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Research Output 1994 2019

  • 1108 Citations
  • 16 h-Index
  • 33 Article
  • 4 Review article
  • 1 Comment/debate
2019
1 Citation (Scopus)

A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer

Mysona, D., Pyrzak, A., Purohit, S. B., Zhi, W., Sharma, A. K., Tran, L., Tran, P., Bai, S., Rungruang, B. J., Ghamande, S. A. & She, J-X., Mar 1 2019, In : Gynecologic Oncology. 152, 3, p. 574-580 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Blood Proteins
Recurrence
Disease-Free Survival
Proteins
2018
15 Citations (Scopus)

Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins

Purohit, S. B., Li, T., Guan, W., Song, X., Song, J., Tian, Y., Li, L., Sharma, A. K., Dun, B., Mysona, D., Ghamande, S. A., Rungruang, B. J., Cummings, R. D., Wang, P. G. & She, J-X., Dec 1 2018, In : Nature Communications. 9, 1, 258.

Research output: Contribution to journalArticle

antibodies
beads
Polysaccharides
Carrier Proteins
Throughput
1 Citation (Scopus)

Proteins of TNF-α and IL6 pathways are elevated in serum of type-1 diabetes patients with microalbuminuria

Purohit, S. B., Sharma, A. K., Zhi, W., Bai, S., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D. & She, J-X., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 154.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Interleukin-6
Serum
Proteins
Cytokine Receptor gp130
2017
8 Citations (Scopus)

Sphingosine Toxicity in EAE and MS: Evidence for Ceramide Generation via Serine-Palmitoyltransferase Activation

Miller, L. G., Young, J. A., Ray, S. K., Wang, G., Purohit, S. B., Banik, N. L. & Dasgupta, S., Oct 1 2017, In : Neurochemical Research. 42, 10, p. 2755-2768 14 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingosine
Autoimmune Experimental Encephalomyelitis
Ceramides
Multiple Sclerosis
2016
5 Citations (Scopus)

IGF-binding proteins in type-1 diabetes are more severely altered in the presence of complications

Sharma, A. K., Purohit, S. B., Sharma, S., Bai, S., Zhi, W., Ponny, S. R., Hopkins, D., Steed, L., Bode, B., Anderson, S. W. & She, J-X., Jan 1 2016, In : Frontiers in Endocrinology. 7, JAN, 2.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 1
Type 1 Diabetes Mellitus
Diabetes Complications
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor Binding Protein 2
2015
16 Citations (Scopus)
Tumor Necrosis Factor Receptors
Diabetic Retinopathy
Type 1 Diabetes Mellitus
Cytokine Receptor gp130
Serum
6 Citations (Scopus)

Large-scale discovery and validation studies demonstrate significant reductions in circulating levels of IL8, IL-1Ra, MCP-1, and MIP-1β in patients with type 1 diabetes

Purohit, S. B., Sharma, A. K., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D., Yang, T. & She, J-X., Sep 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 9, p. E1179-E1187

Research output: Contribution to journalArticle

Interleukin 1 Receptor Antagonist Protein
Validation Studies
Medical problems
Type 1 Diabetes Mellitus
Interleukin-8
9 Citations (Scopus)
Medical problems
Type 1 Diabetes Mellitus
Throughput
Technology
Assays
2014
10 Citations (Scopus)
Squamous Cell Neoplasms
Serum Amyloid A Protein
Uterine Cervical Neoplasms
Blood Proteins
Carcinoembryonic Antigen
2013
18 Citations (Scopus)

Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways

Dun, B., Sharma, A., Teng, Y., Liu, H., Purohit, S., Xu, H., Zeng, L. & She, J. X., Nov 15 2013, In : PloS one. 8, 11, e81702.

Research output: Contribution to journalArticle

Mycophenolic Acid
stomach neoplasms
Stomach Neoplasms
Genes
Cells
2012
5 Citations (Scopus)
Inbred NOD Mouse
T-cells
Regulatory T-Lymphocytes
Medical problems
Up-Regulation
9 Citations (Scopus)
Insulin-Like Growth Factor Binding Protein 6
Diabetes Complications
Medical problems
Type 1 Diabetes Mellitus
Serum
2011
16 Citations (Scopus)

Chemokine (c-c motif) ligand 2 (ccl2) in sera of patients with type 1 diabetes and diabetic complications

Guan, R., Purohit, S. B., Wang, H., Bode, B., Reed, J. C., Steed, R. D., Anderson, S. W., Steed, L., Hopkins, D., Xia, C. & She, J-X., Apr 21 2011, In : PloS one. 6, 4, e17822.

Research output: Contribution to journalArticle

insulin-dependent diabetes mellitus
Chemokine CCL2
Diabetes Complications
Medical problems
Type 1 Diabetes Mellitus
37 Citations (Scopus)

Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays.

