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Research Output 1963 2019

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Article
2019
Open Access
Intraventricular Infusions
Adult Stem Cells
Neural Stem Cells
Gangliosides
Brain
2016
2 Citations (Scopus)

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Käkelä, R., Jul 1 2016, In : Neurochemical Research. 41, 7, p. 1527-1544 18 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Rats
Spinal Cord
Stem Cells
Cells
1 Citation (Scopus)

Anti-Sulfoglucuronosyl Paragloboside Antibody: A Potential Serologic Marker of Amyotrophic Lateral Sclerosis

Li, D., Usuki, S., Quarles, B., Rivner, M. H., Ariga, T. & Yu, R. K., Sep 1 2016, In : ASN Neuro. 8, 5

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Antibodies
Motor Neurons
Serum
sulfate-3-glucuronyl paragloboside
23 Citations (Scopus)

Dietary isomers of sialyllactose increase ganglioside sialic acid concentrations in the corpus callosum and cerebellum and modulate the colonic microbiota of formula-fed piglets

Jacobi, S. K., Yatsunenko, T., Li, D., Dasgupta, S., Yu, R. K., Berg, B. M., Chichlowski, M. & Odle, J., Jan 1 2016, In : Journal of Nutrition. 146, 2, p. 200-208 9 p.

Research output: Contribution to journalArticle

Corpus Callosum
Gangliosides
Microbiota
N-Acetylneuraminic Acid
Cerebellum
13 Citations (Scopus)

GM1 ganglioside is involved in epigenetic activation loci of neuronal cells

Tsai, Y. T., Itokazu, Y. & Yu, R. K., Oct 24 2016, In : Neurochemical Research. 41, 1-2, p. 107-115 9 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Epigenomics
Histones
Gangliosides
Genes
2015
5 Citations (Scopus)

Ganglioside-dependent neural stem cell proliferation in alzheimer’s disease model mice

Koon, N. A., Itokazu, Y. & Yu, R. K., Nov 9 2015, In : ASN Neuro. 7, 6

Research output: Contribution to journalArticle

Neural Stem Cells
Gangliosides
Alzheimer Disease
Cell Proliferation
Glycoconjugates
7 Citations (Scopus)

Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro

Yu, R. K., Usuki, S., Itokazu, Y. & Wu, H. C., Jun 11 2015, In : Glycobiology. 26, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Cholera Toxin
Epithelial Cells
Peptides
Vibrio cholerae
2014
16 Citations (Scopus)
Fucosyltransferases
Neural Stem Cells
Amyloid
Up-Regulation
Peptides
3 Citations (Scopus)

A new approach to ELISA-based anti-glycolipid antibody evaluation of highly adhesive serum samples

Usuki, S., O'Brien, D., Rivner, M. H. & Yu, R. K., Jun 2014, In : Journal of Immunological Methods. 408, p. 52-63 12 p.

Research output: Contribution to journalArticle

Glycolipids
Adhesives
Anti-Idiotypic Antibodies
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Glycosphingolipids
21 Citations (Scopus)

Epigenetic activation of mouse ganglioside synthase genes: Implications for neurogenesis

Tsai, Y. T. & Yu, R. K., Jan 1 2014, In : Journal of Neurochemistry. 128, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Gangliosides
Neurogenesis
Glycosyltransferases
Epigenomics
Gene encoding
28 Citations (Scopus)

Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain

Wang, J., Cheng, A., Wakade, C. & Yu, R. K., Oct 8 2014, In : Journal of Neuroscience. 34, 41, p. 13790-13800 11 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Neurogenesis
Gangliosides
Knockout Mice
Brain

Glycolipid and glycoprotein expression during neural development

Yu, R. K. & Itokazu, Y., 2014, In : Advances in neurobiology. 9, p. 185-222 38 p.

