• 11836 Citations
  • 64 h-Index
1992 …2020

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Article
2019

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway

Xia, Y., Ye, B., Ding, J., Yu, Y., Alptekin, A., Thangaraju, M., Prasad, P. D., Ding, Z. C., Park, E. J., Choi, J. H., Gao, B., Fiehn, O., Yan, C., Dong, Z., Zha, Y. & Ding, H. F., Aug 1 2019, In : Cancer Research. 79, 15, p. 3837-3850 14 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

Canonical wnt signaling in CD11c + APCs regulates microbiota-Induced inflammation and immune cell homeostasis in the colon

Swafford, D., Shanmugam, A., Ranganathan, P., Hussein, M. S., Koni, P. A., Prasad, P. D., Thangaraju, M. & Manicassamy, S., May 1 2018, In : Journal of Immunology. 200, 9, p. 3259-3268 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis

Ranganathan, P., Shanmugam, A. K., Swafford, D., Suryawanshi, A., Bhattacharjee, P., Hussein, M. S., Koni, P., Prasad, P. D., Kurago, Z. B., Thangaraju, M., Ganapathy, V. & Manicassamy, S., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1781-1789 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth

Pathania, R., Ramachandran, S., Mariappan, G., Thakur, P., Shi, H., Choi, J. H., Manicassamy, S., Kolhe, R., Prasad, P. D., Sharma, S., Lokeshwar, B. L., Ganapathy, V. & Thangaraju, M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3224-3235 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Increased retinal expression of the pro-angiogenic receptor GPR91 via BMP6 in a mouse model of juvenile hemochromatosis

Arjunan, P., Gnanaprakasam, J. P., Ananth, S., Romej, M. A., Rajalakshmi, V. K., Prasad, P. D., Martin, P. M., Gurusamy, M., Thangaraju, M., Bhutia, Y. D. & Ganapathy, V., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1612-1619 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Deletion of the amino acid transporter SLC6A14 suppresses tumour growth in spontaneous mouse models of breast cancer

Babu, E., Bhutia, Y. D., Ramachandran, S., Gnana-Prakasam, J. P., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Jul 1 2015, In : Biochemical Journal. 469, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature communications. 6, 6910.

Research output: Contribution to journalArticle

117 Scopus citations
16 Scopus citations

Species-specific influence of lithium on the activity of SLC13A5 (NACT): Lithium-induced activation is specific for the transporter in primates

Gopal, E., Babu, E., Ramachandran, S., Bhutia, Y. D., Prasad, P. D. & Ganapathy, V., Apr 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., Lee, J. R., Offermanns, S. & Ganapathy, V., Jan 16 2014, In : Immunity. 40, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

692 Scopus citations

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

1 Scopus citations

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Lan, L., Singh, N., Martin, P. M., Hawthorn, L., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Feb 15 2014, In : Cancer Research. 74, 4, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

53 Scopus citations
2013

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function

Coothankandaswamy, V., Elangovan, S., Singh, N., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Feb 15 2013, In : Biochemical Journal. 450, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L. & Jansson, T., Mar 2011, In : Endocrinology. 152, 3, p. 1119-1129 11 p.

Research output: Contribution to journalArticle

97 Scopus citations

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate

Babu, E., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Sep 22 2011, In : Oncogene. 30, 38, p. 4026-4037 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

SIRT1 is essential for oncogenic signaling by estrogen/ estrogen receptor α in breast cancer

Elangovan, S., Ramachandran, S., Venkatesan, N., Ananth, S., Gnana-Prakasam, J. P., Martin, P. M., Browning, D. D., Schoenlein, P. V., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 1 2011, In : Cancer Research. 71, 21, p. 6654-6664 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

SLC6A14 (ATB 0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer

Karunakaran, S., Ramachandran, S., Coothankandaswamy, V., Elangovan, S., Babu, E., Periyasamy-Thandavan, S., Gurav, A., Gnanaprakasam, J. P., Singh, N., Schoenlein, P. V., Prasad, P. D., Thangaraju, M. & Ganapathy, V., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31830-31838 9 p.

Research output: Contribution to journalArticle

79 Scopus citations
2010
102 Scopus citations

Molecular and biochemical characterization of folate transport proteins in retinal müller cells

Renee Bozard, B., Ganapathy, P. S., Duplantier, J., Mysona, B., Ha, Y., Roon, P., Smith, R., David Goldman, I., Prasad, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells

Mazurek, M. P., Prasad, P. D., Gopal, E., Fraser, S. P., Bolt, L., Rizaner, N., Palmer, C. P., Foster, C. S., Palmieri, F., Ganapathy, V., Stühmer, W., Djamgoz, M. B. A. & Mycielska, M. E., Jun 1 2010, In : EMBO Reports. 11, 6, p. 431-437 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration

Xu, N., Bhagavath, B., Kim, H. G., Halvorson, L., Podolsky, R. S., Chorich, L. P., Prasad, P. D., Xiong, W., Cameron, R. S. & Layman, L. C., May 5 2010, In : Molecular and Cellular Endocrinology. 319, 1-2, p. 47-55 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

Miyauchi, S., Gopal, E., Babu, E., Srinivas, S. R., Kubo, Y., Umapathy, N. S., Thakkar, S. V., Ganapathy, V. & Prasad, P. D., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1164-1171 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3

Thangaraju, M., Carswell, K. N., Prasad, P. D. & Ganapathy, V., Jan 1 2009, In : Biochemical Journal. 417, 1, p. 379-389 11 p.

