• 5720 Citations
  • 41 h-Index
1986 …2019
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Research Output 1986 2019

Review article
16 Citations (Scopus)

Diabetic retinopathy and the NMDA receptor

Smith, S. B., Jul 2 2002, In : Drug News and Perspectives. 15, 4, p. 226-232 7 p.

Research output: Contribution to journalReview article

Diabetic Retinopathy
N-Methyl-D-Aspartate Receptors
Retina
Glutamate Receptors
N-Methylaspartate
30 Citations (Scopus)

Expression and function of iron-regulatory proteins in retina

Gnana-Prakasam, J. P., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2010, In : IUBMB Life. 62, 5, p. 363-370 8 p.

Research output: Contribution to journalReview article

Iron-Regulatory Proteins
Retina
Iron
Hemochromatosis
Iron Overload
5 Citations (Scopus)

Sigma 1 receptor: A novel therapeutic target in retinal disease

Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 1 2018, In : Progress in Retinal and Eye Research. 67, p. 130-149 20 p.

Research output: Contribution to journalReview article

Retinal Diseases
Therapeutics
Retina
sigma-1 receptor
Photoreceptor Cells
117 Citations (Scopus)

SLC19: The folate/thiamine transporter family

Ganapathy, V., Smith, S. B. & Prasad, P. D., Feb 1 2004, In : Pflugers Archiv European Journal of Physiology. 447, 5, p. 641-646 6 p.

Research output: Contribution to journalReview article

Folic Acid Transporters
Thiamine
Folic Acid
Genes
Substrates
239 Citations (Scopus)

The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities

Lewerenz, J., Hewett, S. J., Huang, Y., Lambros, M., Gout, P. W., Kalivas, P. W., Massie, A., Smolders, I., Methner, A., Pergande, M., Smith, S. B., Ganapathy, V. & Maher, P., Feb 10 2013, In : Antioxidants and Redox Signaling. 18, 5, p. 522-555 34 p.

Research output: Contribution to journalReview article

Antiporters
Cystine
Glutamic Acid
Health
Neurology
Letter
17 Citations (Scopus)
Photoreceptor Cells
Vitiligo
Inbred C57BL Mouse
Retina
Guinea Pigs
2 Citations (Scopus)

Rapid PCR-based construction of specifically enriched libraries from small retina samples

Putilina, T., Smith, S., Gentleman, S. & Chader, G., May 1992, In : Experimental eye research. 54, 5, p. 825-826 2 p.

Research output: Contribution to journalLetter

Retinal Diseases
Gene Library
Libraries
Retina
Polymerase Chain Reaction
Comment/debate
Chapter

D-serine and serine racemase in the retina

Smith, S. B., Ha, Y. & Ganapathy, V., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

retina
serine
Serine
Retina
Retinal Neurons

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperhomocysteinemia
Folic Acid
Retina
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
2 Citations (Scopus)

Mechanisms of ER Stress in Retinal Disease

Smith, S. B., Dec 1 2012, Retina Fifth Edition. Elsevier Inc., Vol. 1. p. 529-536 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retinal Diseases
Article
13 Citations (Scopus)

(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

Research output: Contribution to journalArticle

Pentazocine
Retinal Ganglion Cells
N-Methylaspartate
Cell Death
Knockout Mice

Abnormalities of the retinal pigment epithelium in transgenic mice with APC gene modification

Coulter, E., Rustgi, A., Defoe, D., Smith, S., Kucherlapati, R. & Marcus, D., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S383

Research output: Contribution to journalArticle

APC Genes
Retinal Pigment Epithelium
Transgenic Mice
Histology
Photoreceptor Cells
34 Citations (Scopus)

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: Role of cystine/glutamate exchanger

Gnana-Prakasam, J. P., Thangaraju, M., Liu, K., Ha, Y., Martin, P. M., Smith, S. B. & Ganapathy, V., Dec 1 2009, In : Biochemical Journal. 424, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Retinal Pigments
Cystine
Retinal Pigment Epithelium
Glutamic Acid
5 Citations (Scopus)
Photoreceptor Cells
Retinitis Pigmentosa
Cell Death
Endoplasmic Reticulum Stress
Gliosis
22 Citations (Scopus)

Acetylcholine's effect on vascular resistance and compliance in the pulmonary circulation

Barman, S. A., Senteno, E., Smith, S. B. & Taylor, A. E., Jan 1 1989, In : Journal of Applied Physiology. 67, 4, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

Pulmonary Circulation
Vascular Resistance
Compliance
Acetylcholine
Blood Vessels
17 Citations (Scopus)

A comparison of caveolae and caveolin-1 to folate receptor α in retina and retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Roon, P., Shamsul Ola, M., Kekuda, R., Ganapathy, V., Cameron, R. S., Cameron, P. L. & Smith, S. B., Jan 1 2001, In : Histochemical Journal. 33, 3, p. 149-158 10 p.

