• 1100 Citations
  • 20 h-Index
20072019
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Research Output 2007 2019

  • 1100 Citations
  • 20 h-Index
  • 41 Article
  • 8 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2019

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
Arginase
Oxidative stress
Muscle
Nitric Oxide
Skeletal Muscle
2 Citations (Scopus)

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Stem Cells
Muscles
Mesenchymal Stromal Cells
MicroRNAs
3 Citations (Scopus)

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Elmansi, A. M., Awad, M. E., Eisa, N. H., Kondrikov, D., Hussein, K. A., Aguilar-Pérez, A., Herberg, S., Periyasamy-Thandavan, S., Fulzele, S., Hamrick, M. W., McGee-Lawrence, M. E., Isales, C. M., Volkman, B. F. & Hill, W. D., Jun 2019, In : Pharmacology and Therapeutics. 198, p. 90-108 19 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Peptide Hormones
Proteolysis
Cytokines
Ligands
2018
7 Citations (Scopus)

Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration

Kennon, J. C., Awad, M. E., Chutkan, N., DeVine, J. G. & Fulzele, S. T., Jan 1 2018, In : Biomolecular Concepts. 9, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Intervertebral Disc Degeneration
Intervertebral Disc
Intercellular Signaling Peptides and Proteins
Tissue Engineering
Tissue engineering
1 Citation (Scopus)

Effect of plasma-derived extracellular vesicles on erythrocyte deformability in polymicrobial sepsis

Subramani, K., Raju, S. P., Chu, X., Warren, M., Pandya, C. D., Hoda, MD. N., Fulzele, S. T. & Raju, R. P., Dec 1 2018, In : International Immunopharmacology. 65, p. 244-247 4 p.

Research output: Contribution to journalArticle

Erythrocyte Deformability
Sepsis
Microcirculation
Perfusion
Erythrocytes
2 Citations (Scopus)

Modulation of miRNAS by vitamin C in human bone marrow stromal cells

Kolhe, R., Mondal, A. K., Pundkar, C., Periyasamy-Thandavan, S., Mendhe, B., Hunter, M., Isales, C. M., Hill, W. D., Hamrick, M. W. & Fulzele, S., Feb 8 2018, In : Nutrients. 10, 2, 186.

Research output: Contribution to journalArticle

stromal cells
bone marrow cells
MicroRNAs
Mesenchymal Stromal Cells
microRNA
2017
6 Citations (Scopus)

Adenosine deaminase-2–induced hyperpermeability in human retinal vascular endothelial cells is suppressed by microRNA-146b-3p

Samra, Y. A., Saleh, H. M., Hussein, K. A., Elsherbiny, N. M., Ibrahim, A. S., Elmasry, K., Fulzele, S., El-Shishtawy, M. M., Eissa, L. A., Al-Shabrawey, M. & Liou, G. I., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 933-943 11 p.

Research output: Contribution to journalArticle

Retinal Vessels
Adenosine Deaminase
MicroRNAs
Endothelial Cells
Macrophages
6 Citations (Scopus)

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Alshenibr, W., Tashkandi, M. M., Alsaqer, S. F., Alkheriji, Y., Wise, A., Fulzele, S. T., Mehra, P., Goldring, M. B., Gerstenfeld, L. C. & Bais, M. V., Aug 2 2017, In : Arthritis Research and Therapy. 19, 1, 179.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Temporomandibular Joint
Knee Joint
Osteoarthritis
Cartilage
8 Citations (Scopus)

Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity

Zhu, H., Lemos, H., Bhatt, B., Islam, B. N., Singh, A., Gurav, A., Huang, L., Browning, D. D., Mellor, A., Fulzele, S. & Singh, N., Sep 2017, In : PloS one. 12, 9, e0183484.

Research output: Contribution to journalArticle

Carbidopa
autoimmunity
T-cells
Parkinson disease
Autoimmunity
41 Citations (Scopus)

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific Reports. 7, 1, 2029.

Research output: Contribution to journalArticle

Synovial Fluid
MicroRNAs
Osteoarthritis
Exosomes
Encyclopedias
9 Citations (Scopus)

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H. M., Elsherbiny, N. M., Fulzele, S. T., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A. M., Dec 1 2017, In : Scientific Reports. 7, 1, 09731.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Oxidative Stress
Endothelial Cells
Homocysteine
Blood-Retinal Barrier
21 Citations (Scopus)

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

Refaey, M. E., McGee-Lawrence, M. E., Fulzele, S., Kennedy, E. J., Bollag, W. B., Elsalanty, M., Zhong, Q., Ding, K. H., Bendzunas, N. G., Shi, X. M., Xu, J., Hill, W. D., Johnson, M. H., Hunter, M., Pierce, J. L., Yu, K., Hamrick, M. W. & Isales, C. M., Nov 2017, In : Journal of Bone and Mineral Research. 32, 11, p. 2182-2193 12 p.

Research output: Contribution to journalArticle

Kynurenine
Tryptophan
Bone and Bones
Aromatic Amino Acids
Anabolic Agents
35 Citations (Scopus)
Cell Aging
Cell proliferation
Stem cells
MicroRNAs
Mesenchymal Stromal Cells
2016
14 Citations (Scopus)

AMP-activated protein kinase suppresses autoimmune central nervous system disease by regulating M1-type macrophage-Th17 axis

Mangalam, A. K., Rattan, R., Suhail, H., Singh, J., Hoda, MD. N., Deshpande, M., Fulzele, S. T., Denic, A., Shridhar, V., Kumar, A., Viollet, B., Rodriguez, M. & Giri, S., Aug 1 2016, In : Journal of Immunology. 197, 3, p. 747-760 14 p.

Research output: Contribution to journalArticle

Autoimmune Diseases of the Nervous System
AMP-Activated Protein Kinases
Central Nervous System Diseases
Autoimmune Experimental Encephalomyelitis
Interleukin-17
9 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
2015
5 Citations (Scopus)

Correlation of changes in the mandible and retina/choroid vasculature of a rat model of BRONJ

Borke, J. L., McAllister, B., Harris, T., Neiberg, M., Guevarra-Toth, C., Fulzele, S. T., Stoianovici, C. & Guerra, C., Sep 1 2015, In : Journal of Cranio-Maxillofacial Surgery. 43, 7, p. 1144-1150 7 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Choroid
Diphosphonates
Mandible
Retina
103 Citations (Scopus)

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Pathania, R., Ramachandran, S., Elangovan, S., Padia, R., Yang, P., Cinghu, S., Veeranan-Karmegam, R., Arjunan, P., Gnana-Prakasam, J. P., Sadanand, F., Pei, L., Chang, C. S., Choi, J. H., Shi, H., Manicassamy, S., Prasad, P. D., Sharma, S., Ganapathy, V., Jothi, R. & Thangaraju, M., Apr 22 2015, In : Nature Communications. 6, 6910.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
stem cells
Stem cells
maintenance
Carcinogenesis
36 Citations (Scopus)

MicroRNA-146b-3p regulates retinal inflammation by suppressing adenosine deaminase-2 in diabetes

Fulzele, S. T., El-Sherbini, A., Ahmad, S., Sangani, R., Matragoon, S., El-Remessy, A., Radhakrishnan, R. & Liou, G. I., 2015, In : BioMed Research International. 2015, 846501.

Research output: Contribution to journalArticle

Adenosine Deaminase
Medical problems
MicroRNAs
Genes
Inflammation
15 Citations (Scopus)

MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells

Sangani, R., Periyasamy-Thandavan, S., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Isales, C., Hamrick, M., Hill, W. D. & Fulzele, S., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 19-26 8 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
MicroRNAs
Mesenchymal Stromal Cells
Bone
Small Untranslated RNA
10 Citations (Scopus)

The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis

Sangani, R., Periyasamy-Thandavan, S., Pathania, R., Ahmad, S., Kutiyanawalla, A., Kolhe, R., Bhattacharyya, M. H., Chutkan, N., Hunter, M., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Sep 1 2015, In : Stem Cell Research. 15, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Autophagy
Mesenchymal Stromal Cells
Ascorbic Acid
Apoptosis
2014
1 Citation (Scopus)

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

Blackburn, A. R., Hamrick, M. W., Chutkan, N., Sangani, R., Waller, J. L., Corpe, R., Prasad, P. D., Isales, C. M., Ganapathy, V. & Fulzele, S., Jan 8 2014, In : BMC Musculoskeletal Disorders. 15, 1, 9.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Articular Cartilage
Osteoarthritis
Real-Time Polymerase Chain Reaction
Hematoxylin
11 Citations (Scopus)

Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy

Ahmad, S., Elsherbiny, N. M., Bhatia, K., Elsherbini, A. M., Fulzele, S. T. & Liou, G. I., Dec 15 2014, In : Journal of Neuroimmunology. 277, 1-2, p. 96-104 9 p.

Research output: Contribution to journalArticle

Adenosine Kinase
Optic Nerve Injuries
Inflammation
Adenosine
Purinergic P1 Receptor Agonists
12 Citations (Scopus)

Knockdown of SVCT2 impairs in-vitro cell attachment, migration and wound healing in bone marrow stromal cells

Sangani, R., Pandya, C. D., Bhattacharyya, M. H., Periyasamy-Thandavan, S., Chutkan, N., Markand, S., Hill, W. D., Hamrick, M., Isales, C. & Fulzele, S., Mar 2014, In : Stem Cell Research. 12, 2, p. 354-363 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Wound Healing
Cell Movement
Ascorbic Acid
Oxidative Stress
2013
24 Citations (Scopus)
Leptin Receptors
muscular atrophy
myoblasts
Muscular Atrophy
Myoblasts
29 Citations (Scopus)

ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy

Elsherbiny, N. M., Ahmad, S., Naime, M., Elsherbini, A. M., Fulzele, S., Al-Gayyar, M. M., Eissa, L. A., El-Shishtawy, M. M. & Liou, G. I., Jul 30 2013, In : Life sciences. 93, 2-3, p. 78-88 11 p.

Research output: Contribution to journalArticle

Adenosine Kinase
Diabetic Retinopathy
Adenosine
Inflammation
Medical problems
35 Citations (Scopus)
Myostatin
Bone Density
Muscle
Bone
Bone and Bones
41 Citations (Scopus)

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

Bowser, M., Herberg, S., Arounleut, P., Shi, X., Fulzele, S., Hill, W. D., Isales, C. M. & Hamrick, M. W., Feb 1 2013, In : Experimental Gerontology. 48, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

Myostatin
Follistatin
Muscle Cells
Muscle
Bone
23 Citations (Scopus)

Potential role of A2A adenosine receptor in traumatic optic neuropathy

Ahmad, S., Fatteh, N., El-Sherbiny, N. M., Naime, M., Ibrahim, A. S., El-Sherbini, A. M., El-Shafey, S. A., Khan, S., Fulzele, S., Gonzales, J. & Liou, G. I., Oct 2 2013, In : Journal of Neuroimmunology. 264, 1-2, p. 54-64 11 p.

Research output: Contribution to journalArticle

Optic Nerve Injuries
Adenosine A2A Receptors
Microglia
Reactive Oxygen Species
Cell Death
20 Citations (Scopus)

Potential roles of adenosine deaminase-2 in diabetic retinopathy

Elsherbiny, N. M., Naime, M., Ahmad, S., Elsherbini, A. M., Mohammad, S., Fulzele, S., El-Remessy, A. B., Al-Gayyar, M. M., Eissa, L. A., El-Shishtawy, M. M., Han, G., White, R., Haroldo, T. F. & Liou, G. I., Jul 5 2013, In : Biochemical and Biophysical Research Communications. 436, 3, p. 355-361 7 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
Diabetic Retinopathy
Adenosine Kinase
Adenosine
Swine
6 Citations (Scopus)

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., Dec 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Bone
Bone Marrow
Bone and Bones
Oxidative Stress
9 Citations (Scopus)

Sodium-coupled vitamin C transporter (SVCT2): Expression, function, and regulation in intervertebral disc cells

Chothe, P. P., Chutkan, N., Sangani, R., Wenger, K. H., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V. & Fulzele, S., May 1 2013, In : Spine Journal. 13, 5, p. 549-557 9 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Intervertebral Disc
Ascorbic Acid
Somatomedins
Dexamethasone
17 Citations (Scopus)

Sodium-dependent vitamin C transporter SVCT2: Expression and function in bone marrow stromal cells and in osteogenesis

Fulzele, S., Chothe, P., Sangani, R., Chutkan, N., Hamrick, M., Bhattacharyya, M., Prasad, P. D., Zakhary, I., Bowser, M., Isales, C. & Ganapathy, V., Jan 1 2013, In : Stem Cell Research. 10, 1, p. 36-47 12 p.

