Robert William Caldwell

Professor - Rehired Retiree

  • 5900 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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Article
1970
8 Citations (Scopus)

An evaluation of the vasodilation produced by mephentermine and certain other sympathomimetic amines.

Caldwell, R. W. & Goldberg, L. I., Apr 1 1970, In : Journal of Pharmacology and Experimental Therapeutics. 172, 2, p. 297-309 13 p.

Research output: Contribution to journalArticle

Mephentermine
Metaraminol
Histamine H1 Antagonists
Ephedrine
Phenoxybenzamine
1972
2 Citations (Scopus)

The cardiovascular actions of WR‐149,024 (1,18‐diamino‐7,13‐diaza‐9,10‐dithiaoctadecane tetrahydrochloride)

Caldwell, R. W., HEIFFER, M. H. & HERMAN, E. H., Jan 1 1972, In : British Journal of Pharmacology. 46, 4, p. 637-646 10 p.

Research output: Contribution to journalArticle

Dogs
Vascular Resistance
Hypotension
Adrenergic Receptors
Heart Rate
1973

Acute cardiovascular and autonomic effects of the S 2 (3 amino propylamine) ethyl phosphorothioic acid (WR 2721)

Caldwell, R. W. & Heiffer, M. H., Jan 1 1973, In : Radiation Research. 55, 3, 1 p.

Research output: Contribution to journalArticle

acids

Modification of endotoxin shock with 1,18 diamino 6,13 diaza 9,10 dithiaoctadecane (WR 149,024)

Caldwell, R. W., Vick, J. A. & Heiffer, M. H., Jan 1 1973, In : Federation Proceedings. 32, 3 (I), 1 p.

Research output: Contribution to journalArticle

Endotoxins
Shock
WR 149024
2 Citations (Scopus)

Pharmacological studies of the therapy of shock

Vick, J. A., Heiffer, M. H., Caldwell, R. W., Neis, A. & Roberts, C. R., Jan 1 1973, In : Medicine (United States). 52, 4, p. 279-285 7 p.

Research output: Contribution to journalArticle

Organothiophosphorus Compounds
Ethylamines
Adrenergic alpha-Antagonists
Convulsive Therapy
Autologous Blood Transfusions
Blood pressure
Catecholamines
Blood Pressure
Isoproterenol
Epinephrine
2 Citations (Scopus)

The treatment of hemorrhagic shock with WR 149,024 (1,18 diamino 6,13 diaza 9,10 dithiaoctadecane tetrahydrochloride)

Caldwell, R. W. & Demaree, G. E., Jan 1 1973, In : Journal of Trauma. 13, 11, p. 1003-1010 8 p.

Research output: Contribution to journalArticle

Chromium Radioisotopes
Adrenergic alpha-Antagonists
Autologous Blood Transfusions
Central Venous Pressure
Hemorrhagic Shock
1 Citation (Scopus)

Treatment of hemorrhagic shock with a new vasodilator

Vick, J. A., Roberts, C. R., Heiffer, M. H., Caldwell, R. W. & Nies, A., Dec 1 1973, In : Military Medicine. 138, 8, p. 490-494 5 p.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Vasodilator Agents
Acidosis
Sheep
Central Venous Pressure
1974
1 Citation (Scopus)

Pressor response induced by meta chlorotyrosine in cats

King, C. D. & Caldwell, R. W., Jan 1 1974, In : Pharmacologist. 16, 2

Research output: Contribution to journalArticle

Cats
1975
9 Citations (Scopus)

Acute cardiovascular and autonomic effects of WR 2721: a radioprotective compound

Caldwell, R. W. & Heiffer, M. H., Jan 1 1975, In : RADIAT.RES.. 62, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Autonomic Agents
Amifostine
dogs
cats
vasoconstrictor drugs
1976

Cardiac effects of ASI 222 HCl, a new cardiac glycoside

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Federation Proceedings. 35, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
ASI-222

Cardiopulmonary effects of mefloquine CH3SO3H (MMS)

Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2

Research output: Contribution to journalArticle

Mefloquine
1 Citation (Scopus)

Cardiovascular effect of new 4 amino sugar cardiac glycosides (ASI-222 and ASI-222 HCl)

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Clinical Research. 24, 4

Research output: Contribution to journalArticle

Amino Sugars
Cardiac Glycosides
ASI-222
1 Citation (Scopus)

Cardiovascular responses to perfusion of the nucleus tractus solitarii (NTS) with clonidine (C)

