• 13461 Citations
  • 58 h-Index
1973 …2019
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Research Output 1973 2019

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Review article
2019

Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction

Calmasini, F. B., Klee, N., Webb, R. C. & Priviero, F., Oct 1 2019, In : Sexual Medicine Reviews. 7, 4, p. 604-613 10 p.

Research output: Contribution to journalReview article

Blood Vessels
Immune System
Inflammation
Cardiovascular Diseases
Penile Erection
1 Citation (Scopus)

Toll-like receptor 4 and blood pressure: Lessons from animal studies

Nunes, K. P., De Oliveira, A. A., Lima, V. V. & Webb, R. C., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 655.

Research output: Contribution to journalReview article

Open Access
Toll-Like Receptor 4
Immune System
Animal Models
Blood Pressure
Hypertension
2018
1 Citation (Scopus)

O-Glycosylation with O-linked β-N-acetylglucosamine increases vascular contraction: Possible modulatory role on Interleukin-10 signaling pathway

Miguez, J. S. G., Dela Justina, V., Bressan, A. F. M., Marchi, P. G. F., Honorio-França, A. C., Carneiro, F. S., Webb, R. C., Tostes, R. C., Giachini, F. R. & Lima, V. V., Sep 15 2018, In : Life sciences. 209, p. 78-84 7 p.

Research output: Contribution to journalReview article

Glycosylation
Acetylglucosamine
Interleukin-10
Blood Vessels
Phosphorylation
2017
7 Citations (Scopus)

Out of the frying pan and into the fire: Damage-Associated molecular patterns and cardiovascular toxicity following cancer therapy

Klee, N. S., McCarthy, C. G., Martinez-Quinones, P. & Webb, R. C., Nov 1 2017, In : Therapeutic Advances in Cardiovascular Disease. 11, 11, p. 297-317 21 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
Cardiovascular Diseases
Survivors
Cardiovascular Agents
2014
61 Citations (Scopus)

Mitochondrial damage-associated molecular patterns and vascular function

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Spitler, K., Goulopoulou, S. & Webb, R. C., May 7 2014, In : European Heart Journal. 35, 18, p. 1172-1177 6 p.

Research output: Contribution to journalReview article

Blood Vessels
Immune System
Cell Death
Pattern Recognition Receptors
Cardiovascular System
10 Citations (Scopus)

Therapeutic implications of peptide interactions with G-protein-coupled receptors in diabetic vasculopathy

Carrillo-Sepulveda, M. A., Matsumoto, T., Nunes, K. P. & Webb, R. C., Jan 1 2014, In : Acta Physiologica. 211, 1, p. 20-35 16 p.

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Blood Vessels
Peptides
Carrier Proteins
Therapeutics
91 Citations (Scopus)

Toll-like receptors and damage-associated molecular patterns: Novel links between inflammation and hypertension

McCarthy, C. G., Goulopoulou, S., Wenceslau, C. F., Spitler, K., Matsumoto, T. & Webb, R. C., Jan 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 2

Research output: Contribution to journalReview article

Toll-Like Receptors
Immune System
Hypertension
Inflammation
Vascular Resistance
2013
81 Citations (Scopus)

The influence of perivascular adipose tissue on vascular homeostasis.

Szasz, T., Bomfim, G. F. & Webb, R. C., Jan 1 2013, In : Unknown Journal. 9, p. 105-116 12 p.

Research output: Contribution to journalReview article

Blood Vessels
Adipose Tissue
Homeostasis
Smooth Muscle Myocytes
Cardiovascular Diseases
2012
49 Citations (Scopus)

New insights into hypertension-associated erectile dysfunction

Nunes, K. P., Labazi, H. & Webb, R. C., Mar 1 2012, In : Current opinion in nephrology and hypertension. 21, 2, p. 163-170 8 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Hypertension
Antihypertensive Agents
Quality of Life
Phosphodiesterase 5 Inhibitors
26 Citations (Scopus)

O-glcnacylation and oxidation of proteins: Is signalling in the cardiovascular system becoming sweeter?

