Robert William Caldwell

Professor - Rehired Retiree

  • 5900 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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2011
42 Citations (Scopus)

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis

Cheng, B., Anea, C. B., Yao, L., Chen, F., Patel, V., Merloiu, A., Pati, P., Caldwell, R. W., Fulton, D. J. & Rudic, R. D., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17147-17152 6 p.

Research output: Contribution to journalArticle

Circadian Clocks
Arteriosclerosis
Transplants
Organ Transplantation
Vascular Grafting
2010
23 Citations (Scopus)

Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R., Kaesemeyer, W. H., Chandra, S., Fulton, D. J. & Caldwell, R. W., Aug 1 2010, In : British Journal of Pharmacology. 160, 7, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Scavenger Receptors
Nitric Oxide Synthase Type III
Type C Phospholipases
41 Citations (Scopus)

Novel mechanisms of endothelial dysfunction in diabetes

Yang, G., Lucas, R., Caldwell, R., Yao, L., Romero, M. & Caldwell, R., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Peripheral Arterial Disease
Vascular Diseases
Morbidity
Mortality
37 Citations (Scopus)
Arginase
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide Synthase
Blood Pressure
58 Citations (Scopus)

Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.

El-Remessy, A. B., Tawfik, H. E. S., Matragoon, S., Pillai, B., Caldwell, R. B. & Caldwell, R. W., Jan 1 2010, In : Experimental Diabetes Research. 2010, 1 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Peroxynitrous Acid
Lipid Peroxides
Vasodilation
Biological Availability
39 Citations (Scopus)

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

Retinal Vessels
Angiotensin II
Interleukin-6
Inflammation
Vascular Endothelial Growth Factor A
2009
44 Citations (Scopus)

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M. A., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero Lucas, M. J., Caldwell, R. W. & Caldwell, R. B., Jan 1 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

Arginase
Uveitis
Endotoxins
Inflammation
Lipopolysaccharides
44 Citations (Scopus)

HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy

Bartoli, M., Al-Shabrawey, M., Labazi, M., Ali Behzadian, M., Istanboli, M., El-Remessy, A. B., Caldwell, R. W., Marcus, D. M. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4934-4940 7 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oxygen
fluvastatin
Superoxides
25 Citations (Scopus)

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation

Zhang, W., Rojas, M., Lilly, B., Tsai, N. T., Lemtalsi, T., Liou, G. I., Caldwell, R. W. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 3033-3040 8 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Inflammation
Retinal Vessels
Uveitis
Phosphorylation
12 Citations (Scopus)

Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis

Chamberlain, S. M., Hall, J. D., Patel, J., Lee, J. R., Marcus, D. M., Sridhar, S., Romero Lucas, M. J., Labazi, M., Caldwell, R. W. & Bartoli, M., Jul 1 2009, In : Digestive Diseases and Sciences. 54, 7, p. 1460-1464 5 p.

Research output: Contribution to journalArticle

Carotenoids
Oxidative Stress
Liver Cirrhosis
Liver
Inflammation
2008
238 Citations (Scopus)

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

Romero, M. J., Platt, D. H., Tawfik, H. E., Labazi, M., El-Remessy, A. B., Bartoli, M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2008, In : Circulation research. 102, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Glucose
Citrulline
28 Citations (Scopus)
Electron Transport Complex IV
Reperfusion Injury
Reperfusion
Ischemia
Carbon Monoxide
113 Citations (Scopus)

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
NADPH Oxidase
Diabetic Retinopathy
STAT3 Transcription Factor
Blood-Retinal Barrier
2007
62 Citations (Scopus)

Homocysteine induces endothelial dysfunction via inhibition of arginine transport

Jin, L., Caldwell, R. B., Li-Masters, T. & Caldwell, R. W., Jun 1 2007, In : Journal of Physiology and Pharmacology. 58, 2, p. 191-206 16 p.

