• 5769 Citations
  • 42 h-Index
1986 …2019
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Research Output 1986 2019

Article

Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration.

Duncan, T., Swint, C., Smith, S. B. & Wiggert, B. N., Jun 28 1999, In : Molecular Vision. 5

Research output: Contribution to journalArticle

Retinaldehyde
Retinal Degeneration
Tretinoin
Oxidoreductases
Retina
7 Citations (Scopus)

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Coothankandaswamy, V., Reddy, S. K., Martin, P. M., Thangaraju, M., Smith, S. B. & Ganapathy, V., Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells
Phenotype
Histone Deacetylases
26 Citations (Scopus)

Molecular and biochemical characterization of folate transport proteins in retinal müller cells

Renee Bozard, B., Ganapathy, P. S., Duplantier, J., Mysona, B., Ha, Y., Roon, P., Smith, R., David Goldman, I., Prasad, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Jun 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Ependymoglial Cells
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
Folic Acid
29 Citations (Scopus)

Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid

Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B. & Wiggert, B., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Tretinoin
Genes
Proteins
Testis
Cytoplasm
15 Citations (Scopus)

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Human Mammary Glands
Breast
Mouse mammary tumor virus
18 Citations (Scopus)
Fetal Hemoglobin
Erythroid Cells
Retinal Pigments
Globins
Retina
4 Citations (Scopus)

Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice

Markand, S., Saul, A. B., Tawfik, A. M., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Phenotype
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Blood Vessels
4 Citations (Scopus)

Opsin synthesis in the c57BL/6-mivit/mivit mouse model of retinal degeneration

Smith, S. B., McCoy, J. R. & Cope, B. K., Jan 1 1993, In : Current Eye Research. 12, 8, p. 711-717 7 p.

Research output: Contribution to journalArticle

Opsins
Retinal Degeneration
Leucine
Photoreceptor Cells
Retina
3 Citations (Scopus)

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journalArticle

Fumarates
Sickle Cell Anemia
Oxidative stress
Pathology
Oxidative Stress
55 Citations (Scopus)

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

Osmoregulation
Retinal Pigments
Ganglia
Taurine
Mannitol
7 Citations (Scopus)

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

Phenotype
Intercellular Signaling Peptides and Proteins
Posterior Uveitis
Eye Abnormalities
Pathology
40 Citations (Scopus)

Photoreceptor cells in the vitiligo mouse die by apoptosis: TRPM- 2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium

Smith, S. B., Bora, N., McCool, D., Kutty, G., Wong, P., Kutty, R. K. & Wiggert, B., Jan 1 1995, In : Investigative Ophthalmology and Visual Science. 36, 11, p. 2193-2201 9 p.

Research output: Contribution to journalArticle

Clusterin
Photoreceptor Cells
Vitiligo
Retinal Pigment Epithelium
Retina
174 Citations (Scopus)

Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations

Cayouette, M., Smith, S. B., Becerra, S. P. & Gravel, C., Dec 1999, In : Neurobiology of Disease. 6, 6, p. 523-532 10 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Serine Proteinase Inhibitors
Retinitis Pigmentosa
Retinal Pigments
Retinoblastoma
20 Citations (Scopus)

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

Eicosanoids
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
NADPH Oxidase
Hydroxyeicosatetraenoic Acids
Diabetic Retinopathy
18 Citations (Scopus)

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis

Gnana-Prakasam, J. P., Reddy, S. K., Veeranan-Karmegam, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Nov 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 12, p. 9279-9286 8 p.

Research output: Contribution to journalArticle

Iron Overload
Hemochromatosis
Retinal Pigment Epithelium
Heme
Retina
24 Citations (Scopus)

Prediction of diabetic retinopathy: Role of oxidative stress and relevance of apoptotic biomarkers

Al-Shabrawey, M. & Smith, S. B., Mar 1 2010, In : EPMA Journal. 1, 1, p. 56-72 17 p.

Research output: Contribution to journalArticle

Oxidative stress
Biomarkers
Diabetic Retinopathy
Cell death
Oxidative Stress
67 Citations (Scopus)
Pentazocine
Retinal Ganglion Cells
Glutamic Acid
Homocysteine
Ligands
24 Citations (Scopus)

Progesterone inhibits folic acid transport in human trophoblasts

Keating, E., Gonçalves, P., Lemos, C., Costa, F., Campos, I., Smith, S. B., Bridges, C. C. & Martel, F., Apr 1 2007, In : Journal of Membrane Biology. 216, 2-3, p. 143-152 10 p.

Research output: Contribution to journalArticle

Trophoblasts
Folic Acid
Progesterone
Reduced Folate Carrier Protein
Estradiol
3 Citations (Scopus)

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A. M., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In : Current Eye Research. 41, 8, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Retina
Membranes
Gene Expression
Intestines
11 Citations (Scopus)
Growth Hormone-Releasing Hormone
Diabetic Retinopathy
Retina
Streptozocin
Hormone Antagonists
42 Citations (Scopus)
Reduced Folate Carrier Protein
Limb Buds
Yolk Sac
Rhombencephalon
Neural Tube
29 Citations (Scopus)

Reduction of phagosomes in the vitiligo (C57BL/6-mi(vit)/mi(vit)) mouse model of retinal degeneration

Smith, S. B., Cope, B. K., McCoy, J. R., McCool, D. J. & Defoe, D. M., Jan 1 1994, In : Investigative Ophthalmology and Visual Science. 35, 10, p. 3625-3632 8 p.

Research output: Contribution to journalArticle

Phagosomes
Retinal Degeneration
Vitiligo
Retinal Pigment Epithelium
Rod Cell Outer Segment
9 Citations (Scopus)

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Proton-Coupled Folate Transporter
Neuroglia
Fumarates
Pharmaceutical Preparations
Retinal Diseases
14 Citations (Scopus)
Reduced Folate Carrier Protein
Retinal Pigments
Homocysteine
Epithelial Cells
Folic Acid
7 Citations (Scopus)

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

Naggar, H., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Jan 1 2005, In : Current Eye Research. 30, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Folic Acid
Epithelial Cells
Folic Acid Transporters
2 Citations (Scopus)

Regulation of taurine transporter activity in cultured rat retinal ganglion cells and rat retinal Müller cells

Eissa, L. A., Smith, S. B. & El-Sherbeny, A. A., Jan 1 2006, In : Saudi Pharmaceutical Journal. 14, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Taurine
Nitric Oxide Donors
Diabetic Retinopathy
Glutamic Acid
45 Citations (Scopus)

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Dec 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Retinal Pigments
Taurine
Nitric Oxide
Epithelial Cells
Nitric Oxide Donors
20 Citations (Scopus)

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

Research output: Contribution to journalArticle

Siderophores
Hemochromatosis
Retina
Cholesterol
Iron
25 Citations (Scopus)

Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells

Smith, S. B., Huang, W., Chancy, C. & Ganapathy, V., Apr 13 1999, In : Biochemical and Biophysical Research Communications. 257, 2, p. 279-283 5 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Retinal Pigments
Nitric Oxide
Epithelial Cells
Sulfhydryl Compounds
6 Citations (Scopus)

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M. W., Isales, C. M., Elsalanty, M. E., Smith, S. B., Liou, G. I. & Fulzele, S. T., Jan 1 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Bone
Bone Marrow
Bone and Bones
Oxidative Stress
3 Citations (Scopus)

Relationship between Sigma-1 receptor and BDNF in the visual system

Mysona, B. A., Zhao, J., Smith, S. B. & Bollinger, K. E., Feb 1 2018, In : Experimental eye research. 167, p. 25-30 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Optic Disk
Astrocytes
Retina
Retinal Ganglion Cells
54 Citations (Scopus)

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Sugita, S., Futagami, Y., Smith, S. B., Naggar, H. & Mochizuki, M., Dec 1 2006, In : Experimental Eye Research. 83, 6, p. 1459-1471 13 p.

Research output: Contribution to journalArticle

Ciliary Body
Transforming Growth Factor beta
Epithelium
T-Lymphocytes
Retinal Pigment Epithelium
20 Citations (Scopus)

Retinal degeneration in the mouse. A model induced transplaceatally by methylnitrosourea

Smith, S. B. & Yielding, K. L., Jan 1 1986, In : Experimental Eye Research. 43, 5, p. 791-801 11 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Retinal Degeneration
Retina
Retinal Dysplasia
Teratogens
10 Citations (Scopus)

Retinal degeneration in the mouse induced transplacentally by N-methyl-N-nitrosourea: Effects of constant illumination or total darkness

Smith, S. B., Hashimi, W. & Yielding, K. L., Jan 1 1988, In : Experimental Eye Research. 47, 3, p. 347-359 13 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Retinal Degeneration
Darkness
Lighting
Light
3 Citations (Scopus)

Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In : Molecular Vision. 20, p. 561-574 14 p.

