Robert William Caldwell

Professor - Rehired Retiree

  • 5969 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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Article
2013
25 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
25 Citations (Scopus)

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

Arginase
Diabetic Retinopathy
Retinal Vessels
Retina
Glucose
38 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
21 Citations (Scopus)

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Lucas, R., Parikh, S. J., Sridhar, S., Guo, D. H., Bhagatwala, J., Dong, Y., Caldwell, R., Mellor, A., Caldwell, W., Zhu, H. & Dong, Y., Oct 1 2013, In : Cytokine. 64, 1, p. 310-315 6 p.

Research output: Contribution to journalArticle

Prediabetic State
African Americans
Cytokines
Medical problems
Type 2 Diabetes Mellitus
17 Citations (Scopus)

Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway

Liu, H., Zhang, W., Xu, Z., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 918-931 14 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular Endothelial Growth Factor A
Down-Regulation
Apoptosis
Intraocular Injections
13 Citations (Scopus)

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., Dec 1 2013, In : Frontiers in immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

Citrulline
Arginase
Kidney
Streptozocin
Knockout Mice
56 Citations (Scopus)

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Blood Vessels
Aorta
Protein Isoforms
24 Citations (Scopus)

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular System Injuries
Medical problems
retina
blood vessels
32 Citations (Scopus)

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

Arginase
Retinal Vessels
Myography
Vasodilation
Blood Vessels
2014
10 Citations (Scopus)

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Jan 1 2014, In : American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Endothelins
Oxygen
Physiologic Neovascularization
Vascular Endothelial Growth Factor A
17 Citations (Scopus)

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PloS one. 9, 11, 110604.

Research output: Contribution to journalArticle

Hyperargininemia
hyperoxia
Arginase
arginase
Retinal Vessels
22 Citations (Scopus)

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 1 2014, In : Cell Death and Disease. 5, 2, e1075.

Research output: Contribution to journalArticle

Hyperargininemia
Hyperoxia
Polyamines
Oxygen
Retina
5 Citations (Scopus)

High glucose upregulates arginase 1 and decreases nitric oxide production through ATF-2 and c-Jun transcription factors

Shatanawi, A., Gharaibeh, M. N., Caldwell, R. B. & Caldwell, R. W., Jan 1 2014, In : Life Science Journal. 11, 5, p. 374-379 6 p., 50.

Research output: Contribution to journalArticle

Arginase
Nitric Oxide
Transcription Factors
Up-Regulation
Glucose
9 Citations (Scopus)

New approaches to the design and discovery of therapies to prevent erectile dysfunction

Toque, H. A. & Caldwell, R. W., Dec 1 2014, In : Expert Opinion on Drug Discovery. 9, 12, p. 1447-1469 23 p.

Research output: Contribution to journalArticle

Arginase
Erectile Dysfunction
Therapeutics
Nitric Oxide
Nitric Oxide Synthase
2015
15 Citations (Scopus)

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

Arginase
arginase
angiotensin II
fibrosis
Angiotensin II
24 Citations (Scopus)

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In : European Journal of Pharmacology. 746, p. 106-114 9 p.

Research output: Contribution to journalArticle

Arginase
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide
10 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
1 Citation (Scopus)
Reperfusion Injury
Protein Kinase C
Adenosine Triphosphate
Reperfusion
Peptides
2016
13 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
9 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
5 Citations (Scopus)

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular System Injuries
Retinal Vessels
Endothelial Cells
Polyamines
2017
5 Citations (Scopus)

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In : Scientific Reports. 7, 1, 2653.

Research output: Contribution to journalArticle

Hemorrhagic Shock
Resuscitation
AMP-Activated Protein Kinases
Wounds and Injuries
Orphan Drug Production
7 Citations (Scopus)

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

Medical problems
blood vessels
Blood Vessels
diabetes
aorta
22 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
7 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
2018
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
3 Citations (Scopus)

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

Arginase
Cell Aging
Endothelial cells
Medical problems
Endothelial Cells
2019

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Anxiety
Anxiety Disorders
Pyramidal Cells
NADP
Arginase
Vasodilation
Hyperglycemia
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
1 Citation (Scopus)

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Flores Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Nitric Oxide
Adipocytes
Obesity

Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J., Fritzenwanger, M., Schulze, P. C. & Jung, C., Sep 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 9, p. 1398-1411 14 p.

Research output: Contribution to journalArticle

Arginase
Hyperglycemia
Phosphotransferases
p38 Mitogen-Activated Protein Kinases
Phosphorylation
1 Citation (Scopus)
Open Access
adipose tissues
Arginase
Obese Mice
diets
sucrose

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum