• 5769 Citations
  • 42 h-Index
1986 …2019
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Research Output 1986 2019

Article
96 Citations (Scopus)

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells

Bridges, C. C., Kekuda, R., Wang, H., Prasad, P. D., Mehta, P., Huang, W., Smith, S. B. & Ganapathy, V., Jan 30 2001, In : Investigative Ophthalmology and Visual Science. 42, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Retinal Pigments
Cystine
Epithelial Cells
Light
7 Citations (Scopus)

Synthesis and secretion of interphotoreceptor retinoid-binding protein (IRBP) and developmental expression of IRBP mRNA in normal and rd mouse retinas

Smith, S. B., Lee, L., Nickerson, J., Si, J. S., Chader, G. J. & Wiggert, B., Jun 1992, In : Experimental eye research. 54, 6, p. 957-963 7 p.

Research output: Contribution to journalArticle

Retina
Messenger RNA
Methionine
interstitial retinol-binding protein
Organ Culture Techniques
3 Citations (Scopus)
Butylated Hydroxytoluene
Animals
Antioxidants
Nutrition
Purkinje Cells
19 Citations (Scopus)

The localization and timing of post-translational modifications of rat rhodopsin

St Jules, R. S., Smith, S. B. & O'Brien, P. J., Jan 1 1990, In : Experimental Eye Research. 51, 4, p. 427-434 8 p.

Research output: Contribution to journalArticle

Rhodopsin
Post Translational Protein Processing
Rod Cell Outer Segment
Rough Endoplasmic Reticulum
Glucosamine
3 Citations (Scopus)

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Molecular Chaperones
Cones
Modulation
Antioxidant Response Elements
78 Citations (Scopus)

The rhodopsin cycle is preserved in IRBP 'knockout' mice despite abnormalities in retinal structure and function

Ripps, H., Peachey, N. S., Xu, X., Nozell, S. E., Smith, S. B. & Liou, G. I., Jan 1 2000, In : Visual Neuroscience. 17, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Rhodopsin
Knockout Mice
Retinoids
Retina
Light
51 Citations (Scopus)

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Homocysteine
N-Methyl-D-Aspartate Receptors
D-Aspartic Acid
Ganglia
2 Citations (Scopus)

The role of sigma1R in mammalian retina

Wang, J., Cui, X., Roon, P., Saul, A. B. & Smith, S. B., Jan 1 2017, In : Advances in experimental medicine and biology. 964, p. 267-284 18 p.

Research output: Contribution to journalArticle

Retina
Ganglia
sigma-1 receptor
Cells
Photoreceptor Cells
30 Citations (Scopus)
Autosomal Dominant Optic Atrophy
Dynamins
Optics
Mitochondrial Dynamics
Fusion reactions
62 Citations (Scopus)

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N., Ganapathy, V. & Smith, S. B., Apr 7 2004, In : Molecular Brain Research. 123, 1-2, p. 66-75 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Retinal Ganglion Cells
Homocysteine
Glutamic Acid
13 Citations (Scopus)

The use of C0t-1 probe DNA for the detection of low levels of DNA fragmentation.

Wong, P., Smith, S. B., Bora, N. & Gentleman, S., Jan 1 1994, In : Biochemistry and cell biology = Biochimie et biologie cellulaire. 72, 11-12, p. 649-653 5 p.

Research output: Contribution to journalArticle

DNA Probes
DNA Fragmentation
DNA
Ladders
Ethidium
27 Citations (Scopus)

Transcellular transfer of folate across the retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Ola, M. S., Ganapathy, V. & Smith, S. B., Jan 1 2002, In : Current Eye Research. 24, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Folic Acid
Membranes
Reduced Folate Carrier Protein
Photoreceptor Cells
19 Citations (Scopus)

Transient hyperglycosylation of rhodopsin with galactose

Smith, S. B., St Jules, R. S. & O'Brien, P. J., Jan 1 1991, In : Experimental eye research. 53, 4, p. 525-537 13 p.

Research output: Contribution to journalArticle

Rhodopsin
Galactose
Rod Cell Outer Segment
Oligosaccharides
Griffonia
26 Citations (Scopus)

Transient overexpression of the microphthalmia gene in the eyes of microphthalmia vitiligo mutant mice

Bora, N., Conway, S. J., Liang, H. & Smith, S. B., Nov 1 1998, In : Developmental Dynamics. 213, 3, p. 283-292 10 p.

Research output: Contribution to journalArticle

Microphthalmos
Vitiligo
Retinal Pigment Epithelium
Pigmentation
Genes
97 Citations (Scopus)

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl --Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

Hatanaka, T., Haramura, M., Fei, Y. J., Miyauchi, S., Bridges, C. C., Ganapathy, P. S., Smith, S. B., Ganapathy, V. & Ganapathy, M. E., Mar 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 3, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

valacyclovir
Amino Acid Transport Systems
Prodrugs
Aspartic Acid
Amino Acids
65 Citations (Scopus)

Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

Hatanaka, T., Huang, W., Nakanishi, T., Bridges, C. C., Ganapathy, V., Smith, S. B., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Serine
Colon
Enantiomers
Intestines
7 Citations (Scopus)

