Franklin Chi Meng Tay

Department Chair

  • 34301 Citations
  • 95 h-Index
1984 …2019
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Research Output 1984 2019

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Article
2019
1 Citation (Scopus)

A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation

Sun, Q., Zhang, B., Zhu, W., Wei, W., Ma, J. & Tay, F. C. M., Mar 2019, In : Journal of Dentistry. 82, p. 91-97 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Osteoporosis
MafB Transcription Factor
Computational Biology
1 Citation (Scopus)

Bimodal antibacterial system based on quaternary ammonium silane-coupled core-shell hollow mesoporous silica

Bai, Y. M., Mao, J., Li, D. X., Luo, X. J., Chen, J., Tay, F. C. M. & Niu, L. N., Feb 1 2019, In : Acta biomaterialia. 85, p. 229-240 12 p.

Research output: Contribution to journalArticle

Silanes
Metronidazole
Ammonium Compounds
Silicon Dioxide
Antibiotics

Carbodiimide inactivation of matrix metalloproteinases in radicular dentine

Comba, A., Scotti, N., Mazzoni, A., Maravic, T., Ribeiro Cunha, S., Michelotto Tempesta, R., Carossa, M., Pashley, D. H., Tay, F. C. M. & Breschi, L., Mar 1 2019, In : Journal of Dentistry. 82, p. 56-62 7 p.

Research output: Contribution to journalArticle

Carbodiimides
Dentin
Matrix Metalloproteinases
Ethyldimethylaminopropyl Carbodiimide
Artificial Saliva
2 Citations (Scopus)

Chitosan-Based Extrafibrillar Demineralization for Dentin Bonding

Gu, L. S., Cai, X., Guo, J. M., Pashley, D. H., Breschi, L., Xu, H. H. K., Wang, X. Y., Tay, F. C. M. & Niu, L. N., Feb 1 2019, In : Journal of Dental Research. 98, 2, p. 186-193 8 p.

Research output: Contribution to journalArticle

Chitosan
Dentin
Minerals
Collagen
Analysis of Variance
2 Citations (Scopus)

Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization

Song, Q., Jiao, K., Tonggu, L., Wang, L. G., Zhang, S. L., Yang, Y. D., Zhang, L., Bian, J. H., Hao, D. X., Wang, C. Y., Ma, Y. X., Arola, D. D., Breschi, L., Chen, J. H., Tay, F. C. M. & Niu, L. N., Mar 29 2019, In : Science Advances. 5, 3, eaav9075.

Research output: Contribution to journalArticle

Open Access
biomimetics
collagens
ligands
interactions
calcification

Effect of benzalkonium chloride on dentin bond strength and endogenous enzymatic activity

Comba, A., Maravic, T., Valente, L., Girlando, M., Cunha, S. R., Checchi, V., Salgarello, S., Tay, F. R., Scotti, N., Breschi, L. & Mazzoni, A., Jun 2019, In : Journal of Dentistry. 85, p. 25-32 8 p.

Research output: Contribution to journalArticle

Benzalkonium Compounds
Dentin
Adhesives
Methacrylates
Gelatin
1 Citation (Scopus)

Evaluation of several instrumentation techniques and irrigation methods on the percentage of untouched canal wall and accumulated dentine debris in C-shaped canals

Zhao, Y., Fan, W., Xu, T., Tay, F. C. M., Gutmann, J. L. & Fan, B., Jan 1 2019, In : International Endodontic Journal. 52, 9, p. 1354-1365 12 p.

Research output: Contribution to journalArticle

Dentin
Syringes
Ultrasonics
Needles
Switzerland

Isocyanate-terminated urethane-based dental adhesive bridges dentinal matrix collagen with adhesive resin

Xu, R., Yu, F., Huang, L., Zhou, W., Wang, Y., Wang, F., Sun, X., Chang, G., Fang, M., Zhang, L., Li, F., Tay, F. C. M., Niu, L. & Chen, J., Jan 1 2019, In : Acta biomaterialia. 83, p. 140-152 13 p.

Research output: Contribution to journalArticle

Dental Cements
Isocyanates
Methacrylates
Urethane
Collagen

Management of Large Radicular Lesions Using Decompression: A Case Series and Review of the Literature

Tian, F., Bergeron, B. E., Kalathingal, S. M., Morris, M., Wang, X. Y., Niu, L. N. & Tay, F. C. M., May 1 2019, In : Journal of Endodontics. 45, 5, p. 651-659 9 p.

Research output: Contribution to journalArticle

Decompression
Needles
Dental Pulp Cavity
Gutta-Percha
Endodontics

Micro–computed Tomographic Evaluation of the Prevalence, Distribution, and Morphologic Features of Accessory Canals in Chinese Permanent Teeth

Xu, T., Fan, W., Tay, F. C. M. & Fan, B., Aug 1 2019, In : Journal of Endodontics. 45, 8, p. 994-999 6 p.

Research output: Contribution to journalArticle

Tooth
Dental Pulp Cavity
Bicuspid
Population
Incidence
3 Citations (Scopus)

MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery

Guo, J., Sun, H., Lei, W., Tang, Y., Hong, S., Yang, H., Tay, F. C. M. & Huang, C., May 1 2019, In : Journal of Dental Research. 98, 5, p. 564-571 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 8
Hydrogel
Pharmaceutical Preparations
Drug Delivery Systems
Mouth Diseases
1 Citation (Scopus)

Novel bioactive root canal sealer with antibiofilm and remineralization properties

Baras, B. H., Wang, S., Melo, M. A. S., Tay, F. C. M., Fouad, A. F., Arola, D. D., Weir, M. D. & Xu, H. H. K., Apr 1 2019, In : Journal of Dentistry. 83, p. 67-76 10 p.

Research output: Contribution to journalArticle

Methacrylates
Dental Pulp Cavity
Biofilms
Nanoparticles
Endodontics
1 Citation (Scopus)

Novel multifunctional nanocomposite for root caries restorations to inhibit periodontitis-related pathogens

Xiao, S., Wang, H., Liang, K., Tay, F. C. M., Weir, M. D., Melo, M. A. S., Wang, L., Wu, Y., Oates, T. W., Ding, Y. & Xu, H. H. K., Feb 1 2019, In : Journal of Dentistry. 81, p. 17-26 10 p.

Research output: Contribution to journalArticle

Root Caries
Nanocomposites
Methacrylates
Periodontitis
Biofilms

Poly(amido amine) and rechargeable adhesive containing calcium phosphate nanoparticles for long-term dentin remineralization

Liang, K., Gao, Y., Xiao, S., Tay, F. C. M., Weir, M. D., Zhou, X., Oates, T. W., Zhou, C., Li, J. & Xu, H. H. K., Jun 1 2019, In : Journal of Dentistry. 85, p. 47-56 10 p.

Research output: Contribution to journalArticle

Dentin
Adhesives
Nanoparticles
Amines
Ions

Polymer conjugation optimizes EDTA as a calcium-chelating agent that exclusively removes extrafibrillar minerals from mineralized collagen

Guo, J. M., Makvandi, P., Wei, C. C., Chen, J. H., Xu, H. K., Breschi, L., Pashley, D. H., Huang, C., Niu, L. N. & Tay, F. C. M., May 2019, In : Acta biomaterialia. 90, p. 424-440 17 p.

Research output: Contribution to journalArticle

Ethylenediaminetetraacetic acid
Dentin
Chelation
Glycols
Chitosan
1 Citation (Scopus)

Protection against HeMA-induced mitochondrial injury in vitro by Nrf2 activation

Jiao, Y., Niu, T., Liu, H., Tay, F. C. M. & Chen, J. H., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 3501059.

Research output: Contribution to journalArticle

Open Access
Chemical activation
Synthetic Resins
Wounds and Injuries
Explosive well stimulation
Nuclear Respiratory Factor 1

Self-healing adhesive with antibacterial activity in water-aging for 12 months

Wu, J., Zhou, C., Ruan, J., Weir, M. D., Tay, F. C. M., Sun, J., Melo, M. A. S., Oates, T. W., Chang, X. & Xu, H. H. K., Aug 1 2019, In : Dental Materials. 35, 8, p. 1104-1116 13 p.

Research output: Contribution to journalArticle

Adhesives
Methacrylates
Dentin
Aging of materials
Calcium phosphate
2 Citations (Scopus)

Surface treatments on titanium implants via nanostructured ceria for antibacterial and anti-inflammatory capabilities

Li, X., Qi, M., Sun, X., Weir, M. D., Tay, F. C. M., Oates, T. W., Dong, B., Zhou, Y., Wang, L. & Xu, H. H. K., Aug 1 2019, In : Acta biomaterialia. 94, p. 627-643 17 p.

Research output: Contribution to journalArticle

Cerium compounds
Titanium
Surface treatment
Anti-Inflammatory Agents
Peri-Implantitis
1 Citation (Scopus)

The effect of food medium on the wear behaviour of veneering porcelain: An in vitro study using the three-body abrasion mode

Zhang, H., Sun, Y., Guo, J., Meng, M., He, L., Tay, F. C. M. & Zhang, S., Apr 1 2019, In : Journal of Dentistry. 83, p. 87-94 8 p.

Research output: Contribution to journalArticle

Dental Porcelain
Food
Apium graveolens
Metals
Mastication
1 Citation (Scopus)

Topical application of phenytoin or nifedipine-loaded PLGA microspheres promotes periodontal regeneration in vivo

Zhao, X. H., Tay, F. C. M., Fang, Y. J., Meng, L. Y. & Bian, Z., Jan 1 2019, In : Archives of Oral Biology. 97, p. 42-51 10 p.

Research output: Contribution to journalArticle

glycolic acid
Phenytoin
Nifedipine
Microspheres
Regeneration

Vital pulp therapy: histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure

Ricucci, D., Siqueira, J. F., Li, Y. & Tay, F. C. M., Jul 1 2019, In : Journal of Dentistry. 86, p. 41-52 12 p.

Research output: Contribution to journalArticle

Tooth
Guidelines
Dentin
Pulpotomy
Therapeutics
2018

Air entrapment in demineralized dentin adversely affects bonding

Li, Y., Fang, M., Yu, F., Niu, L., Tay, F. C. M. & Chen, J., Jan 1 2018, In : Journal of Adhesive Dentistry. 20, 3, p. 249-259 11 p.

Research output: Contribution to journalArticle

Dentin
Air
Pressure
Adhesives
Control Groups
7 Citations (Scopus)

Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles

Liu, Y., Zhang, L., Niu, L. N., Yu, T., Xu, H. H. K., Weir, M. D., Oates, T. W., Tay, F. C. M. & Chen, J. H., May 1 2018, In : Journal of Dentistry. 72, p. 53-63 11 p.

Research output: Contribution to journalArticle

Dental Cements
Dental Enamel
Ammonium Compounds
Adhesives
Nanoparticles
2 Citations (Scopus)

Antibacterial efficacy of an endodontic sonic-powered irrigation system: An in vitro study

Zeng, C., Willison, J., Meghil, M. M., Bergeron, B. E., Cutler, C. W., Tay, F. R., Niu, L. & Ma, J., Aug 2018, In : Journal of Dentistry. 75, p. 105-112 8 p.

Research output: Contribution to journalArticle

Endodontics
Syringes
Tooth
Needles
Bacteria
2 Citations (Scopus)

Anti-biofilm efficacy of root canal irrigants against in-situ Enterococcus faecalis biofilms in root canals, isthmuses and dentinal tubules

Ye, W. H., Fan, B., Purcell, W., Meghil, M. M., Cutler, C. W., Bergeron, B. E., Ma, J. Z., Tay, F. R. & Niu, L. N., Dec 2018, In : Journal of Dentistry. 79, p. 68-76 9 p.

