Robert William Caldwell

Professor - Rehired Retiree

  • 5900 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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Article
2019

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Anxiety
Anxiety Disorders
Pyramidal Cells
NADP
Arginase
Vasodilation
Hyperglycemia
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
1 Citation (Scopus)

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Flores Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Nitric Oxide
Adipocytes
Obesity

Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J., Fritzenwanger, M., Schulze, P. C. & Jung, C., Sep 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 9, p. 1398-1411 14 p.

Research output: Contribution to journalArticle

Arginase
Hyperglycemia
Phosphotransferases
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Open Access
adipose tissues
Arginase
Obese Mice
diets
sucrose

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 1 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2018
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
3 Citations (Scopus)

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Narayanan, S. P., Lemtalsi, T., Fouda, A. Y., Rojas, M. A., Xing, J., Fulton, D. J., Caldwell, R. W. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

Arginase
Cell Aging
Endothelial cells
Medical problems
Endothelial Cells
2017
4 Citations (Scopus)

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In : Scientific Reports. 7, 1, 2653.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Resuscitation
AMP-Activated Protein Kinases
Wounds and Injuries
Orphan Drug Production
7 Citations (Scopus)

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Flores Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 1 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

Medical problems
blood vessels
Blood Vessels
diabetes
aorta
17 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Flores Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
6 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Flores Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
2016
13 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A. B., Rojas, M. A., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
8 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
5 Citations (Scopus)

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular System Injuries
Retinal Vessels
Endothelial Cells
Polyamines
2015
13 Citations (Scopus)

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

Arginase
arginase
angiotensin II
fibrosis
Angiotensin II
24 Citations (Scopus)

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In : European Journal of Pharmacology. 746, p. 106-114 9 p.

Research output: Contribution to journalArticle

Arginase
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide
9 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
1 Citation (Scopus)
Reperfusion Injury
Protein Kinase C
Adenosine Triphosphate
Reperfusion
Peptides
2014
10 Citations (Scopus)

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Jan 1 2014, In : American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Endothelins
Oxygen
Physiologic Neovascularization
Vascular Endothelial Growth Factor A
17 Citations (Scopus)

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M. A., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PLoS One. 9, 11, 110604.

Research output: Contribution to journalArticle

Hyperargininemia
hyperoxia
Arginase
arginase
Retinal Vessels
22 Citations (Scopus)

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 1 2014, In : Cell Death and Disease. 5, 2, e1075.

Research output: Contribution to journalArticle

Hyperargininemia
Hyperoxia
Polyamines
Oxygen
Retina
5 Citations (Scopus)

High glucose upregulates arginase 1 and decreases nitric oxide production through ATF-2 and c-Jun transcription factors

Shatanawi, A., Gharaibeh, M. N., Caldwell, R. B. & Caldwell, R. W., Jan 1 2014, In : Life Science Journal. 11, 5, p. 374-379 6 p., 50.

Research output: Contribution to journalArticle

Arginase
Nitric Oxide
Transcription Factors
Up-Regulation
Glucose
9 Citations (Scopus)
Arginase
Erectile Dysfunction
Therapeutics
Nitric Oxide
Nitric Oxide Synthase
2013
28 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Blood Vessels
Nitrergic Neurons
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Flores Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D. Y., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems
8 Citations (Scopus)

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in Immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

Arginase
Acute Lung Injury
Nitric Oxide Synthase Type III
Bacterial Toxins
Lung
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
25 Citations (Scopus)

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M. A., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in Immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

Arginase
Diabetic Retinopathy
Retinal Vessels
Retina
Glucose
36 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
21 Citations (Scopus)

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Lucas, R., Parikh, S. J., Sridhar, S., Guo, D. H., Bhagatwala, J., Dong, Y., Caldwell, R., Mellor, A., Caldwell, W., Zhu, H. & Dong, Y., Oct 1 2013, In : Cytokine. 64, 1, p. 310-315 6 p.

