Paul M O'Connor

Associate Professor

  • 1452 Citations
  • 22 h-Index
20042019
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Research Output 2004 2019

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Article
2019

Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+/H+ exchanger-1 antagonism

Li, W., Ward, R., Dong, G., Ergul, A. & O'Connor, P., Jul 2019, In : Physiological reports. 7, 13, e14142.

Research output: Contribution to journalArticle

Open Access
Sodium-Hydrogen Antiporter
Protons
Stroke
Middle Cerebral Artery Infarction
Reactive Oxygen Species

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2 Citations (Scopus)

Voltage gated proton channels modulate mitochondrial reactive oxygen species production by complex I in renal medullary thick ascending limb

Patel, B., Zheleznova, N. N., Ray, S. C., Sun, J., Cowley, A. W. & O'Connor, P. M., Oct 2019, In : Redox Biology. 27, 101191.

Research output: Contribution to journalArticle

Open Access
Protons
Reactive Oxygen Species
Extremities
Kidney
Electric potential
2018
3 Citations (Scopus)

Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs

Lin, H. P., Singla, B., Ghoshal, P., Faulkner, J. L., Cherian-Shaw, M., O'Connor, P. M., She, J. X., Belin de Chantemele, E. J. & Csányi, G., Sep 2018, In : British Journal of Pharmacology. 175, 18, p. 3640-3655 16 p.

Research output: Contribution to journalArticle

Imipramine
United States Food and Drug Administration
Pharmaceutical Preparations
Endocytosis
Electron Scanning Microscopy
2 Citations (Scopus)

Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A. K., Zhi, W., O'Connor, P. M., Raju, R. P., Lucas, R. & Madaio, M. P., Aug 1 2018, In : Kidney International. 94, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

Nephritis
Protein Kinase C
Kidney
Protein C Inhibitor
Mitochondrial Proteins
4 Citations (Scopus)

Oral NaHCO 3 activates a splenic anti-inflammatory pathway: Evidence that cholinergic signals are transmitted via mesothelial cells

Ray, S. C., Baban, B., Tucker, M. A., Seaton, A. J., Chang, K. C., Mannon, E. C., Sun, J., Patel, B., Wilson, K., Musall, J. B., Ocasio, H., Irsik, D., Filosa, J. A., Sullivan, J. C., Marshall, B., Harris, R. A. & O'Connor, P. M., May 15 2018, In : Journal of Immunology. 200, 10, p. 3568-3586 19 p.

Research output: Contribution to journalArticle

Cholinergic Agents
Anti-Inflammatory Agents
Spleen
Esterases
Acetylcholine
5 Citations (Scopus)

Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats

Ray, S. C., Patel, B., Irsik, D. L., Sun, J., Ocasio, H., Crislip, G. R., Jin, C. H., Chen, J. K., Baban, B., Polichnowski, A. J. & O'Connor, P. M., Jun 15 2018, In : Clinical science (London, England : 1979). 132, 11, p. 1179-1197 19 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Sodium Bicarbonate
Proteinuria
Kidney
Wounds and Injuries
2017
16 Citations (Scopus)

Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis

Mas, A., Stone, L., O’Connor, P. M., Yang, Q., Kleven, D., Simon, C., Walker, C. L. & Al-Hendy, A., Mar 1 2017, In : Stem Cells. 35, 3, p. 666-678 13 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Leiomyoma
Carcinogenesis
Stem Cells
Myometrium
3 Citations (Scopus)
Pericytes
Rectum
Reperfusion
Blood Vessels
Ischemia
2016
17 Citations (Scopus)

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Endothelin-1
Reactive Oxygen Species
Kidney
Wounds and Injuries
21 Citations (Scopus)

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

Farsijani, N. M., Liu, Q., Kobayashi, H., Davidoff, O., Sha, F., Fandrey, J., Ikizler, T. A., O'Connor, P. M. & Haase, V. H., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1425-1437 13 p.

Research output: Contribution to journalArticle

Erythropoiesis
Erythropoietin
Epithelium
Kidney
Nephrons
2015
18 Citations (Scopus)

Chronic ANG II infusion induces sex-specific increases in renal T cells in Sprague-Dawley rats

Zimmerman, M. A., Baban, B., Tipton, A. J., O’Connor, P. M. & Sullivan, J. C., Jan 1 2015, In : American Journal of Physiology - Renal Physiology. 308, 7, p. F706-F712

Research output: Contribution to journalArticle

Sprague Dawley Rats
T-Lymphocytes
Kidney
Interleukin-17
7-Ala-angiotensin (1-7)
23 Citations (Scopus)

ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus

Heimlich, J. B., Speed, J. S., Bloom, C. J., O'Connor, P. M., Pollock, J. S. & Pollock, D. M., Mar 1 2015, In : Acta Physiologica. 213, 3, p. 722-730 9 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Salts
Diet
Endothelial Cells
Knockout Mice
51 Citations (Scopus)

Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension

Cowley, A. W., Abe, M., Mori, T., O’Connor, P. M., Ohsaki, Y. & Zheleznova, N. N., Jan 1 2015, In : American Journal of Physiology - Renal Physiology. 308, 3, p. F179-F197

Research output: Contribution to journalArticle

Reactive Oxygen Species
Sodium
Hypertension
Extremities
Kidney
2014
26 Citations (Scopus)

Basal renal O2 consumption and the efficiency of O2 utilization for Na+ reabsorption

Evans, R. G., Harrop, G. K., Ngo, J. P., Ow, C. P. C. & O'Connor, P. M., Mar 1 2014, In : American Journal of Physiology - Renal Physiology. 306, 5, p. F551-F560

Research output: Contribution to journalArticle

Kidney
Linear Models
Regression Analysis
Rabbits
22 Citations (Scopus)

High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism

Fellner, R. C., Cook, A. K., O'Connor, P. M., Zhang, S., Pollock, D. M. & Inscho, E. W., Jul 1 2014, In : American Journal of Physiology - Renal Physiology. 307, 1, p. F33-F40

Research output: Contribution to journalArticle

Reactive Oxygen Species
Homeostasis
Salts
Diet
Kidney
13 Citations (Scopus)

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats

Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A. & O'Connor, P. M., Sep 2014, In : Hypertension. 64, 3, p. 541-550 10 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Superoxides
Extremities
Sodium
Inbred BN Rats
2013
41 Citations (Scopus)

Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension

Pavlov, T. S., Levchenko, V., O'Connor, P. M., Ilatovskaya, D. V., Palygin, O., Mori, T., Mattson, D. L., Sorokin, A., Lombard, J. H., Cowley, A. W. & Staruschenko, A., Jun 28 2013, In : Journal of the American Society of Nephrology. 24, 7, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Salts
Hypertension
Kidney
Diet
15 Citations (Scopus)

Increased proliferative cells in the medullary thick ascending limb of the loop of henle in the dahl salt-sensitive rat

Yang, C., Stingo, F. C., Ahn, K. W., Liu, P., Vannucci, M., Laud, P. W., Skelton, M., O'Connor, P., Kurth, T., Ryan, R. P., Moreno, C., Tsaih, S. W., Patone, G., Hummel, O., Jacob, H. J., Liang, M. & Cowley, A. W., Jan 1 2013, In : Hypertension. 61, 1, p. 208-215 8 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Loop of Henle
Extremities
Salts
Diet
17 Citations (Scopus)

Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD

Jin, C., Speed, J. S., Hyndman, K. A., O'Connor, P. M. & Pollock, D. M., Oct 15 2013, In : American Journal of Physiology - Renal Physiology. 305, 8, p. F1099-F1104

Research output: Contribution to journalArticle

Endothelin A Receptors
Sex Characteristics
Endothelin-1
Area Under Curve
Natriuretic Agents
2012
82 Citations (Scopus)

Increased expression of NAD(P)H oxidase subunit p67 phox in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension

Feng, D., Yang, C., Geurts, A. M., Kurth, T., Liang, M., Lazar, J., Mattson, D. L., O'Connor, P. M. & Cowley, A. W., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Oxidative Stress
Salts
Hypertension
Kidney
28 Citations (Scopus)

Increase of sodium delivery stimulates the mitochondrial respiratory chain H 2O 2 production in rat renal medullary thick ascending limb

Ohsaki, Y., O'Connor, P., Mori, T., Ryan, R. P., Dickinson, B. C., Chang, C. J., Lu, Y., Ito, S. & Cowley, A. W., Jan 1 2012, In : American Journal of Physiology - Renal Physiology. 302, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Electron Transport
Extremities
Sodium
Kidney
Mitochondria
14 Citations (Scopus)

Medullary thick ascending limb buffer vasoconstriction of renal outer-medullary vasa recta in salt-resistant but not salt-sensitive rats

O'Connor, P. M. & Cowley, A. W., Oct 1 2012, In : Hypertension. 60, 4, p. 965-972 8 p.

Research output: Contribution to journalArticle

Vasoconstriction
Rectum
Buffers
Extremities
Salts
2011
34 Citations (Scopus)

A mathematical model of diffusional shunting of oxygen from arteries to veins in the kidney

Gardiner, B. S., Smith, D. W., O'Connor, P. M. & Evans, R. G., Jun 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 6, p. F1339-F1352

Research output: Contribution to journalArticle

Veins
Theoretical Models
Arteries
Oxygen
Kidney
31 Citations (Scopus)

Factors that render the kidney susceptible to tissue hypoxia in hypoxemia

Evans, R. G., Goddard, D., Eppel, G. A. & O'Connor, P. M., Apr 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 4, p. R931-R940

Research output: Contribution to journalArticle

Kidney
Hindlimb
Oxygen
Perfusion
Hypoxia
21 Citations (Scopus)
Oxygen Consumption
Perfusion
Kidney
Hindlimb
Angiotensin II
2010
7 Citations (Scopus)

Local maximum oxygen disappearance rate has limited utility as a measure of local renal tissue oxygen consumption

Nematbakhsh, M., Eppel, G. A., Goddard, D., O'Connor, P. M. & Evans, R. G., May 1 2010, In : Journal of Pharmacological and Toxicological Methods. 61, 3, p. 297-303 7 p.

Research output: Contribution to journalArticle

Oxygen Consumption
Tissue
Oxygen
Kidney
Rabbits
29 Citations (Scopus)

Multiple mechanisms act to maintain kidney oxygenation during renal ischemia in anesthetized rabbits

Evans, R. G., Eppel, G. A., Michaels, S., Burke, S. L., Nematbakhsh, M., Head, G. A., Carroll, J. F. & O'Connor, P. M., May 1 2010, In : American Journal of Physiology - Renal Physiology. 298, 5, p. F1235-F1243

Research output: Contribution to journalArticle

Ischemia
Rabbits
Kidney
Renal Artery
Oxygen
2009
16 Citations (Scopus)

A novel amiloride-sensitive h+ transport pathway mediates enhanced superoxide production in thick ascending limb of salt-sensitive rats, not Na+/H+ Exchange

O'Connor, P. M., Lu, L., Liang, M. & Cowley, A. W., Aug 1 2009, In : Hypertension. 54, 2, p. 248-254 7 p.

Research output: Contribution to journalArticle

Amiloride
Superoxides
Extremities
Salts
Inbred Dahl Rats
2008
17 Citations (Scopus)

Enhanced amiloride-sensitive superoxide production in renal medullary thick ascending limb of Dahl salt-sensitive rats

O'Connor, P. M., Lu, L., Schreck, C. & Cowley, A. W., Sep 1 2008, In : American Journal of Physiology - Renal Physiology. 295, 3, p. F726-F733

Research output: Contribution to journalArticle

Inbred Dahl Rats
Amiloride
Superoxides
Extremities
Inbred BN Rats
19 Citations (Scopus)

Measurement of renal tissue oxygen tension: Systematic differences between fluorescence optode and microelectrode recordings in anaesthetized rabbits

Leong, C. L., O'Connor, P. M., Eppel, G. A., Anderson, W. P. & Evans, R. G., Mar 1 2008, In : Nephron - Physiology. 108, 2

Research output: Contribution to journalArticle

Microelectrodes
Fluorescence
Oxygen
Rabbits
Kidney
2007
59 Citations (Scopus)

Enhanced superoxide production in renal outer medulla of dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk

Mori, T., O'Connor, P. M., Abe, M. & Cowley, A. W., Jun 1 2007, In : Hypertension. 49, 6, p. 1336-1341 6 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Superoxides
Blood Vessels
Nitric Oxide
Pericytes
70 Citations (Scopus)

Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation

Leong, C. L., Anderson, W. P., O'Connor, P. M. & Evans, R. G., Jun 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 6, p. F1726-F1733

Research output: Contribution to journalArticle

Renal Circulation
Oxygen
Kidney
Oxygen Consumption
Ventilation
20 Citations (Scopus)
Vasopressin Receptors
Arginine Vasopressin
Phosphatidylinositols
Vasopressins
Nitric Oxide
2006
56 Citations (Scopus)

Effect of sodium delivery on superoxide and nitric oxide in the medullary thick ascending limb

Abe, M., O'Connor, P., Kaldunski, M., Liang, M., Roman, R. J. & Cowley, A. W., Aug 4 2006, In : American Journal of Physiology - Renal Physiology. 291, 2, p. F350-F357

Research output: Contribution to journalArticle

Superoxides
Nitric Oxide
Extremities
Sodium
Hypertension
64 Citations (Scopus)

Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow

O'Connor, P. M., Kett, M. M., Anderson, W. P. & Evans, R. G., Mar 1 2006, In : American Journal of Physiology - Renal Physiology. 290, 3, p. F688-F694

Research output: Contribution to journalArticle

Perfusion
Kidney
Ischemia
Renal Circulation
Vasopressins