Robert William Caldwell

Professor - Rehired Retiree

  • 5933 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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Article
1994
2 Citations (Scopus)

Integrative cardiovascular actions of a novel catecholamine, GP-2-128

Abou-Mohamed, G., Caldwell, R. W., Ibrahim, T. M. & Tuttle, R. R., Jan 1 1994, In : Journal of Cardiovascular Pharmacology. 23, 3, p. 485-491 7 p.

Research output: Contribution to journalArticle

Catecholamines
Dobutamine
Vascular Resistance
Isoproterenol
Heart Rate
7 Citations (Scopus)

Interactions of a novel catecholamine, GP-2-128, with adrenoceptors

Abou-Mohamed, G., Caldwell, R. W., Carrier, G. O., Elmazar, M. M. & Tuttie, R. R., Jan 1 1994, In : Journal of Cardiovascular Pharmacology. 23, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Catecholamines
Isoproterenol
Dobutamine
Nadolol
1993
2 Citations (Scopus)

Reversal of effects of morphine by nalmefene

Nagarajan, R., Jeyashree, S., Shanmugam, M., Bala Subramanian, V., Tuttle, R. R. & Caldwell, R. W., Jan 1 1993, In : Journal of Clinical Research and Drug Development. 7, 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

Morphine
Stupor
Tubal Sterilization
Naltrexone
Aptitude
1992
4 Citations (Scopus)

Effect of transient vagal cold blockade upon reflex actions of a polar and nonpolar cardiac glycoside

Caldwell, R. W. & Rebagay, W. R., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 262, 3, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Reflex
Digoxin
Dogs
Rewarming
4 Citations (Scopus)

Effects of sinoaortic denervation on the reflex actions of digoxin and a polar aminocardenolide

Rebagay, W. R. & Caldwell, R. W., Jan 1 1992, In : Journal of Cardiovascular Pharmacology. 19, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

Digoxin
Denervation
Reflex
Carotid Sinus
Pressoreceptors
1990
8 Citations (Scopus)

Actions of the opioid antagonist, nalmefene, and congeners on reperfusion cardiac arrhythmias and regional left coronary blood flow

Caldwell, R. W., Nagarajan, R., Chryssanthis, A. & Tuttle, R. R., Jan 1 1990, In : Pharmacology. 41, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Reperfusion
Cardiac Arrhythmias
Myocardial Reperfusion
Coronary Occlusion
6 Citations (Scopus)

Different patterns of autonomic nerve activity produced by a polar vs. a neutral cardiac glycoside

Rebagay, W. R. & Caldwell, R. W., Jan 1 1990, In : Journal of Pharmacology and Experimental Therapeutics. 253, 1, p. 180-184 5 p.

Research output: Contribution to journalArticle

Autonomic Pathways
Cardiac Glycosides
Digoxin
Carotid Sinus
Cardenolides
2 Citations (Scopus)

The cardiovascular response to digoxin in conscious dogs with left atrial obstruction

Heerdt, P. M. & Caldwell, R. W., Jan 1 1990, In : Journal of Cardiothoracic Anesthesia. 4, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Cardiac Output
Heart Rate
Vasoconstriction
1989
8 Citations (Scopus)

Comparative ability of digoxin and an aminosugar cardiac glycoside to bind to and inhibit Na+,K+-adenosine triphosphatase. Effect of potassium

Songu-Mize, E., Gunter, J. L. & Caldwell, R. W., Nov 1 1989, In : Biochemical Pharmacology. 38, 21, p. 3689-3695 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Adenosine Triphosphatases
Potassium
Potassium Chloride
11 Citations (Scopus)

Interactions of pyridostigmine with cardiopulmonary systems and their relationships to plasma cholinesterase activity

Caldwell, R. W., Lowensohn, H. S., Chryssanthis, M. A. & Nash, C. B., Apr 1 1989, In : Toxicological Sciences. 12, 3, p. 432-441 10 p.

