• 4721 Citations
  • 26 h-Index
1980 …2016
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Research Output 1980 2016

  • 4721 Citations
  • 26 h-Index
  • 48 Article
  • 4 Review article
  • 1 Editorial
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Article
2016
25 Citations (Scopus)

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Liu, F., Li, X., Lu, C., Bai, A., Bielawski, J., Bielawska, A., Marshall, B., Schoenlein, P. V., Lebedyeva, I. O. & Liu, K., Jan 1 2016, In : Oncotarget. 7, 51, p. 83907-83925 19 p.

Research output: Contribution to journalArticle

Cathepsin B
Cathepsin D
Ceramides
Autophagy
Apoptosis
2015
31 Citations (Scopus)

Porphyromonas gingivalis Evasion of Autophagy and Intracellular Killing by Human Myeloid Dendritic Cells Involves DC-SIGN-TLR2 Crosstalk

El-Awady, A. R., Miles, B., Scisci, E., Kurago, Z. B., Palani, C. D., Arce Munoz, R. M., Waller, J. L., Genco, C. A., Slocum, C., Manning, M., Schoenlein, P. V. & Cutler, C. W., Jan 1 2015, In : PLoS Pathogens. 11, 2, e1004647.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Autophagy
Myeloid Cells
Dendritic Cells
Pattern Recognition Receptors
2014
45 Citations (Scopus)

Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke

Buckley, K. M., Hess, D. L., Sazonova, I. Y., Periyasamy Thandavan, S., Barrett, J. R., Kirks, R., Grace, H., Kondrikova, G., Johnson, M. H., Hess, D. C., Schoenlein, P. V., Hoda, MD. N. & Hill, W. D., Jun 21 2014, In : Experimental and Translational Stroke Medicine. 6, 1, 8.

Research output: Contribution to journalArticle

Autophagy
Middle Cerebral Artery
Sirolimus
Ligation
Up-Regulation
2013
14 Citations (Scopus)

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Human Mammary Glands
Breast
Mouse mammary tumor virus
2012
15 Citations (Scopus)

Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER + breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim

Periyasamy Thandavan, S., Takhar, S., Singer, A., Dohn, M. R., Jackson, W. H., Welborn, A. E., LeRoith, D., Marrero, M. B., Thangaraju, M., Huang, S. & Schoenlein, P. V., Mar 19 2012, In : Breast Cancer Research. 14, 2, R52.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Estrogen Receptor Modulators
Somatomedins
Insulin-Like Growth Factor I
Apoptosis
2011
76 Citations (Scopus)

SIRT1 is essential for oncogenic signaling by estrogen/ estrogen receptor α in breast cancer

Elangovan, S., Ramachandran, S., Venkatesan, N., Ananth, S., Gnana-Prakasam, J. P., Martin, P. M., Browning, D. D., Schoenlein, P. V., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 1 2011, In : Cancer Research. 71, 21, p. 6654-6664 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Cyclin G2
Neoplasms
64 Citations (Scopus)

SLC6A14 (ATB 0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer

Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy Thandavan, S., Gurav, A., Gnana-Prakasam, J. P., Singh, N., Schoenlein, P. V., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31830-31838 9 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Estrogen Receptors
Breast Neoplasms
Cells
Pharmaceutical Preparations
2010
37 Citations (Scopus)

Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER + breast cancer cells

Periyasamy Thandavan, S., Jackson, W. H., Samaddar, J. S., Erickson, B., Barrett, J. R., Raney, L., Gopal, E., Ganapathy, V., Hill, W. D., Bhalla, K. N. & Schoenlein, P. V., Jan 1 2010, In : Autophagy. 6, 1, p. 19-35 17 p.

Research output: Contribution to journalArticle

Cathepsins
Endoplasmic Reticulum Stress
Estrogen Receptor Modulators
Autophagy
Caspases
2009
103 Citations (Scopus)

Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance

Schoenlein, P. V., Periyasamy-Thandavan, S., Samaddar, J. S., Jackson, W. H. & Barrett, J. T., Apr 1 2009, In : Autophagy. 5, 3, p. 400-403 4 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Autophagy
Estrogen Receptors
Breast Neoplasms
Tamoxifen
26 Citations (Scopus)

IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression

Yang, D., Wang, S., Brooks, C., Dong, Z., Schoenlein, P. V., Kumar, V., Ouyang, X., Xiong, H., Lahat, G., Hayes-Jordan, A., Lazar, A., Pollock, R., Lev, D. & Liu, K., Feb 1 2009, In : Cancer Research. 69, 3, p. 1080-1088 9 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Caspase 8
Sarcoma
Cell Death
Apoptosis
2008
116 Citations (Scopus)

