Robert William Caldwell

Professor - Rehired Retiree

  • 5969 Citations
  • 42 h-Index
1970 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1970 2019

Filter
Article
1983
12 Citations (Scopus)
Angiotensins
Enzyme activity
Vasoconstriction
Angiotensin II
Lung
13 Citations (Scopus)

Metabolism and cardiac actions of a polar aminocardenolide and digoxin in the conscious dog

Songu Mize, E., Nash, C. B., Elam, J. T. & Caldwell, R. W., Jan 1 1983, In : Journal of Pharmacology and Experimental Therapeutics. 226, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Digitoxigenin
Feces
Urine
8 Citations (Scopus)

Vascular α-adrenergic blocking properties of quinidine

Caldwell, R. W., Elam, J. T., Mecca, T. E. & Nash, C. B., Oct 28 1983, In : European Journal of Pharmacology. 94, 3-4, p. 185-192 8 p.

Research output: Contribution to journalArticle

Quinidine
Adrenergic Agents
Blood Vessels
Dogs
Angiotensin II
1984
1 Citation (Scopus)

Comparative inotropic activity of ouabain (O) and an amino-cardenolide (AC) in the halothane (H) depressed heart

Heerdt, P. M. & Caldwell, R. W., Jan 1 1984, In : Federation Proceedings. 43, 4, p. no. 4439

Research output: Contribution to journalArticle

Cardenolides
Halothane
Ouabain
22 Citations (Scopus)

Elastic fibers in the annulus fibrosus of the dog intervertebral disc

Johnson, E. F., Caldwell, R. W. & Berryman, H. E., Jan 1 1984, In : Acta Anatomica. 118, 4, p. 238-242 5 p.

Research output: Contribution to journalArticle

Elastic Tissue
Intervertebral Disc
Dogs
Annulus Fibrosus
Connective Tissue

Elastic fibers in the anulus fibrosus of the dog intervertebral disc

Johnson, E. F., Caldwell, R. W., Berryman, H. E., Miller, A. & Chetty, K., Jan 1 1984, In : Cells Tissues Organs. 118, 4, p. 238-242 5 p.

Research output: Contribution to journalArticle

Elastic Tissue
Intervertebral Disc
Dogs
Annulus Fibrosus
Connective Tissue
23 Citations (Scopus)

Phasic vascular sodium pump changes in deoxycorticosterone-hypertensive rats

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1984, In : Circulation research. 55, 3, p. 304-308 5 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Desoxycorticosterone
Blood Vessels
Sodium Chloride
Blood Pressure
15 Citations (Scopus)

Role of renal papillae in the regulation of sodium excretion during acute elevation of renal perfusion pressure in the rat

Chen, P. S., Caldwell, R. M. & Hsu, C. H., Jan 1 1984, In : Hypertension. 6, 6, p. 893-898 6 p.

Research output: Contribution to journalArticle

Perfusion
Sodium
Kidney
Pressure
Arterial Pressure
28 Citations (Scopus)

Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2

Bodor, N., Oshiro, Y., Loftsson, T., Katovich, M. & Caldwell, R. W., Jan 1 1984, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 1, 3, p. 120-125 6 p.

Research output: Contribution to journalArticle

Metabolites
Esters
Metoprolol
Pharmaceutical Preparations
Lead compounds
2 Citations (Scopus)

Studies on nalmefene, an opioid antagonist

Nash, C. B., Caldwell, R. V. & Tuttle, R. R., Jan 1 1984, In : Federation Proceedings. 43, 4, p. no. 3987

Research output: Contribution to journalArticle

Narcotic Antagonists
nalmefene
1 Citation (Scopus)

Synthesis and evaluation of novel lidocaine sulfur analogs

Loftsson, T., Matsuo, M., Caldwell, R. W., Gildersleeve, N. & Bodor, N., Dec 1984, In : International Journal of Pharmaceutics. 22, 2-3, p. 345-355 11 p.

Research output: Contribution to journalArticle

Lidocaine
Sulfur
Membranes
Hairless Mouse
Skin
19 Citations (Scopus)

The vasopressor response to centrally administered ouabain

Caldwell, R. W., Songu-Mize, E. & Bealer, S. L., Jan 1 1984, In : Circulation research. 55, 6, p. 773-779 7 p.