Lima, V. V., Spitler, K., Choi, H., Webb, R. C. & Tostes, R. C., Oct 1 2012, In : Clinical Science. 123, 8, p. 473-486 14 p.

Research output: Contribution to journalReview article

Cardiovascular System
Phosphorylation
Post Translational Protein Processing
Glycosylation
Reactive Oxygen Species
2011
21 Citations (Scopus)

O-GlcNAcylation: A novel pathway contributing to the effects of endothelin in the vasculature

Lima, V. V., Giachini, F. R., Hardy, D. M., Webb, R. C. & Tostes, R. C., Feb 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300, 2

Research output: Contribution to journalReview article

Endothelins
Blood Vessels
Endothelin-1
Post Translational Protein Processing
rho-Associated Kinases
34 Citations (Scopus)

Strategies and methods to study sex differences in cardiovascular structure and function: A guide for basic scientists

Miller, V. M., Kaplan, J. R., Schork, N. J., Ouyang, P., Berga, S. L., Wenger, N. K., Shaw, L. J., Webb, R. C., Mallampalli, M., Steiner, M., Taylor, D. A., Merz, C. N. B. & Reckelhoff, J. F., Dec 1 2011, In : Biology of Sex Differences. 2, 1, 14.

Research output: Contribution to journalReview article

Sex Characteristics
Cardiovascular Diseases
Disease
animal
Essential Drugs
2010
39 Citations (Scopus)

Emerging role for TNF-α in erectile dysfunction

Carneiro, F. S., Webb, R. C. & Tostes, R. C., Jan 1 2010, In : Journal of Sexual Medicine. 7, 12, p. 3823-3834 12 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Tumor Necrosis Factor-alpha
Cytokines
Cardiovascular Diseases
Blood Vessels
25 Citations (Scopus)

Heme-dependent and independent soluble guanylate cyclase activators and vasodilation

Priviero, F. & Webb, R. C., Sep 1 2010, In : Journal of Cardiovascular Pharmacology. 56, 3, p. 229-233 5 p.

Research output: Contribution to journalReview article

Heme
Vasodilation
Nitric Oxide
Pharmaceutical Preparations
Soluble Guanylyl Cyclase
96 Citations (Scopus)

RhoA/Rho-kinase and vascular diseases: What is the link?

Nunes, K. P., Rigsby, C. S. & Webb, R. C., Nov 1 2010, In : Cellular and Molecular Life Sciences. 67, 22, p. 3823-3836 14 p.

Research output: Contribution to journalReview article

rho-Associated Kinases
Vascular Diseases
Smooth Muscle
Protein Isoforms
Calcium
2009
2 Citations (Scopus)

Diacylglycerol kinase inhibition and vascular function

Choi, H., Allahdadi, K. J., Tostes, R. C. A. & Webb, R. C., Oct 21 2009, In : Current Enzyme Inhibition. 5, 3, p. 148-152 5 p.

Research output: Contribution to journalReview article

Diacylglycerol Kinase
Blood Vessels
Phosphatidic Acids
Diglycerides
Protein Isoforms
30 Citations (Scopus)

Female sexual dysfunction: Therapeutic options and experimental challenges

Allahdadi, K. J., Tostes, R. C. A. & Webb, R. C., Oct 1 2009, In : Cardiovascular and Hematological Agents in Medicinal Chemistry. 7, 4, p. 260-269 10 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Therapeutics
Orgasm
Lubrication
Phosphodiesterase 5 Inhibitors
25 Citations (Scopus)

O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension

Lima, V. V., Rigsby, C. S., Hardy, D. M., Webb, R. C. & Tostes, R. C., Nov 1 2009, In : Journal of the American Society of Hypertension. 3, 6, p. 374-387 14 p.

Research output: Contribution to journalReview article

Post Translational Protein Processing
Blood Vessels
Hypertension
Health
Proteins
84 Citations (Scopus)

Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1

Wynne, B. M., Chiao, C. W. & Webb, R. C., Mar 1 2009, In : Journal of the American Society of Hypertension. 3, 2, p. 84-95 12 p.