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

Samaddar, J. S., Gaddy, V. T., Duplantier, J., Periyasamy Thandavan, S., Shah, M., Smith, M. J., Browning, D. D., Rawson, J. V., Smith, S. B., Barrett, J. T. & Schoenlein, P. V., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2977-2987 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Autophagy
Cell Death
Breast Neoplasms
Caspases
22 Citations (Scopus)

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

Kwon, I. K., Schoenlein, P. V., Delk, J., Liu, K., Thangaraju, M., Dulin, N. O., Ganapathy, V., Berger, F. G. & Browning, D. D., Apr 1 2008, In : Cancer. 112, 7, p. 1462-1470 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Colon
Carcinoma
Catenins
Neoplasms
2007
14 Citations (Scopus)
Mifepristone
Retinoblastoma Protein
Estrogen Receptor Modulators
Down-Regulation
Breast Neoplasms
66 Citations (Scopus)

Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells

Yang, D., Thangaraju, M., Greeneltch, K., Browning, D. D., Schoenlein, P. V., Tamura, T., Ozato, K., Ganapathy, V., Abrams, S. I. & Liu, K., Apr 1 2007, In : Cancer Research. 67, 7, p. 3301-3309 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Phenotype
Neoplasms
Apoptosis
DNA
2006
45 Citations (Scopus)

An anti-tumor role for cGMP-dependent protein kinase

Hou, Y., Gupta, N., Schoenlein, P., Wong, E., Martindale, R., Ganapathy, V. & Browning, D., Aug 18 2006, In : Cancer Letters. 240, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Colon
Neoplasms
Growth
Oligonucleotide Array Sequence Analysis
22 Citations (Scopus)

A role for cyclic-GMP dependent protein kinase in anoikis

Hou, Y., Wong, E., Martin, J., Schoenlein, P. V., Dostmann, W. R. & Browning, D. D., Jun 1 2006, In : Cellular Signalling. 18, 6, p. 882-888 7 p.

Research output: Contribution to journalArticle

Anoikis
Cyclic GMP-Dependent Protein Kinases
Suspensions
Apoptosis
Colon
36 Citations (Scopus)
Caspases
Cisplatin
Phosphotransferases
Apoptosis
Caspase Inhibitors
2004
43 Citations (Scopus)

Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells

Gaddy, V. T., Barrett, J. T., Delk, J. N., Kallab, A. M., Porter, A. G. & Schoenlein, P. V., Aug 1 2004, In : Clinical Cancer Research. 10, 15, p. 5215-5225 11 p.

Research output: Contribution to journalArticle

Mifepristone
Estrogen Receptor Modulators
Caspases
Estrogen Receptors
Apoptosis
34 Citations (Scopus)

Protective effects of EGCG on salivary gland cells treated with γ-radiation or cis-platinum(II) diammine dichloride

Yamamoto, T., Staples, J., Wataha, J., Lewis, J., Lockwood, P., Schoenlein, P., Rao, S., Osaki, T., Dickinson, D., Kamatani, T., Schuster, G. & Hsu, S., Sep 1 2004, In : Anticancer research. 24, 5 A, p. 3065-3073 9 p.

Research output: Contribution to journalArticle

Salivary Glands
Cisplatin
Radiation
Tea
Polyphenols
2003
70 Citations (Scopus)

Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis

Hsu, S., Lewis, J., Singh, B., Schoenlein, P. V., Osaki, T., Athar, M., Porter, A. G. & Schuster, G., Mar 1 2003, In : Anticancer Research. 23, 2 B, p. 1533-1539 7 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Caspase 3
Mitochondria
Apoptosis
33 Citations (Scopus)
Mifepristone
Estrogen Receptors
Apoptosis
Breast Neoplasms
Therapeutics
21 Citations (Scopus)
oncogenes
chromosomes
Oncogenes
Drug Resistance
genes
2001
118 Citations (Scopus)

Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine

Martin, P. M., El-sherbeny, A., Roon, P., Schoenlein, P. V., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : Experimental Eye Research. 73, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

Excitatory Amino Acids
Retinal Ganglion Cells
Homocysteine
Cell Death
Ganglia
1999
13 Citations (Scopus)
Matrix Attachment Regions
Circular DNA
Cisplatin
Chromosomes
Apoptosis
1998
56 Citations (Scopus)

Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells

El Etreby, M. F., Liang, Y., Wrenn, R. W. & Schoenlein, P. V., Dec 22 1998, In : Breast Cancer Research and Treatment. 51, 2, p. 149-168 20 p.

