• 6117 Citations
  • 42 h-Index
1986 …2020

Research output per year

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Research Output

Article

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-β-synthase mutant mouse

Ganapathy, P. S., Moister, B., Roon, P., Mysona, B. A., Duplantier, J., Dun, Y., Moister, T. K. V. E., Farley, M. J., Prasad, P. D., Liu, K. & Smith, S. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 9, p. 4460-4470 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

28 Scopus citations

Evidence of decreased adhesion between the neural retina and retinal pigmented epithelium of the Mitf(vit) (vitiligo) mutant mouse

Bora, N., Defoe, D. & Smith, S. B., Jan 11 1999, In : Cell and Tissue Research. 295, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium

Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., Roon, P., Ganapathy, V. & Smith, S. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20676-20684 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Srinivas, S. R., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G402-G408

Research output: Contribution to journalArticle

36 Scopus citations
41 Scopus citations

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium

Martin, P. M., Ananth, S., Cresci, G., Roon, P., Smith, S. B. & Ganapathy, V., Feb 16 2009, In : Molecular Vision. 15, p. 362-372 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium

Martin, P. M., Gnana-Prakasam, J. P., Roon, P., Smith, R. G., Smith, S. B. & Ganapathy, V., Oct 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4238-4244 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Expression of folate receptor α in the mammalian retinol pigmented epithelium and retina

Smith, S. B., Kekuda, R., Gu, X., Chancy, C., Conway, S. J. & Ganapathy, V., Apr 13 1999, In : Investigative Ophthalmology and Visual Science. 40, 5, p. 840-848 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Dun, Y., Mysona, B., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V. & Smith, S. B., May 1 2006, In : Cell and Tissue Research. 324, 2, p. 189-202 14 p.

Research output: Contribution to journalArticle

78 Scopus citations

Expression of the extraneuronal monoamine transporter in RPE and neural retina

Rajan, P. D., Kekuda, R., Chancy, C. D., Huang, W., Ganapathy, V. & Smith, S. B., Mar 2000, In : Current Eye Research. 20, 3, p. 195-204 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection

Gnana-Prakasam, J. P., Zhang, M., Martin, P. M., Atherton, S. S., Smith, S. B. & Ganapathy, V., May 1 2009, In : Biochemical Journal. 419, 3, p. 533-543 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina

Martin, P. M., Dun, Y., Mysona, B., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Jul 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
22 Scopus citations

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Shamsul Ola, M., Martin, P. M., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., Ganapathy, V. & Smith, S. B., Nov 1 2001, In : Molecular Brain Research. 95, 1-2, p. 86-95 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor

Seth, P., Ganapathy, M. E., Conway, S. J., Bridges, C. D., Smith, S. B., Casellas, P. & Ganapathy, V., Jul 25 2001, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1540, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B., Itagaki, S., Martin-Studdard, A., Ganapathy, V. & Smith, S. B., Jan 1 2007, In : Experimental eye research. 84, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Functional characterization of folate transport proteins in staten's seruminstitut rabbit corneal epithelial cell line

Jwala, J., Boddu, S. H. S., Paturi, D. K., Shah, S., Smith, S. B., Pal, D. & Mitra, A. K., May 2011, In : Current Eye Research. 36, 5, p. 404-416 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: The cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo

Fei, Y., Matragoon, S., Smith, S. B., Overbeek, P. A., Chen, S., Zack, D. J. & Liou, G. I., Jan 1 1999, In : Journal of Biochemistry. 125, 6, p. 1189-1199 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE

Ananth, S., Karunakaran, S., Martin, P. M., Nagineni, C. N., Hooks, J. J., Smith, S. B., Prasad, P. D. & Ganapathy, V., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

44 Scopus citations

Glial fibrillary acidic protein (GFAP) is synthesized in the early stages of the photoreceptor cell degeneration of the mivit/mivit (vitiligo) mouse.

Smith, S. B., Brodjian, S., Desai, S. & Sarthy, V., Apr 1997, In : Experimental eye research. 64, 4, p. 645-650 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

250 Scopus citations

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir, D., Ananth, S., Veeranan-Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., Ganapathy, V. & Martin, P. M., Jan 1 2012, In : Investigative ophthalmology & visual science. 53, 4, p. 2208-2217 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

Gnana-Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B. & Ganapathy, V., Apr 1 2008, In : Biochemical Journal. 411, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

Ganapathy, P. S., Perry, R. L., Tawfik, A. M., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
69 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journalArticle

11 Scopus citations

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Jan 1 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Hu, H., Miyauchi, S., Bridges, C. C., Smith, S. B. & Ganapathy, V., Oct 1 2003, In : Biochemical Journal. 375, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells

Chothe, P. P., Thakkar, S. V., Gnana-Prakasam, J. P., Ananth, S., Hinton, D. R., Kannan, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Jan 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 1, p. 413-420 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 279-288 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Kutty, R. K., Samuel, W., Chen, S., Vijayasarathy, C., Dun, Y., Mysona, B., Wiggert, B. & Smith, S. B., Sep 1 2006, In : Neuroscience Letters. 404, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Increase in retinyl palmitate concentration in eyes and livers and the concentration of interphotoreceptor retinoid-binding protein in eyes of vitiligo mutant mice

Smith, S. B., Duncan, T., Kutty, G., Kutty, R. K. & Wiggert, B., Jan 1 1994, In : Biochemical Journal. 300, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
6 Scopus citations

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine

Smith, S. B., Duplantier, J., Dun, Y., Mysona, B., Roon, P., Martin, P. M. & Ganapathy, V., Sep 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 9, p. 4154-4161 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Iron-mediated retinal degeneration in haemojuvelin-knockout mice

Gnana-Prakasam, J. P., Tawfik, A., Romej, M., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Jan 15 2012, In : Biochemical Journal. 441, 2, p. 599-608 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In : Scientific reports. 8, 1, 3025.

Research output: Contribution to journalArticle

9 Scopus citations