Research output: Contribution to journalArticle

Caveolin 1
Caveolae
Retinal Pigment Epithelium
Folic Acid
Retina
27 Citations (Scopus)
Retinal Degeneration
Molecular Chaperones
Retinal Diseases
Photoreceptor Cells
Retinal Cone Photoreceptor Cells
8 Citations (Scopus)

Acylation and glycosylation of rhodopsin in the rd mouse

Smith, S. B. & O'Brien, P. J., Jan 1 1991, In : Experimental eye research. 52, 5, p. 599-606 8 p.

Research output: Contribution to journalArticle

Rhodopsin
Acylation
Glycosylation
Rod Cell Outer Segment
Leucine
12 Citations (Scopus)

Addition of the chromophore to rat rhodopsin is an early post-translational event

St Jules, R. S., Wallingford, J. C., Smith, S. B. & O'Brien, P. J., Jan 1 1989, In : Experimental Eye Research. 48, 5, p. 653-665 13 p.

Research output: Contribution to journalArticle

Rhodopsin
Rough Endoplasmic Reticulum
Rod Cell Outer Segment
Agarose Chromatography
Intravitreal Injections
31 Citations (Scopus)

Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Yu, M., Sturgill-Short, G., Ganapathy, P., Tawfik, A. M., Peachey, N. S. & Smith, S. B., Mar 1 2012, In : Experimental eye research. 96, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Hyperhomocysteinemia
Homocysteine
Retinal Pigments
Visual Evoked Potentials
22 Citations (Scopus)

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journalArticle

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
NADPH Oxidase
Arachidonate 15-Lipoxygenase
Diabetic Retinopathy
Hyperglycemia
12 Citations (Scopus)

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Hyperhomocysteinemia
Homocysteine
Tight Junctions
Blood-Retinal Barrier
14 Citations (Scopus)

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A. M., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Jan 1 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journalArticle

Cystathionine
Hyperhomocysteinemia
Zonula Occludens-1 Protein
Occludin
Blood Vessels
9 Citations (Scopus)
Vitiligo
Retinal Pigments
Esterification
Retinoids
Esters
4 Citations (Scopus)

Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In : Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

Research output: Contribution to journalArticle

Glutathione Synthase
Cystathionine
Methylenetetrahydrofolate Reductase (NADPH2)
Hydrogen Sulfide
Taurine
38 Citations (Scopus)

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Retina
Streptozocin
N-Methyl-D-Aspartate Receptors
118 Citations (Scopus)

Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine

Martin, P. M., El-sherbeny, A., Roon, P., Schoenlein, P. V., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : Experimental Eye Research. 73, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

Excitatory Amino Acids
Retinal Ganglion Cells
Homocysteine
Cell Death
Ganglia
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
116 Citations (Scopus)

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

Samaddar, J. S., Gaddy, V. T., Duplantier, J., Thandavan, S. P., Shah, M., Smith, M. J., Browning, D., Rawson, J., Smith, S. B., Barrett, J. T. & Schoenlein, P. V., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2977-2987 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Autophagy
Cell Death
Breast Neoplasms
Caspases
9 Citations (Scopus)
Rod Cell Outer Segment
Retinal Degeneration
Vitiligo
Retina
Radioactivity
4 Citations (Scopus)
Methylnitrosourea
Phospholipids
Proteins
Rod Cell Outer Segment
Alkylating Agents
54 Citations (Scopus)

c/ebpδ null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney

Thangaraju, M., Ananth, S., Martin, P. M., Roon, P., Smith, S. B., Sterneck, E., Prasad, P. D. & Ganapathy, V., Sep 15 2006, In : Journal of Biological Chemistry. 281, 37, p. 26769-26773 5 p.