Research output: Contribution to journalArticle

97 Scopus citations

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-β-synthase mutant mouse

Ganapathy, P. S., Moister, B., Roon, P., Mysona, B. A., Duplantier, J., Dun, Y., Moister, T. K. V. E., Farley, M. J., Prasad, P. D., Liu, K. & Smith, S. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 9, p. 4460-4470 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE

Ananth, S., Karunakaran, S., Martin, P. M., Nagineni, C. N., Hooks, J. J., Smith, S. B., Prasad, P. D. & Ganapathy, V., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice

Jones, H. N., Woollett, L. A., Barbour, N., Prasad, P. D., Powell, T. L. & Jansson, T., Jan 1 2009, In : FASEB Journal. 23, 1, p. 271-278 8 p.

Research output: Contribution to journalArticle

200 Scopus citations

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

Roos, S., Kanai, Y., Prasad, P. D., Powell, T. L. & Jansson, T., Jan 1 2009, In : American Journal of Physiology - Cell Physiology. 296, 1

Research output: Contribution to journalArticle

95 Scopus citations

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

Thangaraju, M., Karunakaran, S. K., Itagaki, S., Gopal, E., Elangovan, S., Prasad, P. D. & Ganapathy, V., Oct 15 2009, In : Cancer. 115, 20, p. 4655-4666 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

An RPE cell line as a useful in vitro model for studying retinoic acid receptor ß :Expression and affinity

Pavan, B., Dalpiaz, A., Biondi, C., Nieddu, M., De Luca, A., Prasad, P. D., Paganetto, G. & Favaloro, B., Dec 1 2008, In : Bioscience Reports. 28, 6, p. 327-334 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter

Talukder, J. R., Kekuda, R., Saha, P., Prasad, P. D., Ganapathy, V. & Sundaram, U., Jun 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 6, p. G1301-G1310

Research output: Contribution to journalArticle

15 Scopus citations

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Karunakaran, S., Siddaramappa, U. N., Thangaraju, M., Hatanaka, T., Itagaki, S., Munn, D. H., Prasad, P. D. & Ganapathy, V., Sep 15 2008, In : Biochemical Journal. 414, 3, p. 343-355 13 p.

Research output: Contribution to journalArticle

63 Scopus citations

Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer

Thangaraju, M., Cresci, G., Itagaki, S., Mellinger, J., Browning, D. D., Berger, F. G., Prasad, P. D. & Ganapathy, V., Oct 1 2008, In : Journal of Gastrointestinal Surgery. 12, 10, p. 1773-1781 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Stimulation of Na+/Cl-coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2

Thakkar, S. V., Miyauchi, S., Prasad, P. D. & Ganapathy, V., Jan 1 2008, In : Drug Metabolism and Pharmacokinetics. 23, 4, p. 254-262 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2007

Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport

Ericsson, A., Säljö, K., Sjöstrand, E., Jansson, N., Prasad, P. D., Powell, T. L. & Jansson, T., Jun 1 2007, In : Journal of Physiology. 581, 3, p. 1323-1332 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E., Umapathy, N. S., Martin, P. M., Ananth, S., Gnana-Prakasam, J. P., Becker, H., Wagner, C. A., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Biochimica et Biophysica Acta - Biomembranes. 1768, 11, p. 2690-2697 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
47 Scopus citations

Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids

Miyauchi, S., Gopal, E., Thakkar, S. V., Ichikawa, S., Prasad, P. D. & Ganapathy, V., Apr 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 321, 1, p. 257-264 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Srinivas, S. R., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G402-G408

Research output: Contribution to journalArticle

36 Scopus citations

Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate

Dalpiaz, A., Filosa, R., de Caprariis, P., Conte, G., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. D. & Pavan, B., May 4 2007, In : International Journal of Pharmaceutics. 336, 1, p. 133-139 7 p.

Research output: Contribution to journalArticle

62 Scopus citations
68 Scopus citations

Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2-/-) mice

Shekhawat, P. S., Srinivas, S. R., Matern, D., Bennett, M. J., Boriack, R., George, V., Xu, H., Prasad, P. D., Roon, P. & Ganapathy, V., Dec 1 2007, In : Molecular Genetics and Metabolism. 92, 4, p. 315-324 10 p.

Research output: Contribution to journalArticle

55 Scopus citations