Research output: Contribution to journalReview article

Endothelin-1
Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Diglycerides
2008
58 Citations (Scopus)

Cigarette smoking and erectile dysfunction: Focus on NO bioavailability and ROS generation

Tostes, R. C., Carneiro, F. S., Lee, A. J., Giachini, F. R. C., Leite, R., Osawa, Y. & Webb, R. C., Jan 1 2008, In : Journal of Sexual Medicine. 5, 6, p. 1284-1295 12 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Biological Availability
Reactive Oxygen Species
Nitric Oxide
Smoking
47 Citations (Scopus)

Endothelin, sex and hypertension

Tostes, R. C., Fortes, Z. B., Callera, G. E., Montezano, A. C., Touyz, R. M., Webb, R. C. & Carvalho, M. H. C., Jan 1 2008, In : Clinical Science. 114, 1-2, p. 85-97 13 p.

Research output: Contribution to journalReview article

Endothelins
Endothelin-1
Hypertension
Sex Characteristics
Endothelin-2
14 Citations (Scopus)

Therapeutic targets in hypertension: Is there a place for antagonists of the most potent vasoconstrictors?

Giachini, F. R. C., Callera, G. E., Carneiro, F. S., Tostes, R. C. & Webb, R. C., Mar 1 2008, In : Expert Opinion on Therapeutic Targets. 12, 3, p. 327-339 13 p.

Research output: Contribution to journalReview article

Vasoconstrictor Agents
Endothelin-1
Hypertension
Blood Vessels
Therapeutics
2007
26 Citations (Scopus)

Neurophysiological basis of penile erection

Priviero, F., Leite, R., Webb, R. C. & Teixeira, C. E., Jun 1 2007, In : Acta Pharmacologica Sinica. 28, 6, p. 751-755 5 p.

Research output: Contribution to journalReview article

Penile Erection
Nitric Oxide
Erectile Dysfunction
Pharmacology
Cyclic GMP
20 Citations (Scopus)

Targets for the treatment of erectile dysfunction: Is NO/cGMP still the answer?

Leite, R., Giachini, F. R. C., Carneiro, F. S., Nunes, K. P., Tostes, R. C. & Webb, R. C., Jun 1 2007, In : Recent Patents on Cardiovascular Drug Discovery. 2, 2, p. 119-132 14 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Nitric Oxide
Investigational Therapies
Patents
Cyclic GMP
2005
14 Citations (Scopus)

Rho-kinase and RGS-containing RhoGEFs as molecular targets for the treatment of erectile dysfunction

Linder, A. E., Webb, R. C., Mills, T. M., Ying, Z., Lewis, R. W. & Teixeira, C. E., Dec 1 2005, In : Current Pharmaceutical Design. 11, 31, p. 4029-4040 12 p.

Research output: Contribution to journalReview article

Rho Guanine Nucleotide Exchange Factors
rho-Associated Kinases
Erectile Dysfunction
Smooth Muscle
Myosin-Light-Chain Phosphatase
4 Citations (Scopus)

Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension

Teixeira, C. E. & Webb, R. C., Oct 31 2005, In : Drug Discovery Today: Therapeutic Strategies. 2, 3, p. 193-199 7 p.

Research output: Contribution to journalReview article

rho-Associated Kinases
Blood Vessels
Hypertension
Muscle Contraction
Vascular Smooth Muscle
2003
7 Citations (Scopus)

Inhibition of the tonic contraction in the treatment of erectile dysfunction

Jin, L., Linder, A. E., Mills, T. M. & Webb, R. C., Apr 1 2003, In : Expert Opinion on Therapeutic Targets. 7, 2, p. 265-276 12 p.

Research output: Contribution to journalReview article

rho-Associated Kinases
Erectile Dysfunction
Vasoconstrictor Agents
Penile Erection
Vasodilator Agents
2001
215 Citations (Scopus)

Angiotensin receptors: Signaling, vascular pathophysiology, and interactions with ceramide

Berry, C., Touyz, R., Dominiczak, A. F., Webb, R. C. & Johns, D. G., Dec 1 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 6 50-6

Research output: Contribution to journalReview article

Angiotensin Receptors
Ceramides
Angiotensin II
Blood Vessels
Renin-Angiotensin System
2000
25 Citations (Scopus)

Novel signaling pathways contributing to vascular changes in hypertension

Johns, D. G., Dorrance, A. M., Leite, R., Weber, D. S. & Webb, R. C., Jan 1 2000, In : Journal of Biomedical Science. 7, 6, p. 431-443 13 p.