Research output: Contribution to journalArticle

Sodium-Coupled Vitamin C Transporters
Mesenchymal Stromal Cells
Osteogenesis
Ascorbic Acid
Bone and Bones
26 Citations (Scopus)

Stromal Cell-derived Factor-1β potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro

Herberg, S., Fulzele, S., Yang, N., Shi, X., Hess, M., Periyasamy-Thandavan, S., Hamrick, M. W., Isales, C. M. & Hill, W. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 1-2, p. 1-13 13 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Bone Morphogenetic Protein 2
Stem cells
Mesenchymal Stromal Cells
Bone
2012
9 Citations (Scopus)

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Proton-Coupled Folate Transporter
Neuroglia
Fumarates
Pharmaceutical Preparations
Retinal Diseases
10 Citations (Scopus)
Acute Lung Injury
NAD
Lipopolysaccharides
Bronchoalveolar Lavage Fluid
Lung
2011
19 Citations (Scopus)

Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression

Elkasrawy, M., Fulzele, S. T., Bowser, M., Wenger, K. & Hamrick, M. W., Dec 1 2011, In : Growth Factors. 29, 6, p. 253-262 10 p.

Research output: Contribution to journalArticle

Myostatin
Chondrogenesis
Chondrocytes
Bone
Mesenchymal Stromal Cells
2010
37 Citations (Scopus)

Effect of whole-body vibration on bone properties in aging mice

Wenger, K. H., Freeman, J. D., Fulzele, S. T., Immel, D. M., Powell, B. D., Molitor, P., Chao, Y. J., Gao, H. S., Elsalanty, M. E., Hamrick, M. W., Isales, C. M. & Yu, J. C., Oct 1 2010, In : Bone. 47, 4, p. 746-755 10 p.

Research output: Contribution to journalArticle

Vibration
Bone and Bones
Bone Density
Femur
Independent Living
48 Citations (Scopus)

Long-range function of an intergenic retrotransposon

Pi, W., Zhu, X., Wu, M., Wang, Y., Fulzele, S. T., Eroglu, A., Ling, J. & Tuan Lo, D., Jul 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 29, p. 12992-12997 6 p.

Research output: Contribution to journalArticle

Retroelements
Terminal Repeat Sequences
Endogenous Retroviruses
Globins
Genes
21 Citations (Scopus)

Role of myostatin (GDF-8) signaling in the human anterior cruciate ligament

Fulzele, S. T., Arounleut, P., Cain, M., Herberg, S., Hunter, D. M., Wenger, K. & Hamrick, M. W., Aug 1 2010, In : Journal of Orthopaedic Research. 28, 8, p. 1113-1118 6 p.

Research output: Contribution to journalArticle

Myostatin
Anterior Cruciate Ligament
Collagen Type I
Tenascin
Fibroblasts
2009
51 Citations (Scopus)

Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume

Kellum, E., Starr, H., Arounleut, P., Immel, D., Fulzele, S. T., Wenger, K. & Hamrick, M. W., Jan 1 2009, In : Bone. 44, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Myostatin
Bony Callus
Bone and Bones
Osteotomy
Bone Morphogenetic Protein 5
2007
100 Citations (Scopus)

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading

Hamrick, M. W., Shi, X., Zhang, W., Pennington, C., Thakore, H., Haque, M., Kang, B., Isales, C. M., Fulzele, S. & Wenger, K. H., Jun 1 2007, In : Bone. 40, 6, p. 1544-1553 10 p.

Research output: Contribution to journalArticle

Myostatin
Mesenchymal Stromal Cells
Bone Marrow
Hindlimb Suspension
Bone and Bones