Research output: Contribution to journalArticle

Neural Tube
Neural Crest
Glycolipids
Neurology
Glycoproteins
2013
36 Citations (Scopus)

Antibodies to heteromeric glycolipid complexes in guillain-barré syndrome

Rinaldi, S., Brennan, K. M., Kalna, G., Walgaard, C., Van Doorn, P., Jacobs, B. C., Yu, R. K., Mansson, J. E., Goodyear, C. S. & Willison, H. J., Dec 16 2013, In : PloS one. 8, 12, e82337.

Research output: Contribution to journalArticle

glycolipids
Glycolipids
gangliosides
Gangliosides
Electrophysiology
43 Citations (Scopus)

Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy

Galban-Horcajo, F., Fitzpatrick, A. M., Hutton, A. J., Dunn, S. M., Kalna, G., Brennan, K. M., Rinaldi, S., Yu, R. K., Goodyear, C. S. & Willison, H. J., Jan 1 2013, In : European Journal of Neurology. 20, 1, p. 62-70 9 p.

Research output: Contribution to journalArticle

Glycolipids
Enzyme-Linked Immunosorbent Assay
Antibodies
Anti-Idiotypic Antibodies
Analysis of Variance
7 Citations (Scopus)

Anti-Chol-1 Antigen, GQ1bα, Antibodies Are Associated with Alzheimer's Disease

Ariga, T., Kubota, M., Nakane, M., Oguro, K., Yu, R. K. & Ando, S., May 23 2013, In : PloS one. 8, 5, e63326.

Research output: Contribution to journalArticle

Alzheimer disease
Anti-Idiotypic Antibodies
Alzheimer Disease
antigens
dementia
15 Citations (Scopus)

Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: Expression of elevated levels of a cholinergic-specific ganglioside, GT1aα

Ariga, T., Itokazu, Y., McDonald, M. P., Hirabayashi, Y., Ando, S. & Yu, R. K., Aug 7 2013, In : ASN Neuro. 5, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

Gangliosides
Cholinergic Agents
Transgenic Mice
Alzheimer Disease
Brain
10 Citations (Scopus)

Effects of amyloid β-peptides and gangliosides on mouse neural stem cells

Itokazu, Y., Kato-Negishi, M., Nakatani, Y., Ariga, T. & Yu, R. K., Oct 1 2013, In : Neurochemical Research. 38, 10, p. 2019-2027 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Gangliosides
Stem cells
Amyloid
Peptides
52 Citations (Scopus)
Neural Stem Cells
Epidermal Growth Factor Receptor
Neurogenesis
Endocytosis
GD3 ganglioside
17 Citations (Scopus)

O-acetylated n-acetylneuraminic acid as a novel target for therapy in human pre-b acute lymphoblastic leukemia

Parameswaran, R., Lim, M., Arutyunyan, A., Abdel-Azim, H., Hurtz, C., Lau, K., Müschen, M., Yu, R. K., von Itzstein, M., Heisterkamp, N. & Groffen, J., Jun 25 2013, In : Journal of Experimental Medicine. 210, 4, p. 805-819 15 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acids
Acetylesterase
Esterases
Therapeutics
2012
35 Citations (Scopus)

Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the notch signaling pathway

Yagi, H., Saito, T., Yanagisawa, M., Yu, R. K. & Kato, K., Jul 13 2012, In : Journal of Biological Chemistry. 287, 29, p. 24356-24364 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Polysaccharides
Brain
Maintenance
6 Citations (Scopus)

Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein

Usuki, S., Kamitani, T., Matsuo, Y. & Yu, R. K., Jun 1 2012, In : Neurochemical Research. 37, 6, p. 1261-1266 6 p.

