• 5769 Citations
  • 42 h-Index
1986 …2019
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Research Output 1986 2019

2019
3 Citations (Scopus)

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 1 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

Homocysteine
Neuroglia
Up-Regulation
Antioxidants
Oxidative Stress
2 Citations (Scopus)

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 1 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
Hyperhomocysteinemia
Retinal Ganglion Cells
Neuroglia
Antioxidants
Excitatory Amino Acids
3 Citations (Scopus)

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Molecular Chaperones
Cones
Modulation
Antioxidant Response Elements
2018
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
1 Citation (Scopus)
Receptor-Interacting Protein Serine-Threonine Kinases
Muromegalovirus
Photoreceptor Cells
Cytomegalovirus Infections
Protein Kinases
5 Citations (Scopus)

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In : Scientific Reports. 8, 1, 3025.

Research output: Contribution to journalArticle

Iron Overload
Diabetic Retinopathy
Renin
Iron
Knockout Mice
3 Citations (Scopus)

Relationship between Sigma-1 receptor and BDNF in the visual system

Mysona, B. A., Zhao, J., Smith, S. B. & Bollinger, K. E., Feb 1 2018, In : Experimental eye research. 167, p. 25-30 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Optic Disk
Astrocytes
Retina
Retinal Ganglion Cells
9 Citations (Scopus)

Sigma 1 receptor: A novel therapeutic target in retinal disease

Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 2018, In : Progress in Retinal and Eye Research. 67, p. 130-149 20 p.

Research output: Contribution to journalReview article

Retinal Diseases
Therapeutics
Retina
sigma-1 receptor
Photoreceptor Cells
2017
7 Citations (Scopus)
Photoreceptor Cells
Retinitis Pigmentosa
Cell Death
Endoplasmic Reticulum Stress
Gliosis
4 Citations (Scopus)

Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In : Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

Research output: Contribution to journalArticle

Glutathione Synthase
Cystathionine
Methylenetetrahydrofolate Reductase (NADPH2)
Hydrogen Sulfide
Taurine
2 Citations (Scopus)

Detailed electroretinographic findings in rd8 mice

Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In : Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

Retina
Phenotype
Amacrine Cells
Light
Retinal Degeneration
9 Citations (Scopus)

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H. M., Elsherbiny, N. M., Fulzele, S. T., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A. M., Dec 1 2017, In : Scientific Reports. 7, 1, 09731.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Oxidative Stress
Endothelial Cells
Homocysteine
Blood-Retinal Barrier
5 Citations (Scopus)
sigma Receptors
Neurodegenerative diseases
Molecular imaging
Retinal Degeneration
Somatoform Disorders
7 Citations (Scopus)

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

Phenotype
Intercellular Signaling Peptides and Proteins
Posterior Uveitis
Eye Abnormalities
Pathology
11 Citations (Scopus)
Growth Hormone-Releasing Hormone
Diabetic Retinopathy
Retina
Streptozocin
Hormone Antagonists
6 Citations (Scopus)
astrocytes
Optic Disk
optics
Astrocytes
Optics
2 Citations (Scopus)

The role of sigma1R in mammalian retina

Wang, J., Cui, X., Roon, P., Saul, A. B. & Smith, S. B., Jan 1 2017, In : Advances in experimental medicine and biology. 964, p. 267-284 18 p.

Research output: Contribution to journalArticle

Retina
Ganglia
sigma-1 receptor
Cells
Photoreceptor Cells
30 Citations (Scopus)
Autosomal Dominant Optic Atrophy
Dynamins
Optics
Mitochondrial Dynamics
Fusion reactions
2016
14 Citations (Scopus)

(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

Research output: Contribution to journalArticle

Pentazocine
Retinal Ganglion Cells
N-Methylaspartate
Cell Death
Knockout Mice
28 Citations (Scopus)
Retinal Degeneration
Molecular Chaperones
Retinal Diseases
Photoreceptor Cells
Retinal Cone Photoreceptor Cells
10 Citations (Scopus)

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Jan 1 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Retinal Pigments
Macular Degeneration
Homocysteine
Choroidal Neovascularization
4 Citations (Scopus)

Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice

Markand, S., Saul, A. B., Tawfik, A. M., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Phenotype
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Blood Vessels
3 Citations (Scopus)