Research output: Contribution to journalArticle

Pyridostigmine Bromide
Cholinesterases
Airway Resistance
Tidal Volume
Respiratory Rate
6 Citations (Scopus)
Nitrous Oxide
Vascular Resistance
Dogs
Lung
Cardiac Output
1988
13 Citations (Scopus)

Mechanisms of altered sodium excretion after preoptic hypothalamic lesions

Bealer, S. L., Caldwell, R. W. & Songu-Mize, E., Jan 1 1988, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 254, 1, p. 23/1

Research output: Contribution to journalArticle

Natriuresis
Sodium
Aldosterone
Renin
Blood Pressure
2 Citations (Scopus)
Pharmacokinetics
Solid Phase Extraction
Catecholamines
Dogs
Technology
1987
5 Citations (Scopus)

Cardiovascular effects of KM-13, a new, orally effective, cardiotonic sympathomimetic amine

Caldwell, R. W., Nash, C. B., Smulkowski, M. & Tuttle, R. R., Jan 1 1987, In : Journal of Cardiovascular Pharmacology. 9, 3, p. 375-384 10 p.

Research output: Contribution to journalArticle

Cardiotonic Agents
Sympathomimetics
Dobutamine
Blood Pressure
Buccal Administration
25 Citations (Scopus)

Effect of DOCA-salt treatment duration and anteroventral third ventricle lesions on a plasma-borne sodium pump inhibitor in rats

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1987, In : Journal of Hypertension. 5, 4, p. 461-467 7 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Sodium-Potassium-Exchanging ATPase
Third Ventricle
Salts
Blood Vessels
9 Citations (Scopus)

High and Low Dietary Potassium Effects on Rat Vascular Sodium Pump Activity

Songu-Mize, E., Caldwell, R. W. & Baer, P. G., Jan 1 1987, In : Proceedings of the Society for Experimental Biology and Medicine. 186, 3, p. 280-287 8 p.

Research output: Contribution to journalArticle

Dietary Potassium
Sodium-Potassium-Exchanging ATPase
Blood Vessels
Rats
Potassium
32 Citations (Scopus)

Noninvasive delivery of a novel inotropic catecholamine: Iontophoretic versus intravenous infusion in dogs

Sanderson, J. E., Caldwell, R. W., Hsiao, J., Dixon, R. & Tuttle, R. R., Mar 1987, In : Journal of Pharmaceutical Sciences. 76, 3, p. 215-218 4 p.

Research output: Contribution to journalArticle

Intravenous Infusions
Catecholamines
Dogs
Iontophoresis
Dobutamine
180 Citations (Scopus)

Pharmacology of the enantiomers of threo-methylphenidate

Patrick, K. S., Caldwell, R. W., Ferris, R. M. & Breese, G. R., Jan 1 1987, In : Journal of Pharmacology and Experimental Therapeutics. 241, 1, p. 152-158 7 p.

Research output: Contribution to journalArticle

Inbred Strains Rats
Corpus Striatum
Methylphenidate
Stereoisomerism
Synaptosomes
1985
3 Citations (Scopus)
Cardiotonic Agents
Dobutamine
High Pressure Liquid Chromatography
Plasmas
Pharmaceutical Preparations
3 Citations (Scopus)

Effect of an aminocardenolide and digoxin upon atrioventricular refractory period in the dog

Caldwell, R. W. & Nash, C. B., Dec 1 1985, In : Journal of Pharmacology and Experimental Therapeutics. 235, 3, p. 583-588 6 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Atropine
Reflex
Premature Cardiac Complexes

Effect of DOCA-salt treatment duration on a plasma-borne sodium pump inhibitor

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Sodium-Potassium-Exchanging ATPase
Salts
6 Citations (Scopus)

Mechanism of the pulmonary vasoconstrictor action of digoxin in the dog

Mecca, T. E., Elam, J. T. & Caldwell, R. W., Jan 1 1985, In : Journal of Cardiovascular Pharmacology. 7, 5, p. 833-840 8 p.

Research output: Contribution to journalArticle

Digoxin
Vasoconstrictor Agents
Dogs
Lung
Vasoconstriction
1984
1 Citation (Scopus)
Cardenolides
Halothane
Ouabain
22 Citations (Scopus)

Elastic fibers in the annulus fibrosus of the dog intervertebral disc

Johnson, E. F., Caldwell, R. W. & Berryman, H. E., Jan 1 1984, In : Acta Anatomica. 118, 4, p. 238-242 5 p.

