• 1167 Citations
  • 18 h-Index
1994 …2020

Research output per year

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Research Output

  • 1167 Citations
  • 18 h-Index
  • 37 Article
  • 5 Review article
  • 1 Comment/debate
2020

A 73-gene proliferative transcriptomic signature predicts uterine serous carcinoma patient survival and response to primary therapy

Tran, L. K. H., Tran, P. M. H., Mysona, D. P., Purohit, S. B., Myers, E., Lee, W. S., Dun, B., Xu, D., Liu, H., Hopkins, D., Nechtman, J., Scelsi, C. L., Mittal, P. K., Kleven, D. T., Wallbillich, J. J., Rungruang, B., Ghamande, S. & She, J. X., Jan 1 2020, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Better survival is observed in cervical cancer patients positive for specific anti-glycan antibodies and receiving brachytherapy

Purohit, S., Ferris, D. G., Alvarez, M., Tran, P. M. H., Tran, L. K. H., Mysona, D. P., Hopkins, D., Zhi, W., Dun, B., Wallbillich, J. J., Cummings, R. D., Wang, P. G. & She, J. X., Apr 2020, In : Gynecologic Oncology. 157, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Niacin for Parkinson's disease

Seamon, M., Purohit, S., Giri, B., Baban, B., Morgan, J., Chong, R. & Wakade, C., Feb 1 2020, In : Clinical and Experimental Neuroimmunology. 11, 1, p. 47-56 10 p.

Research output: Contribution to journalReview article

2019

A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer

Mysona, D., Pyrzak, A., Purohit, S., Zhi, W., Sharma, A., Tran, L., Tran, P., Bai, S., Rungruang, B., Ghamande, S. & She, J. X., Mar 2019, In : Gynecologic Oncology. 152, 3, p. 574-580 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cell-based high throughput screening identified a novel compound that promotes regulatory T cells and prevents autoimmune colitis

Mao, R., Liu, H., Yi, B., Purohit, S., Kuczma, M., Kraj, P. & She, J. X., Nov 2019, In : Biochemical Pharmacology. 169, 113618.

Research output: Contribution to journalArticle

Niacin ameliorates neuro-inflammation in parkinson’s disease via GPR109A

Giri, B., Belanger, K., Seamon, M., Bradley, E., Purohit, S., Chong, R., Morgan, J. C., Baban, B. & Wakade, C., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4559.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins

Purohit, S. B., Li, T., Guan, W., Song, X., Song, J., Tian, Y., Li, L., Sharma, A. K., Dun, B., Mysona, D., Ghamande, S. A., Rungruang, B. J., Cummings, R. D., Wang, P. G. & She, J-X., Dec 1 2018, In : Nature communications. 9, 1, 258.

Research output: Contribution to journalArticle

20 Scopus citations

Proteins of TNF-α and IL6 pathways are elevated in serum of type-1 diabetes patients with microalbuminuria

Purohit, S. B., Sharma, A. K., Zhi, W., Bai, S., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D. & She, J-X., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 154.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Sphingosine Toxicity in EAE and MS: Evidence for Ceramide Generation via Serine-Palmitoyltransferase Activation

Miller, L. G., Young, J. A., Ray, S. K., Wang, G., Purohit, S. B., Banik, N. L. & Dasgupta, S., Oct 1 2017, In : Neurochemical Research. 42, 10, p. 2755-2768 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

IGF-binding proteins in type-1 diabetes are more severely altered in the presence of complications

Sharma, A. K., Purohit, S. B., Sharma, S., Bai, S., Zhi, W., Ponny, S. R., Hopkins, D., Steed, L., Bode, B., Anderson, S. W. & She, J-X., Jan 1 2016, In : Frontiers in Endocrinology. 7, JAN, 2.

