• 6113 Citations
  • 42 h-Index
1986 …2020

Research output per year

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Research Output

Article

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)

Ha, Y., Saul, A. B., Tawfik, A. M., Williams, C., Bollinger, K. E., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Sep 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7749-7760 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitfvit mouse model of retinal degeneration

Duncan, T., Swint, C., Smith, S. B. & Wiggert, B. N., Jan 1 1999, In : Molecular Vision. 5, 9

Research output: Contribution to journalArticle

8 Scopus citations

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Coothankandaswamy, V., Reddy, S. K., Martin, P. M., Thangaraju, M., Smith, S. B. & Ganapathy, V., Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular and biochemical characterization of folate transport proteins in retinal müller cells

Renee Bozard, B., Ganapathy, P. S., Duplantier, J., Mysona, B., Ha, Y., Roon, P., Smith, R., David Goldman, I., Prasad, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Jun 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3226-3235 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid

Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B. & Wiggert, B., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., Nov 6 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
20 Scopus citations

Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice

Markand, S., Saul, A. B., Tawfik, A. M., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Opsin synthesis in the c57BL/6-mivit/mivit mouse model of retinal degeneration

Smith, S. B., McCoy, J. R. & Cope, B. K., Jan 1 1993, In : Current Eye Research. 12, 8, p. 711-717 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Photoreceptor cells in the vitiligo mouse die by apoptosis: TRPM- 2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium

Smith, S. B., Bora, N., McCool, D., Kutty, G., Wong, P., Kutty, R. K. & Wiggert, B., Jan 1 1995, In : Investigative Ophthalmology and Visual Science. 36, 11, p. 2193-2201 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations

Cayouette, M., Smith, S. B., Becerra, S. P. & Gravel, C., Dec 1999, In : Neurobiology of Disease. 6, 6, p. 523-532 10 p.

Research output: Contribution to journalArticle

178 Scopus citations

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis

Gnana-Prakasam, J. P., Reddy, S. K., Veeranan-Karmegam, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Nov 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 12, p. 9279-9286 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Khaled, M. L., Bykhovskaya, Y., Gu, C., Liu, A., Drewry, M. D., Chen, Z., Mysona, B. A., Parker, E., McNabb, R. P., Yu, H., Lu, X., Wang, J., Li, X., Al-Muammar, A., Rotter, J. I., Porter, L. F., Estes, A., Watsky, M. A., Smith, S. B., Xu, H. & 5 others, Abu-Amero, K. K., Kuo, A., Shears, S. B., Rabinowitz, Y. S. & Liu, Y., Dec 1 2019, In : Scientific reports. 9, 1, 19406.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Prediction of diabetic retinopathy: Role of oxidative stress and relevance of apoptotic biomarkers

Al-Shabrawey, M. & Smith, S., Mar 1 2010, In : EPMA Journal. 1, 1, p. 56-72 17 p.

Research output: Contribution to journalArticle

28 Scopus citations
68 Scopus citations

Progesterone inhibits folic acid transport in human trophoblasts

Keating, E., Gonçalves, P., Lemos, C., Costa, F., Campos, I., Smith, S. B., Bridges, C. C. & Martel, F., Apr 1 2007, In : Journal of Membrane Biology. 216, 2-3, p. 143-152 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In : Current Eye Research. 41, 8, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
14 Scopus citations
42 Scopus citations

Reduction of phagosomes in the vitiligo (C57BL/6-mi(vit)/mi(vit)) mouse model of retinal degeneration

Smith, S. B., Cope, B. K., McCoy, J. R., McCool, D. J. & Defoe, D. M., Jan 1 1994, In : Investigative Ophthalmology and Visual Science. 35, 10, p. 3625-3632 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 1 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
14 Scopus citations

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

Naggar, H., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Jan 1 2005, In : Current Eye Research. 30, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of taurine transporter activity in cultured rat retinal ganglion cells and rat retinal Müller cells

Eissa, L. A., Smith, S. B. & El-Sherbeny, A. A., Jan 1 2006, In : Saudi Pharmaceutical Journal. 14, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6, p. C1825-C1836

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells

Smith, S. B., Huang, W., Chancy, C. & Ganapathy, V., Apr 13 1999, In : Biochemical and Biophysical Research Communications. 257, 2, p. 279-283 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., Dec 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Relationship between Sigma-1 receptor and BDNF in the visual system

Mysona, B. A., Zhao, J., Smith, S. & Bollinger, K. E., Feb 2018, In : Experimental eye research. 167, p. 25-30 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Sugita, S., Futagami, Y., Smith, S. B., Naggar, H. & Mochizuki, M., Dec 1 2006, In : Experimental eye research. 83, 6, p. 1459-1471 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Retinal degeneration in the mouse. A model induced transplaceatally by methylnitrosourea

Smith, S. B. & Yielding, K. L., Jan 1 1986, In : Experimental Eye Research. 43, 5, p. 791-801 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Retinal degeneration in the mouse induced transplacentally by N-methyl-N-nitrosourea: Effects of constant illumination or total darkness

Smith, S. B., Hashimi, W. & Yielding, K. L., Sep 1988, In : Experimental eye research. 47, 3, p. 347-359 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In : Molecular Vision. 20, p. 561-574 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
16 Scopus citations

Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption

Marcus, D. M., Rustgi, A. K., Defoe, D., Brooks, S. E., McCormick, R. S., Thompson, T. P., Edelmann, W., Kucherlapati, R. & Smith, S., Jan 1 1997, In : Archives of Ophthalmology. 115, 5, p. 645-650 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In : Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Role of sigma 1 receptor in retinal degeneration of the Ins2Akita/+ murine model of diabetic retinopathy

Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine sensitivity of RGC-5 cells to homocysteine

Ganapathy, P. S., Dun, Y., Ha, Y., Duplantier, J., Allen, J. B., Farooq, A., Bozard, B. R. & Smith, S. B., Jan 1 2010, In : Current Eye Research. 35, 1, p. 80-90 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina

Dun, Y., Duplantier, J., Roon, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2008, In : Journal of Neurochemistry. 104, 4, p. 970-978 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
8 Scopus citations

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc-, the Na+-independent glutamate-cystine exchanger

Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In : Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

Research output: Contribution to journalArticle

56 Scopus citations

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In : Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons

Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V. & Smith, S. B., Jan 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 527-540 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E. & Ganapathy, V., Dec 15 2006, In : Cancer Research. 66, 24, p. 11560-11564 5 p.

Research output: Contribution to journalArticle

95 Scopus citations