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis

Chothe, P. P., Gnana-Prakasam, J. P., Ananth, S., Martin, P. M., Kannan, R., Hinton, D. R., Smith, S. B. & Ganapathy, V., Feb 11 2011, In : Biochemical and Biophysical Research Communications. 405, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

Hepcidins
Oligopeptides
Retinal Pigments
Peptide Hormones
Homeostasis
25 Citations (Scopus)
Sodium
Canavan Disease
Dicarboxylic Acid Transporters
Optic Nerve Diseases
Messenger RNA
68 Citations (Scopus)

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Mar 1 2007, In : Pharmaceutical Research. 24, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

Niacin
Oocytes
Pharmaceutical Preparations
Epithelial Cells
Membranes
7 Citations (Scopus)

Transport of the synthetic opioid peptide DADLE ([d-Ala2,d-Leu5]-Enkephalin) in neuronal cells

Ananth, S., Thakkar, S. V., Gnana-Prakasam, J. P., Martin, P. M., Ganapathy, P. S., Smith, S. B. & Ganapathy, V., Jan 1 2012, In : Journal of Pharmaceutical Sciences. 101, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Opioid Peptides
Enkephalins
Oligopeptides
Peptidomimetics
Leucine Enkephalin
13 Citations (Scopus)

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells

Babu, E., Ananth, S., Veeranan-Karmegam, R., Coothankandaswamy, V., Smith, S. B., Boettger, T., Ganapathy, V. & Martin, P. M., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5749-5757 9 p.

Research output: Contribution to journalArticle

Retinal Pigments
Glutathione
Epithelial Cells
Retina
Ibuprofen
5 Citations (Scopus)

Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption

Marcus, D. M., Rustgi, A. K., Defoe, D., Kucherlapati, R., Edelmann, W., Hamasaki, D., Liou, G. I. & Smith, S. B., Dec 1 2000, In : Molecular Vision. 6, 23, p. 169-177 9 p.

Research output: Contribution to journalArticle

APC Genes
Adenomatous Polyposis Coli
Light
Mutation
Codon
22 Citations (Scopus)

Ultrastructural features of retinal dystrophy in mutant vitiligo mice

Nir, I., Ransom, N. & Smith, S. B., Jan 1 1995, In : Experimental eye research. 61, 3, p. 363-377 15 p.

Research output: Contribution to journalArticle

Retinal Dystrophies
Vitiligo
Epithelium
Melanosomes
Rod Cell Outer Segment
Chapter

D-serine and serine racemase in the retina

Smith, S. B., Ha, Y. & Ganapathy, V., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

retina
serine
Serine
Retina
Retinal Neurons

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperhomocysteinemia
Folic Acid
Retina
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
2 Citations (Scopus)

Mechanisms of ER Stress in Retinal Disease

Smith, S. B., Dec 1 2012, Retina Fifth Edition. Elsevier Inc., Vol. 1. p. 529-536 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retinal Diseases
Comment/debate
Letter
17 Citations (Scopus)
Photoreceptor Cells
Vitiligo
Inbred C57BL Mouse
Retina
Guinea Pigs
2 Citations (Scopus)

Rapid PCR-based construction of specifically enriched libraries from small retina samples

Putilina, T., Smith, S., Gentleman, S. & Chader, G., May 1992, In : Experimental eye research. 54, 5, p. 825-826 2 p.

Research output: Contribution to journalLetter

Retinal Diseases
Gene Library
Libraries
Retina
Polymerase Chain Reaction
Review article
16 Citations (Scopus)

Diabetic retinopathy and the NMDA receptor

Smith, S. B., Jul 2 2002, In : Drug News and Perspectives. 15, 4, p. 226-232 7 p.

Research output: Contribution to journalReview article

Diabetic Retinopathy
N-Methyl-D-Aspartate Receptors
Retina
Glutamate Receptors
N-Methylaspartate
30 Citations (Scopus)

Expression and function of iron-regulatory proteins in retina

Gnana-Prakasam, J. P., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2010, In : IUBMB Life. 62, 5, p. 363-370 8 p.

Research output: Contribution to journalReview article

Iron-Regulatory Proteins
Retina
Iron
Hemochromatosis
Iron Overload
9 Citations (Scopus)

Sigma 1 receptor: A novel therapeutic target in retinal disease

Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 1 2018, In : Progress in Retinal and Eye Research. 67, p. 130-149 20 p.

Research output: Contribution to journalReview article

Retinal Diseases
Therapeutics
Retina
sigma-1 receptor
Photoreceptor Cells
117 Citations (Scopus)

SLC19: The folate/thiamine transporter family

Ganapathy, V., Smith, S. B. & Prasad, P. D., Feb 1 2004, In : Pflugers Archiv European Journal of Physiology. 447, 5, p. 641-646 6 p.

Research output: Contribution to journalReview article

Folic Acid Transporters
Thiamine
Folic Acid
Genes
Substrates
244 Citations (Scopus)

The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities

Lewerenz, J., Hewett, S. J., Huang, Y., Lambros, M., Gout, P. W., Kalivas, P. W., Massie, A., Smolders, I., Methner, A., Pergande, M., Smith, S. B., Ganapathy, V. & Maher, P., Feb 10 2013, In : Antioxidants and Redox Signaling. 18, 5, p. 522-555 34 p.

Research output: Contribution to journalReview article

Antiporters
Cystine
Glutamic Acid
Health
Neurology