Research output: Contribution to journalArticle

8 Scopus citations
2015
16 Scopus citations

Large-scale discovery and validation studies demonstrate significant reductions in circulating levels of IL8, IL-1Ra, MCP-1, and MIP-1β in patients with type 1 diabetes

Purohit, S. B., Sharma, A. K., Hopkins, D., Steed, L., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D., Yang, T. & She, J-X., Sep 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 9, p. E1179-E1187

Research output: Contribution to journalArticle

8 Scopus citations
9 Scopus citations
2014
12 Scopus citations
2013

Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways

Dun, B., Sharma, A., Teng, Y., Liu, H., Purohit, S., Xu, H., Zeng, L. & She, J. X., Nov 15 2013, In : PloS one. 8, 11, e81702.

Research output: Contribution to journalArticle

21 Scopus citations
2012
6 Scopus citations
9 Scopus citations
2011

Chemokine (c-c motif) ligand 2 (ccl2) in sera of patients with type 1 diabetes and diabetic complications

Guan, R., Purohit, S. B., Wang, H., Bode, B., Reed, J. C., Steed, R. D., Anderson, S. W., Steed, L., Hopkins, D., Xia, C. & She, J-X., 2011, In : PloS one. 6, 4, e17822.

Research output: Contribution to journalArticle

19 Scopus citations

Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays.

Zhi, W., Sharma, A., Purohit, S., Miller, E., Bode, B., Anderson, S. W., Reed, J. C., Steed, R. D., Steed, L., Hopkins, D. & She, J. X., Nov 1 2011, In : Molecular & cellular proteomics : MCP. 10, 11

Research output: Contribution to journalArticle

41 Scopus citations
2010
4 Scopus citations

Proteomic technologies for the discovery of type 1 diabetes biomarkers

Zhi, W., Purohit, S., Carey, C., Wang, M. & She, J. X., Jul 2010, In : Journal of Diabetes Science and Technology. 4, 4, p. 993-1002 10 p.

Research output: Contribution to journalReview article

33 Scopus citations
2009

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

Liu, S., Wang, H., Jin, Y., Podolsky, R., Reddy, M. V. P. L., Pedersen, J., Bode, B., Reed, J., Steed, D., Anderson, S., Yang, P., Muir, A., Steed, L., Hopkins, D., Huang, Y., Purohit, S. B., Wang, C. Y., Steck, A. K., Montemari, A., Eisenbarth, G. & 2 others, Rewers, M. & She, J-X., Jan 1 2009, In : Human Molecular Genetics. 18, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

107 Scopus citations
2008

Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase

Majumder, S., Muley, A., Kolluru, G. K., Saurabh, S., Tamilarasan, K. P., Chandrasekhar, S., Reddy, H. B., Purohit, S. & Chatterjee, S., Feb 1 2008, In : Biochemistry and Cell Biology. 86, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Distribution of N- and O-linked oligosaccharides on surface of spermatozoa from normal and infertile subjects

Purohit, S., Laloraya, M. & Kumar, P. G., Feb 1 2008, In : Andrologia. 40, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice

Han, J., Zhong, J., Wei, W., Wang, Y., Huang, Y., Yang, P., Purohit, S. B., Dong, Z., Wang, M-H., She, J-X., Gong, F., Stern, D. M. & Wang, C. Y., Aug 1 2008, In : Diabetes. 57, 8, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

85 Scopus citations
2007

The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function

Ruan, Q. G., Tung, K., Elsenman, D., Setiady, Y., Eckenrode, S., Yi, B., Purohit, S. B., Zheng, W. P., Zhang, Y., Peltonen, L. & She, J-X., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 7173-7180 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2006

Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery

Purohit, S. B., Podolsky, R., Schatz, D., Muir, A., Hopkins, D., Huang, Y. H. & She, J-X., Dec 1 2006, In : Proteomics. 6, 24, p. 6405-6415 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The application of genomic and proteomic technologies in predictive, preventive and personalized medicine

Collins, C. D., Purohit, S., Podolsky, R. H., Zhao, H. S., Schatz, D., Eckenrode, S. E., Yang, P., Hopkins, D., Muir, A., Hoffman, M., McIndoe, R. A., Rewers, M. & She, J. X., Nov 1 2006, In : Vascular Pharmacology. 45, 5, p. 258-267 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2005

Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes

Purohit, S., Podolsky, R., Collins, C., Zheng, W., Schatz, D., Muir, A., Hopkins, D., Huang, Y. H. & She, J. X., Oct 31 2005, In : Journal of Autoimmune Diseases. 2, 8.