Research output: Contribution to journalArticle

Homocysteine
Arginine
Nitric Oxide Synthase Type III
Cationic Amino Acid Transporter 1
Hyperhomocysteinemia
51 Citations (Scopus)
Electron Transport Complex IV
Protein Kinase C
Reperfusion Injury
Mitochondria
Ischemia
2006
46 Citations (Scopus)

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

Banes-Berceli, A. K., Shaw, S., Ma, G., Brands, M., Eaton, D. C., Stern, D. M., Fulton, D., Caldwell, R. W. & Marrero, M. B., Jun 30 2006, In : American Journal of Physiology - Renal Physiology. 291, 1, p. F116-F121

Research output: Contribution to journalArticle

Simvastatin
Mesangial Cells
Angiotensin II
Glucose
Phosphorylation
50 Citations (Scopus)
Myocardial Reperfusion Injury
Reperfusion Injury
Vascular Endothelial Growth Factor A
Myocardial Ischemia
Nitric Oxide Synthase Type III
55 Citations (Scopus)

Simvastatin improves diabetes-induced coronary endothelial dysfunction

Tawfik, H. E., El-Remessy, A. B., Matragoon, S., Ma, G., Caldwell, R. B. & Caldwell, R. W., Oct 2 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 1, p. 386-395 10 p.

Research output: Contribution to journalArticle

Simvastatin
Coronary Vessels
Acetylcholine
Arginine
Oxidative Stress
2005
25 Citations (Scopus)

Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2

Tawfik, A. M., Jin, L., Banes-Berceli, A. K. L., Caldwell, R. B., Ogbi, S., Shirley, A., Barber, D., Catravas, J. D., Stern, D. M., Fulton, D. J., Caldwell, R. W. & Marrero, M. B., Nov 1 2005, In : Vascular Pharmacology. 43, 5, p. 320-326 7 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Hyperglycemia
Reactive Oxygen Species
Endothelial Cells
Apoptosis
154 Citations (Scopus)

Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Platt, D. H., Matragoon, S., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Jan 1 2005, In : American Journal of Pathology. 167, 2, p. 599-607 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Vascular Endothelial Growth Factor A
Retinal Neovascularization
Superoxides
Oxidative Stress
45 Citations (Scopus)

Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: Role of endothelin-1

Ergul, A., Johansen, J. S., Strømhaug, C., Harris, A. K., Hutchinson, J., Tawfik, A., Rahimi, A., Rhim, E., Wells, B., Caldwell, W. W. & Anstadt, M. P., Apr 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Endothelin-1
Blood Vessels
Reactive Oxygen Species
Diabetic Angiopathies
NADPH Oxidase
2004
43 Citations (Scopus)

Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

Abou-Mohamed, G., Johnson, J. A., Jin, L., El-Remessy, A. B., Do, K., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 1, p. 289-299 11 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Nitroglycerin
Superoxides
Protein Kinase C
Endothelial Cells
2003
13 Citations (Scopus)

Estradiol relaxes rat aorta via endothelium-dependent and -independent mechanisms

Abou-Mohamed, G., Elmarakby, A. A., Carrier, G. O., Catravas, J. D., Caldwell, R. W. & White, R. E., Aug 11 2003, In : Pharmacology. 69, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

Endothelium
Aorta
Estradiol
Estrogens
Nitroarginine
169 Citations (Scopus)
Blood-Retinal Barrier
Urokinase Plasminogen Activator Receptors
Vascular Endothelial Growth Factor A
Tyrosine
Retina
102 Citations (Scopus)

High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation

El-Remessy, A. B., Abou-Mohamed, G., Caldwell, R. W. & Caldwell, R. B., Jul 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 7, p. 3135-3143 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Nitric Oxide Synthase Type III
Tyrosine
Nitric Oxide Synthase
Superoxides
162 Citations (Scopus)

Neuroprotective Effect of(-)Δ 9 -Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite

El-Remessy, A. B., Khalil, I. E., Matragoon, S., Abou-Mohamed, G., Tsai, N. J., Roon, P., Caldwell, R. B., Caldwell, R. W., Green, K. & Liou, G. I., Jan 1 2003, In : American Journal of Pathology. 163, 5, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

Cannabidiol
Retinal Neurons
Peroxynitrous Acid
Dronabinol
Neuroprotective Agents
2002
50 Citations (Scopus)