Zhi, W., Sharma, A., Purohit, S., Miller, E., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D., Steed, L., Hopkins, D. & She, J. X., Nov 1 2011, In : Molecular & cellular proteomics : MCP. 10, 11

Research output: Contribution to journalArticle

Liquid chromatography
Medical problems
Type 1 Diabetes Mellitus
Immunoassay
Liquid Chromatography
2010
4 Citations (Scopus)
Biomarkers
Medical problems
Type 1 Diabetes Mellitus
Technology
Throughput
33 Citations (Scopus)

Proteomic technologies for the discovery of type 1 diabetes biomarkers

Zhi, W., Purohit, S., Carey, C., Wang, M. & She, J. X., Jul 2010, In : Journal of Diabetes Science and Technology. 4, 4, p. 993-1002 10 p.

Research output: Contribution to journalReview article

Biomarkers
Medical problems
Type 1 Diabetes Mellitus
Proteomics
Technology
2009
105 Citations (Scopus)

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

Liu, S., Wang, H., Jin, Y., Podolsky, R., Reddy, M. V. P. L., Pedersen, J., Bode, B., Reed, J., Steed, D., Anderson, S., Yang, P., Muir, A., Steed, L., Hopkins, D., Huang, Y., Purohit, S. B., Wang, C. Y., Steck, A. K., Montemari, A., Eisenbarth, G. & 2 others, Rewers, M. & She, J-X., Jan 1 2009, In : Human Molecular Genetics. 18, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Single Nucleotide Polymorphism
Blood Cells
Gene Expression
Chromosomes, Human, Pair 5
2008
36 Citations (Scopus)

Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase

Majumder, S., Muley, A., Kolluru, G. K., Saurabh, S., Tamilarasan, K. P., Chandrasekhar, S., Reddy, H. B., Purohit, S. & Chatterjee, S., Feb 1 2008, In : Biochemistry and Cell Biology. 86, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Nitric Oxide Synthase Type III
Cadmium
Nitric Oxide
Endothelial cells
15 Citations (Scopus)

Distribution of N- and O-linked oligosaccharides on surface of spermatozoa from normal and infertile subjects

Purohit, S., Laloraya, M. & Kumar, P. G., Feb 1 2008, In : Andrologia. 40, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

Oligosaccharides
Spermatozoa
Agglutinins
Glycocalyx
Binding Sites
82 Citations (Scopus)

Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice

Han, J., Zhong, J., Wei, W., Wang, Y., Huang, Y., Yang, P., Purohit, S. B., Dong, Z., Wang, M-H., She, J-X., Gong, F., Stern, D. M. & Wang, C. Y., Aug 1 2008, In : Diabetes. 57, 8, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Type 1 Diabetes Mellitus
Dendritic Cells
Autoimmunity
T-Lymphocytes
2007
38 Citations (Scopus)

The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function

Ruan, Q. G., Tung, K., Elsenman, D., Setiady, Y., Eckenrode, S., Yi, B., Purohit, S. B., Zheng, W. P., Zhang, Y., Peltonen, L. & She, J-X., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 7173-7180 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Gene Expression
Nucleotide Motifs
Chromatin Immunoprecipitation
Autoantigens
2006
30 Citations (Scopus)

Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery

Purohit, S. B., Podolsky, R., Schatz, D., Muir, A., Hopkins, D., Huang, Y. H. & She, J-X., Dec 1 2006, In : Proteomics. 6, 24, p. 6405-6415 11 p.

Research output: Contribution to journalArticle

Biomarkers
Medical problems
Type 1 Diabetes Mellitus
Proteomics
Serum
46 Citations (Scopus)

The application of genomic and proteomic technologies in predictive, preventive and personalized medicine

Collins, C. D., Purohit, S. B., Podolsky, R. H., Zhao, H. S., Schatz, D., Eckenrode, S. E., Yang, P., Hopkins, D., Muir, A., Hoffman, M., McIndoe, R. A., Rewers, M. & She, J-X., Nov 1 2006, In : Vascular Pharmacology. 45, 5, p. 258-267 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Preventive Medicine
Proteomics
Biomarkers
Technology
2005
50 Citations (Scopus)

Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes

Purohit, S. B., Podolsky, R., Collins, C., Zheng, W., Schatz, D., Muir, A., Hopkins, D., Huang, Y. H. & She, J-X., Oct 31 2005, In : Journal of Autoimmune Diseases. 2, 8.

Research output: Contribution to journalArticle

CTLA-4 Antigen
Single Nucleotide Polymorphism
Genotype
Type 1 Diabetes Mellitus
Autoantibodies
36 Citations (Scopus)

Mapping DNA-binding domains of the autoimmune regulator protein

Purohit, S. B., Kumar, P. G., Laloraya, M. & She, J-X., Feb 18 2005, In : Biochemical and Biophysical Research Communications. 327, 3, p. 939-944 6 p.