Research output: Contribution to journalArticle

51 Scopus citations

Mapping DNA-binding domains of the autoimmune regulator protein

Purohit, S. B., Kumar, P. G., Laloraya, M. & She, J-X., Feb 18 2005, In : Biochemical and Biophysical Research Communications. 327, 3, p. 939-944 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

299 Scopus citations

A Mutant Stat5b with Weaker DNA Binding Affinity Defines a Key Defective Pathway in Nonobese Diabetic Mice

Davoodi-Semiromi, A., Laloraya, M., Kumar, G. P., Purohit, S., Jha, R. K. & She, J. X., Mar 19 2004, In : Journal of Biological Chemistry. 279, 12, p. 11553-11561 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Erratum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes (Nature Genetics (2004) 36 (837-841))

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Sep 2004, In : Nature Genetics. 36, 9, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Impaired E-cadherin expression in human spermatozoa in a male factor infertility subset signifies E-cadherin-mediated adhesion mechanisms operative in sperm-oolemma interactions

Purohit, S. B., Brahmaraju, M., Palta, A., Shukla, S., Laloraya, M. & Kumar, P. G., Apr 9 2004, In : Biochemical and Biophysical Research Communications. 316, 3, p. 903-909 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

37 Scopus citations
2000

Altered molecular dynamics and antioxidant status in the spermatozoa in testosterone-induced oligospermia in mouse

Purohit, S. B., Saxena, D., Laloraya, M. & Kumar, P. G., Feb 16 2000, In : Molecular Reproduction and Development. 55, 3, p. 316-325 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation

Saxena, D., Purohit, S. B., Pradeep Kumar, G. & Laloraya, M., Jan 1 2000, In : Nitric Oxide - Biology and Chemistry. 4, 4, p. 384-391 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
1999

Regional heterogeneity in intracellular distribution of superoxide and hydrogen peroxide within the sperm and its relation to sperm development

Agnihotri, S., Purohit, S. B., Laloraya, M. & Kumar, G. P., Oct 4 1999, In : Archives of Andrology. 43, 2, p. 113-121 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa.

Purohit, S. B., Laloraya, M. & Kumar, G. P., Jan 1 1999, In : Asian journal of andrology. 1, 3, p. 95-107 13 p.

Research output: Contribution to journalReview article

12 Scopus citations
1998

Acrosome reaction inducers impose alterations in repulsive strain and hydration barrier in human sperm membranes

Purohit, S. B., Laloraya, M. & Kumar, G. P., Jun 1998, In : Biochemistry and Molecular Biology International. 45, 2, p. 227-235 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Bicarbonate-dependent lipid ordering and protein aggregation are part of the nongenomic action of progesterone on capacitated spermatozoa

Purohit, S. B., Laloraya, M. & Kumar, P. G., Sep 1 1998, In : Journal of Andrology. 19, 5, p. 608-618 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
1997

Vasectomy-lnduced superoxide dismutase inactivation in the male reproductive tract of rat: A prerequisite for spermatic granuloma formation

Chatterjee, S., Purohit, S. B., Laloraya, M. & Kumar, P., Jan 1 1997, In : Urologia Internationalis. 59, 1, p. 23-25 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
1994

Involvement of superoxide radical in signal transduction regulating stomatal movements

Purohit, S., Pradeep Kumar, G., Laloraya, M. & Laloraya, M. M., Nov 30 1994, In : Biochemical and Biophysical Research Communications. 205, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

18 Scopus citations