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1973 …2019
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Research Output 1973 2019

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Article
2019

Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry

Filgueira, F. P., Lobato, N. S., Nascimento, D. L., Ceravolo, G. S., Giachini, F. R. C., Lima, V. V., Dantas, A. P., Fortes, Z. B., Webb, R. C., Tostes, R. C. & Carvalho, M. H. C., Jan 1 2019, In : Steroids. 141, p. 46-54 9 p.

Research output: Contribution to journalArticle

Equilin
Vasodilator Agents
Endothelium
Estradiol
Calcium
3 Citations (Scopus)

Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Calmasini, F. B., Mamenko, M. & Webb, R. C., Mar 1 2019, In : Pharmacological Research. 141, p. 276-290 15 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Polymerization
Actins
Arteries
Blood Vessels
2 Citations (Scopus)

Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4

Abdul, Y., Abdelsaid, M., Li, W., Webb, R. C., Sullivan, J. C., Dong, G. & Ergul, A., Mar 1 2019, In : Molecular Neurobiology. 56, 3, p. 1607-1617 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Blood Vessels
Stroke
Endothelial Cells
Iron

Interleukin-10 negatively modulates extracellular signal-regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion

Bressan, A. F., Fonseca, G. A., Tostes, R. C., Webb, R. C., Lima, V. V. & Giachini, F. R., Feb 1 2019, In : Fundamental and Clinical Pharmacology. 33, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Angiotensin II
Interleukin-10
Aorta
1 Citation (Scopus)

Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension

McCarthy, C. G., Goulopoulou, S. & Webb, R. C., Mar 1 2019, In : Hypertension. 73, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Inflammation

Targeting endothelial barrier dysfunction caused by circulating bacterial and mitochondrial n-formyl peptides with deformylase

Martinez-Quinones, P., Komic, A., McCarthy, C. G., Webb, R. C. & Wenceslau, C. F., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1270.

Research output: Contribution to journalArticle

Open Access
peptide deformylase
Systemic Inflammatory Response Syndrome
Peptides
Formyl Peptide Receptor
Sepsis

Transcriptional profiling of uterine leiomyoma rats treated by a traditional herb pair, curcumae rhizoma and sparganii rhizoma

Yu, C. H., Zhao, J. S., Zhao, H., Peng, T., Shen, D. C., Xu, Q. X., Li, Y., Webb, R. C., Wang, M. H., Shi, X. M., Peng, C. & Ding, W. J., Jan 1 2019, In : Brazilian Journal of Medical and Biological Research. 52, 6, e8132.

Research output: Contribution to journalArticle

Open Access
Leiomyoma
Rats
Microarrays
Metabolism
Gene expression
2018
5 Citations (Scopus)

Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats

Nunes, K. P., de Oliveira, A. A., Szasz, T., Biancardi, V. C. & Webb, R. C., Sep 2018, In : Journal of Sexual Medicine. 15, 9, p. 1235-1245 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Erectile Dysfunction
Cyclic GMP
Oxidative Stress
Phenylephrine

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Tomazini Gonçalves, T., Lazaro, C. M., De Mateo, F. G., Campos, M. C. B., Mezencio, J. G. B., Claudino, M. A., Carvalho, P. D. O., Webb, R. C. & Priviero, F., Jan 1 2018, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 11, p. 321-332 12 p.

Research output: Contribution to journalArticle

High Fat Diet
Blood Vessels
Body Weight
Lipids
Exercise
1 Citation (Scopus)

Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories

Zhao, H., Li, Y., Xu, Q. X., Peng, F., Zhao, J. S., Webb, R. C., Peng, C. & Yu, C. H., Jan 1 2018, In : Brazilian Journal of Medical and Biological Research. 51, 9, e7627.

Research output: Contribution to journalArticle

Chinese Traditional Medicine
Leiomyoma
Medicine
Rats
Progesterone

Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis

Komic, A., Martinez-Quinones, P., McCarthy, C. G., Webb, R. C. & Wenceslau, C. F., Jul 1 2018, In : Clinical Science. 132, 13, p. 1433-1438 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Immune System
Sepsis
Inflammation
Formyl Peptide Receptor
1 Citation (Scopus)

Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation

Wynne, B. M., Labazi, H., Lima, V. V., Carneiro, F. S., Webb, R. C., Tostes, R. C. & Giachini, F. R., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 8, p. 719-727 9 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Inbred SHR Rats
Vasodilation
Nitric Oxide
Stroke