Research output: Contribution to journalArticle

Autoimmune Polyendocrinopathies
Nucleotide Motifs
DNA sequences
DNA
Amino Acids
2004
294 Citations (Scopus)

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genes
Ubiquitin
Single Nucleotide Polymorphism
DNA
31 Citations (Scopus)

A Mutant Stat5b with Weaker DNA Binding Affinity Defines a Key Defective Pathway in Nonobese Diabetic Mice

Davoodi-Semiromi, A., Laloraya, M., Kumar, G. P., Purohit, S. B., Jha, R. K. & She, J-X., Mar 19 2004, In : Journal of Biological Chemistry. 279, 12, p. 11553-11561 9 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
STAT Transcription Factors
Transcription
DNA
Genes

Erratum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes (Nature Genetics (2004) 36 (837-841))

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Sep 1 2004, In : Nature Genetics. 36, 9, 1 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
10 Citations (Scopus)

Impaired E-cadherin expression in human spermatozoa in a male factor infertility subset signifies E-cadherin-mediated adhesion mechanisms operative in sperm-oolemma interactions

Purohit, S. B., Brahmaraju, M., Palta, A., Shukla, S., Laloraya, M. & Kumar, P. G., Apr 9 2004, In : Biochemical and Biophysical Research Communications. 316, 3, p. 903-909 7 p.

Research output: Contribution to journalArticle

Male Infertility
Cadherins
Spermatozoa
Adhesion
Sperm-Ovum Interactions
37 Citations (Scopus)

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

Molecular Cloning
Genes
Proteins
Amino Acid Sequence
Nucleotides
2000
7 Citations (Scopus)

Altered molecular dynamics and antioxidant status in the spermatozoa in testosterone-induced oligospermia in mouse

Purohit, S. B., Saxena, D., Laloraya, M. & Kumar, P. G., Feb 16 2000, In : Molecular Reproduction and Development. 55, 3, p. 316-325 10 p.

Research output: Contribution to journalArticle

Oligospermia
Molecular Dynamics Simulation
Testosterone
Spermatozoa
Antioxidants
43 Citations (Scopus)

Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation

Saxena, D., Purohit, S. B., Pradeep Kumar, G. & Laloraya, M., Jan 1 2000, In : Nitric Oxide - Biology and Chemistry. 4, 4, p. 384-391 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
Uterus
Estrogens
Progesterone
Endometrium
1999
8 Citations (Scopus)

Regional heterogeneity in intracellular distribution of superoxide and hydrogen peroxide within the sperm and its relation to sperm development

Agnihotri, S., Purohit, S. B., Laloraya, M. & Kumar, G. P., Oct 4 1999, In : Archives of Andrology. 43, 2, p. 113-121 9 p.

Research output: Contribution to journalArticle

Superoxides
Hydrogen Peroxide
Spermatozoa
Fluorescence
Vasectomy
11 Citations (Scopus)

Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa.

Purohit, S. B., Laloraya, M. & Kumar, G. P., Jan 1 1999, In : Asian journal of andrology. 1, 3, p. 95-107 13 p.

Research output: Contribution to journalReview article

Acrosome Reaction
Ion Channels
Spermatozoa
Ions
Cholesterol
1998
9 Citations (Scopus)

Acrosome reaction inducers impose alterations in repulsive strain and hydration barrier in human sperm membranes

Purohit, S. B., Laloraya, M. & Kumar, G. P., Jun 1 1998, In : Biochemistry and Molecular Biology International. 45, 2, p. 227-235 9 p.

Research output: Contribution to journalArticle

Acrosome Reaction
Hydration
Spermatozoa
Membranes
Molecules
10 Citations (Scopus)

Bicarbonate-dependent lipid ordering and protein aggregation are part of the nongenomic action of progesterone on capacitated spermatozoa

Purohit, S. B., Laloraya, M. & Kumar, P. G., Sep 1 1998, In : Journal of Andrology. 19, 5, p. 608-618 11 p.

Research output: Contribution to journalArticle

Bicarbonates
Progesterone
Spermatozoa
Lipids
Proteins
1997
1 Citation (Scopus)

Vasectomy-lnduced superoxide dismutase inactivation in the male reproductive tract of rat: A prerequisite for spermatic granuloma formation

Chatterjee, S., Purohit, S. B., Laloraya, M. & Kumar, P., Jan 1 1997, In : Urologia Internationalis. 59, 1, p. 23-25 3 p.

Research output: Contribution to journalArticle

Vasectomy
Granuloma
Superoxide Dismutase
Spermatozoa
Free Radicals
1994
16 Citations (Scopus)

Involvement of superoxide radical in signal transduction regulating stomatal movements

Purohit, S. B., Pradeep Kumar, G., Laloraya, M. & Laloraya, M. M., Nov 30 1994, In : Biochemical and Biophysical Research Communications. 205, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

Signal transduction
Superoxides
Oxidation-Reduction
Signal Transduction
Redox reactions