• 11703 Citations
  • 64 h-Index
1992 …2020

Research output per year

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Research Output

2020

Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity

Suryawanshi, A., Hussein, M. S., Prasad, P. D. & Manicassamy, S., Feb 17 2020, In : Frontiers in immunology. 11, 122.

Research output: Contribution to journalReview article

Open Access
2019

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Vitamin B3: Niacin and transcriptome analysis in relation to the GPR109A receptor

Bridges, A., Rajpurohit, P., Prasad, P. D. & Thangaraju, M., Jan 1 2019, Molecular Nutrition: Vitamins. Elsevier, p. 673-690 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Canonical wnt signaling in CD11c + APCs regulates microbiota-Induced inflammation and immune cell homeostasis in the colon

Swafford, D., Shanmugam, A., Ranganathan, P., Hussein, M. S., Koni, P. A., Prasad, P. D., Thangaraju, M. & Manicassamy, S., May 1 2018, In : Journal of Immunology. 200, 9, p. 3259-3268 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis

Ranganathan, P., Shanmugam, A. K., Swafford, D., Suryawanshi, A., Bhattacharjee, P., Hussein, M. S., Koni, P., Prasad, P. D., Kurago, Z. B., Thangaraju, M., Ganapathy, V. & Manicassamy, S., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1781-1789 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

The Relationship Between Probiotics and Dietary Fiber Consumption and Cardiovascular Health

Prasad, P. D., Gurav, A., Zhu, H., Martin, P. M., Vijay-Kumar, M. & Singh, N., Jul 13 2017, Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health. Elsevier Inc., p. 73-90 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., Jan 1 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sivaprakasam, S., Prasad, P. D. & Singh, N., Aug 1 2016, In : Pharmacology and Therapeutics. 164, p. 144-151 8 p.

Research output: Contribution to journalReview article

69 Scopus citations

Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth

Pathania, R., Ramachandran, S., Mariappan, G., Thakur, P., Shi, H., Choi, J. H., Manicassamy, S., Kolhe, R., Prasad, P. D., Sharma, S., Lokeshwar, B. L., Ganapathy, V. & Thangaraju, M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3224-3235 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Increased retinal expression of the pro-angiogenic receptor GPR91 via BMP6 in a mouse model of juvenile hemochromatosis

Arjunan, P., Gnanaprakasam, J. P., Ananth, S., Romej, M. A., Rajalakshmi, V. K., Prasad, P. D., Martin, P. M., Gurusamy, M., Thangaraju, M., Bhutia, Y. D. & Ganapathy, V., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1612-1619 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Deletion of the amino acid transporter SLC6A14 suppresses tumour growth in spontaneous mouse models of breast cancer

Babu, E., Bhutia, Y. D., Ramachandran, S., Gnana-Prakasam, J. P., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Jul 1 2015, In : Biochemical Journal. 469, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature communications. 6, 6910.

Research output: Contribution to journalArticle

112 Scopus citations
16 Scopus citations

Species-specific influence of lithium on the activity of SLC13A5 (NACT): Lithium-induced activation is specific for the transporter in primates

Gopal, E., Babu, E., Ramachandran, S., Bhutia, Y. D., Prasad, P. D. & Ganapathy, V., Apr 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., Lee, J. R., Offermanns, S. & Ganapathy, V., Jan 16 2014, In : Immunity. 40, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

667 Scopus citations

Butyrate-Mediated Protection Against Colonic Inflammation And Colon Carcinogenesis: Role Of Butyrate Transporters And Butyrate Receptors

Vadivel, G., Prasad, P. D., Thangaraju, M., Martin, P. M. & Singh, N., Apr 1 2014, Butyrate: Food Sources, Functions and Health Benefits. Nova Science Publishers, Inc., p. 157-176 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy

Bhutia, Y. D., Babu, E., Prasad, P. D. & Ganapathy, V., Dec 1 2014, In : Asian Journal of Pharmaceutical Sciences. 9, 6, p. 293-303 11 p.

Research output: Contribution to journalReview article

39 Scopus citations

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Lan, L., Singh, N., Martin, P. M., Hawthorn, L., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Feb 15 2014, In : Cancer Research. 74, 4, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

52 Scopus citations
2013

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function

Coothankandaswamy, V., Elangovan, S., Singh, N., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Feb 15 2013, In : Biochemical Journal. 450, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
108 Scopus citations
2012

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L. & Jansson, T., Mar 1 2011, In : Endocrinology. 152, 3, p. 1119-1129 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

Babu, E., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Sep 22 2011, In : Oncogene. 30, 38, p. 4026-4037 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

SIRT1 is essential for oncogenic signaling by estrogen/ estrogen receptor α in breast cancer