Research output: Contribution to journalArticle

Prediabetic State
African Americans
Cytokines
Medical problems
Type 2 Diabetes Mellitus
17 Citations (Scopus)

Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway

Liu, H., Zhang, W., Xu, Z., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 918-931 14 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular Endothelial Growth Factor A
Down-Regulation
Apoptosis
Intraocular Injections
12 Citations (Scopus)

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., Dec 1 2013, In : Frontiers in Immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

Citrulline
Arginase
Kidney
Streptozocin
Knockout Mice
54 Citations (Scopus)

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Flores Toque, H. A., Bhatta, A., Rojas, M. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Blood Vessels
Aorta
Protein Isoforms
24 Citations (Scopus)

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M. A., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Flores Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular System Injuries
Medical problems
retina
blood vessels
32 Citations (Scopus)

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Flores Toque, H. A., Rojas, M. A., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

Arginase
Retinal Vessels
Myography
Vasodilation
Blood Vessels
2012
58 Citations (Scopus)

Diabetes-induced vascular dysfunction involves arginase

Romero Lucas, M. J., Iddings, J. A., Platt, D. H., Irfan Ali, M., Cederbaum, S. D., Stepp, D. W., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 1

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Fibrosis
Endothelial Cells
Vasodilation
46 Citations (Scopus)

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice

Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., Fulton, D. J. & Rudic, R. D., Oct 12 2012, In : Circulation research. 111, 9, p. 1157-1165 9 p.

Research output: Contribution to journalArticle

Circadian Clocks
Knockout Mice
Nitric Oxide Synthase
Superoxides
Blood Vessels
94 Citations (Scopus)

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

Chandra, S., Romero, M. J., Shatanawi, A., Alkilany, A. M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : British Journal of Pharmacology. 165, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Endothelial Cells
Peroxynitrous Acid
Small Interfering RNA
33 Citations (Scopus)

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

Arginase
Protein Kinase C
Lung
Endothelial cells
Endothelial Cells
52 Citations (Scopus)

Toxicity and cellular uptake of gold nanorods in vascular endothelium and smooth muscles of isolated rat blood vessel: Importance of surface modification

Alkilany, A. M., Shatanawi, A., Kurtz, T., Caldwell, R. B. & Caldwell, R. W., Apr 23 2012, In : Small. 8, 8, p. 1270-1278 9 p.

Research output: Contribution to journalArticle

Nanotubes
Vascular Endothelium
Blood vessels
Nanorods
Vascular Smooth Muscle
2011
83 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Blood Vessels
36 Citations (Scopus)

Arginase 2 deletion reduces Neuro-Glial injury and improves retinal function in a model of Retinopathy of prematurity

Narayanan, S. P., Suwanpradid, J., Saul, A. B., Xu, Z., Still, A., Caldwell, R. W. & Caldwell, R. B., Jul 27 2011, In : PloS one. 6, 7, e22460.

Research output: Contribution to journalArticle

premature birth
Arginase
retinal diseases
arginase
Retinopathy of Prematurity
45 Citations (Scopus)

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Flores Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

Arginase
Knockout Mice
Endothelium
Erectile Dysfunction
Experimental Diabetes Mellitus
67 Citations (Scopus)

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Flores Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Hypertension
Rodentia
Lung
Epidermal Growth Factor
15 Citations (Scopus)
Arginase
Extracellular Signal-Regulated MAP Kinases
Streptozocin
Erectile Dysfunction
Endothelium
16 Citations (Scopus)

Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model

Zhang, W., Yokota, H., Xu, Z., Narayanan, S. P., Yancey, L., Yoshida, A., Marcus, D. M., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Aug 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6384-6395 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular Endothelial Growth Factor A
Pathologic Neovascularization
Astrocytes
Physiologic Neovascularization
50 Citations (Scopus)

Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion

Yokota, H., Narayanan, S. P., Zhang, W., Liu, H., Rojas, M. A., Xu, Z., Lemtalsi, T., Nagaoka, T., Yoshida, A., Brooks, S. E., Caldwell, R. W. & Caldwell, R. B., Oct 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8123-8131 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Reperfusion Injury
Reperfusion
Ischemia
Retina
50 Citations (Scopus)

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Homocysteine
N-Methyl-D-Aspartate Receptors
D-Aspartic Acid
Ganglia