Research output: Contribution to journalArticle

Root Canal Irrigants
Enterococcus faecalis
Dental Pulp Cavity
Biofilms
Bacteria
2 Citations (Scopus)

Antimicrobial efficacy of an apical negative pressure root canal irrigation system against intracanal microorganisms

Zeng, C., Meghil, M. M., Miller, M., Gou, Y., Cutler, C. W., Bergeron, B. E., Niu, L., Ma, J. & Tay, F. R., May 2018, In : Journal of Dentistry. 72, p. 71-75 5 p.

Research output: Contribution to journalArticle

Dental Pulp Cavity
Pressure
Tooth
Stem Cells
Periapical Periodontitis
2 Citations (Scopus)

Association between bruxism and symptomatic gastroesophageal reflux disease: A case-control study

Li, Y., Yu, F., Niu, L., Long, Y., Tay, F. C. M. & Chen, J., Oct 1 2018, In : Journal of Dentistry. 77, p. 51-58 8 p.

Research output: Contribution to journalArticle

Bruxism
Gastroesophageal Reflux
Case-Control Studies
Odds Ratio
Confidence Intervals

Biochemical and immunohistochemical identification of MMP-7 in human dentin

Mazzoni, A., Maravić, T., Tezvergil-Mutluay, A., Tjäderhane, L., Scaffa, P. M. C., Seseogullari-Dirihan, R., Bavelloni, A., Gobbi, P., Pashley, D. H., Tay, F. C. M. & Breschi, L., Dec 1 2018, In : Journal of Dentistry. 79, p. 90-95 6 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 7
Dentin
Matrix Metalloproteinases
Microspheres
Immunoassay
4 Citations (Scopus)
Dentin
Tooth
Dental Pulp Capping
Odontoblasts
Connective Tissue
1 Citation (Scopus)

Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum

Pei, D. D., Sun, J. L., Zhu, C. H., Tian, F., Jiao, K., Anderson, M. R., Yiu, C., Huang, C., Jin, C. X., Bergeron, B. E., Chen, J. H., Tay, F. C. M. & Niu, L. N., Oct 1 2018, In : Advanced Science. 5, 10, 1800873.

Research output: Contribution to journalArticle

Mitochondrial Degradation
calcium phosphates
Calcium phosphate
Mitochondria
mitochondria
6 Citations (Scopus)

Cross-linking effect on dentin bond strength and MMPs activity

Mazzoni, A., Angeloni, V., Comba, A., Maravic, T., Cadenaro, M., Tezvergil-Mutluay, A., Pashley, D. H., Tay, F. C. M. & Breschi, L., Feb 1 2018, In : Dental Materials. 34, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Dentin
Matrix Metalloproteinases
Adhesives
Gelatinases
Aging of materials
1 Citation (Scopus)

Effect of simulated intraosseous sinusoidal pressure on NaOCl extrusion

Cai, X., Wang, X. Y., Santarcangelo, F., Schoeffel, G. J., Bergeron, B. E., Tay, F. C. M. & Niu, L. N., Nov 1 2018, In : Journal of Dentistry. 78, p. 46-50 5 p.

Research output: Contribution to journalArticle

Pressure
Needles
Atmospheric Pressure
Dental Pulp Cavity
Analysis of Variance
1 Citation (Scopus)

Experimental use of an acrolein-based primer as collagen cross-linker for dentine bonding

Maravic, T., Breschi, L., Comba, A., Cunha, S. R., Angeloni, V., Nucci, C., Hebling, J., Pashley, D., Tay, F. & Mazzoni, A., Jan 2018, In : Journal of Dentistry. 68, p. 85-90 6 p.

Research output: Contribution to journalArticle

Acrolein
Dentin
Collagen
Matrix Metalloproteinases
Adhesives
1 Citation (Scopus)

Hollow mesoporous zirconia delivery system for biomineralization precursors

Huang, X. Q., Yang, H. Y., Luo, T., Huang, C., Tay, F. C. M. & Niu, L. N., Feb 1 2018, In : Acta biomaterialia. 67, p. 366-377 12 p.