Rockhold, R. W. & Caldwell, R. W., Jan 1 1976, In : Federation Proceedings. 35, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Perfusion

Comparison of a 4 aminosugar cardiac glycoside with digoxin in the heart lung preparation

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2, p. No.053

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Lung
18 Citations (Scopus)

Pharmacological studies of a new 4 aminosugar cardiac glycoside (ASI 222)

Caldwell, R. W. & Nash, C. B., Dec 1 1976, In : Journal of Pharmacology and Experimental Therapeutics. 197, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Ouabain
Pharmacology
Digitoxigenin
Dogs
1977

Cardiovascular effects of clonidine (C) following lesions of the nucleus tractus solitarius (NTS)

Rockhold, R. W., Caldwell, R. W. & Lawson, J. W., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine

Changes in therapeutic index and cardiac effects by aminogalactose substitution on digitoxigenin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Pharmacologist. 19, 2

Research output: Contribution to journalArticle

Digitoxigenin
Therapeutics
1 Citation (Scopus)
Cardiac Glycosides
Digoxin
Ouabain
sodium-translocating ATPase
6 Citations (Scopus)

Comparison of the cardiac effects of ASI 222 HCl, an aminosugar cardiac glycoside, and digoxin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1977, In : Archives Internationales de Pharmacodynamie et de Therapie. 227, 2, p. 220-232 13 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Dogs
Rabbits
Vagotomy
1 Citation (Scopus)

Comparison of the therapeutic index (TI) of aminosugar cardiac glycosides with digoxin (D)

Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Therapeutics

Effects of aminosugar substitution on cardiac glycoside responses in the heart lung preparation

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
Lung
4 Citations (Scopus)

Pulmonary and cardiovascular effects of mefloquine methanesulfonate

Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Toxicology and Applied Pharmacology. 40, 3, p. 437-448 12 p.

Research output: Contribution to journalArticle

Mefloquine
Drug infusion
Lung
Pharmaceutical Preparations
Observation

The molecular basis for the electrophysiologic action of a new cardiac glycoside

Smith, D. I., Bandura, J. P. & Caldwell, R. W., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
1978

Cardiopulmonary effects of I.V. quinine HCL (Q)

Caldwell, R. W. & Nash, C. B., Jan 1 1978, In : Federation Proceedings. 37, 3

Research output: Contribution to journalArticle

Quinine
10 Citations (Scopus)
Cardiac Glycosides
Digoxin
Ouabain
Adenosine Triphosphatases
Glycosides

Electropharmacological effect of aminosugar substitution on digitoxigenin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1978, In : Federation Proceedings. 37, 3, p. No. 3685

Research output: Contribution to journalArticle

Digitoxigenin

Localization and characterization of action of clonidine in nucleus tractus solitarii (NTS)

Rockhold, R. W. & Caldwell, R. W., Jan 1 1978, In : Federation Proceedings. 37, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine

Respiratory effects of ASI-222 HCl, an aminosugar cardiac glycoside

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1978, In : Pharmacologist. 20, 3, 1 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
ASI-222

Role of cardiac beta-adrenergic receptors in the cardiac toxicity of digoxin and an aminosugar cardenolide

Puryear, S. K., Nash, C. B. & Caldwell, R. W., Jan 1 1978, In : Federation Proceedings. 37, 3

Research output: Contribution to journalArticle

Cardenolides
Receptors, Adrenergic, beta
Digoxin
Cardiotoxicity
1979

Alpha-adrenergic blocking action of quinine

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

Quinine
Adrenergic Agents
22 Citations (Scopus)

Effect of lesions of the nucleus tractus solitarii on the cardiovascular actions of clonidine in conscious rats

Rockhold, R. W. & Caldwell, R. W., Jan 1 1979, In : Neuropharmacology. 18, 4, p. 347-354 8 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Inbred WKY Rats
Bradycardia
Hypotension

Effect of sympathectomy and vagotomy on the cardiotoxicity of an aminosugar cardiac glycoside

Puryear, S. K., Nash, C. B. & Caldwell, R. W., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

Cardiac Glycosides
Sympathectomy
Vagotomy
Cardiotoxicity
Cardiac Glycosides
Denervation
Dogs

Modulation of digitalis induced contractile force responses by adrenergic and cholinergic mechanisms

Cook, L. S., Caldwell, R. W., Nash, C. B. & Doherty, J. E., Jan 1 1979, In : Clinical Research. 27, 5

Research output: Contribution to journalArticle

Digitalis
Adrenergic Agents
Cholinergic Agents
4 Citations (Scopus)

Structure-activity relationships of an aminosugar cardiac glycoside, ASI-222 HCl, in the heart-lung preparation of the dog

Scott Cook, L., Caldwell, R. W. & Nash, C. B., Jan 1 1979, In : Journal of Cardiovascular Pharmacology. 1, 5, p. 551-559 9 p.

