Robert William Caldwell

Professor - Rehired Retiree

  • 6330 Citations
  • 44 h-Index
1970 …2020

Research output per year

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Research Output

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Article
2011

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis

Cheng, B., Anea, C. B., Yao, L., Chen, F., Patel, V., Merloiu, A., Pati, P., Caldwell, R. W., Fulton, D. J. & Rudic, R. D., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17147-17152 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R., Kaesemeyer, W. H., Chandra, S., Fulton, D. J. & Caldwell, R. W., Aug 1 2010, In : British Journal of Pharmacology. 160, 7, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Novel mechanisms of endothelial dysfunction in diabetes

Yang, G., Lucas, R., Caldwell, R., Yao, L., Romero, M. & Caldwell, R., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

p38 Mitogen-Activated Protein Kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice

Toque, H. A., Romero, M. J., Tostes, R. C., Shatanawi, A., Chandra, S., Carneiro, Z. N., Inscho, E. W., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Dec 2010, In : Journal of Sexual Medicine. 7, 12, p. 3857-3867 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.

El-Remessy, A. B., Tawfik, H. E., Matragoon, S., Pillai, B., Caldwell, R. B. & Caldwell, R. W., 2010, In : Experimental diabetes research. 2010, 1 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero, M. J., Caldwell, R. W. & Caldwell, R. B., Aug 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy

Bartoli, M., Al-Shabrawey, M., Labazi, M., Ali Behzadian, M., Istanboli, M., El-Remessy, A. B., Caldwell, R. W., Marcus, D. M. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4934-4940 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation

Zhang, W., Rojas, M., Lilly, B., Tsai, N. T., Lemtalsi, T., Liou, G. I., Caldwell, R. W. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 3033-3040 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis

Chamberlain, S. M., Hall, J. D., Patel, J., Lee, J. R., Marcus, D. M., Sridhar, S., Romero, M. J., Labazi, M., Caldwell, R. W. & Bartoli, M., Jul 1 2009, In : Digestive Diseases and Sciences. 54, 7, p. 1460-1464 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

Romero, M. J., Platt, D. H., Tawfik, H. E., Labazi, M., El-Remessy, A. B., Bartoli, M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2008, In : Circulation research. 102, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

258 Scopus citations
29 Scopus citations

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

118 Scopus citations
2007

Homocysteine induces endothelial dysfunction via inhibition of arginine transport

Jin, L., Caldwell, R. B., Li-Masters, T. & Caldwell, R. W., Jun 1 2007, In : Journal of Physiology and Pharmacology. 58, 2, p. 191-206 16 p.

Research output: Contribution to journalArticle

64 Scopus citations
53 Scopus citations
2006

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

Banes-Berceli, A. K., Shaw, S., Ma, G., Brands, M., Eaton, D. C., Stern, D. M., Fulton, D., Caldwell, R. W. & Marrero, M. B., Jun 30 2006, In : American Journal of Physiology - Renal Physiology. 291, 1, p. F116-F121

Research output: Contribution to journalArticle

49 Scopus citations
50 Scopus citations

Simvastatin improves diabetes-induced coronary endothelial dysfunction

Tawfik, H. E., El-Remessy, A. B., Matragoon, S., Ma, G., Caldwell, R. B. & Caldwell, R. W., Oct 2 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 1, p. 386-395 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2005

Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2

Tawfik, A. M., Jin, L., Banes-Berceli, A. K. L., Caldwell, R. B., Ogbi, S., Shirley, A., Barber, D., Catravas, J. D., Stern, D. M., Fulton, D. J., Caldwell, R. W. & Marrero, M. B., Nov 1 2005, In : Vascular Pharmacology. 43, 5, p. 320-326 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Platt, D. H., Matragoon, S., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Aug 2005, In : American Journal of Pathology. 167, 2, p. 599-607 9 p.

Research output: Contribution to journalArticle

157 Scopus citations

Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: Role of endothelin-1

Ergul, A., Johansen, J. S., Strømhaug, C., Harris, A. K., Hutchinson, J., Tawfik, A., Rahimi, A., Rhim, E., Wells, B., Caldwell, W. W. & Anstadt, M. P., Apr 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2004

Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

Abou-Mohamed, G., Johnson, J. A., Jin, L., El-Remessy, A. B., Do, K., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 1, p. 289-299 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2003

Estradiol relaxes rat aorta via endothelium-dependent and -independent mechanisms

Abou-Mohamed, G., Elmarakby, A., Carrier, G. O., Catravas, J. D., Caldwell, R. W. & White, R. E., Aug 11 2003, In : Pharmacology. 69, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
171 Scopus citations

High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation

El-Remessy, A. B., Abou-Mohamed, G., Caldwell, R. W. & Caldwell, R. B., Jul 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 7, p. 3135-3143 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Neuroprotective Effect of(-)Δ 9 -Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite

El-Remessy, A. B., Khalil, I. E., Matragoon, S., Abou-Mohamed, G., Tsai, N. J., Roon, P., Caldwell, R. B., Caldwell, R. W., Green, K. & Liou, G. I., Nov 2003, In : American Journal of Pathology. 163, 5, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

164 Scopus citations
2002

The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy

Parker, J. O., Parker, J. D., Caldwell, R. W., Farrell, B. & Kaesemeyer, W. H., Apr 3 2002, In : Journal of the American College of Cardiology. 39, 7, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2001

Endothelial cell dysfunction in a model of oxidative stress

Jin, L., Abou-Mohamed, G., Caldwell, R. B. & Caldwell, R. W., Aug 9 2001, In : Medical Science Monitor. 7, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2000

Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production

Ogonowski, A. A., Kaesemeyer, W. H., Jin, L., Ganapathy, V., Leibach, F. H. & Caldwell, R. W., Jan 1 2000, In : American Journal of Physiology - Cell Physiology. 278, 1 47-1, p. C136-C143

Research output: Contribution to journalArticle

61 Scopus citations

Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrate

Kaesemeyer, W. H., Ogonowski, A. A., Jin, L., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 131, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody

Clarke, M. S. F., Vanderburg, C. R., Bamman, M. M., Caldwell, R. W. & Feeback, D. L., Aug 31 2000, In : Journal of Applied Physiology. 89, 2, p. 731-741 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin

Abou-Mohamed, G., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 130, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Vascular and endothelial actions of inhibitors of substance P amidation

Abou-Mohamed, G. A., Huang, J., Oldham, C. D., Taylor, T. A., Jin, L., Caldwell, R. B., May, S. W. & Caldwell, R. W., Jun 13 2000, In : Journal of Cardiovascular Pharmacology. 35, 6, p. 871-880 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
1999
334 Scopus citations
1998

Certain norditerpenoid alkaloids and their cardiovascular action

Desai, H. K., Hart, B. P., Caldwell, R. W., Jianzhong-Huang & Pelletier, S. W., Jun 1 1998, In : Journal of Natural Products. 61, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity

Abou-Mohamed, G., Papapetropoulos, A., D. Catravas, J. & Caldwell, R. W., Jan 12 1998, In : European Journal of Pharmacology. 341, 2-3, p. 265-272 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
1997

Amidative peptide processing and vascular function

Oldham, C. D., Li, C., Feng, J., Scott, R. O., Wang, W. Z., Moore, A. B., Girard, P. R., Huang, J., Caldwell, R. B., William Caldwell, R. & May, S. W., Dec 1 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6, p. C1908-C1914

Research output: Contribution to journalArticle

20 Scopus citations
1996

A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent

Nagarajan, R., Abou-Mohamed, G., Myers, T. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

Abou-Mohamed, G., Nagarajan, R., Ibrahim, T. M. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β

Papapetropoulos, A., Abou-Mohamed, G., Marczin, N., Murad, F., Caldwell, R. W. & Catravas, J. D., Jan 1 1996, In : British Journal of Pharmacology. 118, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

L-arginjne in the development and reversal of tolerance to nitroglycerin

Abou-Molmmed, G., Suarez, A., Kaesemever, W. H., Panapetroooulos, A., Catravas, J. D. & Caldwell, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

2 Scopus citations

Nitrates supplemented with L-arginine for the reversal and treatment of nitrate tolerance: Two case reports

Kaesemeyer, W. H., Abou-Mohamed, G., Crute, T. D. & Caldwell, R. W., Dec 1 1996, In : Applied Cardiopulmonary Pathophysiology. 6, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The role of substance P in myocardial dysfunction during ischemia and reperfusion

Chiao, H. & Caldwell, R. W., Apr 9 1996, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 353, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Vascular actions of an inhffiltor of substance P amidation

Hunny, J. Z., Oldham, C. P., Abou-Mohamed, G., Ulrich, D., Jin, L. M., May, S. W. & Caldwel, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

1995

Contraction-induced cell wounding and release of fibroblast growth factor in heart

Clarke, M. S. F., Caldwell, R. W., Chiao, H., Miyake, K. & McNeil, P. L., Jan 1 1995, In : Circulation Research. 76, 6, p. 927-934 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity

Chiao, H., Pelletier, S. W., Desai, H. K., Rebagay, W. R. & Caldwell, R. W., Sep 5 1995, In : European Journal of Pharmacology. 283, 1-3, p. 103-106 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro

Abou-Mohamed, G., Papapetropoulos, A., Ulrich, D., Catravas, J. D., Tuttle, R. R. & Caldwell, R. W., Dec 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 275, 2, p. 584-591 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Local cardiac effects of substance P: roles of acetylcholine and noradrenaline

Chiao, H. & Caldwell, R. W., Jan 1995, In : British Journal of Pharmacology. 114, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Systemic delivery of sympathomimetic amines by transdermal iontophoresis

Caldwell, R. W., Chryssanthis, M. A. & Davis, V. O., Sep 12 1995, In : International Journal of Pharmaceutics. 123, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle