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Research Output 1990 2019

2019

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 1 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Nephritis
Tumor Necrosis Factor-alpha
Peptides
Serum
2018
1 Citation (Scopus)

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In : Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Peroxidase
Meals
Erythrocytes
Fats
4 Citations (Scopus)

Cytokine-ion channel interactions in pulmonary inflammation

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M., Männel, D. N., Moehrlen, U., Lucas, R. & Stammberger, U., Jan 4 2018, In : Frontiers in immunology. 8, JAN, 1644.

Research output: Contribution to journalReview article

Ion Channels
Pneumonia
Cytokines
Lung
Replantation

Editorial: Cytokine-ion channel interactions in pulmonary inflammation

Vadász, I. & Lucas, R., Nov 6 2018, In : Frontiers in immunology. 9, NOV, 02598.

Research output: Contribution to journalReview article

Ion Channels
Edema
Pneumonia
Cytokines
5 Citations (Scopus)

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

Bacterial Toxins
geranylgeranylacetone
Reactive Oxygen Species
Lung
Pneumonia
1 Citation (Scopus)

Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A. K., Zhi, W., O'Connor, P. M., Raju, R. P., Lucas, R. & Madaio, M. P., Aug 1 2018, In : Kidney International. 94, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

Nephritis
Protein Kinase C
Kidney
Protein C Inhibitor
Mitochondrial Proteins

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In : Toxins. 10, 2, 79.

Research output: Contribution to journalArticle

Epithelial Cells
Peptides
Chemical activation
Pulmonary Edema
Permeability
2017
11 Citations (Scopus)

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Endothelial Cells
Acid Sensing Ion Channels
Lung
Peptides
11 Citations (Scopus)

Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: A phase IIa randomized placebo-controlled trial

Krenn, K., Lucas, R., Croizé, A., Boehme, S., Klein, K. U., Hermann, R., Markstaller, K. & Ullrich, R., Jul 27 2017, In : Critical Care. 21, 1, 194.

Research output: Contribution to journalArticle

Extravascular Lung Water
Adult Respiratory Distress Syndrome
Pulmonary Edema
Randomized Controlled Trials
Placebos
7 Citations (Scopus)

Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes

Puri, M., La Pietra, L., Mraheil, M. A., Lucas, R., Chakraborty, T. & Pillich, H., Sep 5 2017, In : Toxins. 9, 9, 273.

Research output: Contribution to journalArticle

Listeria
Autophagy
Listeria monocytogenes
Phosphotransferases
Growth
17 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Flores Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
6 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Flores Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
2 Citations (Scopus)

Restoration of epithelial sodium channel function by synthetic peptides in pseudohypoaldosteronism type 1B mutants

Willam, A., Aufy, M., Tzotzos, S., Evanzin, H., Chytracek, S., Geppert, S., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., Feb 24 2017, In : Frontiers in Pharmacology. 8, FEB, 85.

Research output: Contribution to journalArticle

Pseudohypoaldosteronism
Epithelial Sodium Channels
Peptides
Hypoaldosteronism
Channelopathies
4 Citations (Scopus)

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins

Chen, F., Wang, Y., Rafikov, R., Haigh, S., Kumar, S., Rafikova, O., Lucas, R., Verin, A. D., Black, S. M. & Fulton, D. J., Mar 1 2017, In : Biochemical Pharmacology. 127, p. 34-45 12 p.

Research output: Contribution to journalArticle

Bacterial Toxins
Nitric Oxide
glutathione-independent formaldehyde dehydrogenase
Lung
Calcium
6 Citations (Scopus)
Adipose Tissue
Caveolin 1
Tumor Necrosis Factor-alpha
Obesity
Dilatation
7 Citations (Scopus)

Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise

Zhou, Q., Wang, D., Liu, Y., Yang, X., Lucas, R. & Fischer, B., Mar 1 2017, In : CHEST. 151, 3, p. 658-667 10 p.