Research output: Contribution to journalArticle

Mifepristone
Tamoxifen
Breast Neoplasms
Down-Regulation
DNA Fragmentation
37 Citations (Scopus)

Efficient transduction of human hematopoietic cells with the human multidrug resistance gene I via SV40 pseudovirions

Rund, D., Dagan, M., Dalyot-Herman, N., Kimchi-Sarfaty, C., Schoenlein, P. V., Gottesman, M. M. & Oppenheim, A., Mar 20 1998, In : Human Gene Therapy. 9, 5, p. 649-657 9 p.

Research output: Contribution to journalArticle

MDR Genes
P-Glycoprotein
Bone Marrow Cells
Genes
Rhodamine 123
21 Citations (Scopus)

Fractionated ionizing radiation accelerates loss of amplified MDR1 genes harbored by extrachromosomal DNA in tumor cells

Sanchez, A. M., Barrett, J. T. & Schoenlein, P. V., Sep 1 1998, In : Cancer Research. 58, 17, p. 3845-3854 10 p.

Research output: Contribution to journalArticle

Circular DNA
Ionizing Radiation
DNA
KB Cells
Genes
1997
21 Citations (Scopus)

Enhanced potency of daunorubicin against multidrug resistant subline KB-Ch(R)-8-5-11 by a pulsed magnetic field

Liang, Y., Hannan, C. J., Chang, B. K. & Schoenlein, P. V., Aug 13 1997, In : Anticancer Research. 17, 3 C, p. 2083-2088 6 p.

Research output: Contribution to journalArticle

Daunorubicin
Magnetic Fields
Pharmaceutical Preparations
P-Glycoprotein
Tumor Burden
1996
12 Citations (Scopus)

MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion

Weaver, J. L., McKinney, L., Schoenlein, P. V., Goldenberg, S., Gottesman, M. M. & Aszalos, A., May 1 1996, In : American Journal of Physiology - Cell Physiology. 270, 5 39-5

Research output: Contribution to journalArticle

Rhodamine 123
P-Glycoprotein
Osmotic Pressure
Flufenamic Acid
Antibody Binding Sites
1995
16 Citations (Scopus)

Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines

Campain, J. A., Slovak, M. L., Schoenlein, P. V., Popescu, N. C., Gottesman, M. M. & Pastan, I., Nov 1 1995, In : Somatic Cell and Molecular Genetics. 21, 6, p. 451-471 21 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Chromosomes, Human, Pair 17
Aneuploidy
Etoposide
Melanoma
72 Citations (Scopus)

Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: Cross-resistance and protein changes

Shen, D. W., Akiyama, S. I., Akiyama, S. I., Schoenlein, P. V. & Gottesman, M. M., Jan 1 1995, In : British Journal of Cancer. 71, 4, p. 676-683 8 p.

Research output: Contribution to journalArticle

KB Cells
Cisplatin
Hepatocellular Carcinoma
Adenocarcinoma
Cell Line
1994
6 Citations (Scopus)

Putative “MDR enhancer” is located on human chromosome 20 and not linked to the MDRI gene on chromosome 7

Germann, U. A., Schoenlein, P. V., Zimonjic, D. B., Popescu, N. C., Pastan, I. & Gottesman, M. M., Jan 1 1994, In : Genes, Chromosomes and Cancer. 10, 4, p. 267-274 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 7
Human Chromosomes
DNA
Genes
1993
98 Citations (Scopus)

A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus

Shui Ping Wang, P. W., Sharma, P. L., Schoenlein, P. V. & Ely, B., Jan 28 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 2, p. 630-634 5 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
Organelles
Genes
Proteins
Gene Expression
24 Citations (Scopus)

Molecular cytogenetics of multiple drug resistance

Schoenlein, P. V., Feb 1 1993, In : Cytotechnology. 12, 1-3, p. 63-89 27 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Cytogenetics
Cells
Gene Amplification
Pharmaceutical Preparations
1992
55 Citations (Scopus)
KB Cells
Circular DNA
Colchicine
Human Chromosomes
Dimerization
11 Citations (Scopus)

The Caulobacter crescentus flaFG region regulates synthesis and assembly of flagellin proteins encoded by two genetically unlinked gene clusters

Schoenlein, P. V., Lui, J., Gallman, L. & Ely, B., Jan 1 1992, In : Journal of Bacteriology. 174, 19, p. 6046-6053 8 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
Flagellin
Multigene Family
Proteins
Genes
87 Citations (Scopus)

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

Mickisch, G. H., Aksentijevich, I., Schoenlein, P. V., Goldstein, L. J., Galski, H., Stahle, C., Sachs, D. H., Pastan, I. & Gottesman, M. M., Feb 26 1992, In : Blood. 79, 4, p. 1087-1093 7 p.