Research output: Contribution to journalArticle

Synucleins
Glucosides
Cytotoxicity
Agglomeration
Amyotrophic Lateral Sclerosis
2011
31 Citations (Scopus)

Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells

Yanagisawa, M., Yoshimura, S. & Yu, R. K., Apr 7 2011, In : ASN Neuro. 3, 2

Research output: Contribution to journalArticle

Neural Stem Cells
Gangliosides
CD15 Antigens
Proteoglycans
Methanol
45 Citations (Scopus)

Genome-wide target profiling of piggyBac and Tol2 in HEK 293: Pros and cons for gene discovery and gene therapy

Meir, Y. J. J., Weirauch, M. T., Yang, H. S., Chung, P. C., Yu, R. K. & Wu, S. C. Y., Mar 30 2011, In : BMC Biotechnology. 11, 28.

Research output: Contribution to journalArticle

Transposases
Genetic Association Studies
Genetic Therapy
Genome
DNA Transposable Elements
31 Citations (Scopus)

Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development

Suzuki, Y., Yanagisawa, M., Ariga, T. & Yu, R. K., Mar 1 2011, In : Journal of Neurochemistry. 116, 5, p. 874-880 7 p.

Research output: Contribution to journalArticle

Acetylation
Glycosyltransferases
Gene expression
Gangliosides
Histones
15 Citations (Scopus)

IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes

Usuki, S., Tsai, Y. Y., Morikawa, K., Nonaka, S., Okuhara, Y., Kise, M. & Yu, R. K., Dec 14 2011, In : PloS one. 6, 12, e28693.

Research output: Contribution to journalArticle

Oxidative stress
Experimental Diabetes Mellitus
brown rice
streptozotocin
Glucosides
6 Citations (Scopus)

Sulfoglucuronosyl paragloboside promotes endothelial cell apoptosis in inflammation: Elucidation of a novel glycosphingolipid-signaling pathway

Dasgupta, S., Wang, G. & Yu, R. K., Nov 1 2011, In : Journal of Neurochemistry. 119, 4, p. 749-759 11 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Endothelial cells
Endothelial Cells
Apoptosis
Inflammation
2010
48 Citations (Scopus)

Characterization of GD3 ganglioside as a novel biomarker of mouse neural stem cells

Nakatani, Y., Yanagisawa, M., Suzuki, Y. & Yu, R. K., Jan 1 2010, In : Glycobiology. 20, 1, p. 78-86 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Biomarkers
Stem cells
Brain
GD3 ganglioside

Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells.

Yanagisawa, M., Ariga, T. & Yu, R. K., Dec 1 2010, In : ASN Neuro. 2, 1

Research output: Contribution to journalArticle

Neuroepithelial Cells
G(M1) Ganglioside
Neural Stem Cells
Amyloid
Peptides
12 Citations (Scopus)

Cytotoxic effects of GM1 ganglioside and amyloid β-peptide on mouse embryonic neural stem cells

Yanagisawa, M., Ariga, T. & Yu, R. K., 2010, In : ASN Neuro. 2, 1, p. 49-56 8 p., e00029.

Research output: Contribution to journalArticle

Neuroepithelial Cells
G(M1) Ganglioside
Neural Stem Cells
Amyloid
Peptides
10 Citations (Scopus)

Development of a novel therapy for Lipo-oligosaccharide-induced experimental neuritis: Use of peptide glycomimics

Usuki, S., Taguchi, K., Gu, Y. H., Thompson, S. A. & Yu, R. K., Apr 1 2010, In : Journal of Neurochemistry. 113, 2, p. 351-362 12 p.

Research output: Contribution to journalArticle

Neuritis
Oligosaccharides
Rats
Gangliosides
Peptides
25 Citations (Scopus)

Ganglioside metabolism in a transgenic mouse model of alzheimer's disease: Expression of chol-1α antigens in the brain

Ariga, T., Yanagisawa, M., Wakade, C., Ando, S., Buccafusco, J. J., McDonald, M. P. & Yu, R. K., Oct 29 2010, In : ASN Neuro. 2, 4, p. 233-241 9 p.