Nitroxyl anion mediates relaxation in mesenteric arteries from angiotensin II hypertensive mice

Wynne, B. M., Labazi, H., Tostes, R. C. & Webb, R. C., Jan 1 2018, In : Current Vascular Pharmacology. 16, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Angiotensin II
Anions
Nitric Oxide
Acetylcholine

Protein kinase Cα deletion causes hypotension and decreased vascular contractility

Wynne, B. M., McCarthy, C. G., Szasz, T., Molina, P. A., Chapman, A. B., Webb, R. C., Klein, J. D. & Hoover, R. S., Mar 1 2018, In : Journal of hypertension. 36, 3, p. 510-519 10 p.

Research output: Contribution to journalArticle

Hypotension
Protein Kinase C
Arterial Pressure
Blood Vessels
Salts
4 Citations (Scopus)

Toll-like receptor 9–dependent AMPKa activation occurs via TAK1 and contributes to RhoA/ROCK signaling and actin polymerization in vascular smooth muscle cells

McCarthy, C. G., Wenceslau, C. F., Ogbi, S., Szasz, T. & Webb, R. C., Apr 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 1, p. 60-71 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Toll-Like Receptors
Vascular Smooth Muscle
Polymerization
Protein Kinases
2017
1 Citation (Scopus)

Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta

Wynne, B. M., Labazi, H., Carneiro, Z. N., Tostes, R. C. & Webb, R. C., Nov 5 2017, In : European Journal of Pharmacology. 814, p. 294-301 8 p.

Research output: Contribution to journalArticle

Endothelin-1
Anions
Blood Vessels
Aorta
Reactive Oxygen Species
5 Citations (Scopus)

Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Baban, B., Matsumoto, T. & Webb, R. C., Feb 1 2017, In : American journal of hypertension. 30, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

Chloroquine
Inbred SHR Rats
Hypertension
Mesenteric Arteries
Myeloid Differentiation Factor 88
6 Citations (Scopus)

High-salt intake augments the activity of the RhoA/ROCK pathway and reduces intracellular calcium in arteries from rats

Crestani, S., Webb, R. C. & Da Silva-Santos, J. E., Jan 1 2017, In : American journal of hypertension. 30, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Arteries
Salts
Calcium
Phenylephrine
3 Citations (Scopus)

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

Martinez-Quinones, P. A., McCarthy, C. G., Mentzer, C. J., Wenceslau, C. F., Holsten, S. B., Webb, R. C. & O'Malley, K. F., Dec 1 2017, In : Journal of Trauma and Acute Care Surgery. 83, 6, p. 1062-1065 4 p.

Research output: Contribution to journalArticle

Peritoneal Lavage
Peritoneal Cavity
Abdomen
Mitochondrial DNA
Systemic Inflammatory Response Syndrome
9 Citations (Scopus)

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

Nunes, K. P., Bomfim, G. F., Flores Toque, H. A., Szasz, T. & Webb, R. C., Dec 15 2017, In : Life sciences. 191, p. 219-226 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Angiotensin II
Nitric Oxide
Nitric Oxide Synthase
Smooth Muscle Myocytes
2016
3 Citations (Scopus)

Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S., Matsumoto, T. & Webb, R. C., Nov 1 2016, In : Pharmacological Research. 113, p. 384-394 11 p.

Research output: Contribution to journalArticle

Chloroquine
Inbred SHR Rats
Blood Pressure
Hypertension
Autoimmunity
10 Citations (Scopus)

Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats

Goulopoulou, S., Wenceslau, C. F., McCarthy, C. G., Matsumoto, T. & Webb, R. C., Apr 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 8, p. H1015-H1025

Research output: Contribution to journalArticle

Vasoconstriction
Oligonucleotides
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Mothers
Hypertension
3 Citations (Scopus)

Formyl peptide receptor activation elicits endothelial cell contraction and vascular leakage

Wenceslau, C. F., McCarthy, C. G. & Webb, R. C., Aug 2 2016, In : Frontiers in immunology. 7, AUG, 297.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Blood Vessels
Endothelial Cells
Systemic Inflammatory Response Syndrome
Sepsis
13 Citations (Scopus)

High-fat diet increases O-GlcNAc levels in cerebral arteries: Link to vascular dysfunction associated with hyperlipidaemia/obesity?