Research output: Contribution to journalArticle

Pulmonary Edema
Occludin
Dimercaprol
Aminophylline
Lung

TNF lectin-like domain restores epithelial sodium channel function in frameshift mutants associated with pseudohypoaldosteronism type 1B

Willam, A., Aufy, M., Tzotzos, S., El-Malazi, D., Poser, F., Wagner, A., Unterköfler, B., Gurmani, D., Martan, D., Iqbal, S. M., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., May 29 2017, In : Frontiers in immunology. 8, MAY, 601.

Research output: Contribution to journalArticle

Pseudohypoaldosteronism
Epithelial Sodium Channels
Lectins
Tumor Necrosis Factor-alpha
Glycosylation
2016
5 Citations (Scopus)
Growth Hormone-Releasing Hormone
Dyslipidemias
Glucagon-Like Peptide 1
Type 1 Diabetes Mellitus
Lipoproteins
8 Citations (Scopus)

The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

Research output: Contribution to journalArticle

Lectins
Peptides
Epithelial Sodium Channels
Membranes
Ubiquitination
5 Citations (Scopus)

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular System Injuries
Retinal Vessels
Endothelial Cells
Polyamines
2015
9 Citations (Scopus)
Caveolin 1
Constriction
Angiotensin II
Arteries
Obesity
21 Citations (Scopus)

Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury

Gross, C. M., Rafikov, R., Kumar, S., Aggarwal, S., Ham, P. B., Meadows, M. L., Cherian-Shaw, M., Kangath, A., Sridhar, S., Lucas, R. & Black, S. M., Mar 18 2015, In : PloS one. 10, 3, e0119918.

Research output: Contribution to journalArticle

Acute Lung Injury
Nitric Oxide Synthase Type III
lipopolysaccharides
Lipopolysaccharides
lungs
7 Citations (Scopus)

Glycosylation-dependent activation of epithelial sodium channel by solnatide

Shabbir, W., Tzotzos, S., Bedak, M., Aufy, M., Willam, A., Kraihammer, M., Holzner, A., Czikora, I., Scherbaum-Hazemi, P., Fischer, H., Pietschmann, H., Fischer, B., Lucas, R. & Lemmens-Gruber, R., Dec 15 2015, In : Biochemical Pharmacology. 98, 4, p. 740-753 14 p.

Research output: Contribution to journalArticle

Glycosylation
Epithelial Sodium Channels
Acute Lung Injury
Chemical activation
Pulmonary Edema
14 Citations (Scopus)

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes

Loose, M., Hudel, M., Zimmer, K. P., Garcia, E., Hammerschmidt, S., Lucas, R., Chakraborty, T. & Pillich, H., Jan 15 2015, In : Journal of Infectious Diseases. 211, 2, p. 306-316 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Mitogens
Protein Kinases
Hydrogen Peroxide
Pyruvate Oxidase
2014
14 Citations (Scopus)

A FIM study to assess safety and exposure of inhaled single doses of AP301 - A specific ENaC channel activator for the treatment of acute lung injury

Schwameis, R., Eder, S., Pietschmann, H., Fischer, B., Mascher, H., Tzotzos, S., Fischer, H., Lucas, R., Zeitlinger, M. & Hermann, R., Jan 1 2014, In : Journal of Clinical Pharmacology. 54, 3, p. 341-350 10 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Healthy Volunteers
Safety
Placebos
Hoarseness
29 Citations (Scopus)

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Czikora, I., Alli, A., Bao, H. F., Kaftan, D., Sridhar, S., Apell, H. J., Gorshkov, B., White, R., Zimmermann, A., Wendel, A., Pauly-Evers, M., Hamacher, J., Garcia-Gabay, I., Fischer, B., Verin, A., Bagi, Z., Pittet, J. F., Shabbir, W., Lemmens-Gruber, R., Chakraborty, T. & 4 others, Lazrak, A., Matthay, M. A., Eaton, D. C. & Lucas, R., Sep 1 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 5, p. 522-532 11 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Tumor Necrosis Factor-alpha
Lectins
Pulmonary Edema
Edema
7 Citations (Scopus)

Arginase in the vascular endothelium: Friend or foe?

Lucas, R., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Jan 1 2014, In : Frontiers in immunology. 5, NOV, 589.

