• 1333 Citations
  • 22 h-Index
20052020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1333 Citations
  • 22 h-Index
  • 55 Article
  • 2 Review article
  • 1 Comment/debate
2020

Characteristics and potential biomarkers of adult sickle cell patients with chronic pain

Albo, C., Kumar, S., Pope, M., Kidwell, K. M., Xu, H., Bowman, L., Wells, L., Barrett, N., Fields, S., Bora, P., Patel, N. & Kutlar, A., Oct 1 2020, In : European Journal of Haematology. 105, 4, p. 419-425 7 p.

Research output: Contribution to journalArticle

Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms

Verin, A. D., Batori, R., Kovacs-Kasa, A., Cherian-Shaw, M., Kumar, S., Czikora, I., Karoor, V., Strassheim, D., Stenmark, K. R. & Gerasimovskaya, E. V., Jul 2020, In : American Journal of Physiology - Cell Physiology. 319, 1, p. C183-C193

Research output: Contribution to journalArticle

1 Scopus citations

TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Sun, X., Lu, Q., Yegambaram, M., Kumar, S., Qu, N., Srivastava, A., Wang, T., Fineman, J. R. & Black, S. M., Sep 2020, In : Redox Biology. 36, 101593.

Research output: Contribution to journalArticle

Open Access
2019

Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening

Bátori, R., Kumar, S., Bordán, Z., Cherian-Shaw, M., Kovács-Kása, A., MacDonald, J. A., Fulton, D. J. R., Erdődi, F. & Verin, A. D., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 5863-5879 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In : Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18

Gross, C. M., Kellner, M., Wang, T., Lu, Q., Sun, X., Zemskov, E. A., Noonepalle, S., Kangath, A., Kumar, S., Gonzalez-Garay, M., Desai, A. A., Aggarwal, S., Gorshkov, B., Klinger, C., Verin, A. D., Catravas, J. D., Jacobson, J. R., Yuan, J. X. J., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., May 1 2018, In : American journal of respiratory cell and molecular biology. 58, 5, p. 614-624 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

Altered carnitine homeostasis in children with increased pulmonary blood flow due to ventricular septal defects

Black, S. M., Field-Ridley, A., Sharma, S., Kumar, S., Keller, R. L., Kameny, R., Maltepe, E., Datar, S. A. & Fineman, J. R., Oct 1 2017, In : Pediatric Critical Care Medicine. 18, 10, p. 931-934 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury

Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E. A., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A. A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J. X. J., Catravas, J. D., Rafikov, R., Garcia, J. G. N. & 1 others, Black, S. M., Jan 1 2017, In : Free Radical Biology and Medicine. 102, p. 217-228 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins

Chen, F., Wang, Y., Rafikov, R., Haigh, S., Kumar, S., Rafikova, O., Lucas, R., Verin, A. D., Black, S. M. & Fulton, D. J. R., Mar 1 2017, In : Biochemical Pharmacology. 127, p. 34-45 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

Kovacs-Kasa, A., Gorshkov, B. A., Kim, K. M., Kumar, S., Black, S. M., Fulton, D. J., Dimitropoulou, C., Catravas, J. D. & Verin, A. D., Dec 15 2016, In : Scientific reports. 6, 39018.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress

Lu, Q., Harris, V. A., Kumar, S., Mansour, H. M. & Black, S. M., Dec 1 2015, In : Redox Biology. 6, p. 516-523 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury

Gross, C. M., Rafikov, R., Kumar, S., Aggarwal, S., Ham, P. B., Meadows, M. L., Cherian-Shaw, M., Kangath, A., Sridhar, S., Lucas, R. & Black, S. M., Mar 18 2015, In : PloS one. 10, 3, e0119918.

Research output: Contribution to journalArticle

22 Scopus citations

Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism

Lu, Q., Harris, V. A., Rafikov, R., Sun, X., Kumar, S. & Black, S. M., Dec 1 2015, In : Redox Biology. 6, p. 112-121 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

Aggarwal, S., Gross, C. M., Kumar, S., Dimitropoulou, C., Sharma, S., Gorshkov, B. A., Sridhar, S., Lu, Q., Bogatcheva, N. V., Jezierska-Drutel, A. J., Lucas, R., Verin, A. D., Catravas, J. D. & Black, S. M., Mar 2014, In : American journal of respiratory cell and molecular biology. 50, 3, p. 614-625 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase

Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lu, Q., Gross, C., Rafikova, O., Lee, S. G., Dasarathy, S., Hou, Y., Meadows, M. L., Han, W., Su, Y., Fineman, J. R. & Black, S. M., Jun 2014, In : American journal of respiratory cell and molecular biology. 50, 6, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167

Rafikov, R., Kumar, S., Aggarwal, S., Hou, Y., Kangath, A., Pardo, D., Fineman, J. R. & Black, S. M., Feb 2014, In : Free Radical Biology and Medicine. 67, p. 255-264 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Heat shock protein 90 inhibitors prevent lps-induced endothelial barrier dysfunction by disrupting Rhoa signaling