Lima, V. V., Giachini, F. R., Matsumoto, T., Li, W., Bressan, A. F. M., Chawla, D., Webb, R. C., Ergul, A. & Tostes, R. C., Jan 1 2016, In : Clinical Science. 130, 11, p. 871-880 10 p.

Research output: Contribution to journalArticle

Cerebral Arteries
High Fat Diet
Hyperlipidemias
Blood Vessels
Obesity
2 Citations (Scopus)

Impaired Ca2+ Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia

Nonato, A. O., Olivon, V. C., Dela Justina, V., Zanotto, C. Z., Webb, R. C., Tostes, R. C., Lima, V. V. & Giachini, F. R., Jun 1 2016, In : Inflammation. 39, 3, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

Endotoxemia
Vasoconstrictor Agents
Homeostasis
Mesenteric Arteries
Vascular Smooth Muscle
6 Citations (Scopus)

Impaired corpus cavernosum relaxation is accompanied by increased oxidative stress and up-regulation of the rho-kinase pathway in diabetic (db/db) mice

Priviero, F., Flores Toque, H. A., Nunes, K. P., Priolli, D. G., Teixeira, C. E. & Webb, R. C., May 1 2016, In : PloS one. 11, 5, e0156030.

Research output: Contribution to journalArticle

rho-Associated Kinases
Oxidative stress
phosphotransferases (kinases)
Oxidative Stress
oxidative stress
15 Citations (Scopus)

Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin II-infused mice

Lima, V. V., Zemse, S. M., Chiao, C. W., Bomfim, G. F., Tostes, R. C., Webb, R. C. & Giachini, F. R., Jan 15 2016, In : Life sciences. 145, p. 137-143 7 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Blood pressure
Angiotensin II
Interleukin-10
Blood Vessels
18 Citations (Scopus)

Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation

Wenceslau, C. F., Szasz, T., McCarthy, C. G., Baban, B., NeSmith, E. G. & Webb, R. C., Apr 1 2016, In : Pulmonary Pharmacology and Therapeutics. 37, p. 49-56 8 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Neutrophil Infiltration
Infiltration
Chemical activation
Systemic Inflammatory Response Syndrome
10 Citations (Scopus)

The toll of the gridiron: Damage-associated molecular patterns and hypertension in American football

McCarthy, C. G. & Webb, R. C., Jan 1 2016, In : FASEB Journal. 30, 1, p. 34-40 7 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Football
Mitochondrial DNA
Hypertension
Pattern Recognition Receptors
14 Citations (Scopus)

Toll-like receptor 4 activation contributes to diabetic bladder dysfunction in a murine model of type 1 diabetes

Szasz, T., Wenceslau, C. F., Burgess, B., Nunes, K. P. & Webb, R. C., Dec 1 2016, In : Diabetes. 65, 12, p. 3754-3764 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Type 1 Diabetes Mellitus
Urinary Bladder
Streptozocin
Knockout Mice
65 Citations (Scopus)

Toll-like receptors in the vascular system: Sensing the dangers within

Goulopoulou, S., McCarthy, C. G. & Webb, R. C., Jan 1 2016, In : Pharmacological Reviews. 68, 1, p. 142-167 26 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Blood Vessels
Ligands
Immune System
Cytokines
2015
2 Citations (Scopus)

A Toll-Like Receptor 1/2 Agonist Augments Contractility in Rat Corpus Cavernosum

Stallmann-Jorgensen, I., Ogbi, S., Szasz, T. & Webb, R. C., Aug 1 2015, In : Journal of Sexual Medicine. 12, 8, p. 1722-1731 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Toll-Like Receptor 2
Blood Vessels
Phenylephrine
rho-Associated Kinases
11 Citations (Scopus)
Penile Erection
Obese Mice
Oxidative Stress
Antioxidants
NADPH Oxidase
62 Citations (Scopus)

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S., Baban, B., Sullivan, J. C., Matsumoto, T. & Webb, R. C., Jul 1 2015, In : Cardiovascular Research. 107, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Inbred SHR Rats
Mitochondrial DNA
Blood Vessels
Blood Pressure
1 Citation (Scopus)

Emerging molecular targets for treatment of erectile dysfunction: Vascular and regenerative therapies on the horizon

Stallmann-Jorgensen, I. & Webb, R. C., May 1 2015, In : Current Drug Targets. 16, 5, p. 427-441 15 p.

Research output: Contribution to journalArticle

Erectile Dysfunction
Blood Vessels
Galanin
Heme Oxygenase-1
Phosphodiesterase Inhibitors
30 Citations (Scopus)

Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Goulopoulou, S. & Clinton Webb, R., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 7, p. 768-777 10 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Systemic Inflammatory Response Syndrome
Controlled Hypotension
Peptides
Hemorrhagic Shock
12 Citations (Scopus)

Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes

Goulopoulou, S., Hannan, J. L., Matsumoto, T., Ogbi, S., Ergul, A. & Webb, R. C., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 2, p. H297-H304

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Blood Vessels
Heme
Mesenteric Arteries
Cyclic GMP
2 Citations (Scopus)

The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Thompson, J. A., Hardigan, T. A., Carrillo-Sepulveda, M. A., Mintz, J. D., Ergul, A., Diamond, M. P. & Webb, R. C., Aug 6 2015, In : Placenta. 36, 10, p. 1204-1206 3 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Obesity
Mothers
Diet
Inflammation
34 Citations (Scopus)

Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats

Bomfim, G. F., Echem, C., Martins, C. B., Costa, T. J., Sartoretto, S. M., Dos Santos, R. A., Oliveira, M. A., Akamine, E. H., Fortes, Z. B., Tostes, R. C., Webb, R. C. & Carvalho, M. H. C., Feb 1 2015, In : Life sciences. 122, p. 1-7 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Inbred SHR Rats
Blood Vessels
Rats
Inflammation
2014
10 Citations (Scopus)

Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats

Giachini, F. R., Leite, R., Osmond, D. A., Lima, V. V., Inscho, E. W., Webb, R. C. & Tostes, R. C., Mar 17 2014, In : PloS one. 9, 3, e91890.

Research output: Contribution to journalArticle

clopidogrel
Platelets
aorta
blood vessels
Angiotensin II
10 Citations (Scopus)

Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: Implications for vascular adaptations to pregnancy

Goulopoulou, S., Hannan, J. L., Matsumoto, T., Ergul, A. & Webb, R. C., Feb 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 4, p. H610-H618

Research output: Contribution to journalArticle

Uterine Artery
Type 2 Diabetes Mellitus
Blood Vessels
Dilatation
Vascular Smooth Muscle
35 Citations (Scopus)

Endoplasmic reticulum stress contributes to aortic stiffening via proapoptotic and fibrotic signaling mechanisms

Spitler, K. M. & Webb, R. C., Mar 1 2014, In : Hypertension. 63, 3, p. e40-e45

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Tunicamycin
Angiotensin II
Apoptosis
Fibrosis
11 Citations (Scopus)

Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet

Crestani, S., Gasparotto Júnior, A., Marques, M. C. A., Sullivan, J. C., Webb, R. C. & Da Silva-Santos, J. E., Feb 1 2014, In : Vascular Pharmacology. 60, 2, p. 67-74 8 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Angiotensin II
Sodium
Diet
Arterial Pressure
8 Citations (Scopus)

Lipoxin A4 mediates aortic contraction via rhoa/rho kinase, endothelial dysfunction and reactive oxygen species

Wenceslau, C. F., Mccarthy, C. G., Szasz, T. & Webb, R. C., Mar 6 2014, In : Journal of Vascular Research. 51, 6, p. 407-417 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Reactive Oxygen Species
Aspirin
Lipoxins
Angioplasty
18 Citations (Scopus)
Vasoconstriction
Vascular Smooth Muscle
Vascular Resistance
Smooth Muscle Myocytes
Hypertension
1 Citation (Scopus)

Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain

Lima, V. V., Lobato, N. S., Filgueira, F. P., Webb, R. C., Tostes, R. C. & Giachini, F. R., Oct 1 2014, In : Brazilian Journal of Medical and Biological Research. 47, 10, p. 826-833 8 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Phosphatase
Myosin Light Chains
Myosin-Light-Chain Kinase
Blood Vessels
Phenylephrine
2013
28 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Blood Vessels
Nitrergic Neurons
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
4 Citations (Scopus)

Axonal fasciculation and the role of polysialic acid-neural cell adhesion molecule in rat cortical neurons

Wakade, C. G., Mehta, S. H., Maeda, M., Webb, R. C. & Chiu, F. C., Nov 1 2013, In : Journal of Neuroscience Research. 91, 11, p. 1408-1418 11 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Neuraminidase
Neurons
Neuronal Cell Adhesion Molecules
Brain