Research output: Contribution to journalArticle

Elastic Tissue
Intervertebral Disc
Dogs
Annulus Fibrosus
Connective Tissue

Elastic fibers in the anulus fibrosus of the dog intervertebral disc

Johnson, E. F., Caldwell, R. W., Berryman, H. E., Miller, A. & Chetty, K., Jan 1 1984, In : Cells Tissues Organs. 118, 4, p. 238-242 5 p.

Research output: Contribution to journalArticle

Elastic Tissue
Intervertebral Disc
Dogs
Annulus Fibrosus
Connective Tissue
23 Citations (Scopus)

Phasic vascular sodium pump changes in deoxycorticosterone-hypertensive rats

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1984, In : Circulation research. 55, 3, p. 304-308 5 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Desoxycorticosterone
Blood Vessels
Sodium Chloride
Blood Pressure
15 Citations (Scopus)

Role of renal papillae in the regulation of sodium excretion during acute elevation of renal perfusion pressure in the rat

Chen, P. S., Caldwell, R. M. & Hsu, C. H., Jan 1 1984, In : Hypertension. 6, 6, p. 893-898 6 p.

Research output: Contribution to journalArticle

Perfusion
Sodium
Kidney
Pressure
Arterial Pressure
28 Citations (Scopus)

Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2

Bodor, N., Oshiro, Y., Loftsson, T., Katovich, M. & Caldwell, R. W., Jan 1 1984, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 1, 3, p. 120-125 6 p.

Research output: Contribution to journalArticle

Metabolites
Esters
Metoprolol
Pharmaceutical Preparations
Lead compounds
2 Citations (Scopus)

Studies on nalmefene, an opioid antagonist

Nash, C. B., Caldwell, R. W. & Tuttle, R. R., Jan 1 1984, In : Federation Proceedings. 43, 4

Research output: Contribution to journalArticle

Narcotic Antagonists
nalmefene
1 Citation (Scopus)

Synthesis and evaluation of novel lidocaine sulfur analogs

Loftsson, T., Matsuo, M., Caldwell, R. W., Gildersleeve, N. & Bodor, N., Jan 1 1984, In : International Journal of Pharmaceutics. 22, 2-3, p. 345-355 11 p.

Research output: Contribution to journalArticle

Lidocaine
Sulfur
Membranes
Hairless Mouse
Skin
19 Citations (Scopus)

The vasopressor response to centrally administered ouabain

Caldwell, R. W., Songu-Mize, E. & Bealer, S. L., Jan 1 1984, In : Circulation research. 55, 6, p. 773-779 7 p.

Research output: Contribution to journalArticle

Ouabain
Renin
Blood Pressure
Kidney
Adrenergic Receptors
1983
10 Citations (Scopus)

Effect of Anteroventral Third Ventricle Lesions on Vascular Sodium-Pump Activity in Two-Kidney Goldblatt Hypertension

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1983, In : Hypertension. 5, 2, p. I-89-I-93

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Renovascular Hypertension
Third Ventricle
Blood Vessels
Kidney
12 Citations (Scopus)
Angiotensins
Enzyme activity
Vasoconstriction
Angiotensin II
Lung
13 Citations (Scopus)

Metabolism and cardiac actions of a polar aminocardenolide and digoxin in the conscious dog

Songu Mize, E., Nash, C. B., Elam, J. T. & Caldwell, R. W., Jan 1 1983, In : Journal of Pharmacology and Experimental Therapeutics. 226, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Digoxin
Dogs
Digitoxigenin
Feces
Urine
8 Citations (Scopus)

Vascular α-adrenergic blocking properties of quinidine

Caldwell, R. W., Elam, J. T., Mecca, T. E. & Nash, C. B., Oct 28 1983, In : European Journal of Pharmacology. 94, 3-4, p. 185-192 8 p.

Research output: Contribution to journalArticle

Quinidine
Adrenergic Agents
Blood Vessels
Dogs
Angiotensin II
1982
12 Citations (Scopus)

Adrenergic and cholinergic mechanisms in digitalis inotrophy

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 233, 3, p. 761-765 5 p.