Research output: Contribution to journalArticle

Ouabain
Renin
Blood Pressure
Kidney
Adrenergic Receptors
1985
3 Citations (Scopus)
Cardiotonic Agents
Dobutamine
High Pressure Liquid Chromatography
Plasmas
Pharmaceutical Preparations
3 Citations (Scopus)

Effect of an aminocardenolide and digoxin upon atrioventricular refractory period in the dog

Caldwell, R. W. & Nash, C. B., Dec 1 1985, In : Journal of Pharmacology and Experimental Therapeutics. 235, 3, p. 583-588 6 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Atropine
Reflex
Premature Cardiac Complexes

Effect of DOCA-salt treatment duration on a plasma-borne sodium pump inhibitor

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Sodium-Potassium-Exchanging ATPase
Salts
5 Citations (Scopus)

Mechanism of the pulmonary vasoconstrictor action of digoxin in the dog

Mecca, T. E., Elam, J. T. & Caldwell, R. W., Jan 1 1985, In : Journal of Cardiovascular Pharmacology. 7, 5, p. 833-840 8 p.

Research output: Contribution to journalArticle

Digoxin
Vasoconstrictor Agents
Dogs
Lung
Vasoconstriction
1987
5 Citations (Scopus)

Cardiovascular effects of KM-13, a new, orally effective, cardiotonic sympathomimetic amine

Caldwell, R. W., Nash, C. B., Smulkowski, M. & Tuttle, R. R., Jan 1 1987, In : Journal of Cardiovascular Pharmacology. 9, 3, p. 375-384 10 p.

Research output: Contribution to journalArticle

Cardiotonic Agents
Sympathomimetics
Dobutamine
Blood Pressure
Buccal Administration
25 Citations (Scopus)

Effect of DOCA-salt treatment duration and anteroventral third ventricle lesions on a plasma-borne sodium pump inhibitor in rats

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1987, In : Journal of Hypertension. 5, 4, p. 461-467 7 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Sodium-Potassium-Exchanging ATPase
Third Ventricle
Salts
Blood Vessels
9 Citations (Scopus)

High and Low Dietary Potassium Effects on Rat Vascular Sodium Pump Activity

Songu-Mize, E., Caldwell, R. W. & Baer, P. G., Dec 1987, In : Proceedings of the Society for Experimental Biology and Medicine. 186, 3, p. 280-287 8 p.

Research output: Contribution to journalArticle

Dietary Potassium
Sodium-Potassium-Exchanging ATPase
Blood Vessels
Rats
Potassium
32 Citations (Scopus)

Noninvasive delivery of a novel inotropic catecholamine: Iontophoretic versus intravenous infusion in dogs

Sanderson, J. E., Caldwell, R. W., Hsiao, J., Dixon, R. & Tuttle, R. R., Mar 1987, In : Journal of Pharmaceutical Sciences. 76, 3, p. 215-218 4 p.

Research output: Contribution to journalArticle

Intravenous Infusions
Catecholamines
Dogs
Iontophoresis
Dobutamine
181 Citations (Scopus)

Pharmacology of the enantiomers of threo-methylphenidate

Patrick, K. S., Caldwell, R. W., Ferris, R. M. & Breese, G. R., Jan 1 1987, In : Journal of Pharmacology and Experimental Therapeutics. 241, 1, p. 152-158 7 p.

Research output: Contribution to journalArticle

Inbred Strains Rats
Corpus Striatum
Methylphenidate
Stereoisomerism
Synaptosomes
1988
13 Citations (Scopus)

Mechanisms of altered sodium excretion after preoptic hypothalamic lesions

Bealer, S. L., Caldwell, R. W. & Songu-Mize, E., Jan 1 1988, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 254, 1, p. 23/1

Research output: Contribution to journalArticle

Natriuresis
Sodium
Aldosterone
Renin
Blood Pressure
2 Citations (Scopus)
Pharmacokinetics
Solid Phase Extraction
Catecholamines
Dogs
Technology
1989
8 Citations (Scopus)

Comparative ability of digoxin and an aminosugar cardiac glycoside to bind to and inhibit Na+,K+-adenosine triphosphatase. Effect of potassium

Songu-Mize, E., Gunter, J. L. & Caldwell, R. W., Nov 1 1989, In : Biochemical Pharmacology. 38, 21, p. 3689-3695 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Adenosine Triphosphatases
Potassium
Potassium Chloride
11 Citations (Scopus)

Interactions of pyridostigmine with cardiopulmonary systems and their relationships to plasma cholinesterase activity