Research output: Contribution to journalArticle

Chemotherapy
Bone Marrow Transplantation
Transgenic Mice
Bone
Genes
1991
94 Citations (Scopus)

Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells

Weaver, J. L., Pine, P. S., Aszalos, A., Schoenlein, P. V., Currier, S. J., Padmanabhan, R. & Gottesman, M. M., Jan 1 1991, In : Experimental Cell Research. 196, 2, p. 323-329 7 p.

Research output: Contribution to journalArticle

Rhodamine 123
Daunorubicin
Confocal Microscopy
Doxorubicin
Pharmaceutical Preparations
1990
9 Citations (Scopus)

A Caulobacter gene involved in polar morphogenesis

Driks, A., Schoenlein, P. V., DeRosier, D. J., Shapiro, L. & Ely, B., Jan 1 1990, In : Journal of Bacteriology. 172, 4, p. 2113-2123 11 p.

Research output: Contribution to journalArticle

Caulobacter
Morphogenesis
Flagella
Genes
Caulobacter crescentus
14 Citations (Scopus)

Nucleotide sequence of the Caulobacter crescents flaF and flbt genes and analysis of codon usage in organisms with G+C-rich genomes

Schoenlein, P. V., Gallman, L. S., Winkler, M. E. & Ely, B., Sep 1 1990, In : Gene. 93, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Caulobacter
Codon
Caulobacter crescentus
Genome
Genes
1989
8 Citations (Scopus)
Caulobacter crescentus
Flagellin
Phenotype
Mutation
Chemotaxis
36 Citations (Scopus)

Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12

Schoenlein, P. V., Roa, B. B. & Winkler, M. E., Jan 1 1989, In : Journal of Bacteriology. 171, 11, p. 6084-6092 9 p.

Research output: Contribution to journalArticle

Escherichia coli
Pyridoxine
ribonuclease T(2)
Serum
Serine
13 Citations (Scopus)

Organization of the flaFG gene cluster and identification of two additional genes involved in flagellum biogenesis in Caulobacter crescentus

Schoenlein, P. V., Gallman, L. S. & Ely, B., Jan 1 1989, In : Journal of Bacteriology. 171, 3, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
Flagella
Multigene Family
Mutation
Genes
1988
6 Citations (Scopus)

Use of transmissible plasmids as cloning vectors in Caulobacter crescentus

Schoenlein, P. V., Gallman, L. M. & Ely, B., Oct 30 1988, In : Gene. 70, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Caulobacter crescentus
Genetic Vectors
Replicon
Plasmids
Operon
1984
5 Citations (Scopus)

Genetic and physical analyses of Caulobacter rescentus trp genes

Winkler, M. E., Schoenlein, P. V., Ross, C. M., Barrett, J. T. & Ely, B., Dec 19 1984, In : Journal of Bacteriology. 160, 1, p. 279-287 9 p.

Research output: Contribution to journalArticle

Caulobacter
Caulobacter crescentus
Genes
Pseudomonas putida
Escherichia coli
1983
1 Citation (Scopus)

Plasmids and bacteriocins in Caulobacter species

Schoenlein, P. V. & Ely, B., Jan 1 1983, In : Journal of Bacteriology. 153, 2, p. 1092-1094 3 p.

Research output: Contribution to journalArticle

Bacteriocin Plasmids
Caulobacter
Species Specificity
Bacteriocins
Plasmids
1982
9 Citations (Scopus)

Genetic mapping with Tn5-derived auxotrophs of Caulobacter crescentus

Barrett, J. T., Croft, R. H., Ferber, D. M., Gerardot, C. J., Schoenlein, P. V. & Ely, B., Nov 29 1982, In : Journal of Bacteriology. 151, 2, p. 888-898 11 p.

Research output: Contribution to journalArticle

Genetic Transduction
Genetic Conjugation
Caulobacter crescentus
Bacterial Chromosomes
Bacterial Genes
1980
6 Citations (Scopus)

Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Bryan, C. S., Parker, E., Schoenlein, P. V., Northey, J., Ely, B. & John, J. F., Jan 1 1980, In : American Journal of Infection Control. 8, 3, p. 65-71 7 p.

Research output: Contribution to journalArticle

Microbial Drug Resistance
Gentamicins
Plasmids
Serratia
Serratia marcescens