Joshi, A. D., Dimitropoulou, C., Thangjam, G., Snead, C., Feldman, S., Barabutis, N., Fulton, D., Hou, Y., Kumar, S., Patel, V., Gorshkov, B., Verin, A. D., Black, S. M. & Catravas, J. D., Jan 2014, In : American journal of respiratory cell and molecular biology. 50, 1, p. 170-179 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding

Aggarwal, S., Gross, C. M., Rafikov, R., Kumar, S., Fineman, J. R., Ludewig, B., Jonigk, D. & Black, S. M., Mar 14 2014, In : Journal of Biological Chemistry. 289, 11, p. 7948-7961 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins

Chen, F., Kumar, S., Yu, Y., Aggarwal, S., Gross, C., Wang, Y., Chakraborty, T., Verin, A. D., Catravas, J. D., Lucas, R., Black, S. M. & Fulton, D. J. R., Jul 14 2014, In : PloS one. 9, 7, e99823.

Research output: Contribution to journalArticle

34 Scopus citations

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

Rafikov, R., Kumar, S., Aggarwal, S., Pardo, D., Fonseca, F. V., Ransom, J., Rafikova, O., Chen, Q., Springer, M. L. & Black, S. M., Apr 2014, In : Redox Biology. 2, 1, p. 156-164 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sox18 Preserves the Pulmonary Endothelial Barrier Under Conditions of Increased Shear Stress

Gross, C. M., Aggarwal, S., Kumar, S., Tian, J., Kasa, A., Bogatcheva, N., Datar, S. A., Verin, A. D., Fineman, J. R. & Black, S. M., Nov 2014, In : Journal of Cellular Physiology. 229, 11, p. 1802-1816 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonaryhypertension

Rafikova, O., Rafikov, R., Kumar, S., Sharma, S., Aggarwal, S., Schneider, F., Jonigk, D., Black, S. M. & Tofovic, S. P., Mar 2013, In : Free Radical Biology and Medicine. 56, p. 28-43 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow

Sun, X., Sharma, S., Fratz, S., Kumar, S., Rafikov, R., Aggarwal, S., Rafikova, O., Lu, Q., Burns, T., Dasarathy, S., Wright, J., Schreiber, C., Radman, M., Fineman, J. R. & Black, S. M., May 10 2013, In : Antioxidants and Redox Signaling. 18, 14, p. 1739-1752 14 p.

Research output: Contribution to journalReview article

21 Scopus citations

Erratum: Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow (Pediatric Research (2013) 73 (54-61) DOI: 10.1038/pr.2012.149)

Oishi, P. E., Sharma, S., Datar, S. A., Kumar, S., Aggarwal, S., Lu, Q., Raff, G., Azakie, A., Hsu, J. H., Sajti, E., Fratz, S., Black, S. M. & Fineman, J. R., Dec 2013, In : Pediatric research. 74, 6, p. 742 1 p.

Research output: Contribution to journalComment/debate

L-Carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow

Sharma, S., Aramburo, A., Rafikov, R., Sun, X., Kumar, S., Oishi, P. E., Datar, S. A., Raff, G., Xoinis, K., Kalkan, G., Fratz, S., Fineman, J. R. & Black, S. M., Jul 2013, In : Pediatric research. 74, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung

Barabutis, N., Handa, V., Dimitropoulou, C., Rafikov, R., Snead, C., Kumar, S., Joshi, A., Thangjam, G., Fulton, D., Black, S. M., Patel, V. & Catravas, J. D., Jun 15 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 12, p. L883-l893

Research output: Contribution to journalArticle

20 Scopus citations

Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels

Puttabyatappa, Y., Stallone, J. N., Ergul, A., El-Remessy, A. B., Kumar, S., Black, S. M., Johnson, M. H., Owen, M. P. & White, R. E., Apr 2013, In : Journal of Pharmacology and Experimental Therapeutics. 345, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells

Sharma, S., Sun, X., Agarwal, S., Rafikov, R., Dasarathy, S., Kumar, S. & Black, S. M., Jan 2013, In : International journal of molecular sciences. 14, 1, p. 255-272 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow

Oishi, P. E., Sharma, S., Datar, S. A., Kumar, S., Aggarwal, S., Lu, Q., Raff, G., Azakie, A., Hsu, J. H., Sajti, E., Fratz, S., Black, S. M. & Fineman, J. R., Jan 2013, In : Pediatric research. 73, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow

Kumar, S., Oishi, P. E., Rafikov, R., Aggarwal, S., Hou, Y., Datar, S. A., Sharma, S., Azakie, A., Fineman, J. R. & Black, S. M., Feb 2013, In : Journal of cellular biochemistry. 114, 2, p. 435-447 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice

Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., Fulton, D. J. R. & Rudic, R. D., Oct 12 2012, In : Circulation research. 111, 9, p. 1157-1165 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

PPAR-γ Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow

Sharma, S., Sun, X., Rafikov, R., Kumar, S., Hou, Y., Oishi, P. E., Datar, S. A., Raff, G., Fineman, J. R. & Black, S. M., Sep 4 2012, In : PloS one. 7, 9, e41555.

Research output: Contribution to journalArticle

25 Scopus citations

Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase i

Sharma, S., Sun, X., Kumar, S., Rafikov, R., Aramburo, A., Kalkan, G., Tian, J., Rehmani, I., Kallarackal, S., Fineman, J. R. & Black, S. M., Jul 15 2012, In : Free Radical Biology and Medicine. 53, 2, p. 216-229 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: Role of protein kinase G nitration

Aggarwal, S., Gross, C. M., Kumar, S., Datar, S., Oishi, P., Kalkan, G., Schreiber, C., Fratz, S., Fineman, J. R. & Black, S. M., Dec 2011, In : Journal of Cellular Physiology. 226, 12, p. 3104-3113 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow

Sun, X., Fratz, S., Sharma, S., Hou, Y., Rafikov, R., Kumar, S., Rehmani, I., Tian, J., Smith, A., Schreiber, C., Reiser, J., Naumann, S., Haag, S., Hess, J., Catravas, J. D., Patterson, C., Fineman, J. R. & Black, S. M., Jul 1 2011, In : American journal of respiratory cell and molecular biology. 45, 1, p. 163-171 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

Rafikov, R., Fonseca, F. V., Kumar, S., Pardo, D., Darragh, C., Elms, S., Fulton, D. & Black, S. M., Sep 2011, In : Journal of Endocrinology. 210, 3, p. 271-284 14 p.

Research output: Contribution to journalArticle

140 Scopus citations

Purification and functional analysis of protein kinase G-1α using a bacterial expression system

Aggarwal, S., Rafikov, R., Gross, C. M., Kumar, S., Pardo, D. & Black, S. M., Oct 2011, In : Protein Expression and Purification. 79, 2, p. 271-276 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2010

Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN

Church, J. E., Qian, J., Kumar, S., Black, S. M., Venema, R. C., Papapetropoulos, A. & Fulton, D. J. R., May 2010, In : Vascular Pharmacology. 52, 5-6, p. 191-198 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine

Sharma, S., Smith, A., Kumar, S., Aggarwal, S., Rehmani, I., Snead, C., Harmon, C., Fineman, J., Fulton, D., Catravas, J. D. & Black, S. M., May 2010, In : Vascular Pharmacology. 52, 5-6, p. 182-190 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow

Sharma, S., Kumar, S., Wiseman, D. A., Kallarackal, S., Ponnala, S., Elgaish, M., Tian, J., Fineman, J. R. & Black, S. M., Jul 2010, In : Vascular Pharmacology. 53, 1-2, p. 38-52 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
38 Scopus citations

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-α inhibition

Xiong, C., Yang, G., Kumar, S., Aggarwal, S., Leustik, M., Snead, C., Hamacher, J., Fischer, B., Siddaramappa, U. N., Hossain, H., Wendel, A., Catravas, J. D., Verin, A. D., Fulton, D. J., Black, S. M., Chakraborty, T. & Lucas, R., May 2010, In : Vascular Pharmacology. 52, 5-6, p. 207-213 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

The lectin-like doMain of tumor necrosis factor improves lung function after rat lung transplantation-Potential role for a reduction in reactive oxygen species generation

Hamacher, J., Stammberger, U., Roux, J., Kumar, S., Yang, G., Xiong, C., Schmid, R. A., Fakin, R. M., Chakraborty, T., Hossain, H. M. D., Pittet, J. F., Wendel, A., Black, S. M. & Lucas, R., Mar 2010, In : Critical care medicine. 38, 3, p. 871-878 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2009

Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow

Sharma, S., Kumar, S., Sud, N., Wiseman, D. A., Tian, J., Rehmani, I., Datar, S., Oishi, P., Fratz, S., Venema, R. C., Fineman, J. R. & Black, S. M., Nov 2009, In : Vascular Pharmacology. 51, 5-6, p. 359-364 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of PPARγ inhibition on pulmonary endothelial cell gene expression: Gene profiling in pulmonary hypertension

Tian, J., Smith, A., Nechtman, J., Podolsky, R., Aggarwal, S., Snead, C., Kumar, S., Elgaish, M., Oishi, P., Göerlach, A., Fratz, S., Hess, J., Catravas, J. D., Verin, A. D., Fineman, J. R., She, J. X. & Black, S. M., Jan 2009, In : Physiological Genomics. 40, 1, p. 48-60 13 p.

Research output: Contribution to journalArticle

35 Scopus citations
9 Scopus citations

GTP cyclohydrolase I expression is regulated by nitric oxide: Role of cyclic AMP

Kumar, S., Sun, X., Sharma, S., Aggarwal, S., Ravi, K., Fineman, J. R. & Black, S. M., Aug 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 297, 2, p. L309-L317

Research output: Contribution to journalArticle

13 Scopus citations

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity

Kumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D. & Black, S. M., Mar 1 2009, In : DNA and cell biology. 28, 3, p. 119-129 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
13 Scopus citations