Research output: Contribution to journalEditorial

Arginase
Vascular Endothelium
Capillary Permeability
Reactive Oxygen Species
18 Citations (Scopus)

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

Aggarwal, S., Gross, C. M., Kumar, S., Dimitropoulou, C., Sharma, S., Gorshkov, B. A., Sridhar, S., Lu, Q., Bogatcheva, N. V., Jezierska-Drutel, A. J., Lucas, R., Verin, A. D., Catravas, J. D. & Black, S. M., Mar 2014, In : American journal of respiratory cell and molecular biology. 50, 3, p. 614-625 12 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Lung
Oxidative stress
Nitration
Vascular System Injuries
28 Citations (Scopus)

Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA

Rafikov, R., Dimitropoulou, C., Aggarwal, S., Kangath, A., Gross, C., Pardo, D., Sharma, S., Jezierska-Drutel, A., Patel, V. S., Snead, C., Lucas, R., Verin, A. D., Fulton, D. J., Catravas, J. D. & Black, S. M., Feb 21 2014, In : Journal of Biological Chemistry. 289, 8, p. 4710-4722 13 p.

Research output: Contribution to journalArticle

Nitration
Acute Lung Injury
Lung Injury
Lipopolysaccharides
Chemical activation
29 Citations (Scopus)

PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins

Chen, F., Kumar, S., Yu, Y., Aggarwal, S., Gross, C., Wang, Y., Chakraborty, T., Verin, A. D., Catravas, J. D., Lucas, R., Black, S. M. & Fulton, D. J., Jul 14 2014, In : PloS one. 9, 7, e99823.

Research output: Contribution to journalArticle

Phosphorylation
Nitric Oxide Synthase Type III
phosphorylation
toxins
Endothelial cells
29 Citations (Scopus)

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

Gonzales, J. N., Gorshkov, B. A., Varn, M. N., Zemskova, M. A., Zemskov, E. A., Sridhar, S., Lucas, R. & Verin, A. D., Mar 15 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 6

Research output: Contribution to journalArticle

Purinergic P1 Receptors
Acute Lung Injury
Adenosine-5'-(N-ethylcarboxamide)
Adenosine
Lipopolysaccharides
10 Citations (Scopus)

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., Jan 1 2014, In : Frontiers in Physiology. 5 JUL, 00259.

Research output: Contribution to journalArticle

Bacterial Toxins
Growth Hormone-Releasing Hormone
Cyclic AMP-Dependent Protein Kinases
Lung
Endothelial Cells
50 Citations (Scopus)

Regulation of NADPH oxidase 5 by protein kinase C isoforms

Chen, F., Yu, Y., Haigh, S., Johnson, J., Lucas, R., Stepp, D. W. & Fulton, D. J. R., Feb 5 2014, In : PloS one. 9, 2, e88405.

Research output: Contribution to journalArticle

NADPH Oxidase
protein kinase C
NADP
NADP (coenzyme)
Protein Kinase C
2013
13 Citations (Scopus)

A Combined impedance and alphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Önder, K., Kopecky, J., Schütt, W. & Hundsberger, H., Jan 1 2013, In : Journal of Biomolecular Screening. 18, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Intercellular Adhesion Molecule-1
Electric Impedance
Interleukin-8
Endothelium
19 Citations (Scopus)

Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling

Siddaramappa, U. N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In : PloS one. 8, 4, e59733.

Research output: Contribution to journalArticle

Vasa Vasorum
Adenosine A1 Receptors
Endothelial cells
adenosine
microfilaments
16 Citations (Scopus)

AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na+ current in primary dog, pig and rat alveolar type II cells

Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R., Dupré, G., Lemmens-Gruber, R., Hazemi, P., Prymaka, V. & Shabbir, W., Jun 1 2013, In : Pulmonary Pharmacology and Therapeutics. 26, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Amiloride
Lectins
Rats
Swine
8 Citations (Scopus)

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in Immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

Arginase
Acute Lung Injury
Nitric Oxide Synthase Type III
Bacterial Toxins
Lung
Vasa Vasorum
Adenosine A1 Receptors
adenosine
microfilaments
Actin Cytoskeleton
21 Citations (Scopus)

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Lucas, R., Parikh, S. J., Sridhar, S., Guo, D. H., Bhagatwala, J., Dong, Y., Caldwell, R., Mellor, A., Caldwell, W., Zhu, H. & Dong, Y., Oct 1 2013, In : Cytokine. 64, 1, p. 310-315 6 p.

