• 15990 Citations
  • 61 h-Index
1963 …2020

Research output per year

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Research Output

2003

Role of tumor-associated gangliosides in cancer progression

Birklé, S., Zeng, G., Gao, L., Yu, R. K. & Aubry, J., Jan 1 2003, In : Biochimie. 85, 3-4, p. 455-463 9 p.

Research output: Contribution to journalReview article

176 Scopus citations
8 Scopus citations

Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: Functional role of GC-box and CRE

Tencomnao, T., Kapitonov, D., Bieberich, E. & Yu, R. K., Dec 1 2003, In : Glycoconjugate Journal. 20, 5, p. 339-351 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2002

Age-dependent reduction in sialidase activity of nuclear membranes from mouse brain

Saito, M., Hagita, H., Ito, M., Ando, S. & Yu, R. K., Jul 2 2002, In : Experimental Gerontology. 37, 7, p. 937-941 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Differential effects of three inhibitors of glycosphingolipid biosynthesis on neuronal differentiation of embryonal carcinoma stem cells

Liour, S. S. & Yu, R. K., Nov 1 2002, In : Neurochemical Research. 27, 11, p. 1507-1512 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Novel ceramide analogs are new anti-cancer drugs

Bieberich, E., Hu, B., Silva, J., MacKinnon, S., Yu, R. K. & Ottenbrite, R. M., 2002, In : American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 43, 2, p. 756-757 2 p.

Research output: Contribution to journalConference article

1 Scopus citations

Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases

Bieberich, E., MacKinnon, S., Silva, J., Li, D. D., Tencomnao, T., Irwin, L., Kapitonov, D. & Yu, R. K., Sep 24 2002, In : Biochemistry. 41, 38, p. 11479-11487 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

Bieberich, E., Hu, B., Silva, J., MacKinnon, S., Yu, R. K., Fillmore, H., Broaddus, W. C. & Ottenbrite, R. M., Jul 8 2002, In : Cancer Letters. 181, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed

Zeng, G., Gao, L., Suetake, K., Joshi, R. M. & Yu, R. K., Apr 8 2002, In : Cancer Letters. 178, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2001

Characterization of a phospholipid antigen reacting with serum antibody in patients with peripheral neuropathies and paraproteinemia

Suzuki, M., Suetake, K., Kasama, T., Ariga, T., Shiina, M., Kusunoki, S. & Yu, R. K., 2001, In : Journal of Neurochemistry. 79, 5, p. 970-975 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Characterization of the human UDP-galactose: Ceramide galactosyltransferase gene promoter

Tencomnao, T., Yu, R. K. & Kapitonov, D., Feb 16 2001, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1517, 3, p. 416-423 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells

Ren, S., Kambe, N., Du, Z., Li, Y., Xia, H. Z., Kambe, M., Bieberich, E., Pozez, A., Grimes, M., Yu, R. K., Irani, A. M. & Schwartz, L. B., 2001, In : Journal of Allergy and Clinical Immunology. 107, 2, p. 322-330 9 p., 38953.

Research output: Contribution to journalArticle

7 Scopus citations

Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID

Liour, S. S., Jones, M. Z., Suzuki, M., Bieberich, E. & Yu, R. K., Jan 1 2001, In : Molecular Genetics and Metabolism. 72, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Recent studies on the roles of antiglycosphingolipids in the pathogenesis of neurological disorders

Ariga, T., Miyatake, T. & Yu, R. K., Sep 1 2001, In : Journal of Neuroscience Research. 65, 5, p. 363-370 8 p.

Research output: Contribution to journalShort survey

29 Scopus citations

Regulation of Apoptosis during Neuronal Differentiation by Ceramide and b-Series Complex Gangliosides

Bieberich, E., MacKinnon, S., Silva, J. & Yu, R. K., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44396-44404 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Regulation of glycosyltransferases in ganglioside biosynthesis by phosphorylation and dephosphorylation

Yu, R. K. & Bieberich, E., May 25 2001, In : Molecular and Cellular Endocrinology. 177, 1-2, p. 19-24 6 p.