Research output: Contribution to journalReview article

Vascular Resistance
Cell signaling
Blood Vessels
Hypertension
Vasoconstriction
1998
69 Citations (Scopus)

Does nitric oxide regulate smooth muscle cell proliferation? A critical appraisal

Sarkar, R. & Webb, R. C., May 1 1998, In : Journal of Vascular Research. 35, 3, p. 135-142 8 p.

Research output: Contribution to journalReview article

Smooth Muscle Myocytes
Nitric Oxide
Cell Proliferation
Blood Vessels
Hyperplasia
1992
24 Citations (Scopus)

Oscillatory contractions in vertebral arteries from hypertensive subjects

Webb, R. C., Schreur, K. D. & Papadopoulos, S. M., Jan 1 1992, In : Clinical Physiology. 12, 1, p. 69-77 9 p.

Research output: Contribution to journalReview article

Vertebral Artery
Arteries
Tail
Endothelins
Nitroglycerin
1988
52 Citations (Scopus)

Effects of lead on vascular reactivity

Chai, S. & Webb, R. C., Jan 1 1988, In : Environmental Health Perspectives. 78, p. 85-89 5 p.

Research output: Contribution to journalReview article

Blood Vessels
Protein Kinase C
Hypertension
Blood Pressure
Calcium
89 Citations (Scopus)

Vascular smooth muscle membrane in hypertension

Bohr, D. F. & Webb, R. C., Jan 1 1988, In : Annual Review of Pharmacology and Toxicology. 28, p. 389-409 21 p.

Research output: Contribution to journalReview article

Cell membranes
Ion Channels
Vascular Smooth Muscle
Muscle
Animals
1986
6 Citations (Scopus)

Calcium and vascular smooth muscle membrane in hypertension.

Furspan, P. B., Lamb, F. S., Ross, P. V., Webb, R. C. & Bohr, D. F., Jan 1 1986, In : Progress in Clinical and Biological Research. 219, p. 225-243 19 p.

Research output: Contribution to journalReview article

Vascular Smooth Muscle
Hypertension
Calcium
Membranes
Permeability
1984
5 Citations (Scopus)

Serotonin and vasodilatation.

Mecca, T. E. & Webb, R. C., Dec 1 1984, In : Bibliotheca cardiologica. 38, p. 81-90 10 p.

Research output: Contribution to journalReview article

Adrenergic Fibers
Muscle Relaxation
Serotonin Receptors
Vascular Smooth Muscle
Vasodilation
77 Citations (Scopus)

Vascular smooth muscle function and its changes in hypertension

Bohr, D. F. & Webb, R. C., Jan 1 1984, In : American Journal of Medicine. 77, 4 A, p. 3-16 14 p.

Research output: Contribution to journalReview article

Vascular Smooth Muscle
Hypertension
Calcium
Cell Membrane
Muscle Contraction
1981
340 Citations (Scopus)

Local modulation of adrenergic neuroeffector interaction in the blood vessel well.

Vanhoutte, P. M., Verbeuren, T. J. & Webb, R. C., Jan 1 1981, In : Physiological reviews. 61, 1, p. 151-247 97 p.

Research output: Contribution to journalReview article

Neuroeffector Junction
Neural Inhibition
Adrenergic Fibers
Vasoconstriction
Vascular Smooth Muscle
1980
34 Citations (Scopus)

Pre- and post-junctional adrenergic mechanisms and hypertension

Vanhoutte, P. M., Webb, R. C. & Collis, M. G., Dec 1 1980, In : Clinical Science. 59, SUPPL.6

Research output: Contribution to journalReview article

Sodium-Potassium-Exchanging ATPase
Nerve Endings
Sympathetic Nervous System
Exocytosis
Tyrosine 3-Monooxygenase