Research output: Contribution to journalArticle

Gangliosides
Transgenic Mice
Alzheimer Disease
Brain
Cholinergic Neurons
40 Citations (Scopus)

HNK-1 epitope-carrying tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells

Yagi, H., Yanagisawa, M., Suzuki, Y., Nakatani, Y., Ariga, T., Kato, K. & Yu, R. K., Nov 26 2010, In : Journal of Biological Chemistry. 285, 48, p. 37293-37301 9 p.

Research output: Contribution to journalArticle

Tenascin
Neural Stem Cells
Stem cells
Epitopes
Neurology
24 Citations (Scopus)

Involvement of β1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells

Suzuki, Y., Yanagisawa, M., Yagi, H., Nakatani, Y. & Yu, R. K., Jun 11 2010, In : Journal of Biological Chemistry. 285, 24, p. 18443-18451 9 p.

Research output: Contribution to journalArticle

Neuroepithelial Cells
Fibroblast Growth Factor 2
Epidermal Growth Factor
Integrins
Up-Regulation
15 Citations (Scopus)

Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in mouse neural stem cells

Yagi, H., Yanagisawa, M., Kato, K. & Yu, R. K., Mar 31 2010, In : Glycobiology. 20, 8, p. 976-981 6 p., cwq054.

Research output: Contribution to journalArticle

CD15 Antigens
Lysosome-Associated Membrane Glycoproteins
Neural Stem Cells
Stem cells
Carrier Proteins
17 Citations (Scopus)

Novel anti-idiotype antibody therapy for lipooligosaccharide-induced experimental autoimmune neuritis: Use relevant to Guillain-Barré syndrome

Usuki, S., Taguchi, K., Thompson, S. A., Chapman, P. B. & Yu, R. K., Jun 1 2010, In : Journal of Neuroscience Research. 88, 8, p. 1651-1663 13 p.

Research output: Contribution to journalArticle

Experimental Autoimmune Neuritis
Anti-Idiotypic Antibodies
Gangliosides
Antibodies
Campylobacter jejuni
2009
14 Citations (Scopus)

Cav2.1 voltage-dependent Ca 2+ channel current is inhibited by serum from select patients with guillain-barré syndrome

Nakatani, Y., Hotta, S., Utsunomiya, I., Tanaka, K., Hoshi, K., Ariga, T., Yu, R. K., Miyatake, T. & Taguchi, K., Jan 1 2009, In : Neurochemical Research. 34, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

Calcium Channels
Purkinje Cells
Electric potential
Serum
Guillain-Barre Syndrome
72 Citations (Scopus)

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

Bernardo, A., Harrison, F. E., McCord, M., Zhao, J., Bruchey, A., Davies, S. S., Jackson Roberts, L., Mathews, P. M., Matsuoka, Y., Ariga, T., Yu, R. K., Thompson, R. & McDonald, M. P., Nov 1 2009, In : Neurobiology of Aging. 30, 11, p. 1777-1791 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Transgenic Mice
Gangliosides
Amyloid
Astrocytes
36 Citations (Scopus)
Trehalose
Neural Stem Cells
Huntington Disease
Eating
Transplantation
9 Citations (Scopus)

N-Glycans modulate the activation of gp130 in mouse embryonic neural precursor cells

Yanagisawa, M. & Yu, R. K., Aug 14 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

Neuroepithelial Cells
Glycosylation
Polysaccharides
OSM-LIF Receptors
Chemical activation
24 Citations (Scopus)

O-linked β-N-acetylglucosaminylation in mouse embryonic neural precursor cells

Yanagisawa, M. & Yu, R. K., Dec 1 2009, In : Journal of Neuroscience Research. 87, 16, p. 3535-3545 11 p.

