, N. A. & Terry, A. V., Nov 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Internalization dissociates β2-adrenergic receptors

Lan, T. H., Kuravi, S. & Lambert, N. A., 2011, In : PloS one. 6, 2, e17361.

Research output: Contribution to journalArticle

35 Scopus citations

Making structural sense of dimerization interfaces of delta opioid receptor homodimers

Johnston, J. M., Aburi, M., Provasi, D., Bortolato, A., Urizar, E., Lambert, N. A., Javitch, J. A. & Filizola, M., Mar 15 2011, In : Biochemistry. 50, 10, p. 1682-1690 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
2010
102 Scopus citations

Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

Lambert, N. A., Johnston, C. A., Cappell, S. D., Kuravi, S., Kimple, A. J., Willard, F. S. & Siderovski, D. P., Apr 13 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7066-7071 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
30 Scopus citations
2009

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

Instability of a class A G protein-coupled receptor oligomer interface

Fonseca, J. M. & Lambert, N. A., Jun 1 2009, In : Molecular pharmacology. 75, 6, p. 1296-1299 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

Hollins, B., Kuravi, S., Digby, G. J. & Lambert, N. A., Jun 1 2009, In : Cellular Signalling. 21, 6, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
2008

Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins

Qin, K., Sethi, P. R. & Lambert, N. A., Aug 1 2008, In : FASEB Journal. 22, 8, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Activity-dependent regulation of the dopamine transporter is mediated by Ca2+/calmodulin-dependent protein kinase signaling

Padmanabhan, S., Lambert, N. A. & Prasad, B. M., Nov 1 2008, In : European Journal of Neuroscience. 28, 10, p. 2017-2027 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

A point mutation to Gαi selectively blocks GoLoco motif binding: Direct evidence for Gα·GoLoco complexes in mitotic spindle dynamics

Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q. & Siderovski, D. P., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36698-36710 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Differential dissociation of G protein heterotrimers

Digby, G. J., Sethi, P. R. & Lambert, N. A., Jul 1 2008, In : Journal of Physiology. 586, 14, p. 3325-3335 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Three-dimensional neural constructs: A novel platform for neurophysiological investigation

Irons, H. R., Cullen, D. K., Shapiro, N. P., Lambert, N. A., Lee, R. H. & LaPlaca, M. C., Sep 15 2008, In : Journal of Neural Engineering. 5, 3, p. 333-341 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2007

Active Gαq subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane

Clark, M. A., Sethi, P. R. & Lambert, N. A., Feb 20 2007, In : FEBS Letters. 581, 4, p. 764-770 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2006
6 Scopus citations

Rapid activation of inwardly rectifying potassium channels by immobile G-protein-coupled receptors

Lober, R. M., Pereira, M. A. & Lambert, N. A., Nov 29 2006, In : Journal of Neuroscience. 26, 48, p. 12602-12608 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Some G protein heterotrimers physically dissociate in living cells

Digby, G. J., Lober, R. M., Sethi, P. R. & Lambert, N. A., Nov 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 47, p. 17789-17794 6 p.

Research output: Contribution to journalArticle

84 Scopus citations
2004

Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture

Schulz, T. C., Noggle, S. A., Palmarini, G. M., Weiler, D. A., Lyons, I. G., Pensa, K. A., Meedeniya, A. C. B., Davidson, B. P., Lambert, N. A. & Condie, B. G., Dec 24 2004, In : Stem Cells. 22, 7, p. 1218-1238 21 p.

Research output: Contribution to journalArticle

201 Scopus citations
10 Scopus citations