The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy

Parker, J. O., Parker, J. D., Caldwell, R. W., Farrell, B. & Kaesemeyer, W. H., Apr 3 2002, In : Journal of the American College of Cardiology. 39, 7, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

Nitroglycerin
Arginine
Walking
Capsules
Therapeutics
2001
30 Citations (Scopus)

Endothelial cell dysfunction in a model of oxidative stress

Jin, L., Abou-Mohamed, G., Caldwell, R. B. & Caldwell, R. W., Aug 9 2001, In : Medical Science Monitor. 7, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

Arginine
Oxidative Stress
Endothelial Cells
Hyperhomocysteinemia
Cationic Amino Acid Transporter 1
2000
60 Citations (Scopus)

Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production

Ogonowski, A. A., Kaesemeyer, W. H., Jin, L., Ganapathy, V., Leibach, F. H. & Caldwell, R. W., Feb 29 2000, In : American Journal of Physiology - Cell Physiology. 278, 1 47-1

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Superoxides
Endothelial Cells
Substance P
Amino Acid Transport System y+
52 Citations (Scopus)

Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrate

Kaesemeyer, W. H., Ogonowski, A. A., Jin, L., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 131, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitroglycerin
Superoxides
Endothelial Cells
NG-Nitroarginine Methyl Ester
6 Citations (Scopus)

In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody

Clarke, M. S. F., Vanderburg, C. R., Bamman, M. M., Caldwell, R. W. & Feeback, D. L., Aug 31 2000, In : Journal of Applied Physiology. 89, 2, p. 731-741 11 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Cholesterol
Monoclonal Antibodies
Membranes
Sarcoplasmic Reticulum
62 Citations (Scopus)

Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin

Abou-Mohamed, G., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 130, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Nitroglycerin
Blood Vessels
Arginine
Nitric Oxide Synthase
Endothelial Cells
7 Citations (Scopus)

Vascular and endothelial actions of inhibitors of substance P amidation

Abou-Mohamed, G. A., Huang, J., Oldham, C. D., Taylor, T. A., Jin, L., Caldwell, R. B., May, S. W. & Caldwell, R. W., Jun 13 2000, In : Journal of Cardiovascular Pharmacology. 35, 6, p. 871-880 10 p.

Research output: Contribution to journalArticle

Substance P
Blood Vessels
peptidylamidoglycolate lyase
Nitric Oxide
Endothelial Cells
1999
332 Citations (Scopus)
Pravastatin
Nitric Oxide Synthase Type III
Cholesterol
Simvastatin
Nitric Oxide
1998
41 Citations (Scopus)

Certain norditerpenoid alkaloids and their cardiovascular action

Desai, H. K., Hart, B. P., Caldwell, R. W., Jianzhong-Huang & Pelletier, S. W., Jun 1 1998, In : Journal of Natural Products. 61, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

diterpenoid alkaloids
Diterpenes
Alkaloids
Oxides
oxides
38 Citations (Scopus)

Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity

Abou-Mohamed, G., Papapetropoulos, A., D. Catravas, J. & Caldwell, R. W., Jan 12 1998, In : European Journal of Pharmacology. 341, 2-3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Nitric Oxide
Anti-Inflammatory Agents
Bradykinin
Nitric Oxide Synthase Type II
1997
20 Citations (Scopus)

Amidative peptide processing and vascular function

Oldham, C. D., Li, C., Feng, J., Scott, R. O., Wang, W. Z., Moore, A. B., Girard, P. R., Huang, J., Caldwell, R. B., William Caldwell, R. & May, S. W., Dec 1 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6

Research output: Contribution to journalArticle

Substance P
Blood Vessels
Endothelial cells
Peptides
Nitric Oxide Synthase
1996
2 Citations (Scopus)

A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent

Nagarajan, R., Abou-Mohamed, G., Myers, T. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Catecholamines
Dobutamine
Pharmacology
Vascular Resistance
Dogs
6 Citations (Scopus)

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

Abou-Mohamed, G., Nagarajan, R., Ibrahim, T. M. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Pharmacology
Isoproterenol
Adrenergic Receptors
arbutamine
76 Citations (Scopus)

Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β

Papapetropoulos, A., Abou-Mohamed, G., Marczin, N., Murad, F., Caldwell, R. W. & Catravas, J. D., Jan 1 1996, In : British Journal of Pharmacology. 118, 6, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Cyclic GMP
Interleukin-1
Endotoxins
Down-Regulation
Protein Isoforms
2 Citations (Scopus)

L-arginjne in the development and reversal of tolerance to nitroglycerin

Abou-Molmmed, G., Suarez, A., Kaesemever, W. H., Panapetroooulos, A., Catravas, J. D. & Caldwell, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Nitroglycerin
arginine
Arginine
Tissue
vasodilator agents
5 Citations (Scopus)

Nitrates supplemented with L-arginine for the reversal and treatment of nitrate tolerance: Two case reports

Kaesemeyer, W. H., Abou-Mohamed, G., Crute, T. D. & Caldwell, R. W., Dec 1 1996, In : Applied Cardiopulmonary Pathophysiology. 6, 4, p. 255-262 8 p.

Research output: Contribution to journalArticle

Nitrates
Arginine
Unstable Angina
Vascular Smooth Muscle
Smooth Muscle Myocytes
23 Citations (Scopus)

The role of substance P in myocardial dysfunction during ischemia and reperfusion

Chiao, H. & Caldwell, R. W., Apr 9 1996, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 353, 4, p. 400-407 8 p.

Research output: Contribution to journalArticle

Substance P
Reperfusion
Ischemia
Ventricular Pressure
Myocardial Stunning

Vascular actions of an inhffiltor of substance P amidation

Hunny, J. Z., Oldham, C. P., Abou-Mohamed, G., Ulrich, D., Jin, L. M., May, S. W. & Caldwell, R. W., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Substance P
Blood Vessels
Endothelial cells
Endothelial Cells
Phenylephrine
1995
163 Citations (Scopus)

Contraction-induced cell wounding and release of fibroblast growth factor in heart

Clarke, M. S. F., Caldwell, R. W., Chiao, H., Miyake, K. & McNeil, P. L., Jan 1 1995, In : Circulation Research. 76, 6, p. 927-934 8 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Cardiac Myocytes
Cell Membrane
Serum Albumin
Adrenergic Agents
21 Citations (Scopus)

Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity

Chiao, H., Pelletier, S. W., Desai, H. K., Rebagay, W. R. & Caldwell, R. W., Sep 5 1995, In : European Journal of Pharmacology. 283, 1-3, p. 103-106 4 p.

Research output: Contribution to journalArticle

Diterpenes
Alkaloids
Reflex
Arterial Pressure
Heart Rate
26 Citations (Scopus)

HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro

Abou-Mohamed, G., Papapetropoulos, A., Ulrich, D., Catravas, J. D., Tuttle, R. R. & Caldwell, R. W., Dec 1 1995, In : Journal of Pharmacology and Experimental Therapeutics. 275, 2, p. 584-591 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Lipopolysaccharides
Peptides
Nitric Oxide Synthase Type II
Interleukin-1
26 Citations (Scopus)

Local cardiac effects of substance P: roles of acetylcholine and noradrenaline

Chiao, H. & Caldwell, R. W., Jan 1 1995, In : British Journal of Pharmacology. 114, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Substance P
Acetylcholine
Norepinephrine
Heart Atria
Nadolol

Systemic delivery of sympathomimetic amines by transdermal iontophoresis

Caldwell, R. W., Chryssanthis, M. A. & Davis, V. O., Sep 12 1995, In : International Journal of Pharmaceutics. 123, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle

Iontophoresis
Sympathomimetics
Dogs
Electrodes
Tolazoline
1994
2 Citations (Scopus)

Effect of halothane on in vivo and in vitro cardiotoxicity of an aminocardenolide

Heerdt, P. M., Gallagher, J. D. & Caldwell, R. W., Jan 1 1994, In : Journal of Cardiovascular Pharmacology. 23, 6, p. 890-896 7 p.

Research output: Contribution to journalArticle

Halothane
Purkinje Fibers
Dogs
Digitalis
Cardiotoxicity