Research output: Contribution to journalArticle

Neuroepithelial Cells
Neural Stem Cells
Cell Death
Phosphatidylinositol 3-Kinase
Sp1 Transcription Factor
6 Citations (Scopus)
Cell Adhesion
Ligands
T-Lymphocytes
Small Interfering RNA
Transferases
2008
12 Citations (Scopus)

Glycosphingolipid antigens in neural tumor cell lines and anti-glycosphingolipid antibodies in sera of patients with neural tumors

Ariga, T., Suetake, K., Nakane, M., Kubota, M., Usuki, S., Kawashima, I. & Yu, R. K., Feb 1 2008, In : NeuroSignals. 16, 2-3, p. 226-234 9 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Tumor Cell Line
Anti-Idiotypic Antibodies
Antigens
Subependymal Glioma
1 Citation (Scopus)

Identification and analysis of novel functional sites in human GD3-synthase

Gu, Y. & Yu, R. K., May 23 2008, In : Biochemical and Biophysical Research Communications. 370, 1, p. 67-71 5 p.

Research output: Contribution to journalArticle

Sialyltransferases
Vertebrates
Proteins
Molecular modeling
Gangliosides
5 Citations (Scopus)

Identification of gangliosides recognized by IgG anti-GalNAc-GD1a antibodies in bovine spinal motor neurons and motor nerves

Yoshino, H., Ariga, T., Suzuki, A., Yu, R. K. & Miyatake, T., Aug 28 2008, In : Brain Research. 1227, p. 216-220 5 p.

Research output: Contribution to journalArticle

Gangliosides
Motor Neurons
Immunoglobulin G
Antibodies
Thin Layer Chromatography

Introduction to thematic series on sphingolipids in honor of Professor Herbert E. Carter (1910-2007)

Law, J. H. & Yu, R. K., May 1 2008, In : Journal of Lipid Research. 49, 5, p. 907-908 2 p.

Research output: Contribution to journalArticle

Sphingolipids
25 Citations (Scopus)

Structural analysis of novel bioactive acylated steryl glucosides in pre-germinated brown rice bran

Usuki, S., Ariga, T., Dasgupta, S., Kasama, T., Morikawa, K., Nonaka, S., Okuhara, Y., Kise, M. & Yu, R. K., Dec 1 2008, In : Journal of Lipid Research. 49, 10, p. 2188-2196 9 p.

Research output: Contribution to journalArticle

Glucosides
Structural analysis
Lipids
Enzyme Activators
Column chromatography
6 Citations (Scopus)

Topology and patch-clamp analysis of the sodium channel in relationship to the anti-lipid A antibody in campylobacteriosis

Usuki, S., Nakatani, Y., Taguchi, K., Fujita, T., Tanabe, S., Ustunomiya, I., Gu, Y., Cawthraw, S. A., Newell, D. G., Pajaniappan, M., Thompson, S. A., Ariga, T. & Yu, R. K., Dec 8 2008, In : Journal of Neuroscience Research. 86, 15, p. 3359-3374 16 p.

Research output: Contribution to journalArticle

Lipid A
Sodium Channels
Antibodies
Anti-Idiotypic Antibodies
Chickens
2007
8 Citations (Scopus)

Chemical validation of molecular mimicry: Interaction of cholera toxin with Campylobacter lipooligosaccharides

Usuki, S., Pajaniappan, M., Thompson, S. A. & Yu, R. K., Apr 1 2007, In : Glycoconjugate Journal. 24, 2-3, p. 167-180 14 p.

Research output: Contribution to journalArticle

Molecular Mimicry
Campylobacter
Molecular interactions
Cholera Toxin
Campylobacter jejuni
137 Citations (Scopus)

Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains

Ngamukote, S., Yanagisawa, M., Ariga, T., Ando, S. & Yu, R. K., Dec 1 2007, In : Journal of Neurochemistry. 103, 6, p. 2327-2341 15 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Gangliosides
Brain
Glycosyltransferases
Glycolipids
29 Citations (Scopus)

Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats

Usuki, S., Ito, Y., Morikawa, K., Kise, M., Ariga, T., Rivner, M. & Yu, R. K., Dec 1 2007, In : Nutrition and Metabolism. 4, 25.

Research output: Contribution to journalArticle

Diabetic Neuropathies
Streptozocin
Homocysteine
Diet
LDL Lipoproteins