Research output: Contribution to journalArticle

Nanocapsules
Biomineralization
Tissue Engineering
Zirconia
Bone
1 Citation (Scopus)

Intrafibrillar silicified collagen scaffold promotes in-situ bone regeneration by activating the monocyte p38 signaling pathway

Sun, J. L., Jiao, K., Song, Q., Ma, C. F., Ma, C., Tay, F. C. M., Niu, L. N. & Chen, J. H., Feb 1 2018, In : Acta biomaterialia. 67, p. 354-365 12 p.

Research output: Contribution to journalArticle

Bone Regeneration
Scaffolds (biology)
Collagen
Scaffolds
Monocytes
1 Citation (Scopus)

Mechanism of bioactive molecular extraction from mineralized dentin by calcium hydroxide and tricalcium silicate cement

Huang, X. Q., Camba, J., Gu, L. S., Bergeron, B. E., Ricucci, D., Pashley, D. H., Tay, F. C. M. & Niu, L. N., Feb 1 2018, In : Dental Materials. 34, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

Silicate Cement
Calcium Hydroxide
Hydrated lime
Dentin
Collagen
3 Citations (Scopus)

Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities

Gou, Y. P., Meghil, M. M., Pucci, C. R., Breschi, L., Pashley, D. H., Cutler, C. W., Niu, L. N., Li, J. Y. & Tay, F. C. M., Jul 15 2018, In : Acta biomaterialia. 75, p. 171-182 12 p.

Research output: Contribution to journalArticle

Dentin
Silanes
Adhesives
Ammonium Compounds
Resins
5 Citations (Scopus)

Protein-repelling adhesive resin containing calcium phosphate nanoparticles with repeated ion-recharge and re-releases

al-Qarni, F. D., Tay, F. C. M., Weir, M. D., Melo, M. A. S., Sun, J., Oates, T. W., Xie, X. & Xu, H. H. K., Nov 1 2018, In : Journal of Dentistry. 78, p. 91-99 9 p.

Research output: Contribution to journalArticle

Phosphorylcholine
Adhesives
Nanoparticles
Ions
Biofilms
4 Citations (Scopus)

Quaternary ammonium silane-based antibacterial and anti-proteolytic cavity cleanser

Gou, Y. P., Li, J. Y., Meghil, M. M., Cutler, C. W., Xu, H. H. K., Tay, F. C. M. & Niu, L. N., Dec 1 2018, In : Dental Materials. 34, 12, p. 1814-1827 14 p.

Research output: Contribution to journalArticle

Silanes
Ammonium Compounds
Dentin
Control Groups
Permeability
3 Citations (Scopus)

Release of ICTP and CTX telopeptides from demineralized dentin matrices: Effect of time, mass and surface area

Turco, G., Cadenaro, M., Maravić, T., Frassetto, A., Marsich, E., Mazzoni, A., Di Lenarda, R., Tay, F. R., Pashley, D. H. & Breschi, L., Mar 1 2018, In : Dental Materials. 34, 3, p. 452-459 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Collagen
Aging of materials
Artificial Saliva
Dentin
5 Citations (Scopus)

Synergistic mechanism of Ag+-Zn2+ in anti-bacterial activity against Enterococcus faecalis and its application against dentin infection

Fan, W., Sun, Q., Li, Y., Tay, F. C. M. & Fan, B., Jan 31 2018, In : Journal of Nanobiotechnology. 16, 1, 10.

Research output: Contribution to journalArticle

Enterococcus faecalis
Biofilms
Dentin
Cytotoxicity
Chlorhexidine
2 Citations (Scopus)

Water-associated attributes in the contemporary dentin bonding milieu

Pucci, C. R., Gu, L. S., Zhang, H. Y., Song, Q., Xia, V. W., Davis, L. B., de Souza Andrade, D., Mazzoni, A., Breschi, L., Pashley, D. H., Tay, F. R. & Niu, L. N., Jul 2018, In : Journal of Dentistry. 74, p. 79-89 11 p.

Research output: Contribution to journalArticle

Dentin
Adhesives
Water
Tooth
Benchmarking
6 Citations (Scopus)

Zymography of Hybrid Layers Created Using Extrafibrillar Demineralization

Gu, L., Mazzoni, A., Gou, Y., Pucci, C., Breschi, L., Pashley, D. H., Niu, L. & Tay, F. R., Apr 1 2018, In : Journal of Dental Research. 97, 4, p. 409-415 7 p.

Research output: Contribution to journalArticle

Dentin
carbopol 940
Fluorescence
Gelatin
Fluorescein
2017
5 Citations (Scopus)

Biodegradable mesoporous delivery system for biomineralization precursors

Yang, H. Y., Niu, L. N., Sun, J. L., Huang, X. Q., Pei, D. D., Huang, C. & Tay, F. C. M., Jan 25 2017, In : International journal of nanomedicine. 12, p. 839-854 16 p.

Research output: Contribution to journalArticle

Biomineralization
Calcium phosphate
Nanoparticles
Silicon Dioxide
Bone
8 Citations (Scopus)

Chemical affinity of 10-methacryloyloxydecyl dihydrogen phosphate to dental zirconia: Effects of molecular structure and solvents

Chen, Y., Lu, Z., Qian, M., Zhang, H., Chen, C., Xie, H. & Tay, F. C. M., Dec 2017, In : Dental Materials. 33, 12, p. e415-e427

Research output: Contribution to journalArticle

Molecular Structure
Zirconia
Molecular structure
Tooth
Phosphates
52 Citations (Scopus)

Collagen intrafibrillar mineralization as a result of the balance between osmotic equilibrium and electroneutrality

Niu, L. N., Jee, S. E., Jiao, K., Tonggu, L., Li, M., Wang, L., Yang, Y. D., Bian, J. H., Breschi, L., Jang, S. S., Chen, J. H., Pashley, D. H. & Tay, F. C. M., Mar 1 2017, In : Nature Materials. 16, 3, p. 370-378 9 p.

Research output: Contribution to journalArticle

collagens
Collagen
Polyelectrolytes
Biomimetic processes
Fibrillar Collagens
9 Citations (Scopus)

Effect of a novel quaternary ammonium silane cavity disinfectant on durability of resin–dentine bond

Daood, D., Yiu, C. K. Y., Burrow, M. F., Niu, L. N. & Tay, F. C. M., May 1 2017, In : Journal of Dentistry. 60, p. 77-86 10 p.

Research output: Contribution to journalArticle

Silanes
Disinfectants
Ammonium Compounds
Adhesives
Chlorhexidine
15 Citations (Scopus)

Effect of a novel quaternary ammonium silane on dentin protease activities

Umer, D., Yiu, C. K. Y., Burrow, M. F., Niu, L. N. & Tay, F. C. M., Mar 1 2017, In : Journal of Dentistry. 58, p. 19-27 9 p.

Research output: Contribution to journalArticle

Silanes
Dentin
Ammonium Compounds
Peptide Hydrolases
Cathepsin K
5 Citations (Scopus)

Effect of a one-step self-etch adhesive on endogenous dentin matrix metalloproteinases

Apolonio, F. M., Mazzoni, A., Angeloni, V., Scaffa, P. M. C., Santi, S., Saboia, V. D. P. A., Tay, F. C. M., Pashley, D. H. & Breschi, L., Apr 1 2017, In : European Journal of Oral Sciences. 125, 2, p. 168-172 5 p.

Research output: Contribution to journalArticle

Dentin
Matrix Metalloproteinases
Adhesives
Enzyme Assays
Collagen

Effect of Canal Anastomosis on Periapical Fluid Pressure Build-up during Needle Irrigation in Single Roots with Double Canals using a Polycarbonate Model

Huang, Q., Barnes, J. B., Schoeffel, G. J., Fan, B., Tay, C., Bergeron, B. E., Ferreira Susin, L., Ling, J. Q., Niu, L. N. & Tay, F. C. M., Dec 1 2017, In : Scientific Reports. 7, 1, 1582.

Research output: Contribution to journalArticle

Canals
Polycarbonates
Irrigation
Needles
Fluids