Caldwell, R. W., Lowensohn, H. S., Chryssanthis, M. A. & Nash, C. B., Apr 1 1989, In : Toxicological Sciences. 12, 3, p. 432-441 10 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Cholinesterases
Airway Resistance
Tidal Volume
Respiratory Rate
6 Citations (Scopus)
Nitrous Oxide
Vascular Resistance
Dogs
Lung
Cardiac Output
1990
8 Citations (Scopus)

Actions of the opioid antagonist, nalmefene, and congeners on reperfusion cardiac arrhythmias and regional left coronary blood flow

Caldwell, R. W., Nagarajan, R., Chryssanthis, A. & Tuttle, R. R., Jan 1 1990, In : Pharmacology. 41, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Reperfusion
Cardiac Arrhythmias
Myocardial Reperfusion
Coronary Occlusion
6 Citations (Scopus)

Different patterns of autonomic nerve activity produced by a polar vs. a neutral cardiac glycoside

Rebagay, W. R. & Caldwell, R. W., Jan 1 1990, In : Journal of Pharmacology and Experimental Therapeutics. 253, 1, p. 180-184 5 p.

Research output: Contribution to journalArticle

Autonomic Pathways
Cardiac Glycosides
Digoxin
Carotid Sinus
Cardenolides
2 Citations (Scopus)

The cardiovascular response to digoxin in conscious dogs with left atrial obstruction

Heerdt, P. M. & Caldwell, R. W., Jan 1 1990, In : Journal of Cardiothoracic Anesthesia. 4, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Cardiac Output
Heart Rate
Vasoconstriction
1992
4 Citations (Scopus)

Effect of transient vagal cold blockade upon reflex actions of a polar and nonpolar cardiac glycoside

Caldwell, R. W. & Rebagay, W. R., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 262, 3, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Reflex
Digoxin
Dogs
Rewarming
4 Citations (Scopus)

Effects of sinoaortic denervation on the reflex actions of digoxin and a polar aminocardenolide

Rebagay, W. R. & Caldwell, R. W., Jan 1992, In : Journal of Cardiovascular Pharmacology. 19, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

Digoxin
Denervation
Reflex
Carotid Sinus
Pressoreceptors
1993
2 Citations (Scopus)

Reversal of effects of morphine by nalmefene

Nagarajan, R., Jeyashree, S., Shanmugam, M., Bala Subramanian, V., Tuttle, R. R. & Caldwell, R. W., Jan 1 1993, In : Journal of Clinical Research and Drug Development. 7, 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

Morphine
Stupor
Tubal Sterilization
Naltrexone
Aptitude
1994
2 Citations (Scopus)

Effect of halothane on in vivo and in vitro cardiotoxicity of an aminocardenolide

Heerdt, P. M., Gallagher, J. D. & Caldwell, R. W., Jun 1994, In : Journal of Cardiovascular Pharmacology. 23, 6, p. 890-896 7 p.

Research output: Contribution to journalArticle

Halothane
Purkinje Fibers
Dogs
Digitalis
Cardiotoxicity
2 Citations (Scopus)

Integrative cardiovascular actions of a novel catecholamine, GP-2-128

Abou-Mohamed, G., Caldwell, R. W., Ibrahim, T. M. & Tuttle, R. R., Jan 1 1994, In : Journal of Cardiovascular Pharmacology. 23, 3, p. 485-491 7 p.

Research output: Contribution to journalArticle

Catecholamines
Dobutamine
Vascular Resistance
Isoproterenol
Heart Rate
7 Citations (Scopus)

Interactions of a novel catecholamine, GP-2-128, with adrenoceptors

Abou-Mohamed, G., Caldwell, R. W., Carrier, G. O., Elmazar, M. M. & Tuttie, R. R., Jan 1 1994, In : Journal of Cardiovascular Pharmacology. 23, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Catecholamines
Isoproterenol
Dobutamine
Nadolol
1995
163 Citations (Scopus)

Contraction-induced cell wounding and release of fibroblast growth factor in heart

Clarke, M. S. F., Caldwell, R. W., Chiao, H., Miyake, K. & McNeil, P. L., Jan 1 1995, In : Circulation Research. 76, 6, p. 927-934 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Cardiac Myocytes
Cell Membrane
Serum Albumin
Adrenergic Agents
21 Citations (Scopus)

Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity

Chiao, H., Pelletier, S. W., Desai, H. K., Rebagay, W. R. & Caldwell, R. W., Sep 5 1995, In : European Journal of Pharmacology. 283, 1-3, p. 103-106 4 p.