Research output: Contribution to journalArticle

Lactic Acid
Kidney
Uric Acid
Monocarboxylic Acid Transporters
Tissue
34 Citations (Scopus)
Photoreceptor Cells
Retinal Degeneration
Rhodopsin
Retina
Light
3 Citations (Scopus)

Ciliary neurotrophic factor (CNTF) induces reactive gliosis and gfap expression in müller cells

Sarthy, V., Brodjian, S. J. & Smith, S. B., Dec 1 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Gliosis
Glial Fibrillary Acidic Protein
Retina
Staining and Labeling
35 Citations (Scopus)

Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway

Wang, Y., Smith, S. B., Ogilvie, J. M., McCool, D. J. & Sarthy, V., Oct 23 2002, In : Current Eye Research. 24, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Glial Fibrillary Acidic Protein
Signal Transduction
Immunohistochemistry
Intravitreal Injections
43 Citations (Scopus)
Proton-Coupled Folate Transporter
Retina
Organism Cloning
Folic Acid
Xenopus laevis
15 Citations (Scopus)

Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In : Journal of Immunology. 187, 9, p. 4426-4430 5 p.

Research output: Contribution to journalArticle

Myeloid Cells
Knockout Mice
Cell Lineage
Genetic Promoter Regions
Bone Marrow Cells
11 Citations (Scopus)

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A. M., Ha, Y., Gnana-Prakasam, J. P., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 1 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Retina
Cystathionine
Liver
Enzyme Assays
312 Citations (Scopus)

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

Retinal Neurons
Streptozocin
Ganglia
Retina
Cell Death
10 Citations (Scopus)

Delayed rhodopsin regeneration and altered distribution of interphotoreceptor retinoid binding protein (IRBP) in the mi(vit)/mi(vit) (vitiligo) mouse

Smith, S. B., McClung, J., Wiggert, B. N. & Nir, I., Oct 20 1997, In : Journal of Neurocytology. 26, 9, p. 605-613 9 p.

Research output: Contribution to journalArticle

Vitiligo
Rhodopsin
Regeneration
Retina
Retinal Pigment Epithelium
8 Citations (Scopus)
Iron-Regulatory Proteins
Gliosis
Retina
Blood Vessels
Microglia
Receptor-Interacting Protein Serine-Threonine Kinases
Muromegalovirus
Photoreceptor Cells
Cytomegalovirus Infections
Protein Kinases
2 Citations (Scopus)

Detailed electroretinographic findings in rd8 mice

Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In : Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

Retina
Phenotype
Amacrine Cells
Light
Retinal Degeneration
32 Citations (Scopus)

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor

Ha, Y., Saul, A. B., Tawfik, A. M., Zorrilla, E. P., Ganapathy, V. & Smith, S. B., Nov 30 2012, In : Molecular Vision. 18, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Intraocular Pressure
Neuroprotective Agents
Oxidative Stress
26 Citations (Scopus)

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PloS one. 8, 1, e54692.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Medical problems
diabetes
Chemical activation
Cells
8 Citations (Scopus)

Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: A RPE specific phenomenon

Ananth, S., Zhuang, L., Gopal, E., Itagaki, S., Ellappan, B., Smith, S. B., Ganapathy, V. & Martin, P. M., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 75-80 6 p.

Research output: Contribution to journalArticle

Diclofenac
Xenopus laevis
Anti-Inflammatory Agents
MCF-7 Cells
Pharmaceutical Preparations
11 Citations (Scopus)

Downregulation of cystine transporter xc- by irinotecan in human head and neck cancer FaDu xenografts

Chintala, S., Tóth, K., Yin, M. B., Bhattacharya, A., Smith, S. B., Ola, M. S., Cao, S., Durrani, F. A., Zinia, T. R., Dean, R., Slocum, H. K. & Rustum, Y. M., Jun 1 2010, In : Chemotherapy. 56, 3, p. 223-233 11 p.

Research output: Contribution to journalArticle

irinotecan
Cystine
Head and Neck Neoplasms
Heterografts
Down-Regulation
28 Citations (Scopus)

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Reduced Folate Carrier Protein
Retinal Pigments
Down-Regulation
Epithelial Cells
15 Citations (Scopus)

Dysregulation of system xc- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Jan 1 2014, In : Neurochemistry International. 76, p. 59-69 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Huntington Disease
Oxidative Stress
Cell Line
Proteins