Robert William Caldwell

Professor - Rehired Retiree

  • 6343 Citations
  • 44 h-Index
1970 …2020

Research output per year

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Research Output

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Article
1999
334 Scopus citations
2000

Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production

Ogonowski, A. A., Kaesemeyer, W. H., Jin, L., Ganapathy, V., Leibach, F. H. & Caldwell, R. W., Jan 1 2000, In : American Journal of Physiology - Cell Physiology. 278, 1 47-1, p. C136-C143

Research output: Contribution to journalArticle

61 Scopus citations

Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrate

Kaesemeyer, W. H., Ogonowski, A. A., Jin, L., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 131, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

In situ localization of cholesterol in skeletal muscle by use of a monoclonal antibody

Clarke, M. S. F., Vanderburg, C. R., Bamman, M. M., Caldwell, R. W. & Feeback, D. L., 2000, In : Journal of Applied Physiology. 89, 2, p. 731-741 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin

Abou-Mohamed, G., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 1 2000, In : British Journal of Pharmacology. 130, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Vascular and endothelial actions of inhibitors of substance P amidation

Abou-Mohamed, G. A., Huang, J., Oldham, C. D., Taylor, T. A., Jin, L., Caldwell, R. B., May, S. W. & Caldwell, R. W., Jun 13 2000, In : Journal of Cardiovascular Pharmacology. 35, 6, p. 871-880 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

Endothelial cell dysfunction in a model of oxidative stress

Jin, L., Abou-Mohamed, G., Caldwell, R. B. & Caldwell, R. W., Aug 9 2001, In : Medical Science Monitor. 7, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2002

The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy

Parker, J. O., Parker, J. D., Caldwell, R. W., Farrell, B. & Kaesemeyer, W. H., Apr 3 2002, In : Journal of the American College of Cardiology. 39, 7, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2003

Estradiol relaxes rat aorta via endothelium-dependent and -independent mechanisms

Abou-Mohamed, G., Elmarakby, A., Carrier, G. O., Catravas, J. D., Caldwell, R. W. & White, R. E., Aug 11 2003, In : Pharmacology. 69, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
171 Scopus citations

High glucose-induced tyrosine nitration in endothelial cells: Role of eNOS uncoupling and aldose reductase activation

El-Remessy, A. B., Abou-Mohamed, G., Caldwell, R. W. & Caldwell, R. B., Jul 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 7, p. 3135-3143 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Neuroprotective Effect of(-)Δ 9 -Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite

El-Remessy, A. B., Khalil, I. E., Matragoon, S., Abou-Mohamed, G., Tsai, N. J., Roon, P., Caldwell, R. B., Caldwell, R. W., Green, K. & Liou, G. I., Nov 2003, In : American Journal of Pathology. 163, 5, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

164 Scopus citations
2004

Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

Abou-Mohamed, G., Johnson, J. A., Jin, L., El-Remessy, A. B., Do, K., Kaesemeyer, W. H., Caldwell, R. B. & Caldwell, R. W., Jan 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 1, p. 289-299 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2005

Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2

Tawfik, A. M., Jin, L., Banes-Berceli, A. K. L., Caldwell, R. B., Ogbi, S., Shirley, A., Barber, D., Catravas, J. D., Stern, D. M., Fulton, D. J., Caldwell, R. W. & Marrero, M. B., Nov 1 2005, In : Vascular Pharmacology. 43, 5, p. 320-326 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Platt, D. H., Matragoon, S., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Aug 2005, In : American Journal of Pathology. 167, 2, p. 599-607 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: Role of endothelin-1

Ergul, A., Johansen, J. S., Strømhaug, C., Harris, A. K., Hutchinson, J., Tawfik, A., Rahimi, A., Rhim, E., Wells, B., Caldwell, W. W. & Anstadt, M. P., Apr 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2006

Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells

Banes-Berceli, A. K., Shaw, S., Ma, G., Brands, M., Eaton, D. C., Stern, D. M., Fulton, D., Caldwell, R. W. & Marrero, M. B., Jun 30 2006, In : American Journal of Physiology - Renal Physiology. 291, 1, p. F116-F121

Research output: Contribution to journalArticle

49 Scopus citations
50 Scopus citations

Simvastatin improves diabetes-induced coronary endothelial dysfunction

Tawfik, H. E., El-Remessy, A. B., Matragoon, S., Ma, G., Caldwell, R. B. & Caldwell, R. W., Oct 2 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 1, p. 386-395 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2007

Homocysteine induces endothelial dysfunction via inhibition of arginine transport

Jin, L., Caldwell, R. B., Li-Masters, T. & Caldwell, R. W., Jun 1 2007, In : Journal of Physiology and Pharmacology. 58, 2, p. 191-206 16 p.