Research output: Contribution to journalReview article

14 Scopus citations
2000
40 Scopus citations

Effect of N-glycosylation on turnover and subcellular distribution of N- acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells

Bieberich, E., Tencomnao, T., Kapitonov, D. & Yu, R. K., Jun 5 2000, In : Journal of Neurochemistry. 74, 6, p. 2359-2364 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Expression of gangliosides in neuronal development of P19 embryonal carcinoma stem cells

Liour, S. S., Kapitonov, D. & Yu, R. K., Nov 1 2000, In : Journal of Neuroscience Research. 62, 3, p. 363-373 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Ganglioside analysis by high-performance thin-layer chromatography

Yu, R. K. & Ariga, T., 2000, In : Methods in Enzymology. 312, p. 115-134 20 p.

Research output: Contribution to journalArticle

37 Scopus citations

Glycosphingolipid composition of a new immortalized human cerebromicrovascular endothelial cell line

Duvar, S., Suzuki, M., Muruganandam, A. & Yu, R. K., Jan 1 2000, In : Journal of Neurochemistry. 75, 5, p. 1970-1976 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mammalian ganglioside sialidases: Preparation and activity assays

Bieberich, E., Liour, S. S. & Yu, R. K., 2000, In : Methods in Enzymology. 312, p. 339-358 20 p.

Research output: Contribution to journalArticle

7 Scopus citations

N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells

Bieberich, E., Kawaguchi, T. & Yu, R. K., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 177-181 5 p.

Research output: Contribution to journalArticle

80 Scopus citations

Protein-ribosome-mRNA display: Affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single-tube reaction

Bieberich, E., Kapitonov, D., Tencomnao, T. & Yu, R. K., Dec 15 2000, In : Analytical Biochemistry. 287, 2, p. 294-298 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
46 Scopus citations

Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production

Zeng, G., Gao, L., Birkle, S. & Yu, R. K., Dec 1 2000, In : Cancer Research. 60, 23, p. 6670-6676 7 p.

Research output: Contribution to journalArticle

87 Scopus citations
1999

Alteration of ganglioside composition by stable transfection with antisense vectors against GD3-synthase gene expression

Zeng, G., Li, D. D., Gao, L., Birklé, S., Bieberich, E., Tokuda, A. & Yu, R. K., Jul 6 1999, In : Biochemistry. 38, 27, p. 8762-8769 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Combinatorial PCR approach to homology-based cloning: Cloning and expression of mouse and human GM3-synthase

Kapitonov, D., Bieberich, E. & Yu, R. K., Nov 25 1999, In : Glycoconjugate Journal. 16, 7, p. 337-350 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Conserved domains of glycosyltransferases

Kapitonov, D. & Yu, R. K., Oct 1 1999, In : Glycobiology. 9, 10, p. 961-978 18 p.

Research output: Contribution to journalArticle

134 Scopus citations

Differential effects of glycolipid biosynthesis inhibitors on ceramide- induced cell death in neuroblastoma cells

Bieberich, E., Freischütz, B., Suzuki, M. & Yu, R. K., Feb 24 1999, In : Journal of Neurochemistry. 72, 3, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Down-regulation of the expression of O-acetyl-GD3 by the O- acetylesterase cDNA in hamster melanoma cells: Effects on cellular proliferation, differentiation, and melanogenesis

Birklé, S., Ren, S., Slominski, A., Zeng, G., Gao, L. & Yu, R. K., 1999, In : Journal of Neurochemistry. 72, 3, p. 954-961 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

GM1 inhibits amyloid β-protein-induced cytokine release

Ariga, T. & Yu, R. K., Feb 13 1999, In : Neurochemical Research. 24, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Molecular cloning and expression of mouse brain sialidase

Fronda, C. L., Zeng, G., Gao, L. & Yu, R. K., May 19 1999, In : Biochemical and Biophysical Research Communications. 258, 3, p. 727-731 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Multi-enzyme kinetic analysis of glycolipid biosynthesis

Bieberich, E. & Yu, R. K., Jun 15 1999, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1432, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Myelinated dorsal root ganglion cultures activate both the alternative and classical pathways of complement

Scott-Zaki, P., Purkall, D., Bigbee, J., Ruddy, S. & Yu, R. K., Jun 1 1999, In : Journal of the Neurological Sciences. 165, 2, p. 160-169 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
1998

Antiglycolipid antibodies in motor neuropathies

Baumann, N., Harpin, M. L., Marie, Y., Lemerle, K., Chassande, B., Bouche, P., Meininger, V., Yu, R. K. & Léger, J. M., 1998, In : Annals of the New York Academy of Sciences. 845, p. 322-329 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cloning of promoter for rat GD3-synthase gene

Gao, L., Zeng, G. & Yu, R. K., Jan 1 1998, In : Annals of the New York Academy of Sciences. 845, 1 p.

Research output: Contribution to journalArticle

Developmental expression of rat brain GD3-and GT3-synthases

Zeng, G., Gao, L., Freischütz, B., Tokuda, A. & Yu, R. K., Jan 1 1998, In : Annals of the New York Academy of Sciences. 845, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

GM1 ganglioside inhibits amyloid β-protein induced-cytokine release

Ariga, T. & Yu, R. K., Jan 1 1998, In : Annals of the New York Academy of Sciences. 845, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Heterogeneity of antibody specificity in Taiwanese patients with polyneuropathy and IgM paraproteinemia

Lin, K. P., Tsai, C. P., Yamawaki, M., Ariga, T. & Yu, R. K., Jan 1 1998, In : Journal of Biomedical Science. 5, 6, p. 441-445 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation and functional analysis of the promoter of the rat CMP-NeuAc:GM3 α 2,8 sialyltransferase gene

Zeng, G., Gao, L. & Yu, R. K., Apr 27 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1397, 2, p. 126-130 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

On the specificity of anti-sulfoglucuronosyl glycolipid antibodies

Tokuda, A., Ariga, T., Isogai, Y., Komba, S., Kiso, M., Hasegawa, A., Tai, T. & Yu, R. K., Jan 1 1998, In : Journal of Carbohydrate Chemistry. 17, 4-5, p. 535-546 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Permanent alteration of endogenous gangliosides in neuroblastoma cells by stable transfection with antisense vector

Zeng, G., Gao, L., Li, D. D., Tokuda, A. & Yu, R. K., Jan 1 1998, In : Annals of the New York Academy of Sciences. 845, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regulation of ganglioside metabolism by phosphorylation and dephosphorylation

Bieberich, E., Freischütz, B., Liour, S. S. & Yu, R. K., Sep 1998, In : Journal of Neurochemistry. 71, 3, p. 972-979 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Role of sphingolipid-mediated cell death in neurodegenerative diseases

Ariga, T., Jarvis, W. D. & Yu, R. K., Jan 1 1998, In : Journal of Lipid Research. 39, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

156 Scopus citations

Sulfoglucuronosyl glycolipids as putative antigens for autoimmune inner ear disease

Yamawaki, M., Ariga, T., Gao, Y., Tokuda, A., Yu, J. S., Sismanis, A. & Yu, R. K., Apr 15 1998, In : Journal of Neuroimmunology. 84, 2, p. 111-116 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The role of globo-series glycolipids in neuronal cell differentiation - A Review

Ariga, T. & Yu, R. K., Mar 24 1998, In : Neurochemical Research. 23, 3, p. 291-303 13 p.

Research output: Contribution to journalReview article

13 Scopus citations

The role of glycosphinglipids in neurological disorders - Mechanisms of immune action

Yu, R. K. & Ariga, T., 1998, In : Annals of the New York Academy of Sciences. 845, p. 285-306 22 p.

Research output: Contribution to journalArticle

35 Scopus citations
1997

Antibodies to glycosphingolipid antigens in patients with immune-mediated cochleovestibular disorders

Lake, G. M., Sismanis, A., Ariga, T., Yamawaki, M., Gao, Y. & Yu, R. K., Mar 1 1997, In : American Journal of Otology. 18, 2, p. 175-178 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA

Kapitonov, D. & Yu, R. K., Mar 17 1997, In : Biochemical and Biophysical Research Communications. 232, 2, p. 449-453 5 p.

Research output: Contribution to journalArticle

22 Scopus citations