Research output: Contribution to journalArticle

Diterpenes
Alkaloids
Reflex
Arterial Pressure
Heart Rate
27 Citations (Scopus)

HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro

Abou-Mohamed, G., Papapetropoulos, A., Ulrich, D., Catravas, J. D., Tuttle, R. R. & Caldwell, R. W., Dec 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 275, 2, p. 584-591 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Lipopolysaccharides
Peptides
Nitric Oxide Synthase Type II
Interleukin-1
26 Citations (Scopus)

Local cardiac effects of substance P: roles of acetylcholine and noradrenaline

Chiao, H. & Caldwell, R. W., Jan 1995, In : British Journal of Pharmacology. 114, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Substance P
Acetylcholine
Norepinephrine
Heart Atria
Nadolol

Systemic delivery of sympathomimetic amines by transdermal iontophoresis

Caldwell, R. W., Chryssanthis, M. A. & Davis, V. O., Sep 12 1995, In : International Journal of Pharmaceutics. 123, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle

Iontophoresis
Sympathomimetics
Dogs
Electrodes
Tolazoline
1996
2 Citations (Scopus)

A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent

Nagarajan, R., Abou-Mohamed, G., Myers, T. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Catecholamines
Dobutamine
Pharmacology
Vascular Resistance
Dogs
6 Citations (Scopus)

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

Abou-Mohamed, G., Nagarajan, R., Ibrahim, T. M. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Pharmacology
Isoproterenol
Adrenergic Receptors
arbutamine
77 Citations (Scopus)

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β

Papapetropoulos, A., Abou-Mohamed, G., Marczin, N., Murad, F., Caldwell, R. W. & Catravas, J. D., Jan 1 1996, In : British Journal of Pharmacology. 118, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Cyclic GMP
Interleukin-1
Endotoxins
Down-Regulation
Protein Isoforms
2 Citations (Scopus)

L-arginjne in the development and reversal of tolerance to nitroglycerin

Abou-Molmmed, G., Suarez, A., Kaesemever, W. H., Panapetroooulos, A., Catravas, J. D. & Caldwell, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Nitroglycerin
arginine
Arginine
Tissue
vasodilator agents
5 Citations (Scopus)

Nitrates supplemented with L-arginine for the reversal and treatment of nitrate tolerance: Two case reports

Kaesemeyer, W. H., Abou-Mohamed, G., Crute, T. D. & Caldwell, R. W., Dec 1 1996, In : Applied Cardiopulmonary Pathophysiology. 6, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

Nitrates
Arginine
Unstable Angina
Vascular Smooth Muscle
Smooth Muscle Myocytes
23 Citations (Scopus)

The role of substance P in myocardial dysfunction during ischemia and reperfusion

Chiao, H. & Caldwell, R. W., Apr 9 1996, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 353, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

Substance P
Reperfusion
Ischemia
Ventricular Pressure
Myocardial Stunning

Vascular actions of an inhffiltor of substance P amidation

Hunny, J. Z., Oldham, C. P., Abou-Mohamed, G., Ulrich, D., Jin, L. M., May, S. W. & Caldwell, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Substance P
Blood Vessels
Endothelial cells
Endothelial Cells
Phenylephrine
1997
20 Citations (Scopus)

Amidative peptide processing and vascular function

Oldham, C. D., Li, C., Feng, J., Scott, R. O., Wang, W. Z., Moore, A. B., Girard, P. R., Huang, J., Caldwell, R. B., William Caldwell, R. & May, S. W., Dec 1 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6, p. C1908-C1914

Research output: Contribution to journalArticle

Substance P
Blood Vessels
Endothelial cells
Peptides
Nitric Oxide Synthase
1998
41 Citations (Scopus)

Certain norditerpenoid alkaloids and their cardiovascular action

Desai, H. K., Hart, B. P., Caldwell, R. W., Jianzhong-Huang & Pelletier, S. W., Jun 1 1998, In : Journal of Natural Products. 61, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

diterpenoid alkaloids
Diterpenes
Alkaloids
Oxides
oxides
38 Citations (Scopus)

Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity

Abou-Mohamed, G., Papapetropoulos, A., D. Catravas, J. & Caldwell, R. W., Jan 12 1998, In : European Journal of Pharmacology. 341, 2-3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Nitric Oxide
Anti-Inflammatory Agents
Bradykinin
Nitric Oxide Synthase Type II