Research output: Contribution to journalArticle

Prediabetic State
African Americans
Cytokines
Medical problems
Type 2 Diabetes Mellitus
12 Citations (Scopus)

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., Dec 1 2013, In : Frontiers in Immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

Citrulline
Arginase
Kidney
Streptozocin
Knockout Mice
15 Citations (Scopus)

Mechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel

Shabbir, W., Scherbaum-Hazemi, P., Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R. & Lemmens-Gruber, R., Dec 1 2013, In : Molecular Pharmacology. 84, 6, p. 899-910 12 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Edema
Lung
Therapeutics
Amiloride
18 Citations (Scopus)

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Gorshkov, B. A., Siddaramappa, U. N., Oseghale, A., Lawson, J., Verin, A. D., Rick, F. G., Block, N. L., Pillich, H., Romero Lucas, M. J., Leustik, M., Schally, A. V. & Chakraborty, T., Jul 1 2013, In : Toxins. 5, 7, p. 1244-1260 17 p.

Research output: Contribution to journalReview article

Anti-Bacterial Agents
Lung
Edema
Sodium
Epithelial Sodium Channels
19 Citations (Scopus)

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

Chen, F., Lucas, R. & Fulton, D. J., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 184.

Research output: Contribution to journalShort survey

Arginine
Nitric Oxide Synthase Type III
Nitric Oxide
Enzymes
Arginase
2012
7 Citations (Scopus)

A computational study of the oligosaccharide binding sites in the lectin-like domain of tumor necrosis factor and the TNF-derived TIP peptide

Dulebo, A., Ettrich, R., Lucas, R. & Kaftan, D., Sep 21 2012, In : Current Pharmaceutical Design. 18, 27, p. 4236-4243 8 p.

Research output: Contribution to journalArticle

Oligosaccharides
Lectins
Tumor Necrosis Factor-alpha
Binding Sites
Peptides
34 Citations (Scopus)

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

Research output: Contribution to journalArticle

Growth Hormone-Releasing Hormone
Pulmonary Edema
Permeability
Edema
Lung
8 Citations (Scopus)

Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population

Wang, H. D., Zhu, B. F., Shen, C. M., Yuan, G. L., Yang, G., Guo, J. N., Yan, J. W., Qin, H. X., Guo, J. X., Zhang, L. P., Jia, X. Q. & Lucas, R., Mar 1 2012, In : Molecular Biology Reports. 39, 3, p. 3017-3028 12 p.

Research output: Contribution to journalArticle

KIR Receptors
Genetic Polymorphisms
Population
Genes
Gene Frequency
33 Citations (Scopus)

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

Arginase
Protein Kinase C
Lung
Endothelial cells
Endothelial Cells
10 Citations (Scopus)
Acute Lung Injury
NAD
Lipopolysaccharides
Bronchoalveolar Lavage Fluid
Lung
2011
113 Citations (Scopus)

Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases

Bencherif, M., Lippiello, P. M., Lucas, R. & Marrero, M. B., Mar 1 2011, In : Cellular and Molecular Life Sciences. 68, 6, p. 931-949 19 p.

Research output: Contribution to journalReview article

Nicotinic Receptors
Cytokines
Inflammation
Cholinergic Agents
alpha7 Nicotinic Acetylcholine Receptor
35 Citations (Scopus)

Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: An overview

Marrero, M. B., Bencherif, M., Lippiello, P. M. & Lucas, R., Feb 1 2011, In : Pharmaceutical Research. 28, 2, p. 413-416 4 p.

Research output: Contribution to journalComment/debate

alpha7 Nicotinic Acetylcholine Receptor
Cholinergic Agonists
Cytokines
Macrophages
Interleukins