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journalArticle

Fumarates
Sickle Cell Anemia
Oxidative stress
Pathology
Oxidative Stress
3 Citations (Scopus)

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A. M., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In : Current Eye Research. 41, 8, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Retina
Membranes
Gene Expression
Intestines
4 Citations (Scopus)

Role of sigma 1 receptor in retinal degeneration of the Ins2Akita/+ murine model of diabetic retinopathy

Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Diabetic Retinopathy
Pentazocine
Gliosis
Ganglia
2015
22 Citations (Scopus)

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journalArticle

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
NADPH Oxidase
Arachidonate 15-Lipoxygenase
Diabetic Retinopathy
Hyperglycemia
26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
57 Citations (Scopus)
Acute Kidney Injury
Hyperglycemia
Apoptosis
Kidney
Glucose
20 Citations (Scopus)

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

Eicosanoids
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
NADPH Oxidase
Hydroxyeicosatetraenoic Acids
Diabetic Retinopathy
15 Citations (Scopus)
Methylenetetrahydrofolate Reductase (NADPH2)
Hyperhomocysteinemia
Retinal Ganglion Cells
Immunohistochemistry
Electroretinography
48 Citations (Scopus)

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc -, the Na+-independent glutamate-cystine exchanger

Wang, J., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In : Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

Research output: Contribution to journalArticle

Oxidative stress
Cystine
Neuroglia
Glutamic Acid
Oxidative Stress
9 Citations (Scopus)

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Shanmugam, A. K., Wang, J., Markand, S., Perry, R. L., Tawfik, A. M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In : Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

Research output: Contribution to journalArticle

Interleukin-12
Neuroglia
Lipopolysaccharides
Chemical activation
Cytokines
2014
14 Citations (Scopus)

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A. M., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Jan 1 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journalArticle

Cystathionine
Hyperhomocysteinemia
Zonula Occludens-1 Protein
Occludin
Blood Vessels
8 Citations (Scopus)
Iron-Regulatory Proteins
Gliosis
Retina
Blood Vessels
Microglia
15 Citations (Scopus)

Dysregulation of system xc- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Jan 1 2014, In : Neurochemistry International. 76, p. 59-69 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Oxidative Stress
Cell Line
Proteins

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperhomocysteinemia
Folic Acid
Retina
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
7 Citations (Scopus)

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S. B., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

Muromegalovirus
Retinal Pigments
Autophagy
Cytomegalovirus Infections
Epithelial Cells
18 Citations (Scopus)
Fetal Hemoglobin
Erythroid Cells
Retinal Pigments
Globins
Retina
20 Citations (Scopus)

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

Research output: Contribution to journalArticle

Siderophores
Hemochromatosis
Retina
Cholesterol
Iron
3 Citations (Scopus)

Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In : Molecular Vision. 20, p. 561-574 14 p.

Research output: Contribution to journalArticle

Serine Proteases
Retina
Homeostasis
Iron
Hepcidins
4 Citations (Scopus)

Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In : Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

Research output: Contribution to journalArticle

Cytomegalovirus Retinitis
Muromegalovirus
Receptor-Interacting Protein Serine-Threonine Kinases
Caspases
Caspase 3
29 Citations (Scopus)

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Retina
Transcriptome
Proto-Oncogene Proteins c-bcl-2
Cell Death
31 Citations (Scopus)

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Microglia
Ligands
Lipopolysaccharides
2013
12 Citations (Scopus)

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Hyperhomocysteinemia
Homocysteine
Tight Junctions
Blood-Retinal Barrier
11 Citations (Scopus)

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A. M., Ha, Y., Gnana-Prakasam, J. P., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 1 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Retina
Cystathionine
Liver
Enzyme Assays
26 Citations (Scopus)

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PloS one. 8, 1, e54692.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Medical problems
diabetes
Chemical activation
Cells
42 Citations (Scopus)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Cell Death
Activating Transcription Factor 4
Phosphorylation
Ubiquitin-Protein Ligases
8 Citations (Scopus)

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Premature Birth
Homocysteine
Pregnancy
Dinoprostone
7 Citations (Scopus)

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Coothankandaswamy, V., Reddy, S. K., Martin, P. M., Thangaraju, M., Smith, S. B. & Ganapathy, V., Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells
Phenotype
Histone Deacetylases