Research output: Contribution to journalArticle

Serine Proteases
Retina
Homeostasis
Iron
Hepcidins
15 Citations (Scopus)
Methylenetetrahydrofolate Reductase (NADPH2)
Hyperhomocysteinemia
Retinal Ganglion Cells
Immunohistochemistry
Electroretinography
27 Citations (Scopus)

Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption

Marcus, D. M., Rustgi, A. K., Defoe, D., Brooks, S. E., McCormick, R. S., Thompson, T. P., Edelmann, W., Kucherlapati, R. & Smith, S. B., Jan 1 1997, In : Archives of Ophthalmology. 115, 5, p. 645-650 6 p.

Research output: Contribution to journalArticle

APC Genes
Retinal Pigment Epithelium
Adenomatous Polyposis Coli
Codon
Retina
4 Citations (Scopus)

Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In : Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

Research output: Contribution to journalArticle

Cytomegalovirus Retinitis
Muromegalovirus
Receptor-Interacting Protein Serine-Threonine Kinases
Caspases
Caspase 3
4 Citations (Scopus)

Role of sigma 1 receptor in retinal degeneration of the Ins2Akita/+ murine model of diabetic retinopathy

Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Diabetic Retinopathy
Pentazocine
Gliosis
Ganglia
20 Citations (Scopus)

Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine sensitivity of RGC-5 cells to homocysteine

Ganapathy, P. S., Dun, Y., Ha, Y., Duplantier, J., Allen, J. B., Farooq, A., Bozard, B. R. & Smith, S. B., Jan 1 2010, In : Current Eye Research. 35, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

Staurosporine
Homocysteine
Cell Death
Ganglia
Neurites
38 Citations (Scopus)

Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina

Dun, Y., Duplantier, J., Roon, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2008, In : Journal of Neurochemistry. 104, 4, p. 970-978 9 p.

Research output: Contribution to journalArticle

Ganglia
Serine
Retina
Vertebrates
serine racemase
6 Citations (Scopus)
astrocytes
Optic Disk
optics
Astrocytes
Optics
48 Citations (Scopus)

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc -, the Na+-independent glutamate-cystine exchanger

Wang, J., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In : Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

Research output: Contribution to journalArticle

Oxidative stress
Cystine
Neuroglia
Glutamic Acid
Oxidative Stress
9 Citations (Scopus)

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Shanmugam, A. K., Wang, J., Markand, S., Perry, R. L., Tawfik, A. M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In : Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

Research output: Contribution to journalArticle

Interleukin-12
Neuroglia
Lipopolysaccharides
Chemical activation
Cytokines
53 Citations (Scopus)

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons

Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V. & Smith, S. B., Jan 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 527-540 14 p.

Research output: Contribution to journalArticle

Retinal Neurons
Pentazocine
Endoplasmic Reticulum Stress
Oxidative Stress
Phosphorylation
29 Citations (Scopus)

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Retina
Transcriptome
Proto-Oncogene Proteins c-bcl-2
Cell Death
31 Citations (Scopus)

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Microglia
Ligands
Lipopolysaccharides
88 Citations (Scopus)

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E. & Ganapathy, V., Dec 15 2006, In : Cancer Research. 66, 24, p. 11560-11564 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pyruvic Acid
Apoptosis
Lactic Acid
Neoplasms
19 Citations (Scopus)

Stable and efficient gene transfer into the mutant retinal pigment epithelial cells of the Mitf(vit) mouse using a lentiviral vector

Galileo, D. S., Hunter, K. & Smith, S. B., Jan 1 1999, In : Current Eye Research. 18, 2, p. 135-142 8 p.

Research output: Contribution to journalArticle

Retinal Pigments
Epithelial Cells
Vitiligo
Microphthalmos
Photoreceptor Cells
76 Citations (Scopus)

Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39469-39476 8 p.

Research output: Contribution to journalArticle

Citric Acid
Brain
Sodium
Liver
Rats