Research output: Contribution to journalArticle

Digitoxigenin
Cardiac Glycosides
Digitalis
Adrenergic Agents
Cholinergic Agents
1 Citation (Scopus)

ASI-222 and ASI-254

Caldwell, R. W., Jan 1 1982, In : Drugs of the Future. 7, 10, p. 719-721 3 p.

Research output: Contribution to journalArticle

ASI-222
ASI 254

Effect of a polar cardenolide and digoxin upon A-V refractory period

Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Federation Proceedings. 41, 5

Research output: Contribution to journalArticle

Cardenolides
Digoxin
120 Citations (Scopus)

Effect of AV3V lesions on development of DOCA-Salt hypertension and vascular Na+-pump activity

Songu-Mize, E., Bealer, S. L. & Caldwell, R. W., Jan 1 1982, In : Hypertension. 4, 5, p. 575-580 6 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Blood Vessels
Salts
Desoxycorticosterone
Hypertension

The pulmonary vasoconstrictor action of digoxin: Site of action on the sympathetic nervous system

Mecca, T. E. & Caldwell, R. W., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Digoxin
Sympathetic Nervous System
Vasoconstrictor Agents
Lung
1981
5 Citations (Scopus)

Digoxin uptake into peripheral autonomic cardiac nerves: Possible mechanism of digitalis-induced antiarrhythmic and toxic electrophysiologic actions

Cook, L. S., Doherty, J. E., Straub, K. D., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : American Heart Journal. 102, 1, p. 58-62 5 p.

Research output: Contribution to journalArticle

Toxic Actions
Autonomic Pathways
Digitalis
Digoxin
Peripheral Nervous System
9 Citations (Scopus)

Effect of cardiac β-adrenergic blockade or denervation on cardiotoxicity of digoxin and an aminosugar cardenolide

Puryear, S. K., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Journal of Cardiovascular Pharmacology. 3, 1, p. 113-127 15 p.

Research output: Contribution to journalArticle

Cardenolides
Digoxin
Denervation
Adrenergic Agents
Practolol

Halothane anesthesia and angiotensin I conversion in the dog

Heerdt, P. M., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Clinical Research. 29, 4

Research output: Contribution to journalArticle

Angiotensin I
Halothane
Anesthesia
Dogs

Mechanism of the pulmonary vasoconstrictor action of digoxin

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Federation Proceedings. 40, 3 I, 1 p.

Research output: Contribution to journalArticle

Digoxin
Vasoconstrictor Agents
Lung
1 Citation (Scopus)

Renal tubular transport of a polar cardiac glycoside, ASI-222, in rats; Clearance and micropuncture studies

Kauker, M. L., Nash, C. B. & Caldwell, R. W., Jan 1 1981, In : Journal of Pharmacology and Experimental Therapeutics. 218, 3, p. 686-691 6 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Punctures
Kidney
Nephrons
Cardenolides
1980
32 Citations (Scopus)

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

Rockhold, R. W. & Caldwell, R. W., Jan 1 1980, In : Neuropharmacology. 19, 9, p. 919-922 4 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Microinjections
Blood Pressure
Yohimbine
10 Citations (Scopus)

Changes in cardiac glycoside activity produced by aminosugar addition

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1980, In : Journal of Pharmacology and Experimental Therapeutics. 215, 1, p. 198-204 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digitoxigenin
Poisons
Cardenolides
Cardiotonic Agents
12 Citations (Scopus)

α-adrenergic blocking properties of quinine HCl

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., May 2 1980, In : European Journal of Pharmacology. 63, 2-3, p. 159-166 8 p.

Research output: Contribution to journalArticle

Quinine
Adrenergic Agents
Blood Pressure
Angiotensin II
Norepinephrine
1979

Alpha-adrenergic blocking action of quinine

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

Quinine
Adrenergic Agents
22 Citations (Scopus)

Effect of lesions of the nucleus tractus solitarii on the cardiovascular actions of clonidine in conscious rats

Rockhold, R. W. & Caldwell, R. W., Jan 1 1979, In : Neuropharmacology. 18, 4, p. 347-354 8 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Inbred WKY Rats
Bradycardia
Hypotension