• 3641 Citations
  • 37 h-Index
1989 …2020

Research output per year

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Article

Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins

Qin, K., Sethi, P. R. & Lambert, N. A., Aug 2008, In : FASEB Journal. 22, 8, p. 2920-2927 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Wright, S. C., Kozielewicz, P., Kowalski-Jahn, M., Petersen, J., Bowin, C. F., Slodkowicz, G., Marti-Solano, M., Rodríguez, D., Hot, B., Okashah, N., Strakova, K., Valnohova, J., Babu, M. M., Lambert, N. A., Carlsson, J. & Schulte, G., Dec 1 2019, In : Nature communications. 10, 1, 667.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Activated G protein Gαs samples multiple endomembrane compartments

Martin, B. R. & Lambert, N. A., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20295-20302 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Active Gαq subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane

Clark, M. A., Sethi, P. R. & Lambert, N. A., Feb 20 2007, In : FEBS Letters. 581, 4, p. 764-770 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Activity-dependent regulation of the dopamine transporter is mediated by Ca2+/calmodulin-dependent protein kinase signaling

Padmanabhan, S., Lambert, N. A. & Prasad, B. M., Nov 1 2008, In : European Journal of Neuroscience. 28, 10, p. 2017-2027 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus

Lambert, N. A. & Teyler, T. J., Jan 14 1991, In : Neuroscience Letters. 122, 1, p. 50-52 3 p.

Research output: Contribution to journalArticle

104 Scopus citations

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

Stoeber, M., Jullié, D., Li, J., Chakraborty, S., Majumdar, S., Lambert, N. A., Manglik, A. & von Zastrow, M., Feb 2020, In : eLife. 9, e54208.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A high-throughput drug screening strategy for detecting rhodopsin P23H mutant rescue and degradation

Chen, Y., Tang, H., Seibel, W., Papoian, R., Li, X., Lambert, N. A. & Palczewski, K., 2015, In : Investigative Ophthalmology and Visual Science. 56, 4, p. 2553-2567 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R., Choy, K. H. C., Lambert, N. A., Sexton, P. M., Christopoulos, A. & Canals, M., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15856-15866 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
22 Scopus citations

A point mutation to Gαi selectively blocks GoLoco motif binding: Direct evidence for Gα·GoLoco complexes in mitotic spindle dynamics

Willard, F. S., Zheng, Z., Guo, J., Digby, G. J., Kimple, A. J., Conley, J. M., Johnston, C. A., Bosch, D., Willard, M. D., Watts, V. J., Lambert, N. A., Ikeda, S. R., Du, Q. & Siderovski, D. P., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36698-36710 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

A Triple Arg Motif Mediates α 2B-Adrenergic Receptor Interaction with Sec24C/D and Export

Dong, C., Nichols, C. D., Guo, J., Huang, W., Lambert, N. A. & Wu, G., Jun 2012, In : Traffic. 13, 6, p. 857-868 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+

Lambert, N. A., Harrison, N. L. & Teyler, T. J., May 3 1991, In : Brain Research. 547, 2, p. 349-352 4 p.

Research output: Contribution to journalArticle

24 Scopus citations
103 Scopus citations

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

Lambert, N. A., Harrison, N. L., Kerr, D. I. B., Ong, J., Prager, R. H. & Teyler, T. J., Dec 15 1989, In : Neuroscience Letters. 107, 1-3, p. 125-128 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

Lan, T. H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., May 8 2015, In : Scientific reports. 5, 10166.

Research output: Contribution to journalArticle

28 Scopus citations

Calcium influx is required for endocytotic membrane retrieval

Vogel, S. S., Smith, R. M., Baibakov, B., Ikebuchi, Y. & Lambert, N. A., Apr 27 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 9, p. 5019-5024 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons

Lambert, N. A. & Teyler, T. J., Oct 2 1991, In : European Journal of Pharmacology. 203, 1, p. 129-131 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

Urizar, E., Yano, H., Kolster, R., Galés, C., Lambert, N. & Javitch, J. A., Sep 2011, In : Nature Chemical Biology. 7, 9, p. 624-630 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

Common activation mechanism of class a GPCRs

Zhou, Q., Yang, D., Wu, M., Guo, Y., Guo, W., Zhong, L., Cai, X., Dai, A., Jang, W., Shakhnovich, E., Liu, Z. J., Stevens, R. C., Lambert, N. A., Babu, M. M., Wang, M. W. & Zhao, S., Dec 2019, In : eLife. 8, e50279.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β2-adrenergic receptor activation

Bondar, A., Jang, W., Sviridova, E. & Lambert, N. A., Apr 1 2020, In : Traffic. 21, 4, p. 324-332 9 p.

Research output: Contribution to journalArticle

Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors

Wetherington, J. P. & Lambert, N. A., Feb 15 2002, In : Journal of Neuroscience. 22, 4, p. 1248-1255 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Differential dissociation of G protein heterotrimers

Digby, G. J., Sethi, P. R. & Lambert, N. A., Jul 2008, In : Journal of Physiology. 586, 14, p. 3325-3335 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture

Schulz, T. C., Noggle, S. A., Palmarini, G. M., Weiler, D. A., Lyons, I. G., Pensa, K. A., Meedeniya, A. C. B., Davidson, B. P., Lambert, N. A. & Condie, B. G., 2004, In : Stem Cells. 22, 7, p. 1218-1238 21 p.

Research output: Contribution to journalArticle

201 Scopus citations

Differentiation of rhesus embryonic stem cells to neural progenitors and neurons

Calhoun, J. D., Lambert, N. A., Mitalipova, M. M., Noggle, S. A., Lyons, I., Condie, B. G. & Stice, S. L., Jun 20 2003, In : Biochemical and Biophysical Research Communications. 306, 1, p. 191-197 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
39 Scopus citations

Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons

Middlemore-Risher, M. L., Adam, B. L., Lambert, N. A. & Terry, A. V., Nov 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 341-349 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
6 Scopus citations
42 Scopus citations
10 Scopus citations

Evidence for μ opiate receptors on inhibitory terminals in area CA1 of rat hippocampus

Lambert, N. A., Harrison, N. L. & Teyler, T. J., Mar 11 1991, In : Neuroscience Letters. 124, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Exocytotic insertion of calcium channels constrains compensatory endocytosis to sites of exocytosis

Smith, R. M., Baibakov, B., Ikebuchi, Y., White, B. H., Lambert, N. A., Kaczmarek, L. K. & Vogel, S. S., Feb 21 2000, In : Journal of Cell Biology. 148, 4, p. 755-767 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

Mathiasen, S., Palmisano, T., Perry, N. A., Stoveken, H. M., Vizurraga, A., McEwen, D. P., Okashah, N., Langenhan, T., Inoue, A., Lambert, N. A., Tall, G. G. & Javitch, J. A., 2020, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

10 Scopus citations

GABAB receptor activation desensitizes postsynaptic GABAB and A1 adenosine responses in rat hippocampal neurones

Wetherington, J. P. & Lambert, N. A., Oct 15 2002, In : Journal of Physiology. 544, 2, p. 459-467 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export

Zhang, M., Davis, J. E., Li, C., Gao, J., Huang, W., Lambert, N. A., Terry, A. V. & Wu, G., Apr 1 2016, In : Molecular and Cellular Biology. 36, 7, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

260 Scopus citations

Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons

Lambert, N. A. & Wilson, W. A., Dec 1993, In : Neuron. 11, 6, p. 1057-1067 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABAB receptors

Lambert, N. A. & Wilson, W. A., Apr 1 1996, In : Journal of Physiology. 492, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A. & O'Connor, P. M., Sep 2014, In : Hypertension. 64, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hyperpolarizing and depolarizing GABA(A) receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus

Lambert, N. A., Borroni, A. M., Grover, L. M. & Teyler, T. J., Jan 1 1991, In : Journal of Neurophysiology. 66, 5, p. 1538-1548 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inactive-state preassembly of Gq-coupled receptors and G q heterotrimers

Qin, K., Dong, C., Wu, G. & Lambert, N. A., Oct 2011, In : Nature Chemical Biology. 7, 10, p. 740-747 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Induction and reversal of long-term potentiation by low- and high- intensity theta pattern stimulation

Barr, D. S., Lambert, N. A., Hoyt, K. L., Moore, S. D. & Wilson, W. A., 1995, In : Journal of Neuroscience. 15, 7 II, p. 5402-5410 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors

Lambert, N. A., Levitin, M. & Harrison, N. L., Feb 3 1992, In : Neuroscience Letters. 135, 2, p. 215-218 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inhibition of dendritic calcium influx by activation of G-protein - Coupled receptors in the hippocampus

Chen, H. & Lambert, N. A., Dec 1997, In : Journal of Neurophysiology. 78, 6, p. 3484-3488 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Instability of a class A G protein-coupled receptor oligomer interface

Fonseca, J. M. & Lambert, N. A., Jun 2009, In : Molecular pharmacology. 75, 6, p. 1296-1299 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

Internalization dissociates β2-adrenergic receptors

Lan, T. H., Kuravi, S. & Lambert, N. A., 2011, In : PloS one. 6, 2, e17361.

Research output: Contribution to journalArticle

37 Scopus citations

L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium

Promsote, W., Veeranan-Karmegam, R., Ananth, S., Shen, D., Chan, C. C., Lambert, N. A., Ganapathy, V. & Martin, P. M., Jan 7 2014, In : Molecular Vision. 20, p. 73-88 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Lan, T. H., Wu, G. & Lambert, N. A., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome

Pritchard, A. B., Kanai, S. M., Krock, B., Schindewolf, E., Oliver-Krasinski, J., Khalek, N., Okashah, N., Lambert, N. A., Tavares, A. L. P., Zackai, E. & Clouthier, D. E., May 1 2020, In : American Journal of Medical Genetics, Part A. 182, 5, p. 1104-1116 13 p.

Research output: Contribution to journalArticle