Research output: Contribution to journalArticle

64 Scopus citations
53 Scopus citations
2008

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

Romero, M. J., Platt, D. H., Tawfik, H. E., Labazi, M., El-Remessy, A. B., Bartoli, M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2008, In : Circulation research. 102, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

260 Scopus citations
29 Scopus citations

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

Al-Shabrawey, M., Bartoli, M., El-Remessy, A. B., Ma, G., Matragoon, S., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Jul 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 7, p. 3231-3238 8 p.

Research output: Contribution to journalArticle

119 Scopus citations
2009

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero, M. J., Caldwell, R. W. & Caldwell, R. B., Aug 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy

Bartoli, M., Al-Shabrawey, M., Labazi, M., Ali Behzadian, M., Istanboli, M., El-Remessy, A. B., Caldwell, R. W., Marcus, D. M. & Caldwell, R. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4934-4940 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation

Zhang, W., Rojas, M., Lilly, B., Tsai, N. T., Lemtalsi, T., Liou, G. I., Caldwell, R. W. & Caldwell, R. B., 2009, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 3033-3040 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis

Chamberlain, S. M., Hall, J. D., Patel, J., Lee, J. R., Marcus, D. M., Sridhar, S., Romero, M. J., Labazi, M., Caldwell, R. W. & Bartoli, M., Jul 1 2009, In : Digestive Diseases and Sciences. 54, 7, p. 1460-1464 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R., Kaesemeyer, W. H., Chandra, S., Fulton, D. J. & Caldwell, R. W., Aug 1 2010, In : British Journal of Pharmacology. 160, 7, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Novel mechanisms of endothelial dysfunction in diabetes

Yang, G., Lucas, R., Caldwell, R., Yao, L., Romero, M. & Caldwell, R., Jan 1 2010, In : Journal of Cardiovascular Disease Research. 1, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

p38 Mitogen-Activated Protein Kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice

Toque, H. A., Romero, M. J., Tostes, R. C., Shatanawi, A., Chandra, S., Carneiro, Z. N., Inscho, E. W., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Dec 2010, In : Journal of Sexual Medicine. 7, 12, p. 3857-3867 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.

El-Remessy, A. B., Tawfik, H. E., Matragoon, S., Pillai, B., Caldwell, R. B. & Caldwell, R. W., 2010, In : Experimental diabetes research. 2010, 1 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Role of IL-6 in angiotensin II-induced retinal vascular inflammation

Rojas, M., Zhang, W., Lee, D. L., Romero, M. J., Nguyen, D. T., Al-Shabrawey, M., Tsai, N. T., Liou, G. I., Brands, M. W., Caldwell, R. W. & Caldwell, R. B., Mar 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 3, p. 1709-1718 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2011
90 Scopus citations

Arginase 2 deletion reduces Neuro-Glial injury and improves retinal function in a model of Retinopathy of prematurity

Narayanan, S. P., Suwanpradid, J., Saul, A., Xu, Z., Still, A., Caldwell, R. W. & Caldwell, R. B., 2011, In : PloS one. 6, 7, e22460.

Research output: Contribution to journalArticle

37 Scopus citations

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Mar 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

70 Scopus citations
16 Scopus citations

Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model

Zhang, W., Yokota, H., Xu, Z., Narayanan, S. P., Yancey, L., Yoshida, A., Marcus, D. M., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Aug 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6384-6395 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion

Yokota, H., Narayanan, S. P., Zhang, W., Liu, H., Rojas, M., Xu, Z., Lemtalsi, T., Nagaoka, T., Yoshida, A., Brooks, S. E., Caldwell, R. W. & Caldwell, R. B., Oct 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8123-8131 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis

Cheng, B., Anea, C. B., Yao, L., Chen, F., Patel, V., Merloiu, A., Pati, P., Caldwell, R. W., Fulton, D. J. & Rudic, R. D., Oct 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 41, p. 17147-17152 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
2012

Diabetes-induced vascular dysfunction involves arginase

Romero, M. J., Iddings, J. A., Platt, D. H., Irfan Ali, M., Cederbaum, S. D., Stepp, D. W., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 1, p. H159-H166

Research output: Contribution to journalArticle

61 Scopus citations

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice

Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., Fulton, D. J. R. & Rudic, R. D., Oct 12 2012, In : Circulation research. 111, 9, p. 1157-1165 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

Chandra, S., Romero, M. J., Shatanawi, A., Alkilany, A. M., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : British Journal of Pharmacology. 165, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

101 Scopus citations

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Toxicity and cellular uptake of gold nanorods in vascular endothelium and smooth muscles of isolated rat blood vessel: Importance of surface modification

Alkilany, A. M., Shatanawi, A., Kurtz, T., Caldwell, R. B. & Caldwell, R. W., Apr 23 2012, In : Small. 8, 8, p. 1270-1278 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
2013
32 Scopus citations

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

20 Scopus citations

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

10 Scopus citations