Elangovan, S., Ramachandran, S., Venkatesan, N., Ananth, S., Gnana-Prakasam, J. P., Martin, P. M., Browning, D. D., Schoenlein, P. V., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 1 2011, In : Cancer Research. 71, 21, p. 6654-6664 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

SLC6A14 (ATB 0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer

Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy-Thandavan, S., Gurav, A., Gnanaprakasam, J. P., Singh, N., Schoenlein, P. V., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31830-31838 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2010
100 Scopus citations

Molecular and biochemical characterization of folate transport proteins in retinal müller cells

Renee Bozard, B., Ganapathy, P. S., Duplantier, J., Mysona, B., Ha, Y., Roon, P., Smith, R., David Goldman, I., Prasad, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Jun 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells

Mazurek, M. P., Prasad, P. D., Gopal, E., Fraser, S. P., Bolt, L., Rizaner, N., Palmer, C. P., Foster, C. S., Palmieri, F., Ganapathy, V., Stühmer, W., Djamgoz, M. B. A. & Mycielska, M. E., Jun 1 2010, In : EMBO Reports. 11, 6, p. 431-437 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration

Xu, N., Bhagavath, B., Kim, H. G., Halvorson, L., Podolsky, R. S., Chorich, L. P., Prasad, P. D., Xiong, W., Cameron, R. S. & Layman, L. C., May 5 2010, In : Molecular and Cellular Endocrinology. 319, 1-2, p. 47-55 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

Miyauchi, S., Gopal, E., Babu, E., Srinivas, S. R., Kubo, Y., Umapathy, N. S., Thakkar, S. V., Ganapathy, V. & Prasad, P. D., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1164-1171 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

Thangaraju, M., Carswell, K. N., Prasad, P. D. & Ganapathy, V., Jan 1 2009, In : Biochemical Journal. 417, 1, p. 379-389 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-β-synthase mutant mouse

Ganapathy, P. S., Moister, B., Roon, P., Mysona, B. A., Duplantier, J., Dun, Y., Moister, T. K. V. E., Farley, M. J., Prasad, P. D., Liu, K. & Smith, S. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 9, p. 4460-4470 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE

Ananth, S., Karunakaran, S., Martin, P. M., Nagineni, C. N., Hooks, J. J., Smith, S. B., Prasad, P. D. & Ganapathy, V., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

244 Scopus citations

High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice

Jones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L. & Jansson, T., Jan 1 2009, In : FASEB Journal. 23, 1, p. 271-278 8 p.

Research output: Contribution to journalArticle

197 Scopus citations

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

Ganapathy, V., Thangaraju, M. & Prasad, P. D., Jan 1 2009, In : Pharmacology and Therapeutics. 121, 1, p. 29-40 12 p.

Research output: Contribution to journalReview article

442 Scopus citations

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

Roos, S., Kanai, Y., Prasad, P. D., Powell, T. L. & Jansson, T., Jan 1 2009, In : American Journal of Physiology - Cell Physiology. 296, 1

Research output: Contribution to journalArticle

93 Scopus citations

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

Thangaraju, M., Karunakaran, S. K., Itagaki, S., Gopal, E., Elangovan, S., Prasad, P. D. & Ganapathy, V., Oct 15 2009, In : Cancer. 115, 20, p. 4655-4666 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

An RPE cell line as a useful in vitro model for studying retinoic acid receptor ß :Expression and affinity

Pavan, B., Dalpiaz, A., Biondi, C., Nieddu, M., De Luca, A., Prasad, P. D., Paganetto, G. & Favaloro, B., Dec 1 2008, In : Bioscience Reports. 28, 6, p. 327-334 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter

Talukder, J. R., Kekuda, R., Saha, P., Prasad, P. D., Ganapathy, V. & Sundaram, U., Jun 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 6, p. G1301-G1310

Research output: Contribution to journalArticle

15 Scopus citations

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Karunakaran, S., Siddaramappa, U. N., Thangaraju, M., Hatanaka, T., Itagaki, S., Munn, D. H., Prasad, P. D. & Ganapathy, V., Sep 15 2008, In : Biochemical Journal. 414, 3, p. 343-355 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Sodium-coupled monocarboxylate transporters in normal tissues and in cancer

Ganapathy, V., Thangaraju, M., Gopal, E., Martin, P. M., Itagaki, S., Miyauchi, S. & Prasad, P. D., Apr 4 2008, In : AAPS Journal. 10, 1, p. 193-199 7 p.

Research output: Contribution to journalShort survey

138 Scopus citations

Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer

Thangaraju, M., Cresci, G., Itagaki, S., Mellinger, J., Browning, D. D., Berger, F. G., Prasad, P. D. & Ganapathy, V., Oct 1 2008, In : Journal of Gastrointestinal Surgery. 12, 10, p. 1773-1781 9 p.

Research output: Contribution to journalArticle

59 Scopus citations