Research output: Contribution to journalArticle

Digitoxigenin
Cardiac Glycosides
Digoxin
Structure-Activity Relationship
Stroke
1980
32 Citations (Scopus)

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

Rockhold, R. W. & Caldwell, R. W., Jan 1 1980, In : Neuropharmacology. 19, 9, p. 919-922 4 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Microinjections
Blood Pressure
Yohimbine
10 Citations (Scopus)

Changes in cardiac glycoside activity produced by aminosugar addition

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1980, In : Journal of Pharmacology and Experimental Therapeutics. 215, 1, p. 198-204 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digitoxigenin
Poisons
Cardenolides
Cardiotonic Agents
12 Citations (Scopus)

α-adrenergic blocking properties of quinine HCl

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., May 2 1980, In : European Journal of Pharmacology. 63, 2-3, p. 159-166 8 p.

Research output: Contribution to journalArticle

Quinine
Adrenergic Agents
Blood Pressure
Angiotensin II
Norepinephrine
1981
5 Citations (Scopus)

Digoxin uptake into peripheral autonomic cardiac nerves: Possible mechanism of digitalis-induced antiarrhythmic and toxic electrophysiologic actions

Cook, L. S., Doherty, J. E., Straub, K. D., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : American Heart Journal. 102, 1, p. 58-62 5 p.

Research output: Contribution to journalArticle

Toxic Actions
Autonomic Pathways
Digitalis
Digoxin
Peripheral Nervous System
9 Citations (Scopus)

Effect of cardiac β-adrenergic blockade or denervation on cardiotoxicity of digoxin and an aminosugar cardenolide

Puryear, S. K., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Journal of Cardiovascular Pharmacology. 3, 1, p. 113-127 15 p.

Research output: Contribution to journalArticle

Cardenolides
Digoxin
Denervation
Adrenergic Agents
Practolol

Halothane anesthesia and angiotensin I conversion in the dog

Heerdt, P. M., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Clinical Research. 29, 4

Research output: Contribution to journalArticle

Angiotensin I
Halothane
Anesthesia
Dogs

Mechanism of the pulmonary vasoconstrictor action of digoxin

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Federation Proceedings. 40, 3 I, 1 p.

Research output: Contribution to journalArticle

Digoxin
Vasoconstrictor Agents
Lung
1 Citation (Scopus)

Renal tubular transport of a polar cardiac glycoside, ASI-222, in rats; Clearance and micropuncture studies

Kauker, M. L., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Journal of Pharmacology and Experimental Therapeutics. 218, 3, p. 686-691 6 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Punctures
Kidney
Nephrons
Cardenolides
1982
12 Citations (Scopus)

Adrenergic and cholinergic mechanisms in digitalis inotrophy

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 233, 3, p. 761-765 5 p.

Research output: Contribution to journalArticle

Digitoxigenin
Cardiac Glycosides
Digitalis
Adrenergic Agents
Cholinergic Agents
1 Citation (Scopus)

ASI-222 and ASI-254

Caldwell, R. W., Jan 1 1982, In : Drugs of the Future. 7, 10, p. 719-721 3 p.

Research output: Contribution to journalArticle

ASI-222
ASI 254

Effect of a polar cardenolide and digoxin upon A-V refractory period

Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Federation Proceedings. 41, 5

Research output: Contribution to journalArticle

Cardenolides
Digoxin
120 Citations (Scopus)

Effect of AV3V lesions on development of DOCA-Salt hypertension and vascular Na+-pump activity

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1982, In : Hypertension. 4, 5, p. 575-580 6 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Blood Vessels
Salts
Desoxycorticosterone
Hypertension

The pulmonary vasoconstrictor action of digoxin: Site of action on the sympathetic nervous system

Mecca, T. E. & Caldwell, R. W., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Digoxin
Sympathetic Nervous System
Vasoconstrictor Agents
Lung
1983
10 Citations (Scopus)

Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1983, In : Hypertension. 5, 2, p. I-89-I-93

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Renovascular Hypertension
Third Ventricle
Blood Vessels
Kidney